Mutational signatures associated with tobacco smoking in human cancer

Alexandrov, Ludmil B., Ju, Young Seok, Haase, Kerstin, Van Loo, Peter, Martincorena, Iñigo, Nik-Zainal, Serena, Totoki, Yasushi, Fujimoto, Akihiro +6 more·2016·Science

DOI 10.1126/science.aag0299

Cited by (1,000)

Items 101–200 of 1,000

Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice
Keith Anthony Grimaldi, Ben van Ommen, José María Ordovás, Laurence D. Parnell, John Cummings Mathers, Igor Bendik, Lorraine Brennan, Carlos A. Celis-Morales, Elisa Cirillo, Hannelore Daniel et al. · 2017 · Genes & Nutrition
Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System
Shinichi Yachida, Yasushi Totoki, Michaël Noë, Yoichiro Nakatani, Masafumi Horie, Kenta Kawasaki, Hiromi K. Nakamura, Mihoko Saito-Adachi, Masami Suzuki, Erina Takai et al. · 2022 · Utrecht University Repository (Utrecht University)
Multiple Primary Malignant Tumors - A Clinical Analysis of 15,321 Patients with Malignancies at a Single Center in China
Chongya Zhai, Yulan Cai, Fang Lou, Zhen Liu, Jiansheng Xie, Xiaoyun Zhou, Zhanggui Wang, Yong Fang, Hongming Pan, Weidong Han · 2018 · Journal of Cancer
Predictive Value of Soluble PD-1, PD-L1, VEGFA, CD40 Ligand and CD44 for Nivolumab Therapy in Advanced Non-Small Cell Lung Cancer: A Case-Control Study
Manuela Tiako Meyo, Anne Jouinot, Etienne Giroux Leprieur, Elizabeth Fabre, Marie Wislez, Marco Alifano, Karen Leroy, Pascaline Boudou, Camille Tlemsani, Nihel Khoudour et al. · 2020 · Cancers
The translational challenges of precision oncology
Oriol Pich, Chris Bailey, Thomas B.K. Watkins, Simone Zaccaria, Mariam Jamal‐Hanjani, Charles Swanton · 2022 · Cancer Cell
Dissemination of Mycobacterium abscessus via global transmission networks
Christopher Ruis, Josephine M. Bryant, Scott Cameron Bell, Rachel Mary Thomson, Rebecca M. Davidson, Nabeeh A. Hasan, Jakko van Ingen, Michael Strong, R. Andrés Floto, Julian Parkhill · 2021 · Nature Microbiology
Moving pan-cancer studies from basic research toward the clinic
Feng Chen, Michael C. Wendl, Matthew A. Wyczalkowski, Matthew H. Bailey, Yize Li, Li Ding · 2021 · Nature Cancer
Anti–PD-1 and Anti–PD-L1 in Head and Neck Cancer: A Network Meta-Analysis
Andrea Botticelli, Alessio Cirillo, Lidia Strigari, Filippo Valentini, Bruna Cerbelli, Simone Scagnoli, Edoardo Cerbelli, Ilaria Grazia Zizzari, Carlo Della Rocca, Giulia d’Amati et al. · 2021 · Frontiers in Immunology
Human genome-wide repair map of DNA damage caused by the cigarette smoke carcinogen benzo[a]pyrene
Wentao Li, Jinchuan Hu, Ogün Adebalı, Sheera Adar, Yanyan Yang, Yi‐Ying Chiou, Aziz Sancar · 2017 · Proceedings of the National Academy of Sciences
Challenges and Opportunities in Cancer Metabolomics
Ashish Kumar, Biswapriya B. Misra · 2019 · PROTEOMICS
The Confounders of Cancer Immunotherapy: Roles of Lifestyle, Metabolic Disorders and Sociological Factors
Ravindra Pramod Deshpande, Sambad Sharma, Kounosuke Watabe · 2020 · Cancers
Detecting presence of mutational signatures in cancer with confidence
Xiaoqing Huang, Damian Wójtowicz, Teresa M. Przytycka · 2017 · Bioinformatics
Immunotherapy in small-cell lung cancer: from molecular promises to clinical challenges
Alberto Pavan, Ilaria Attili, Giulia Pasello, Valentina Guarneri, PierFranco Conte, Laura Bonanno · 2019 · Journal for ImmunoTherapy of Cancer
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics
Ren‐Bo Ding, Ping Chen, Barani Kumar Rajendran, Xueying Lyu, Haitao Wang, Jiaolin Bao, Jianming Zeng, Wenhui Hao, Heng Sun, Ada Hang‐Heng Wong et al. · 2021 · Nature Communications
Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity
Ian P. Winters, Shin‐Heng Chiou, Nicole K. Paulk, Christopher D. McFarland, Pranav V. Lalgudi, Rosanna K. Ma, Leszek Lisowski, Andrew J. Connolly, Dmitri A. Petrov, Mark A. Kay et al. · 2017 · Nature Communications
Molecular landscape of esophageal cancer: implications for early detection and personalized therapy
Fazlur Rahman Talukdar, Massimiliano di Pietro, Maria Secrier, Markus Hermann Moehler, Katrin Goepfert, Sheila Coelho Soares‐Lima, Luís Felipe Ribeiro Pinto, Denver T. Hendricks, Mohamed Iqbal Parker, Zdenko Herceg · 2018 · Annals of the New York Academy of Sciences
Pan-cancer proteogenomics characterization of tumor immunity
Francesca Petralia, Weiping Ma, Tomer M. Yaron, Francesca Pia Caruso, Nicole L. Tignor, Joshua M. Wang, Daniel Charytonowicz, Jared Lee Johnson, Emily M. Huntsman, Giacomo B. Marino et al. · 2024 · Cell
Current views on tumor mutational burden in patients with non-small cell lung cancer treated by immune checkpoint inhibitors
Berland, Léa, Heeke, Simon, Humbert, Olivier, Macocco, Adam, Long-Mira, Elodie, Lassalle, Sandra, Lespinet-Fabre, Virginie, Lalvée, Salomé, Bordone, Olivier, Cohen, Charlotte et al. · 2019 · Journal of Thoracic Disease
Clinical utility of tumor mutational burden in patients with non-small cell lung cancer treated with immunotherapy
Lizza E.L. Hendriks, Étienne Rouleau, Benjamin Besse · 2018 · Translational Lung Cancer Research
Temporal trend of gastric cancer burden along with its risk factors in China from 1990 to 2019, and projections until 2030: comparison with Japan, South Korea, and Mongolia
Xiaorong Yang, Tongchao Zhang, Hong Zhang, Shaowei Sang, Hui Chen, Xiuli Zuo · 2021 · Biomarker Research
Cell-free DNA approaches for cancer early detection and interception
Jamie E. Medina, Nicholas C. Dracopoli, Peter Brian Bach, Anna Lau, Robert B. Scharpf, Gerrit A. Meijer, Claus L. Andersen, Victor E. Velculescu · 2023 · Journal for ImmunoTherapy of Cancer
Age influences on the molecular presentation of tumours
Constance H. Li, Syed Aleem Haider, Paul Christopher Boutros · 2022 · Nature Communications
Vaping, Environmental Toxicants Exposure, and Lung Cancer Risk
Shaimaa A. Shehata, Eman Ali Toraih, Ezzat A. Ismail, Abeer M. Hagras, Ekramy Mahmoud Elmorsy, Manal Said Fawzy · 2023 · Cancers
A gene set enrichment analysis for cancer hallmarks
Otília Menyhárt, William Jayasekara Kothalawala, Balázs Győrffy · 2024 · Journal of Pharmaceutical Analysis
Integrative genomic analysis of mouse and human hepatocellular carcinoma
Michelle Dow, R. Pyke, Brian Y. Tsui, L. Alexandrov, Hayato Nakagawa, K. Taniguchi, E. Seki, O. Harismendy, S. Shalapour, M. Karin et al. · 2018 · Proceedings of the National Academy of Sciences of the United States of America
Mutalisk: a web-based somatic MUTation AnaLyIS toolKit for genomic, transcriptional and epigenomic signatures
Jongkeun Lee, A. Lee, Junehwak Lee, Jongkul Park, Youngoh Kwon, Seongyeol Park, Hyonho Chun, Y. Ju, D. Hong · 2018 · Nucleic Acids Res.
Genome-wide identification of transcription factors that are critical to non-small cell lung cancer
Da-Lin Zhang, Li-Wei Qu, Liang Ma, Yongchun Zhou, Guizhen Wang, Xinchun Zhao, Chen Zhang, Yanfei Zhang, Min Wang, Meiying Zhang et al. · 2018 · Cancer Letters
Diagnosis of Lynch Syndrome and Strategies to Distinguish Lynch-Related Tumors from Sporadic MSI/dMMR Tumors
Julie Leclerc, Catherine Vermaut, Marie‐Pierre Buisine · 2021 · Cancers
A review on the 40th anniversary of the first regulation of drinking water disinfection by‐products
David M. DeMarini · 2020 · Environmental and Molecular Mutagenesis
Arsenic co-carcinogenesis: Inhibition of DNA repair and interaction with zinc finger proteins
Xixi Zhou, Rachel M. Speer, Lindsay B. Volk, Laurie G. Hudson, Ke Jian Liu · 2021 · Seminars in Cancer Biology
Translating insights into tumor evolution to clinical practice: promises and challenges
Matthew W. Fittall, Peter Van Loo · 2019 · Genome Medicine
Epigenetic memory in response to environmental stressors
Paolo Vineis, Aristotelis A. Chatziioannou, Vincent T. Cunliffe, James M. Flanagan, Mark A. Hanson, Micheline Kirsch‐Volders, Soterios Α. Kyrtopoulos · 2017 · The FASEB Journal
Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans
Hu, Jinchuan, Selby, Christopher P., Adar, Sheera, Adebali, Ogun, Sancar, Aziz · 2017 · Journal of Biological Chemistry
Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features
Luan Nguyen, Arne van Hoeck, Edwin P. J. G. Cuppen · 2022 · Nature Communications
Timing somatic events in the evolution of cancer
Clemency Jolly, Peter Van Loo · 2018 · Genome biology
Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing
Takafumi Nakagaki, Miyuki Tamura, Kenta Kobashi, Ryota Koyama, Hisayo Fukushima, Tomoko Ohashi, Masashi Idogawa, Kazuhiro Ogi, Hiroyoshi Hiratsuka, Takashi Tokino et al. · 2017 · Oncotarget
Immunotherapy for small cell lung cancer: mechanisms of resistance
Gerhard Hamilton, Barbara Rath · 2019 · Expert Opinion on Biological Therapy
Comprehensive analysis of indels in whole-genome microsatellite regions and microsatellite instability across 21 cancer types
Akihiro Fujimoto, Masashi Fujita, Takanori Hasegawa, Jing Hao Wong, Kazuhiro Maejima, Aya Oku‐Sasaki, Kaoru Nakano, Yuichi Shiraishi, Satoru Miyano, Seiya Imoto et al. · 2020 · Genome Research
Mutational spectra and mutational signatures: Insights into cancer aetiology and mechanisms of DNA damage and repair
David H. Phillips · 2018 · DNA repair
Integrated analysis of the immunological and genetic status in and across cancer types: impact of mutational signatures beyond tumor mutational burden
Jan Budczies, Anja Seidel, Petros Christopoulos, Volker Endris, Matthias Kloor, Balázs Győrffy, Barbara Seliger, Peter Schirmacher, Albrecht Stenzinger, Carsten Denkert · 2018 · OncoImmunology
Electronic Cigarettes Induce Mitochondrial DNA Damage and Trigger TLR9 (Toll-Like Receptor 9)-Mediated Atherosclerosis
Jieliang Li, Do Luong Huynh, William D. Cornwell, Moon‐shong Tang, Hannah Leah Tadeja Simborio, Jing Huang, Beata Kośmider, Thomas J. Rogers, Huaqing Zhao, Michael B. Steinberg et al. · 2020 · Arteriosclerosis Thrombosis and Vascular Biology
Measuring Clonal Evolution in Cancer with Genomics
Marc J. Williams, Andrea Sottoriva, Trevor A. Graham · 2019 · Annual Review of Genomics and Human Genetics
Killing SCLC: insights into how to target a shapeshifting tumor
Kate D. Sutherland, Abbie S. Ireland, Trudy G. Oliver · 2022 · Genes & Development
Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression
Shaolong Cao, Jennifer Rui Wang, Shuangxi Ji, Yang Peng, Yaoyi Dai, Shuai Guo, Matthew D. Montierth, John Paul Shen, Xiao Hong Zhao, Jingxiao Chen et al. · 2022 · Nature Biotechnology
The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities
Abby M. Green, Matthew D. Weitzman · 2019 · DNA repair
Molecular origins of APOBEC-associated mutations in cancer
Mia Petljak, John Maciejowski · 2020 · DNA repair
Understanding EGFR heterogeneity in lung cancer
Antonio Passaro, Umberto Malapelle, Marzia Del Re, Ilaria Attili, Alessandro Russo, Elena Guerini‐Rocco, Caterina Fumagalli, Pasquale Pisapia, Francesco Pepe, Caterina De Luca et al. · 2020 · ESMO Open
Reverse cardio-oncology: Exploring the effects of cardiovascular disease on cancer pathogenesis
Graeme J. Koelwyn, Joseph Pierre Aboumsallem, Kathryn J. Moore, Rudolf A. de Boer · 2021 · Journal of Molecular and Cellular Cardiology
Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology
Inês Sequeira, Mamunur Rashid, Inês M. Tomás, Marc J. Williams, Trevor A. Graham, David J. Adams, Alessandra Vigilante, Fiona M. Watt · 2020 · Nature Communications
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2
Li Ren Kong, Komal Gupta, Annan Wu, David Perera, Roland Iványi-Nagy, Syed Moiz Ahmed, Tuan Zea Tan, Shawn Lu-Wen Tan, Alessandra Fuddin, Elayanambi Sundaramoorthy et al. · 2024 · Cell
Molecular Pathology of Lung Cancer
James Joseph Saller, Theresa A. Boyle · 2021 · Cold Spring Harbor Perspectives in Medicine
Genome sequencing analysis of liver cancer for precision medicine
Hidewaki Nakagawa, Masashi Fujita, Akihiro Fujimoto · 2018 · Seminars in Cancer Biology
Lung cancer risk in never-smokers: An overview of environmental and genetic factors
Elvin S. Cheng, Marianne Frances Weber, Julia Steinberg, Xue Qin Yu · 2021 · Chinese Journal of Cancer Research
Smoking-induced microbial dysbiosis in health and disease
Hagit Shapiro, Kim Goldenberg, Karina Ratiner, Eran Elinav · 2022 · Clinical Science
APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential
Kelly E. Butler, Abdul Rouf Banday · 2023 · Journal of Hematology & Oncology
Ground-glass nodules of the lung in never-smokers and smokers: clinical and genetic insights
Yoshihisa Kobayashi, Chiara Ambrogio, Tetsuya Mitsudomi · 2018 · Translational Lung Cancer Research
Neutral tumor evolution?
The PCAWG Evolution and Heterogeneity Working Group, Maxime Tarabichi, Inigo Martincorena, Moritz Gerstung, Armand Marie Leroi, Florian M. Markowetz, Paul T. Spellman, Quaid Morris, Ole Christian Lingjærde, David C. Wedge et al. · 2018 · Nature Genetics
Smoking History as a Potential Predictor of Immune Checkpoint Inhibitor Efficacy in Metastatic Non-Small Cell Lung Cancer
Xinan Wang, Biagio Ricciuti, Joao V. Alessi, Tom T. Nguyen, Mark Magdi Awad, Xihong Lin, Bruce Evan Johnson, David C. Christiani · 2021 · JNCI Journal of the National Cancer Institute
APOBEC: From mutator to editor
Bei Yang, Xiaosa Li, Liqun Lei, Jia Chen · 2017 · Journal of genetics and genomics/Journal of Genetics and Genomics
Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability
Jäkel, Cornelia, Bergmann, Frank, Toth, Reka, Assenov, Yassen, van der Duin, Daniel, Strobel, Oliver, Hank, Thomas, Klöppel, Günter, Dorrell, Craig, Grompe, Markus et al. · 2017 · Nature Communications
Asbestos‐associated genome‐wide DNA methylation changes in lung cancer
Eeva Kettunen, Héctor Hernández‐Vargas, Marie‐Pierre Cros, Geoffroy Durand, Florence Le Calvez‐Kelm, Kristina Stuopelytė, Sonata Jarmalaitė, Kaisa Salmenkivi, Sisko L. Anttila, Henrik J. Wolff et al. · 2017 · International Journal of Cancer
Tobacco, air pollution, environmental carcinogenesis, and thoughts on conquering strategies of lung cancer
Guang‐Biao Zhou · 2019 · Cancer Biology and Medicine
Smoking, immunity, and DNA damage
Nise Hitomi Yamaguchi · 2019 · Translational Lung Cancer Research
Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden
Mingrui Zhu, Jiwoong Kim, Qing Deng, Biagio Ricciuti, Joao V. Alessi, Buse Eglenen-Polat, Matthew E. Bender, Hai-Cheng Huang, Ryan R Kowash, Ileana Cuevas et al. · 2023 · Cancer Cell
Comprehensive Molecular Characterization of Mitochondrial Genomes in Human Cancers
Yuan Yuan, Young Seok Ju, Young-Wook Kim, Jun Li, Yumeng Wang, Jean Yee Hwa Yang, Sancha Martin, Chad J. Creighton, John N. Weinstein, Yanxun Xu et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
Integrated structural variation and point mutation signatures in cancer genomes using correlated topic models
Tyler Funnell, Allen W. Zhang, Diljot S. Grewal, Steven E. McKinney, Ali Bashashati, Yi Kan Wang, Sohrab P. Shah · 2019 · PLoS Computational Biology
The α9 Nicotinic Acetylcholine Receptor Mediates Nicotine-Induced PD-L1 Expression and Regulates Melanoma Cell Proliferation and Migration
Hai Duong Nguyen, You-Cheng Liao, Yuan‐Soon Ho, Li-Ching Chen, Hui-Wen Chang, Tzu‐Chun Cheng, Donald Liu, Woan-Ruoh Lee, Shing‐Chuan Shen, Chih‐Hsiung Wu et al. · 2019 · Cancers
Single-molecule genome-wide mutation profiles of cell-free DNA for non-invasive detection of cancer
Daniel C. Bruhm, Dimitrios Mathios, Zachariah H. Foda, Akshaya Vijaya Annapragada, Jamie E. Medina, Vilmos Adleff, Elaine Jiayuee Chiao, Leonardo Ferreira, Stephen Cristiano, James Robert White et al. · 2023 · Nature Genetics
Club cells form lung adenocarcinomas and maintain the alveoli of adult mice
Μάγδα Σπέλλα, Ioannis Lilis, Mario A. A. Pepe, Yuanyuan Chen, Marietta Armaka, Anne‐Sophie Lamort, Dimitra E. Zazara, Fani Roumelioti, Malamati Vreka, Nikolaos I. Kanellakis et al. · 2019 · eLife
Helminth infection–induced malignancy
Paul J. Brindley, Alex C. Loukas · 2017 · PLoS Pathogens
Mechanisms of DNA damage repair in adult stem cells and implications for cancer formation
Clare E. Weeden, Marie-Liesse Asselin-Labat · 2017 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight
Carolyn D. Hurst, Guo Cheng, Fiona M. Platt, Mauro A. A. Castro, Nour‐Al‐Dain Marzouka, Pontus Eriksson, Emma V. I. Black, Olivia Alder, Andrew R. J. Lawson, Sia V. Lindskrog et al. · 2021 · Cell Reports Medicine
Tobacco and alcohol-induced epigenetic changes in oral carcinoma
Yasmine Ghantous, Juliana Lucena Schussel, Mariana Brait · 2018 · Current Opinion in Oncology
Multi-omic molecular profiling reveals potentially targetable abnormalities shared across multiple histologies of brain metastasis
Kazutaka Fukumura, Prit Benny Malgulwar, Grant M. Fischer, Xiaoding Hu, Xizeng Mao, Xingzhi Song, Sharia D. Hernandez, Xiang H.-F. Zhang, Jianhua Zhang, Edwin Roger Parra et al. · 2021 · Acta Neuropathologica
Mutational signatures and mutable motifs in cancer genomes
Rogozin, Igor B., Pavlov, Youri I., Goncearenco, Alexander, De, Subhajyoti, Lada, Artem G., Poliakov, Eugenia, Panchenko, Anna R., Cooper, David N. · 2017 · Briefings in Bioinformatics
Evolving neoantigen profiles in colorectal cancers with DNA repair defects
Giuseppe Rospo, Annalisa Lorenzato, Nabil Amirouchene-Angelozzi, Alessandro Magrì, Carlotta Cancelliere, Giorgio Corti, Carola Negrino, Vito Amodio, Monica Montone, Alice Bartolini et al. · 2019 · Genome Medicine
A Review of Toxicity Mechanism Studies of Electronic Cigarettes on Respiratory System
Lilan Wang, Yao Wang, Jianwen Chen, Peiqing Liu, Min Li · 2022 · International Journal of Molecular Sciences
DNA Repair Pathway Alterations in Bladder Cancer
Kent William Mouw · 2017 · Cancers
Population Modeling of Tumor Kinetics and Overall Survival to Identify Prognostic and Predictive Biomarkers of Efficacy for Durvalumab in Patients With Urothelial Carcinoma
Yanan Zheng, Rajesh Narwal, ChaoYu Jin, Paul Baverel, Xiaoping Jin, Ashok Kumar Gupta, Yong Ben, Bing Wang, Pralay Mukhopadhyay, Brandon W. Higgs et al. · 2017 · Clinical Pharmacology & Therapeutics
Within-Host Variations of Human Papillomavirus Reveal APOBEC Signature Mutagenesis in the Viral Genome
Yusuke Hirose, Mamiko Onuki, Yuri Tenjimbayashi, Seiichiro Mori, Yoshiyuki Ishii, Takamasa Takeuchi, Nobutaka Tasaka, Toyomi Satoh, Tohru Morisada, Takashi Iwata et al. · 2018 · Journal of Virology
Integrative genomic analyses of APOBEC-mutational signature, expression and germline deletion of APOBEC3 genes, and immunogenicity in multiple cancer types
Zhishan Chen, Wanqing Wen, Jiandong Bao, Krystle A. Lang Kuhs, Qiuyin Cai, Jirong Long, Xiao‐Ou Shu, Wei Zheng, Xingyi Guo · 2019 · BMC Medical Genomics
Evaluation of a Hybrid Capture–Based Pan-Cancer Panel for Analysis of Treatment Stratifying Oncogenic Aberrations and Processes
Leonie I. Kroeze, Richarda M. de Voer, Eveline J. Kamping, Daniel T. von Rhein, Erik A. M. Jansen, Mandy J. W. Hermsen, Massimo C.P. Barberis, Johan Botling, Eva Maria Garrido-Martin, Florian Haller et al. · 2020 · Journal of Molecular Diagnostics
Lung cancer in never-smokers: a hidden disease
Anand Singh Bhopal, Michael D. Peake, David Gilligan, Paul A Cosford · 2019 · Journal of the Royal Society of Medicine
FOXM1 is required for small cell lung cancer tumorigenesis and associated with poor clinical prognosis
Sheng‐Kai Liang, Chia-Chan Hsu, Hsiang‐Lin Song, Yu-Chi Huang, Chun-Wei Kuo, Xiang Yao, Chien‐Cheng Li, Hui-Chen Yang, Yu-Ling Hung, Sheng-Yang Chao et al. · 2021 · Oncogene
Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients
Jurrian K. de Kanter, Flavia Peci, Eline J.M. Bertrums, Axel Rosendahl Huber, Anaïs J.C.N. van Leeuwen, Markus J. van Roosmalen, Freek Manders, Mark Verheul, Rurika Oka, Arianne M. Brandsma et al. · 2021 · Cell stem cell
Risk of Cancer in Inflammatory Bowel Diseases: Umbrella Review and Reanalysis of Meta-analyses
Daniele Piovani, Cesare Hassan, Alessandro Repici, Lorenza Rimassa, Carmelo Carlo‐Stella, Georgios K. Nikolopoulos, Elio Ríboli, Stefanos Bonovas · 2022 · Gastroenterology
The origin of human mutation in light of genomic data
Vladimir B. Seplyarskiy, Shamil R. Sunyaev · 2021 · Nature Reviews Genetics
Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures
Ammal Abbasi, Ludmil B. Alexandrov · 2021 · DNA repair
Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1
Fan Liang, Guizhen Wang, Yan Wang, Yaning Yang, Zhesheng Wen, Dongni Shao Chen, Wenfeng Fang, Bin Zhang, Lu Yang, Chen Zhang et al. · 2022 · Signal Transduction and Targeted Therapy
The clock-like accumulation of germline and somatic mutations can arise from the interplay of DNA damage and repair
Natanael Spisak, Marc de Manuel, William R. Milligan, Guy Sella, Molly Przeworski · 2024 · PLoS Biology
Challenges in the treatment of small cell lung cancer in the era of immunotherapy and molecular classification
Enrico Caliman, Sara Fancelli, Giulia Petroni, Marta Rita Gatta Michelet, Federica Cosso, Carlotta Ottanelli, Francesca Mazzoni, Luca Voltolini, Serena Pillozzi, Lorenzo Antonuzzo · 2022 · Lung Cancer
A genetic roadmap of pancreatic cancer: still evolving
Faiyaz Notta, Stephan A. Hahn, Francisco X. Real · 2017 · Gut
The innate immune architecture of lung tumors and its implication in disease progression
Simon Milette, Pierre Fiset, Logan A. Walsh, Jonathan David Spicer, Daniela F. Quail · 2019 · The Journal of Pathology
Mutational processes contributing to the development of multiple myeloma
Phuc H. Hoang, Alex J. Cornish, Sara E. Dobbins, Martin Kaiser, Richard S. Houlston · 2019 · Blood Cancer Journal
Tumor Mutational Burden Is Site Specific in Non–Small-Cell Lung Cancer and Is Highest in Lung Adenocarcinoma Brain Metastases
Matthew K. Stein, Manjari K Pandey, Joanne Xiu, Hongseok Tae, Jeffrey J. Swensen, Sandeep Mittal, Andrew Jacob Brenner, Wolfgang Michael Korn, Amy B. Heimberger, Mike G. Martin · 2019 · JCO Precision Oncology
MutSignatures: an R package for extraction and analysis of cancer mutational signatures
Damiano Fantini, Vania Vidimar, Yanni Yu, Salvatore Condello, Joshua J. Meeks · 2020 · Scientific Reports
New possible silver lining for pancreatic cancer therapy: Hydrogen sulfide and its donors
Xu Hu, Yan Xiao, Jianan Sun, Bao Ji, Shanshan Luo, Bo Wu, Chao Zheng, Peng Wang, Fanxing Xu, Keguang Cheng et al. · 2020 · Acta Pharmaceutica Sinica B
The mutational landscape of human somatic and germline cells
Luiza Moore, Alex Cagan, Tim H. H. Coorens, Matthew D. C. Neville, Rashesh Sanghvi, Mathijs Arnoud Sanders, Thomas R. W. Oliver, Daniel A. Leongamornlert, Peter Ellis, Ayesha Noorani et al. · 2022 · Yearbook of pediatric endocrinology
Topography of mutational signatures in human cancer
Burçak Otlu, Marcos Díaz‐Gay, Ian Vermes, Erik N. Bergstrom, Maria Zhivagui, Mark D. Barnes, Ludmil B. Alexandrov · 2023 · Cell Reports
Invasive squamous cell carcinomas and precursor lesions on UV-exposed epithelia demonstrate concordant genomic complexity in driver genes
Lorena Lazo de la Vega, Nolan R. Bick, Kevin S. Hu, Samantha Rahrig, Camilla Duarte Silva, Suzana Matayoshi, Patrícia Picciarelli de Lima, Xiaoming Wang, Alan Sugar, Hunson Kaz Soong et al. · 2020 · Modern Pathology