Mutational signatures associated with tobacco smoking in human cancer

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1. Tumor Mutational Burden in Breast Cancer: Current Evidence, Challenges, and Opportunities
   Romualdo Barroso‐Sousa, Jana Priscila Medeiros Pacifico, Sarah LeNoir Sammons, Sara M. Tolaney · 2023 · Cancers
2. Learning mutational signatures and their multidimensional genomic properties with TensorSignatures
   Harald S. Vöhringer, Arne van Hoeck, Edwin P. J. G. Cuppen, Moritz Gerstung · 2021 · Nature Communications
3. Immunogenomic analysis of human brain metastases reveals diverse immune landscapes across genetically distinct tumors
   Ángel F. Álvarez-Prado, Roeltje R. Maas, Klara Soukup, Florian Klemm, Mara Kornete, Fanny S. Krebs, Vincent Zoete, Sabina Berezowska, Jean‐Philippe Brouland, Andreas Felix Hottinger et al. · 2023 · Cell Reports Medicine
4. Smoking and Risk of Colorectal Cancer Sub-Classified by Tumor-Infiltrating T Cells
   Tsuyoshi Hamada, Jonathan Andrew Nowak, Yohei Masugi, David A. Drew, Mingyang Song, Yin Cao, Keisuke Kosumi, Kosuke Mima, Tyler S. Twombly, Li Liu et al. · 2018 · JNCI Journal of the National Cancer Institute
5. Protein liposomes-mediated targeted acetylcholinesterase gene delivery for effective liver cancer therapy
   Kai Wang, Fusheng Shang, Dagui Chen, Tieliu Cao, Xiaowei Wang, Jianpeng Jiao, Shengli He, Xiaofei Liang · 2021 · Journal of Nanobiotechnology
6. Tobacco smoking induces metabolic reprogramming of renal cell carcinoma
   James K. Reigle, Dina Secic, Jacek Biesiada, Collin Wetzel, Behrouz Shamsaei, Johnson Chu, Yuanwei Zang, Xiang Zhang, Nicholas J. Talbot, Megan E. Bischoff et al. · 2020 · Journal of Clinical Investigation
7. Lung Cancer in Nonsmoking Individuals
   Cian Murphy, Tej Pandya, Charles Swanton, Benjamin Solomon · 2025 · JAMA
8. Molecular classification of pulmonary sarcomatoid carcinomas suggests new therapeutic opportunities
   Nicolas Pécuchet, Thibault Vieira, Nathalie Rabbe, Martine Antoine, Hélène Blons, Jacques L. Cadranel, Pierre Laurent‐Puig, Marie Wislez · 2017 · Annals of Oncology
9. Ultrasensitive High-Resolution Mass Spectrometric Analysis of a DNA Adduct of the Carcinogen Benzo[a]pyrene in Human Lung
   Peter W. Villalta, J. Bradley Hochalter, Stephen S. Hecht · 2017 · Analytical Chemistry
10. Computational approaches for discovery of mutational signatures in cancer
    Adrian Baez‐Ortega, Kevin C. Gori · 2017 · Briefings in Bioinformatics
11. Automated 3-D Printed Arrays to Evaluate Genotoxic Chemistry: E-Cigarettes and Water Samples
    Karteek Kadimisetty, Spundana Malla, James F. Rusling · 2017 · ACS Sensors
12. Connecting Cancer to Its Causes Requires Incorporation of Effects on Tissue Microenvironments
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13. Environment, cancer and inequalities—The urgent need for prevention
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14. AACR White Paper: Shaping the Future of Cancer Prevention – A Roadmap for Advancing Science and Public Health
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15. Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer
    Mia Petljak, Abby M. Green, John Maciejowski, Matthew D. Weitzman · 2022 · Nature Genetics
16. Changing mutational and adaptive landscapes and the genesis of cancer
    L. Alexander Liggett, James V. DeGregori · 2017 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
17. Identifying Putative Susceptibility Genes and Evaluating Their Associations with Somatic Mutations in Human Cancers
    Zhishan Chen, Wanqing Wen, Alicia C. Beeghly-Fadiel, Xiao‐Ou Shu, Virginia Díez‐Obrero, Jirong Long, Jiandong Bao, Jing Wang, Qi Liu, Qiuyin Cai et al. · 2019 · The American Journal of Human Genetics
18. Profilin 2 promotes growth, metastasis, and angiogenesis of small cell lung cancer through cancer-derived exosomes
    Qi Cao, Yihan Liu, Ying Hua Wu, Hu Caijiao, Lei Sun, Jinghui Wang, Changlong Li, Meng Guo, Xin Liu, Jianyi Lv et al. · 2020 · Aging
19. Concordance of hydrogen peroxide–induced 8-oxo-guanine patterns with two cancer mutation signatures of upper GI tract tumors
    Seung‐Gi Jin, Yingying Meng, Jennifer S. Johnson, Piroska E. Szabó, Gerd P. Pfeifer · 2022 · Science Advances
20. Mutant p53 drives an immune cold tumor immune microenvironment in oral squamous cell carcinoma
    Yewen Shi, Tongxin Xie, Bingbing Wang, Rong Wang, Yu Cai, Bo Yuan, Frederico O. Gleber‐Netto, Xiangjun Tian, Alanis Enid Rodriguez-Rosario, Abdullah A. Osman et al. · 2022 · Communications Biology
21. Association of HLA diversity with the risk of 25 cancers in the UK Biobank
    Qiao-Ling Wang, Tong‐Min Wang, Changmi Deng, Wenli Zhang, Yong‐Qiao He, Wen‐Qiong Xue, Ying Liao, Dawei Yang, Mei‐Qi Zheng, Wei‐Hua Jia · 2023 · EBioMedicine
22. The Microbiota and Pancreatic Cancer
    Tomasz M. M Karpiński · 2019 · Gastroenterology Clinics of North America
23. Metabolic reprogramming by tobacco-specific nitrosamines (TSNAs) in cancer
    Saharnaz Sarlak, Claude Lalou, Nívea Dias Amoêdo, Rodrigue Rossignol · 2019 · Seminars in Cell and Developmental Biology
24. Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
    Yulia Rubanova, Ruian Shi, Caitlin F. Harrigan, Roujia Li, Jeff A. Wintersinger, Nil Sahin, Amit G. Deshwar, PCAWG Evolution and Heterogeneity Working Group, Stefan C. Dentro, Ignaty Leshchiner et al. · 2020 · Nature Communications
25. Overcoming KRAS-Mutant Lung Cancer
    Jia Luo, Jonathan M. L. Ostrem, Bruna Pellini, Denis Imbody, Yaakov E. Stern, Hitendra S. Solanki, Eric B. Haura, Liza C. Villaruz · 2022 · American Society of Clinical Oncology Educational Book
26. Undifferentiated and Dedifferentiated Metastatic Melanomas Masquerading as Soft Tissue Sarcomas: Mutational Signature Analysis and Immunotherapy Response
    Israel S. Kasago, Walid Khaled Chatila, Cecilia M. Lezcano, Christopher A. Febres‐Aldana, Nikolaus D. Schultz, Chad Vanderbilt, Snjezana Doğan, Edmund K. Bartlett, Sandra P. D’Angelo, William D. Tap et al. · 2023 · Modern Pathology
27. Combination immunotherapy strategies in advanced non-small cell lung cancer (NSCLC): Does biological rationale meet clinical needs?
    Ilaria Attili, Antonio Passaro, Alberto Pavan, PierFranco Conte, Filippo de Marinis, Laura Bonanno · 2017 · Critical Reviews in Oncology/Hematology
28. Clonal Hematopoiesis Mutations in Patients with Lung Cancer Are Associated with Lung Cancer Risk Factors
    Hong Wei, Ang Li, Yanhong Liu, Xiangjun Xiao, David C. Christiani, Rayjean J. Hung, James McKay, John K. Field, Christopher Ian Amos, Chao Cheng · 2021 · Cancer Research
29. Acrylamide levels in smoke from conventional cigarettes and heated tobacco products and exposure assessment in habitual smokers
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30. Cancer of the Lung
    Luiz Henrique Araujo, Leora Horn, Robert E. Merritt, Konstantin Shilo, Meng Xu‐Welliver, David Paul Carbone · 2020 · Elsevier eBooks
31. Mutational Landscapes of Smoking-Related Cancers in Caucasians and African Americans: Precision Oncology Perspectives at Wake Forest Baptist Comprehensive Cancer Center
    Ville Kytölä, Ümit Topaloĝlu, Lance David Miller, Rhonda Lynn Bitting, Michael Moses Goodman, Ralph B. D`Agostino, Rodwige J. Desnoyers, Carol A. Albright, George Yacoub, Shadi A. Qasem et al. · 2017 · Theranostics
32. Experimental Evolution of Extreme Resistance to Ionizing Radiation in Escherichia coli after 50 Cycles of Selection
    Steven T. Bruckbauer, Joseph D. Trimarco, Joel Martin, Brian Bushnell, Katherine A Senn, Wendy Schackwitz, Anna Lipzen, Matthew J. Blow, Elizabeth A. Wood, Wesley S. Culberson et al. · 2019 · Journal of Bacteriology
33. Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers
    Maria Teresa Landi, Naoise C. Synnott, Jennifer Rosenbaum, Tongwu Zhang, Bin Zhu, Jianxin Shi, Zhao Wei, Michael Kebede, Jian Sang, Jiyeon Choi et al. · 2020 · American Journal of Epidemiology
34. The effects of everyday-life exposure to polycyclic aromatic hydrocarbons on biological age indicators
    Sofia Pavanello, Manuela Campisi, Giuseppe Mastrangelo, Mirjam Hoxha, Valentina Bollati · 2020 · Environmental Health
35. The major mechanism of melanoma mutations is based on deamination of cytosine in pyrimidine dimers as determined by circle damage sequencing
    Seung‐Gi Jin, Dean Pettinga, Jennifer S. Johnson, Peipei Li, Gerd P. Pfeifer · 2021 · Science Advances
36. Molecular Subtyping and Prognostic Assessment Based on Tumor Mutation Burden in Patients with Lung Adenocarcinomas
    Changzheng Wang, Fuqiang Li, Guoyun Xie, Sitan Qiao, Xulian Shi, Jianlian Deng, Han Liang, Cong Lin, Xin Zhao, Kui Wu et al. · 2019 · International Journal of Molecular Sciences
37. Systems-epigenomics inference of transcription factor activity implicates aryl-hydrocarbon-receptor inactivation as a key event in lung cancer development
    Yuting Chen, Martin Widschwendter, Andrew Erich Teschendorff · 2017 · Genome biology
38. A Prospective Cohort Study to Define the Clinical Features and Outcome of Lung Cancers Harboring HER2 Aberration in Japan (HER2-CS STUDY)
    Kiichiro Ninomiya, Tae Hata, Hiroshige Yoshioka, Kadoaki Ohashi, Akihiro Bessho, Shinobu Hosokawa, Nobuhisa Ishikawa, Masahiro Yamasaki, Takuo Shibayama, Keisuke Aoe et al. · 2019 · CHEST Journal
39. Next generation sequencing of lung adenocarcinoma subtypes with intestinal differentiation reveals distinct molecular signatures associated with histomorphology and therapeutic options
    Philipp Sebastian Jurmeister, Claudia Vollbrecht, Anke Behnke, Nikolaj Frost, Alexander Arnold, Denise Treue, Jens‐Carsten Rückert, Jens Neudecker, Leonille Schweizer, Frederick Klauschen et al. · 2019 · Lung Cancer
40. Using sigLASSO to optimize cancer mutation signatures jointly with sampling likelihood
    Shantao Li, Forrest W. Crawford, Mark Gerstein · 2020 · Nature Communications
41. Quantitative and qualitative mutational impact of ionizing radiation on normal cells
    Jeonghwan Youk, Hyun Woo Kwon, Joonoh Lim, Eunji Kim, Taewoo Kim, Ryul Kim, Seongyeol Park, Kijong Yi, Chang Hyun Nam, Sara Jeon et al. · 2024 · Cell Genomics
42. Prognostic value of PD-L1 overexpression for pancreatic cancer: evidence from a meta-analysis
    Yongxun Zhuansun, Fengting Huang, Min Feng, Xinbao Zhao, Wen‐Ying Chen, Zhe Zhu, Shineng Zhang · 2017 · OncoTargets and Therapy
43. Benchmark dose analyses of multiple genetic toxicity endpoints permit robust, cross-tissue comparisons of MutaMouse responses to orally delivered benzo[a]pyrene
    Alexandra S. Long, John W. Wills, Dorothy Krolak, Matthew D. Guo, Stephen D. Dertinger, Volker Manfred Arlt, Paul A. White · 2017 · Archives of Toxicology
44. Deleterious Pulmonary Surfactant System Gene Mutations in Lung Adenocarcinomas Associated With Usual Interstitial Pneumonia
    Takayuki Honda, Hiroyuki Sakashita, Kyohei Masai, Hirohiko Totsuka, Noriko Motoi, Masashi Kobayashi, Takumi Akashi, Sachiyo Mimaki, Katsuya Tsuchihara, Suenori Chiku et al. · 2018 · JCO Precision Oncology
45. A scalable solution for tumor mutational burden from formalin-fixed, paraffin-embedded samples using the Oncomine Tumor Mutation Load Assay
    Ruchi Chaudhary, Luca Quagliata, Philip M. Jermann, Ilaria Alborelli, Dinesh Cyanam, Vinay Mittal, Warren Tom, Janice K. Au-Young, Seth E. Sadis, Fiona C. L. Hyland · 2018 · Translational Lung Cancer Research
46. Prolonged persistence of mutagenic DNA lesions in somatic cells
    Michael Spencer Chapman, Emily Mitchell, Kenichi Yoshida, Nicholas Williams, Margarete A. Fabre, Anna Maria Ranzoni, Philip S. Robinson, Lori D. Kregar, Christian Matthias Wilk, Steffen Boettcher et al. · 2025 · Nature
47. De novo mutational signature discovery in tumor genomes using SparseSignatures
    Avantika Lal, Keli Liu, Robert John Tibshirani, Arend Sidow, Daniele Ramazzotti · 2021 · PLoS Computational Biology
48. Cigarette smoke-promoted increases in osteopontin expression attract mesenchymal stem cell recruitment and facilitate lung cancer metastasis
    Yajing Jiang, Chia‐Chia Chao, An‐Chen Chang, Po‐Chun Chen, Fang‐Ju Cheng, Ju‐Fang Liu, Po‐I Liu, Chang‐Lun Huang, Jeng‐Hung Guo, Wei‐Chien Huang et al. · 2021 · Journal of Advanced Research
49. Human Variation in DNA Repair, Immune Function, and Cancer Risk
    Ana W. Y. Cheong, Zachary David Nagel · 2022 · Frontiers in Immunology
50. Aging and atrial fibrillation: A vicious circle
    Pan Gao, Xinyi Gao, Bingxin Xie, Gary Tse, Tong Liu · 2023 · International Journal of Cardiology
51. Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer
    Tracy L. Leong, Velimir Gayevskiy, Daniel Steinfort, Marc Robert de Massy, Álvaro González-Rajal, Kieren D. Marini, Emily C.A. Stone, Venessa T. Chin, Adrian P. Havryk, M. Plit et al. · 2018 · Oncogene
52. Genome-wide somatic mutation analysis via Hawk-Seq™ reveals mutation profiles associated with chemical mutagens
    Shoji Matsumura, Hirayuki Sato, Yuki Otsubo, Junichi Tasaki, Naohiro Ikeda, Osamu Morita · 2019 · Archives of Toxicology
53. Clinical and Genomic Characteristics of Small Cell Lung Cancer in Never Smokers
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54. The genomic and epigenomic evolutionary history of papillary renal cell carcinomas
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55. Geroscience
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56. The paradox of mutations and cancer
    Stephen Jacob Chanock · 2018 · Science
57. POLQ Overexpression Is Associated with an Increased Somatic Mutation Load and PLK4 Overexpression in Lung Adenocarcinoma
    Kazuya Shinmura, Hisami Kato, Yuichi Kawanishi, Katsuhiro Yoshimura, Kazuo Tsuchiya, Yoshiyuki Takahara, Seiji Hosokawa, Akikazu Kawase, Kazuhito Funai, Haruhiko Sugimura · 2019 · Cancers
58. Unraveling most abundant mutational signatures in head and neck cancer
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59. European Laryngological Society position paper on laryngeal dysplasia Part I: aetiology and pathological classification
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60. Mutation analysis links angioimmunoblastic T-cell lymphoma to clonal hematopoiesis and smoking
    Shuhua Cheng, Wei Zhang, Giorgio Inghirami, Wayne Tam · 2021 · eLife
61. Translating premalignant biology to accelerate non-small-cell lung cancer interception
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62. Mutational Signatures: From Methods to Mechanisms
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63. The complexity of tobacco smoke-induced mutagenesis in head and neck cancer
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64. Genomic Signature of Oral Squamous Cell Carcinomas from Non-Smoking Non-Drinking Patients
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65. Heterogeneous impact of smoking on major salivary gland cancer according to histopathological subtype: A case‐control study
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66. Mutational burden and signatures in 4000 Japanese cancers provide insights into tumorigenesis and response to therapy
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67. Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans
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68. Prognostic and Predictive Biomarkers in Non-Small Cell Lung Cancer Patients on Immunotherapy—The Role of Liquid Biopsy in Unraveling the Puzzle
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69. Putative predictors of efficacy for immune checkpoint inhibitors in non-small-cell lung cancer: facing the complexity of the immune system
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70. Impact of smoking on multiple primary cancers survival: a retrospective analysis
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71. Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancer
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72. Mutational Processes in Hepatocellular Carcinoma: The Story of Aristolochic Acid
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73. Association of PD-L1 expression in oral squamous cell carcinoma with smoking, sex, and p53 expression
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74. The genomics of undifferentiated sarcoma of soft tissue: Progress, challenges and opportunities
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75. Identification of structural properties influencing the metabolism of polycyclic aromatic hydrocarbons by cytochrome P450 1A1
    Chao Chen, Jiemiao Shen, Yang Liu, Wen Zhang, Rong Mu Xia, Fei Huan, Xing Gong, Li Wang, Chao Wang, Haoliang Yuan et al. · 2020 · The Science of The Total Environment
76. Treatment Represents a Key Driver of Metastatic Cancer Evolution
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77. Multiple gene-specific DNA methylation in blood leukocytes and colorectal cancer risk: a case-control study in China
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78. Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice
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79. Identification of Smoking-Associated Differentially Methylated Regions Using Reduced Representation Bisulfite Sequencing and Cell type–Specific Enhancer Activation and Gene Expression
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80. Impact of Long Non-Coding RNA HOTAIR Genetic Variants on the Susceptibility and Clinicopathologic Characteristics of Patients with Urothelial Cell Carcinoma
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81. Mutational Landscape of Esophageal Squamous Cell Carcinoma in an Indian Cohort
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82. Performance‐weighted‐voting model: An ensemble machine learning method for cancer type classification using whole‐exome sequencing mutation
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83. The Role of Artificial Intelligence in Deciphering Diet–Disease Relationships: Case Studies
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84. PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models
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85. Entinostat Enhances the Efficacy of Chemotherapy in Small Cell Lung Cancer Through S-phase Arrest and Decreased Base Excision Repair
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86. DNA repair as an emerging target for COPD-lung cancer overlap
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87. Adoptive cell therapy with tumour-infiltrating lymphocytes: the emerging importance of clonal neoantigen targets for next-generation products in non-small cell lung cancer
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88. Genomics of MPNST (GeM) Consortium: Rationale and Study Design for Multi-Omic Characterization of NF1-Associated and Sporadic MPNSTs
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89. Genomic characteristics of invasive mucinous adenocarcinoma of the lung with multiple pulmonary sites of involvement
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90. Association of mutation signature effectuating processes with mutation hotspots in driver genes and non-coding regions
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91. Computational Methods for Characterizing Cancer Mutational Heterogeneity
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92. Transcription-associated events affecting genomic integrity
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93. Analyzing somatic mutations by single-cell whole-genome sequencing
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94. Somatic mutations in aging and disease
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95. The molecular impact of cigarette smoking resembles aging across tissues
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96. Hidden Markov models lead to higher resolution maps of mutation signature activity in cancer
    Xiaoqing Huang, Itay Sason, Damian Wójtowicz, Yoo-Ah Kim, Mark D.M. Leiserson, Teresa M. Przytycka, Roded Sharan · 2019 · Genome Medicine
97. From Tumor Mutational Burden to Blood T Cell Receptor: Looking for the Best Predictive Biomarker in Lung Cancer Treated with Immunotherapy
    Andrea Sesma, Julián Pardo, Mara Cruellas, Eva M. Gálvez, Marta Gascón Ruiz, Dolores Isla, Luis Martínez‐Lostao, Maitane Ocáriz, José Ramón Paño, Elisa Quílez et al. · 2020 · Cancers
98. Benzo[a]pyrene and Caenorhabditis elegans: defining the genotoxic potential in an organism lacking the classical CYP1A1 pathway
    Mustafa Abbass, Yuzhi Chen, Volker Manfred Arlt, Stephen Richard Stürzenbaum · 2021 · Archives of Toxicology
99. Tumor Mutational Burden as a Predictor of Survival with Durvalumab and/or Tremelimumab Treatment in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
    Sophie Wildsmith, Weimin Li, Song Wu, Ross A. Stewart, Nassim Morsli, Rajiv G. Raja, Qu Zhang, Jiabu Ye, Philip He, Jagdish Shetty et al. · 2023 · Clinical Cancer Research
100. Paternal exposure to benzo(a)pyrene induces genome-wide mutations in mouse offspring
     Marc A. Beal, Matthew J. Meier, Andrew Williams, Andrea Rowan‐Carroll, Rémi Gagné, Sarah Lindsay, Tomas W. Fitzgerald, Matthew E. Hurles, Francesco Marchetti, Carole Lyn Yauk · 2019 · Communications Biology