Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

Gandal, Michael J., Haney, Jillian R., Parikshak, Neelroop N., Leppa, Virpi, Ramaswami, Gokul, Hartl, Chris, Schork, Andrew J., Appadurai, Vivek +82 more·2018·Science

DOI 10.1126/science.aad6469

Cited by (1,003)

Items 101–200 of 1,003

An insula hierarchical network architecture for active interoceptive inference
Fermin, Alan S. R., Friston, Karl, Yamawaki, Shigeto · 2022 · Royal Society Open Science
Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk
Andrew E. Jaffe, Daniel J. Hoeppner, Takeshi Saito, Lou T. Blanpain, Joy Ukaigwe, Emily E. Burke, Leonardo Collado‐Torres, Ran Tao, Katsunori Tajinda, Kristen R. Maynard et al. · 2020 · Nature Neuroscience
Transcriptional signatures of the cortical morphometric similarity network gradient in first-episode, treatment-naive major depressive disorder
Kaizhong Xue, Lining Guo, Wenshuang Zhu, Sixiang Liang, Qiang Xu, Lin Ma, Mengge Liu, Yong Zhang, Feng Liu · 2022 · Neuropsychopharmacology
The Neuropsychology of Anxiety
Neil McNaughton, J.A. Gray · 2024
Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs
Alexander B. Niculescu, Helen Le-Niculescu, Daniel F. Levey, K. Roseberry, Katherine C. Soe, J. Rogers, Faisal Khan, T. Jones, S. Judd, M. A. McCormick et al. · 2019 · Molecular Psychiatry
Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits
Wen Zhang, Georgios Voloudakis, Veera Manikandan Rajagopal, Ben Readhead, Joel T. Dudley, Eric E. Schadt, Johan Björkegren, Yungil Kim, John F. Fullard, Gabriel E. Hoffman et al. · 2019 · Nature Communications
Harnessing endophenotypes and network medicine for Alzheimer's drug repurposing
Jiansong Fang, Andrew A. Pieper, Ruth Nussinov, Garam Lee, Lynn M. Bekris, James B. Leverenz, Jeffrey L. Cummings, Feixiong Cheng · 2020 · Medicinal Research Reviews
Neurexins in autism and schizophrenia—a review of patient mutations, mouse models and potential future directions
Alisha Tromp, Bryan J. Mowry, Jean Giacomotto · 2020 · Molecular Psychiatry
Bayesian estimation of cell type–specific gene expression with prior derived from single-cell data
Jiebiao Wang, Kathryn Roeder, Bernie Devlin · 2021 · Genome Research
Wnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind
Joanna Bem, Nikola Brożko, Chaitali Chakraborty, Marcin Andrzej Lipiec, Kamil Koziński, Andrzej Nagalski, Łukasz Mateusz Szewczyk, Marta Barbara Wisniewska · 2019 · FEBS Letters
Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk
Jennie G. Pouget, Buhm Han, Yang Wu, Emmanuel Jean-Marie Mignot, Hanna Maria Ollila, Jonathan Barker, Sarah L. Spain, Nick Dand, Richard C. Trembath, Javier J. Martin et al. · 2019 · Human Molecular Genetics
Genetic regulatory subnetworks and key regulating genes in rat hippocampus perturbed by prenatal malnutrition: implications for major brain disorders
Jiaying Chen, Xinzhi Zhao, Li Cui, Guang He, Xinhui Wang, Fudi Wang, Shiwei Duan, Lin He, Qiang Li, Xiaodan Yu et al. · 2020 · Aging
The pathophysiological impact of stress on the dopamine system is dependent on the state of the critical period of vulnerability
Gomes, Felipe V., Zhu, Xiyu, Grace, Anthony A. · 2020 · Molecular Psychiatry
Identifying psychiatric disorder-associated gut microbiota using microbiota-related gene set enrichment analysis
Shiqiang Cheng, Bei Han, Miao Ding, Yan Fei Wen, Mei Ma, Lu Zhang, Xin Qi, Bolun Cheng, Ping Li, Om Prakash Kafle et al. · 2019 · Briefings in Bioinformatics
Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis
Shraddha Pai, Peipei Li, Bryan A. Killinger, Lee L. Marshall, Peixin Jia, Ji Liao, Artūras Petronis, Piroska E. Szabó, Viviane Labrie · 2019 · Nature Communications
Increased and Decreased Superficial White Matter Structural Connectivity in Schizophrenia and Bipolar Disorder
Ellen Ji, Pamela Guevara, Miguel Guevara, Antoine Grigis, Nicole Labra, Samuel Sarrazin, Nora Hamdani, Frank Bellivier, Marine Delavest, Marion Leboyer et al. · 2019 · Schizophrenia Bulletin
Major Depressive Disorder Is Associated With Differential Expression of Innate Immune and Neutrophil-Related Gene Networks in Peripheral Blood: A Quantitative Review of Whole-Genome Transcriptional Data From Case-Control Studies
Gayle M. Wittenberg, Jon Greene, Petra E. Vértes, Wayne Curtis Drevets, Edward Thomas Bullmore · 2020 · Biological Psychiatry
Emerging evidence for astrocyte dysfunction in schizophrenia
Eva C de Oliveira Figueiredo, Corrado Calì, Francesco Petrelli, Paola Bezzi · 2022 · Glia
The genetic architecture of schizophrenia, bipolar disorder, obsessive-compulsive disorder and autism spectrum disorder
Kevin Sean O’Connell, Nathaniel W. McGregor, Christine Löchner, Robin Alexander Emsley, Louise Warnich · 2018 · Molecular and Cellular Neuroscience
Impaired regulatory T cell control of astroglial overdrive and microglial pruning in schizophrenia
Fabiana Maria das Graças Corsi Zuelli, J.F.W. Deakin · 2021 · Neuroscience & Biobehavioral Reviews
Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility
Christopher Hartl, Gokul Ramaswami, William G. Pembroke, Sandrine Muller, Greta Pintacuda, Ashis Saha, Princy Parsana, Alexis J. Battle, Kasper Lage, Daniel H. Geschwind · 2021 · Nature Neuroscience
Cognitive Dysfunction and Prefrontal Cortical Circuit Alterations in Schizophrenia: Developmental Trajectories
Samuel J. Dienel, Kirsten E. Schoonover, David A. Lewis · 2022 · Biological Psychiatry
Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study
Yihui Zhu, Charles E. Mordaunt, Dag H. Yasui, Ria Marathe, Rochelle L. Coulson, Keith W. Dunaway, Julia M. Jianu, Cheryl K. Walker, Sally J. Ozonoff, Irva Hertz‐Picciotto et al. · 2019 · Human Molecular Genetics
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder
Nora I. Strom, Zachary F. Gerring, Marco Galimberti, Dongmei Yu, Matthew Halvorsen, Abdel Abdellaoui, Cristina Rodriguez‐Fontenla, Julia Sealock, Tim B. Bigdeli, Jonathan R. I. Coleman et al. · 2025 · Nature Genetics
Sex-differential DNA methylation and associated regulation networks in human brain implicated in the sex-biased risks of psychiatric disorders
Xia, Yan, Dai, Rujia, Wang, Kangli, Jiao, Chuan, Zhang, Chunling, Xu, Yuchen, Li, Honglei, Jing, Xi, Chen, Yu, Jiang, Yi et al. · 2021 · Molecular Psychiatry
Recent Advances in the Genetics of Schizophrenia
Dimitrios Avramopoulos · 2018 · Complex Psychiatry
Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes
Charles E. Mordaunt, Julia M. Jianu, Benjamin I. Laufer, Yihui Zhu, Hyeyeon Hwang, Keith W. Dunaway, Kelly M. Bakulski, Jason I. Feinberg, Heather E. Volk, Kristen Lyall et al. · 2020 · Genome Medicine
Evolutionary conservation and divergence of the human brain transcriptome
William G. Pembroke, Christopher Hartl, Daniel H. Geschwind · 2021 · Genome biology
De novo mutations from whole exome sequencing in neurodevelopmental and psychiatric disorders: From discovery to application
Wang, Weidi, Corominas, Roser, Lin, Guan Ning · 2019 · Frontiers in Genetics
Identification of Conserved Proteomic Networks in Neurodegenerative Dementia
Swarup, Vivek, Chang, Timothy S., Duong, Duc M., Dammer, Eric B., Dai, Jingting, Lah, James J., Johnson, Erik C.B., Seyfried, Nicholas T., Levey, Allan I., Geschwind, Daniel H. · 2020 · Cell Reports
Genetic contributions to suicidal thoughts and behaviors
DiBlasi, Emily, Kang, Jooeun, Docherty, Anna R. · 2021 · Psychological Medicine
Chemokine Dysregulation and Neuroinflammation in Schizophrenia: A Systematic Review
Evgeny A. Ermakov, Irina A. Mednova, Anastasiia S. Boiko, Valentina N. Buneva, Svetlana А. Ivanova · 2023 · International Journal of Molecular Sciences
Identification of conserved proteomic networks in neurodegenerative dementia
Swarup, Vivek, Chang, Timothy S., Duong, Duc M., Dammer, Eric B., Lah, James J., Johnson, Erik E.C.B., Seyfried, Nicholas T., Levey, Allan I., Geschwind, Daniel H. · 2019
American psychiatry in the new millennium: a critical appraisal
Andrew T Scull · 2021 · Psychological Medicine
Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder
Karina Griesi‐Oliveira, Mariana Soares Fogo, Bruna Garbes Gonçalves Pinto, Aline Yasuda Alves, Ângela May Suzuki, Andressa Gois Morales, Suzana Ezquina, Julio Sosa, Gavin J. Sutton, Daniele Yumi Sunaga et al. · 2020 · Molecular Psychiatry
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia
Minsoo Kim, Jillian R. Haney, Pan Zhang, Leanna M. Hernandez, Lee-kai Wang, Laura Pérez‐Cano, Loes M. Olde Loohuis, Luis de la Torre-Ubieta, Michael J. Gandal · 2021 · Nature Neuroscience
Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes
Kynon JM Benjamin, Qiang Chen, Andrew E. Jaffe, Joshua M. Stolz, Leonardo Collado‐Torres, Louise A. Huuki-Myers, Emily E. Burke, Ria Arora, Arthur Sant’Anna Feltrin, Amilton de Lima Barbosa et al. · 2022 · Nature Neuroscience
Early or Late Gestational Exposure to Maternal Immune Activation Alters Neurodevelopmental Trajectories in Mice: An Integrated Neuroimaging, Behavioral, and Transcriptional Study
Elisa Guma, Pedro do Couto Bordignon, Gabriel A. Devenyi, Daniel Gallino, Chloe Anastassiadis, Vedrana Cvetkovska, Amadou Barry, Emily Snook, Jürgen Germann, Celia M.T. Greenwood et al. · 2021 · Biological Psychiatry
Connectivity alterations in autism reflect functional idiosyncrasy
Oualid M. Benkarim, Casey Paquola, Bo‐yong Park, Seok‐Jun Hong, Jessica Royer, Reinder Vos de Wael, Sara Larivière, Sofie Louise Valk, Danilo Bzdok, Laurent Mottron et al. · 2021 · Communications Biology
Genome-Wide Analysis of Differential Gene Expression and Splicing in Excitatory Neurons and Interneuron Subtypes
Melanie A. Huntley, Karpagam Srinivasan, Brad A. Friedman, Tzu-Ming Wang, Ada Xin Yee, Yuanyuan Wang, Joshua S. Kaminker, Morgan Sheng, David V. Hansen, Jesse E. Hanson · 2019 · Journal of Neuroscience
Schizophrenia: A Narrative Review of Etiopathogenetic, Diagnostic and Treatment Aspects
Laura Orsolini, Simone Pompili, Umberto Volpe · 2022 · Journal of Clinical Medicine
Joint factorial structure of psychopathology and personality
Tom Henrik Rosenström, Line C. Gjerde, Robert Frank Krueger, Steven H. Aggen, Nikolai Olavi Czajkowski, Nathan A. Gillespie, Kenneth S. Kendler, Ted Reichborn‐Kjennerud, Fartein Ask Torvik, Eivind Ystrøm · 2018 · Psychological Medicine
Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP
Jiang, Shan, Wen, Natalie, Li, Zeran, Dube, Umber, Del Aguila, Jorge, Budde, John, Martinez, Rita, Hsu, Simon, Fernandez, Maria V., Cairns, Nigel J. et al. · 2018 · Translational Psychiatry
The neuropathology of bipolar disorder: systematic review and meta-analysis
Paul J. Harrison, Lucy Colbourne, Charlotte H. Harrison · 2018 · Molecular Psychiatry
Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders
Singh, Katyayani, Jayaram, Mohan, Kaare, Maria, Leidmaa, Este, Jagomäe, Toomas, Heinla, Indrek, Hickey, Miriam A., Kaasik, Allen, Schäfer, Michael K., Innos, Jürgen et al. · 2019 · Scientific Reports
Detecting schizophrenia with 3D structural brain MRI using deep learning
Junhao Zhang, Vishwanatha Mitnala Rao, Ye Tian, Yanting Yang, Nicolas Acosta, Zihan Wan, Pin-Yu Lee, Chloe Zhang, Lawrence S. Kegeles, Scott A. Small et al. · 2023 · Scientific Reports
Intracellular calcium dysregulation in autism spectrum disorder: An analysis of converging organelle signaling pathways
Rachel L. Nguyen, Yuliya V. Medvedeva, Tejasvi Ayyagari, Galina Schmunk, John Jay Gargus · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Occurrence of psychosis and bipolar disorder in adults with autism: A systematic review and meta-analysis
Kandice J. Varcin, Sarah E. Herniman, Ashleigh Peng Lin, Yanyu Chen, Yael Perry, Charlotte Pugh, Katharine Chisholm, Andrew Whitehouse, Stephen James Wood · 2022 · Neuroscience & Biobehavioral Reviews
Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders
Yu Chen, Rujia Dai, Longfei Tang, Tatiana Mikhailova, Qiuman Liang, Miao Li, Jiaqi Zhou, Richard F. Kopp, Cynthia Shannon Weickert, Chao Chen et al. · 2022 · Molecular Psychiatry
Transcriptome-wide analysis of differential expression in perturbation atlases
Nadig, Ajay, Replogle, Joseph M., Pogson, Angela N., Murthy, Mukundh, McCarroll, Steven A., Weissman, Jonathan S., Robinson, Elise B., O’Connor, Luke J. · 2025 · Nature Genetics
The DGCR5 long noncoding RNA may regulate expression of several schizophrenia-related genes
Qingtuan Meng, Kangli Wang, Tonya M. Brunetti, Yan Xia, Chuan Jiao, Rujia Dai, Dominic Fitzgerald, Amber Flora Thomas, Lindsey Jay, Heather Eckart et al. · 2018 · Science Translational Medicine
STAB: a spatio-temporal cell atlas of the human brain
Liting Song, Shaojun Pan, Zi-Chao Zhang, Longhao Jia, Wei-Hua Chen, Xing‐Ming Zhao · 2020 · Nucleic Acids Research
A loss of mature microglial markers without immune activation in schizophrenia
Gijsje J. L. Snijders, Welmoed van Zuiden, Marjolein A. M. Sneeboer, Amber Berdenis van Berlekom, Astrid Tjitske van der Geest, Tatiana P. Schnieder, Donald J. MacIntyre, Elly M. Hol, René S. Kahn, Lot D. de Witte · 2021 · Glia
Biophysical Modeling of Large-Scale Brain Dynamics and Applications for Computational Psychiatry
John D. Murray, Murat Demirtaş, Alan Anticevic · 2018 · Biological Psychiatry Cognitive Neuroscience and Neuroimaging
New considerations for hiPSC-based models of neuropsychiatric disorders
Gabriel E. Hoffman, Nadine Schrode, Erin K. Flaherty, Kristen Brennand · 2018 · Molecular Psychiatry
The role of genetics and genomics in clinical psychiatry
Margret R. Hoehe, Deborah J. Morris-Rosendahl · 2018 · Dialogues in Clinical Neuroscience
Proteomic analysis reveals a biosignature of decreased synaptic protein in cerebrospinal fluid of major depressive disorder
MHD Rami Al Shweiki, Patrick Oeckl, Petra Steinacker, Peggy Barschke, Cornelia Dorner‐Ciossek, Bastian Hengerer, Carlos Schönfeldt‐Lecuona, Markus Otto · 2020 · Translational Psychiatry
Sex Differences in Neurodevelopmental Disorders: A Key Role for the Immune System
Breach, Michaela R., Lenz, Kathryn M. · 2022 · Current Topics in Behavioral Neurosciences
Disruption of the blood–brain barrier in 22q11.2 deletion syndrome
Alexis Mary Crockett, Sean K. Ryan, Adriana Hernandez Vásquez, Caroline Canning, Nickole Kanyuch, Hania Kébir, Guadalupe Ceja, James Gesualdi, Elaine H. Zackai, Donna M. McDonald‐McGinn et al. · 2021 · Brain
Depression From a Precision Mental Health Perspective: Utilizing Personalized Conceptualizations to Guide Personalized Treatments
Reem Deif, Mohamed Salama · 2021 · Frontiers in Psychiatry
A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics
Haojie Lu, Jiahao Qiao, Zhonghe Shao, Ting Wang, Shuiping Huang, Ping Zeng · 2021 · BMC Medicine
Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs
Helen Le-Niculescu, K. Roseberry, Daniel F. Levey, J. Rogers, K. Kosary, Srishti Prabha, T. Jones, S. Judd, M. A. McCormick, A. R. Wessel et al. · 2019 · Molecular Psychiatry
Genome-Scale Transcriptional Regulatory Network Models of Psychiatric and Neurodegenerative Disorders
Jocelynn R. Pearl, Carlo Colantuoni, Dani E. Bergey, Cory C. Funk, Paul T. Shannon, Bijoya Basu, Alex M. Casella, Rediet T. Oshone, Leroy Hood, Nathan D. Price et al. · 2019 · Cell Systems
Cytoplasmic-predominant Pten increases microglial activation and synaptic pruning in a murine model with autism-like phenotype
Nick Sarn, Ritika Jaini, Stetson Thacker, Hyunpil Lee, Ranjan Dutta, Charis Eng · 2020 · Molecular Psychiatry
Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism
Satterstrom, F. Kyle, Kosmicki, Jack A., Wang, Jiebiao, Breen, Michael S., De Rubeis, Silvia, An, Joon-Yong, Peng, Minshi, Collins, Ryan, Grove, Jakob, Klei, Lambertus et al. · 2018
Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex
Matthew Schwede, Shailender Nagpal, Michael J. Gandal, Neelroop Parikshak, Károly Mirnics, Daniel H. Geschwind, Eric M. Morrow · 2018 · Journal of Neurodevelopmental Disorders
Mitochondrial Dysfunction in Schizophrenia
Peiyan Ni, Sangmi Chung · 2020 · BioEssays
A characterization of the molecular phenotype and inflammatory response of schizophrenia patient-derived microglia-like cells
Paul R. Ormel, Chotima Böttcher, Frederieke A. J. Gigase, Roy D. Missall, Welmoed van Zuiden, M. Camila Fernández Zapata, Dilara Ilhan, Michelle H.M. de Goeij, Evan Udine, Iris E. Sommer et al. · 2020 · Brain Behavior and Immunity
Altered dopaminergic pathways and therapeutic effects of intranasal dopamine in two distinct mouse models of autism
Owen Yuan-Hsin Chao, Salil Saurav Pathak, Hao Zhang, Nathan Dunaway, Jay‐Shake Li, Claudia Mattern, Susanne Nikolaus, Joseph P. Huston, Yi Yang · 2020 · Molecular Brain
A Machine Learning Approach to Predicting Autism Risk Genes: Validation of Known Genes and Discovery of New Candidates
Ying Lin, Shiva Afshar, Anjali M. Rajadhyaksha, James B. Potash, Shizhong Han · 2020 · Frontiers in Genetics
Sex-specific transcriptional and proteomic signatures in schizophrenia
Jari Tiihonen, Marja Koskuvi, Markus Storvik, Ida Hyötyläinen, Yanyan Gao, Katja A. Puttonen, Raisa Giniatullina, Ekaterina Poguzhelskaya, Ilkka Ojansuu, Olli Vaurio et al. · 2019 · Nature Communications
Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
Klaus Oliver Schubert, Anbupalam Thalamuthu, Azmeraw T. Amare, Joseph Frank, Fabian Streit, Mazda Adl, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias et al. · 2021 · Translational Psychiatry
Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents
Jessica Mauer, Gabriela Xavier, Vanessa Ota, Samar Nasser Chehimi, Fernanda Mafra, Cássia Cuóco, Lucas Toshio Ito, Rafaella Ormond, Paula Fontes Asprino, Adrielle Oliveira et al. · 2023 · Translational Psychiatry
Small cells with big implications: Microglia and sex differences in brain development, plasticity and behavioral health
Lars H. Nelson, Angela I. Saulsbery, Kathryn M. Lenz · 2018 · Progress in Neurobiology
Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior
Avanti Gokhale, Cortnie L. Hartwig, Amanda A. H. Freeman, Julia Bassell‐Hawkins, Stephanie A. Zlatic, Christie Sapp Savas, Trishna Vadlamudi, Farida Abudulai, Tyler T. Pham, Amanda J. Crocker et al. · 2018 · Journal of Neuroscience
Synaptic and Gene Regulatory Mechanisms in Schizophrenia, Autism, and 22q11.2 Copy Number Variant–Mediated Risk for Neuropsychiatric Disorders
Jennifer K. Forsyth, Daniel C. Nachun, Michael J. Gandal, Daniel H. Geschwind, Ariana Anderson, Giovanni Coppola, Carrie E. Bearden · 2019 · Biological Psychiatry
Transcriptomic Insight Into the Polygenic Mechanisms Underlying Psychiatric Disorders
Leanna M. Hernandez, Minsoo Kim, Gil D. Hoftman, Jillian R. Haney, Luis de la Torre-Ubieta, Bogdan Paşaniuc, Michael J. Gandal · 2020 · Biological Psychiatry
Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions
Andrey D. Volgin, Oleg A. Yakovlev, Konstantin A. Demin, Murilo S. de Abreu, Polina A. Alekseeva, Ashton Jeremy Friend, Anton M. Lakstygal, Tamara G. Amstislavskaya, Wandong Bao, Cai Song et al. · 2018 · Journal of Neuroscience Research
Microglia in post-mortem brain tissue of patients with bipolar disorder are not immune activated
Marjolein A. M. Sneeboer, Gijsje J. L. Snijders, Woutje M. Berdowski, Alba Fernández-Andreu, Psychiatric Donor Program of the Netherlands Brain Bank (NBB-Psy), Hans C. van Mierlo, Amber Berdenis van Berlekom, Manja Litjens, René S. Kahn, Elly M. Hol et al. · 2019 · Translational Psychiatry
Dysregulation of Neurite Outgrowth and Cell Migration in Autism and Other Neurodevelopmental Disorders
Smrithi Prem, James H. Millonig, Emanuel M. DiCicco-Bloom · 2020 · Advances in neurobiology
Cocaine'omics: Genome‐wide and transcriptome‐wide analyses provide biological insight into cocaine use and dependence
Spencer B. Huggett, Michael C. Stallings · 2019 · Addiction Biology
Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype
Monica Frega, Martijn M. Selten, Britt Mossink, Jason M. Keller, Katrin Linda, Rebecca Moerschen, Jieqiong Qu, Pierre Koerner, Sophie Martina Johanna Jansen, Elske Bijvank et al. · 2020 · Cell Reports
Single-Nucleus Transcriptome Profiling of Dorsolateral Prefrontal Cortex: Mechanistic Roles for Neuronal Gene Expression, Including the 17q21.31 Locus, in PTSD Stress Response
Chris Chatzinakos, Cameron D. Pernia, Filomene G. Morrison, Artemis Iatrou, Kenneth M. McCullough, Heike Schuler, Clara Snijders, Thomas Bajaj, Christopher P. DiPietro, Marina Soliva Estruch et al. · 2023 · American Journal of Psychiatry
Diagnosis- and Cell Type-Specific Mitochondrial Functional Pathway Signatures in Schizophrenia and Bipolar Disorder
Jill R. Glausier, John F. Enwright, David A. Lewis · 2020 · American Journal of Psychiatry
Cortical morphology at birth reflects spatiotemporal patterns of gene expression in the fetal human brain
Gareth Ball, Jakob Seidlitz, Jonathan O’Muircheartaigh, Ralica Dimitrova, Daphna Fenchel, Antonios Makropoulos, Daan Christiaens, Andreas Schuh, Jonathan Passerat‐Palmbach, Jana Maria Hutter et al. · 2020 · PLoS Biology
Dissecting autism and schizophrenia through neuroimaging genomics
Clara A. Moreau, Armin Raznahan, Pierre Bellec, M. Mallar Chakravarty, Paul M. Thompson, Sébastien Jacquemont · 2021 · Brain
Genetics on the neurodiversity spectrum: Genetic, phenotypic and endophenotypic continua in autism and ADHD
Polaris Koi · 2021 · Studies in History and Philosophy of Science Part A
Mitochondrial dysfunction in psychiatric disorders
Peiyan Ni, Yao Ma, Sangmi Chung · 2022 · Schizophrenia Research
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders
Greta Pintacuda, Yu-Han H. Hsu, Kalliopi Tsafou, Ka Wan Li, Jacqueline M. Martín, Jackson Riseman, Julia C. Biagini, Joshua K.T. Ching, Daya Mena, Miguel A. Gonzalez‐Lozano et al. · 2023 · Cell Genomics
Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain
Cindy H. Wen, Michael P. Margolis, Rujia Dai, Pan Zhang, Pawel F. Przytycki, Daniel Vo, Arjun Bhattacharya, Nana Matoba, Miao Tang, Chuan Jiao et al. · 2024 · Science
Interactions between the lipidome and genetic and environmental factors in autism
Chloe X. Yap, Anjali K. Henders, Gail A. Alvares, Corey Giles, Kevin Huynh, Anh Nguyen, Leanne M. Wallace, Tiana McLaren, Yuanhao Yang, Leanna M. Hernandez et al. · 2023 · Nature Medicine
Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
Mohamed Edfawy, Joana Ribeiro Guedes, Marta Isabel Pereira, Mariana Laranjo, Maria Lucilene de Carvalho, Xian Gao, Pedro A. Ferreira, Gladys L. Caldeira, Lara O. Franco, Dongqing Wang et al. · 2019 · Nature Communications
Genetic Architecture and Molecular Neuropathology of Human Cocaine Addiction
Spencer B. Huggett, Michael C. Stallings · 2020 · Journal of Neuroscience
Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism
Le Wang, Vincent R. Mirabella, Rujia Dai, Xiao Yi Su, Ranjie Xu, Azadeh Jadali, Matteo Bernabucci, Ishnoor Singh, Yu Chen, Jianghua Tian et al. · 2022 · Molecular Psychiatry
Forecasting risk gene discovery in autism with machine learning and genome-scale data
Leo Brueggeman, Tanner Koomar, Jacob J. Michaelson · 2020 · Scientific Reports
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Mary-Ellen Lynall, Blagoje Soskic, James D. Hayhurst, Jeremy Schwartzentruber, Daniel F. Levey, Gita A. Pathak, Renato A Polimanti, Joel E. Gelernter, Murray B. Stein, Gosia Trynka et al. · 2022 · Nature Communications
Cortical remodelling in childhood is associated with genes enriched for neurodevelopmental disorders
Gareth Ball, Jakob Seidlitz, Richard J Beare, Marc L. Seal · 2020 · NeuroImage
Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term Memory, and Cognitive Flexibility and Alters Dendritic Spine Properties
Amelia Nash, Tim D. Aumann, Martina Pigoni, Stefan F. Lichtenthaler, Hiroshi Takeshima, Kathryn M. Munro, Jenny Margaret Gunnersen · 2019 · Cerebral Cortex
Psychiatric drugs impact mitochondrial function in brain and other tissues
Shawna T. Chan, Michael J. McCarthy, Marquis P. Vawter · 2019 · Schizophrenia Research
Patterns of cilia gene dysregulations in major psychiatric disorders
Wedad Alhassen, Siwei Chen, Marquis P. Vawter, Brianna Robbins, Henry N. Nguyen, Thant Myint, Yumiko Saito, Anton Schulmann, Surya M. Nauli, Olivier Civelli et al. · 2021 · Progress in Neuro-Psychopharmacology and Biological Psychiatry