Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice
Open accessAbstract
Mom's diet affects growth: Nutrition is important during development. This appears to be true even in utero, with potential long-lasting effects on adult phenotype and disease. Epigenetic factors are prime suspects in identifying the corresponding molecular mechanism because they can be maintained throughout cell division. Holland et al. show in mice that in utero nutritional deficits influence offspring growth through epigenetic states at multicopy ribosomal DNA elements. This effect is influenced by the genetic variation that naturally exists within the ribosomal RNA. Science , this issue p. 495
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A protein restriction diet in mice can induce DNA methylation and repression of a subset of ribosomal DNA genes.
“A protein restriction diet in mice can also induce DNA methylation and repression of a subset of ribosomal DNA (rDNA) genes 90 , although the inducer and the roles of this rDNA 'epiallele' remain to be identified.”
From Advances in epigenetics link genetics to the environment and disease (2019) · cites this paper as [90]
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- Authors
- Holland, M. L., Lowe, R., Caton, P. W., Gemma, C., Carbajosa, G., Danson, A. F., Carpenter, A. A. M., Loche, E., Ozanne, S. E., & Rakyan, V. K.
- Affiliations
- Queen Mary University of London (GB)
- King's College London (GB)
- University of Cambridge (GB)
- Corresponding author
- Holland, Michelle L.
- Lowe, Robert
- Gemma, Carolina
- Carbajosa, Guillermo
- Rakyan, Vardhman K.
- ORCID
- Venue
- Science
- Published
- 2016-07-29
- Volume
- 353
- Issue
- 6298
- Pages
- 495-498
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5734613
- OpenAlex
- W2468218308
- Cited by
- 106
- References
- 23
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 8 · 2023: 8 · 2022: 6 · 2021: 13 · 2020: 9 · 2019: 14 · 2018: 17 · 2017: 16 · 2016: 3
- FWCI
- 19.39
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (acceptedVersion, other-oa)
- Apollo (University of Cambridge) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
- Apollo
- Funders
- Biotechnology and Biological Sciences Research Council (BB/M012494/1, BB/G00711/X/1)
- Research Council UK Academic Fellowship
- British Heart Foundation (FS/12/64/30001)
- Medical Research Council (MC_UU_12012/4)
- Engineering and Physical Sciences Research Council (EP/K000128/1)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- early life nutrition, protein restriction, ribosomal DNA, DNA methylation, epigenetics, growth restriction, maternal diet, high-fat diet, obesogenic diet, developmental programming, mice
- MeSH terms
- Animals, DNA, Ribosomal, Female, Male, Nutritional Status, Obesity, Pregnancy, Promoter Regions, Genetic, Genetic Variation, Weaning, Diet, Protein-Restricted, DNA Methylation, Maternal Nutritional Physiological Phenomena, Epigenesis, Genetic, Mice, Diet, High-Fat, Gene-Environment Interaction
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