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Cited by 1,019

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

ATP as a biological hydrotrope

Patel, Avinash, Malinovska, Liliana, Saha, Shambaditya, Wang, Jie, Alberti, Simon, Krishnan, Yamuna, Hyman, Anthony A.·2017·Science
DOI 10.1126/science.aaf6846
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Abstract

ATP boosts protein solubility: Adenosine triphosphate (ATP) has well-characterized roles in providing energy for biochemical reactions within cells. Patel et al. find that ATP may also enhance protein solubility, which could help explain why such high concentrations of ATP are maintained in cells (see the Perspective by Rice and Rosen). Protein concentrations in cells can exceed 100 mg/ml. The authors found that ATP at concentrations found in cells could act as a hydrotrope to help solubilize hydrophobic proteins. The results raise the possibility that ATP concentrations could influence processes such as protein aggregation that occur in disease or liquid-liquid phase separations that occur within cells. Science , this issue p. 753 ; see also p. 701

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Research works printed but not linked: 37

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Cited by

Metadata

Authors
Patel, A., Malinovska, L., Saha, S., Wang, J., Alberti, S., Krishnan, Y., & Hyman, A. A.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2017-05-19
Volume
356
Issue
6339
Pages
753-756
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.aaf6846
Cited by
1,019
References
3
Language
en
Licence
www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 365 d)
Funders
  • Alexander von Humboldt Foundation (GRO/1156614 STP-2, USA/1153678 STP)
  • EMBO ALTF (608-2013)
  • German Federal Ministry of Research and Education (BMBF 031A359A)

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.