Mutational signatures associated with tobacco smoking in human cancer

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Items 601–700 of 1,000

1. Mutational signatures and the genomic landscape of betel quid chewing‐associated tongue carcinoma
   Weilong Zhang, Mu Wang, Qifeng Wu, Qing Zhu, Yuchen Jiao, Yiming Zhu, Beibei Yang, Song Ni, Jianjun Yu, Hong Sun et al. · 2019 · Cancer Medicine
2. Transplacental exposure to carcinogens and risks to children: evidence from biomarker studies and the utility of omic profiling
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3. An Unusual Occurrence of Multiple Metachronous and Synchronous Primary Cancers in a Female Patient
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4. [Correlation between Gut Microbiota and Lung Cancer].
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5. Can smoking duration alone replace pack-years to predict the risk of smoking-related oncogenic mutations in non-small cell lung cancer? A cross-sectional study in Japan
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6. Possible Immunotherapeutic Strategies Based on Carcinogen-Dependent Subgroup Classification for Oral Cancer
   Jiwei Sun, Qingming Tang, Junyuan Zhang, Guangjin Chen, Jinfeng Peng, Lili Chen · 2021 · Frontiers in Molecular Biosciences
7. Liquid Biopsy Biomarkers for Immunotherapy in Non-Small Cell Lung Carcinoma: Lessons Learned and the Road Ahead
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8. Role of Chromatin Modifying Complexes and Therapeutic Opportunities in Bladder Cancer
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9. Rauchen – Noxen und immunologische Folgen
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10. Joint Effects of Cigarette Smoking and Green Tea Consumption with miR-29b and DNMT3B mRNA Expression in the Development of Lung Cancer
    Chia-Chen Huang, Chung‐Yu Lai, I‐Hsin Lin, Chin-Hung Tsai, Shi-Mei Tsai, Kit-Lai Lam, Jiun-Yao Wang, Chun‐Chieh Chen, Ruey‐Hong Wong · 2022 · Genes
11. A compendium of co-regulated mitoribosomal proteins in pan-cancer uncovers collateral defective events in tumor malignancy
    Ching-Wen Chang, Zhuang Wei, Stewart R. Durell, Lichun Ma, Marshonna Forgues, Xin Wei Wang · 2022 · iScience
12. Genomic and Glycolytic Entropy Are Reliable Radiogenomic Heterogeneity Biomarkers for Non-Small Cell Lung Cancer
    Yu‐Hung Chen, Kun‐Han Lue, Chih‐Bin Lin, Kuang-Chi Chen, Sheng-Chieh Chan, Sung‐Chao Chu, Bee-Song Chang, Yen‐Chang Chen · 2023 · International Journal of Molecular Sciences
13. Efficacy and safety of immune checkpoint inhibitors combined with chemotherapy in patients with extensive-stage small cell lung cancer: a systematic review and meta-analysis of randomized controlled trials
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14. How does the social environment during life course embody in and influence the development of cancer?
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15. Integrative genomic analysis identifies associations of molecular alterations to APOBEC and BRCA1/2 mutational signatures in breast cancer
    Víctor Treviño · 2019 · Molecular Genetics & Genomic Medicine
16. “High Treg” Inflammations Promote (Most) Non-Hematologic Cancers While “Low Treg” Inflammations Promote Lymphoid Cancers
    Zeev Elkoshi · 2020 · Journal of Inflammation Research
17. Whole-exome sequencing identifies biosignatures that predict adverse survival outcomes in surgically treated patients with oral cavity squamous cell carcinoma
    Chun‐Ta Liao, Lan‐Yan Yang, Li‐Yu Lee, Chien‐Yu Lin, Hung‐Ming Wang, Shu‐Hang Ng, Tzu‐Chen Yen, Wen‐Lang Fan, Chia‐Hsun Hsieh · 2021 · Oral Oncology
18. Integrated single-nucleotide and structural variation signatures of DNA-repair deficient human cancers
    Tyler Funnell, Allen Zhang, Yu-Jia Shiah, Diljot S. Grewal, Robert Lesurf, Steven E. McKinney, Ali Bashashati, Yi Kan Wang, Paul Christopher Boutros, Sohrab P. Shah · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
19. Heavy mutagenesis by tobacco leads to lung adenocarcinoma tumors with KRAS G12 mutations other than G12D, leading KRAS G12D tumors—on average—to exhibit a lower mutation burden
    Chichun Tan, Jeffrey D. Mandell, Krishna Dasari, Vincent L. Cannataro, Jorge A. Alfaro-Murillo, Jeffrey P. Townsend · 2021 · Lung Cancer
20. Massive parallel sequencing of head and neck conventional squamous cell carcinomas: A comprehensive review
    Alfons Nadal, Antonio Cardesa, Abbas Agaimy, Alhadi Almangush, Alessandro Franchi, Henrik B. Hellquist, Ilmo V.V. Leivo, Nina Zidar, Alfio Ferlito · 2024 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
21. Advances in TIL therapy: Expanding the horizons beyond melanoma
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22. Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia
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23. APOBEC mutational signature predicts prognosis and immunotherapy response in nonsmoking patients with lung adenocarcinoma
    Jianli Ma, Xudong Yang, Jing Zhang, Mara B. Antonoff, Qianjiang Wu, Hongfei Ji · 2023 · Translational Lung Cancer Research
24. Environmental carcinogen benzo[a]pyrene alters neutral lipid storage via a cyp-35A2 mediated pathway in Caenorhabditis elegans
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25. Risk factors of secondary cancer in laryngeal, oropharyngeal, or hypopharyngeal cancer after definitive therapy
    Goshi Nishimura, Hideaki Takahashi, Daisuke Sano, Yasuhiro Arai, Takashi Hatano, Yosuke Kitani, Nobuhiko Oridate · 2023 · International Journal of Clinical Oncology
26. Beyond bad luck: induced mutations and hallmarks of cancer
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27. Circulating CD137+CD8+ T cells accumulate along with increased functional regulatory T cells and thoracic tumour burden in lung cancer patients
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28. Characterizing the mutational landscape of MM and its precursor MGUS.
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29. A comprehensive next generation sequencing tissue assay for Asian-prevalent cancers—Analytical validation and performance evaluation with clinical samples
    Cedric Chuan Young Ng, Sandy Lim, Abner Herbert Lim, Nur Diyana Md Nasir, Jingxian Zhang, Vikneswari Rajasegaran, Jing Yi Lee, Jessica Sook-Ting Kok, Aye Aye Thike, Johnathan Xiande Lim et al. · 2022 · Frontiers in Molecular Biosciences
30. Genomic features and its potential implication in bone oligometastatic NSCLC
    Rongxin Liao, Guangming Yi, Lu Shen, Xiaoyue Zhang, Zaicheng Xu, Yuan Peng, Zhenzhou Yang · 2023 · BMC Pulmonary Medicine
31. Sequence dependencies and mutation rates of localized mutational processes in cancer
    Gustav Alexander Poulsgaard, Simon Grund Sørensen, Randi Istrup Juul, Morten Muhlig Nielsen, Jakob Skou Pedersen · 2023 · Genome Medicine
32. Mutational signatures in oral cancer indicate a complex role for tobacco smoke carcinogens
    Grace Bradley, Marco A. O. Magalhães, Martin D. Hyrcza · 2017 · Oral Diseases
33. SUITOR: Selecting the number of mutational signatures through cross-validation
    Donghyuk Lee, Difei Wang, Xiaohong Rose Yang, Jianxin Shi, Maria Teresa Landi, Bin Zhu · 2022 · PLoS Computational Biology
34. Mutational spectra analysis reveals bacterial niche and transmission routes
    Christopher Ruis, Aaron Weimann, Gerry Q. Tonkin‐Hill, Arun Prasad Pandurangan, Marta Matuszewska, Gemma G. R. Murray, Roger C. Lévesque, Tom L. Blundell, R. Andrés Floto, Julian Parkhill · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
35. Molecular landscapes of oral cancers of unknown etiology
    Sophie Deneuve, Béatrice Fervers, Sergey Senkin, Liacine Bouaoun, Olivia Pérol, Bérénice Chavanel, Lingeng Lu, Isabelle Coste, Toufic Renno, Jiří Zavadil et al. · 2023 · medRxiv
36. HOXA1 3′UTR Methylation Is a Potential Prognostic Biomarker in Oral Squamous cell Carcinoma
    Bruna Pereira Sorroche, Keila Cristina Miranda, Caroline Moraes Beltrami, Lídia Maria Rebolho Batista Arantes, Luiz Paulo Kowalski, Fábio Albuquerque Marchi, Sílvia Regina Rogatto, Janete Días Almeida · 2024 · Cancers
37. An overview of traditional smoking cessation interventions and E-cigarettes
    Fahad S. Alshehri · 2024 · Frontiers in Pharmacology
38. Increased PD ‐1/ PD ‐ L1 Immune Checkpoint Expression Is Associated With Oral Squamous Cell Carcinoma in Never‐Smokers and Never‐Drinkers
    Mathias Fiedler, Alisa Off, Andreas Gärtner, Gero Brockhoff, Jonas Eichberger, Maximilian Gottsauner, Johannes G. Schuderer, Michael Maurer, Richard Josef Bauer, Michael Gerken et al. · 2024 · Head & Neck
39. Mutational Landscape of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Association with Immune Checkpoint Inhibitor Outcomes
    Patricia E. Mccoon, Ying Wang, Zhongwu Lai, Qu Zhang, Weimin Li, Sophie Wildsmith, Nassim Morsli, Rajiv G. Raja, Nicholas Holoweckyj, Jill Walker et al. · 2025 · Clinical Cancer Research
40. The association of nutritional and inflammatory status with cardiovascular and all-cause mortality risk among US patients with metabolic syndrome
    Xuanchun Huang, Lanshuo Hu, Jun Li, Xiaoling Xie, Shiyi Tao, Tiantian Xue, Wenjie Zhang · 2025 · Scientific Reports
41. Combinatory analysis of immune cell subsets and tumor-specific genetic variants predict clinical response to PD-1 blockade in patients with non-small cell lung cancer
    Nikita Dutta, Anna Rohlin, Ella Äng Eklund, Maria K. Magnusson, Frida Nilsson, Levent M. Akyürek, Per Torstensson, Volkan I. Sayin, Anna Lundgren, Andreas Hallqvist et al. · 2023 · Frontiers in Oncology
42. Frequency and prognostic influence of ASXL1 mutations and its potential association with BCR-ABL1 transcript type and smoke in chronic myeloid leukemia patients
    Aras Rafiq Mohammed, Dlnya Assad, Golale Rostami, Mohammad Hamid · 2023 · Gene
43. Genomic Mosaicism of the Brain: Origin, Impact, and Utility
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44. The effect of smoking on tumor immunoediting: Friend or foe?
    Yixia Jiang, Hequan Li · 2024 · Tobacco Induced Diseases
45. A new era of mutation rate analyses: Concepts and methods
    Kun Wu, 浙江大学医学院生命演化研究中心和第四附属医院, 浙江 杭州 310058, 中国, Danqi Qin, Yang Qian, Haoxuan Liu · 2024 · 动物学研究
46. Genomic Characteristics and the Potential Clinical Implications in Oligometastatic Non–Small Cell Lung Cancer
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47. Model selection and robust inference of mutational signatures using Negative Binomial non-negative matrix factorization
    Marta Pelizzola, Ragnhild Laursen, A. Hobolth · 2022 · BMC Bioinformatics
48. Predictive value of 18F‐FDG PET / CT and serum tumor markers for tumor mutational burden in patients with non‐small cell lung cancer
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49. Decreases in Smoking-Related Cancer Mortality Rates Are Associated with Birth Cohort Effects in Korean Men
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50. The failure of rodent carcinogenesis as a model for Man
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51. Study on heat transfer process of a heat not burn tobacco product flow field
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52. Elevated Expression of the RAGE Variant-V in SCLC Mitigates the Effect of Chemotherapeutic Drugs
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53. TrackSig: reconstructing evolutionary trajectories of mutations in cancer
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54. Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer
    Yoo-Ah Kim, Damian Wójtowicz, Rebecca Sarto Basso, Itay Sason, Welles Robinson, Dorit S. Hochbaum, Mark D.M. Leiserson, Roded Sharan, Fabio Vandin, Teresa M. Przytycka · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
55. Impact of smoking on the complement system: a narrative review
    Ahmed B. Alarabi, Fatima Z. Alshbool, Fadi T. Khasawneh · 2025 · Frontiers in Immunology
56. Lung cancer in non-smoking women (LCINSW): from risk factors to precision therapy
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57. Long-term Survival and Molecular Biomarker Evaluation of a Phase II Cetuximab and Nivolumab Clinical Trial in Recurrent/Metastatic Head and Neck Cancer
    Ritu Chaudhary, Graydon Moorhead, Robin Park, Jiannong Li, Michael J. Schell, Xiaofei Song, Aik Choon Tan, Robbert J.C. Slebos, Maria I. Biernacki, Samuel S. Freeman et al. · 2025 · Clinical Cancer Research
58. A comparison of clinical guidelines, treatment characteristics and outcomes in small cell lung cancer between East Asia and Europe/North America
    Chi‐Lu Chiang, Ross Andrew Soo, Tony S.K. Mok, Pei Jye Voon, Lucksamon Thamlikitkul, Ying Cheng, Hidehito Horinouchi, Byoung Chul Cho, Krista Lin Xu, Myung‐Ju Ahn · 2025 · Frontiers in Oncology
59. Kras G12C– and G12D–driven lung cancers differ in oncogenic potency, immunogenicity, and relapse after Kras inhibition in mouse models
    Hai-Cheng Huang, Qing Deng, Lei Guo, Teresa Gorría, Federica Pecci, Daniella Yang, Scott J. Rodig, Luis E. De Las Casas, Jill F. Hallin, James G. Christensen et al. · 2026 · Science Translational Medicine
60. Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers
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61. Tumour promotion through the lens of evolution
    Núria López-Bigas, Eve E. Kandyba, Abel González-Pérez, Paul Brennan, Allan Balmain · 2026 · Nature
62. LRT-CLUSTER: A New Clustering Algorithm Based on Likelihood Ratio Test to Identify Driving Genes
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63. Genome-modified Caenorhabditis elegans expressing the human cytochrome P450 (CYP1A1 and CYP1A2) pathway: An experimental model for environmental carcinogenesis and pharmacological research
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64. Proposed mechanisms of neuroprotection for nicotine in Parkinson's disease
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65. Dysphagia predict the response to second cycle neoadjuvant chemotherapy in first cycle no response esophageal carcinoma
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66. Discriminating Spontaneous From Cigarette Smoke and THS 2.2 Aerosol Exposure-Related Proliferative Lung Lesions in A/J Mice by Using Gene Expression and Mutation Spectrum Data
    Yang Xiang, Karsta Luettich, Florian Pierre Martin, James N. D. Battey, Keyur Trivedi, Laurent Neau, Ee Tsin Wong, Emmanuel Guedj, Rémi Dulize, Dariusz Peric et al. · 2021 · Frontiers in Toxicology
67. Detection and Localization of Solid Tumors Utilizing the Cancer-Type-Specific Mutational Signatures
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68. Unveiling the interplay between mutational signatures and tumor microenvironment: a pan-cancer analysis
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69. Integrative analysis of genetics, epigenetics and RNA expression data reveal three susceptibility loci for smoking behavior in Chinese Han population
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70. Multi‐regional sequencing reveals the genetic and immune heterogeneity of non‐cancerous tissues in gastric cancer
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71. Investigation of the presence in human urine of mercapturic acids derived from phenanthrene, a representative polycyclic aromatic hydrocarbon
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72. eNOS and XRCC4 VNTR variants contribute to formation of nicotine dependence and/or schizophrenia
    Sacide Pehlıvan, Mehmet Atilla Uysal, Pınar Çetinay Aydın, Mustafa Pehlıvan, Ayşe Feyda Nursal, Hazal Yavuzlar Cıvan, Selin Kurnaz, Ülgen Sever, Kaasim Fatih Yavuz, Suna Uysal et al. · 2017 · Bratislavské lekárske listy/Bratislava medical journal
73. The genomic imprint of cancer therapies helps timing the formation of metastases
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74. Carcinogen‐induced tumors in SFN ‐transgenic mice harbor a characteristic mutation spectrum of human lung adenocarcinoma
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75. [Research Progress of Immunotherapy and Prognostic Markers in Small Cell Lung Cancer].
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76. Parallelized Latent Dirichlet Allocation Provides a Novel Interpretability of Mutation Signatures in Cancer Genomes
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77. Multi-Omics Analysis to Characterize Cigarette Smoke Induced Molecular Alterations in Esophageal Cells
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78. Genomic evolutionary trajectory of metastatic squamous cell carcinoma of the lung
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79. Impact of Adjuvant Therapy on Survival in Surgically Resected Limited-Stage Small Cell Lung Cancer
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80. Risk Factors of Relapse After Smoking Cessation: Results in China Family Panel Studies From 2010 to 2018
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81. Mutational Signatures as Sensors of Environmental Exposures: Analysis of Smoking-Induced Lung Tissue Remodeling
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82. Cancer hygiene hypothesis: A test from wild captive mammals
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83. The Genome-Wide Molecular Landscape of HPV-Driven and HPV-Negative Head and Neck Squamous Cell Carcinoma
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84. Oncolytic immunotherapy for metastatic cancer: lessons and future strategies
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85. Free Radical and Nicotine Yields in Mainstream Smoke of Chinese Marketed Cigarettes: Variation with Smoking Regimens and Cigarette Brands
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86. A selection-based next generation sequencing approach to develop robust, genotype-specific mutation profiles in Saccharomyces cerevisiae
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87. Comprehensive analysis of molecular features, prognostic values, and immune landscape association of m6A-regulated immune-related lncRNAs in smoking-associated lung squamous cell carcinoma
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88. Long-lasting response to afatinib that persisted after treatment discontinuation in a case of EGFR-mutated lung adenocarcinoma
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89. Enter the matrix: factorization uncovers knowledge from omics Names/Affiliations
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90. Deficiency of nucleotide excision repair explains mutational signature observed in cancer
    Myrthe Jager, Francis Blokzijl, Ewart Kuijk, Johanna Bertl, Maria Vougioukalaki, Roel Janssen, Nicolle J.M. Besselink, Sander Boymans, Joep de Ligt, Jakob Skou Pedersen et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
91. Preface: lung cancer in never smokers
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92. Ancestry Influences on the Molecular Presentation of Tumours
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93. Tumor cell total mRNA expression shapes the molecular and clinical phenotype of cancer
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94. IL-17-mediated inflammation promotes cigarette smoke-induced genomic instability
    Chao Cao, Baoping Tian, Xinwei Geng, Hongbin Zhou, Zhiwei Xu, Tianwen Lai, Yanping Wu, Zhengqiang Bao, Zhihua Chen, Wen Li et al. · 2021 · Research Square
95. Mutational signature decomposition with deep neural networks reveals origins of clock-like processes and hypoxia dependencies
    Clàudia Serrano Colomé, Oleguer Canal, Vladimir B. Seplyarskiy, Donate Weghorn · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
96. APOBEC shapes tumor evolution and age at onset of lung cancer in smokers
    Tongwu Zhang, Jian Sang, Phuc H. Hoang, Wei Zhao, Jennifer Rosenbaum, Kofi Ennu Johnson, Leszek J. Klimczak, John P. McElderry, Alyssa Klein, Christopher Wirth et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
97. Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature
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98. Large-scale single-cell phylogenetic mapping of clonal evolution in the human aging esophagus
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99. KRAS G12C-associated immunotherapy benefit in NSCLC is substantially mediated by tobacco-induced tumor mutation burden, not allele-specific effects
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100. Is Candida albicans a promoting factor, rather than an inducing factor for oral cancer?
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