Mutational signatures associated with tobacco smoking in human cancer

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

Lim, S. S., Vos, T., Flaxman, A. D., Danaei, G., Shibuya, K., Adair-Rohani, H., AlMazroa, M. A., Amann, M., Anderson, H. R., Andrews, K. G., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61766-8 · Cited by 11,805 · see citing works

Signatures of mutational processes in human cancer

Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660 · see citing works

An integrated map of genetic variation from 1,092 human genomes

The 1000 Genomes Project Consortium (2012) · Nature · doi:10.1038/nature11632 · Cited by 7,711 · see citing works

dbSNP: the NCBI database of genetic variation

Sherry, S. T. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.1.308 · Cited by 7,502 · see citing works

Robust regression using iteratively reweighted least-squares.

Holland, P. W., & Welsch, R. E. (1977) · Communications in Statistics - Theory and Methods · doi:10.1080/03610927708827533 · Cited by 2,115 · see citing works

Mutational Processes Molding the Genomes of 21 Breast Cancers

Nik-Zainal, S., Alexandrov, L. B., Wedge, D. C., Van Loo, P., Greenman, C. D., Raine, K., Jones, D., Hinton, J., Marshall, J., Stebbings, L. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.024 · Cited by 1,909 · see citing works

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

Schulze, K., Imbeaud, S., Letouzé, E., Alexandrov, L. B., Calderaro, J., Rebouissou, S., Couchy, G., Meiller, C., Shinde, J., Soysouvanh, F., et al. (2015) · Nature Genetics · doi:10.1038/ng.3252 · Cited by 1,803 · see citing works

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

Imielinski, M., Berger, A. H., Hammerman, P. S., Hernandez, B., Pugh, T. J., Hodis, E., Cho, J., Suh, J., Capelletti, M., Sivachenko, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.029 · Cited by 1,789 · see citing works

Robust Statistics

Huber, P. J., & Ronchetti, E. M. (2009) · Wiley series in probability and statistics · doi:10.1002/9780470434697 · Cited by 1,725 · see citing works

Preferential Formation of Benzo[ <i>a</i> ]pyrene Adducts at Lung Cancer Mutational Hotspots in <i>P53</i>

Denissenko, M. F., Pao, A., Tang, M.-S., & Pfeifer, G. P. (1996) · Science · doi:10.1126/science.274.5286.430 · Cited by 1,650 · see citing works

Tobacco carcinogens, their biomarkers and tobacco-induced cancer

Hecht, S. S. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1190 · Cited by 1,551 · see citing works

The Age Distribution of Cancer and a Multi-stage Theory of Carcinogenesis

Armitage, P., & Doll, R. (1954) · British Journal of Cancer · doi:10.1038/bjc.1954.1 · Cited by 1,549 · see citing works

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

Ley, T. J., Mardis, E. R., Ding, L., Fulton, B., McLellan, M. D., Chen, K., Dooling, D. J., Dunford-Shore, B. H., McGrath, S. D., Hickenbotham, M. T., et al. (2008) · Nature · doi:10.1038/nature07485 · Cited by 1,415 · see citing works

The age distribution of cancer and a multi-stage theory of carcinogenesis

Armitage, P., & Doll, R. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602297 · Cited by 1,309 · see citing works

Deciphering Signatures of Mutational Processes Operative in Human Cancer

Alexandrov, L. B., Nik‐Zainal, S., Wedge, D. C., Campbell, P. J., & Stratton, M. R. (2013) · Cell Reports · doi:10.1016/j.celrep.2012.12.008 · Cited by 1,277 · see citing works

Allele-specific copy number analysis of tumors

Loo, P. V., Nord, S., Lingjærde, O. C., Russnes, H. G., Rye, I. H., Sun, W., Weigman, V., Marynen, P., Zetterberg, A., Naume, B., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009843107 · Cited by 1,231 · see citing works

Effects of cigarette smoke on the immune system

Sopori, M. L. (2002) · Nature reviews. Immunology · doi:10.1038/nri803 · Cited by 1,219 · see citing works

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

Gerlinger, M., Horswell, S. D., Larkin, J., Rowan, A., Salm, M., Varela, I., Fisher, R. A., McGranahan, N., Matthews, N., Santos, C. R., et al. (2014) · Nature Genetics · doi:10.1038/ng.2891 · Cited by 1,211 · see citing works

Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers

Govindan, R., Ding, L., Griffith, M., Subramanian, J., Dees, N. D., Kanchi, K., Maher, C. A., Fulton, R. S., Fulton, L., Wallis, J. W., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.024 · Cited by 1,144 · see citing works

A review of human carcinogens–Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish

Secretan, B., Straif, K., Baan, R., Grosse, Y., El Ghissassi, F., Bouvard, V., Benbrahim-Tallaa, L., Guha, N., Freeman, C., Galichet, L., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70326-2 · Cited by 1,114 · see citing works

Clock-like mutational processes in human somatic cells

Alexandrov, L. B., Jones, P. H., Wedge, D. C., Sale, J. E., Campbell, P. J., Nik‐Zainal, S., & Stratton, M. R. (2015) · Nature Genetics · doi:10.1038/ng.3441 · Cited by 1,038 · see citing works

p53 and Human Cancer: The First Ten Thousand Mutations

Hainaut, P. L., & Hollstein, M. C. (1999) · Advances in cancer research · doi:10.1016/s0065-230x(08)60785-x · Cited by 980 · see citing works

Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants

Fu, W., O’Connor, T. D., Jun, G., Kang, H. M., Abecasis, G. R., Leal, S. M., Gabriel, S., Rieder, M. J., Altshuler, D., Shendure, J., et al. (2012) · Nature · doi:10.1038/nature11690 · Cited by 951 · see citing works

Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

Bolli, N., Avet-Loiseau, H., Wedge, D. C., Van Loo, P., Alexandrov, L. B., Martincorena, I., Dawson, K. J., Iorio, F., Nik-Zainal, S., Bignell, G. R., et al. (2014) · Nature Communications · doi:10.1038/ncomms3997 · Cited by 875 · see citing works

Mechanisms underlying mutational signatures in human cancers

Helleday, T., Eshtad, S., & Nik‐Zainal, S. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3729 · Cited by 841 · see citing works

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

Yates, L. R., Gerstung, M., Knappskog, S., Desmedt, C., Gundem, G., Loo, P. V., Aas, T., Alexandrov, L. B., Larsimont, D., Davies, H., et al. (2015) · Nature Medicine · doi:10.1038/nm.3886 · Cited by 812 · see citing works

A New Theory on the Cancer-inducing Mechanism

Nordling, C. O. (1953) · British Journal of Cancer · doi:10.1038/bjc.1953.8 · Cited by 779 · see citing works

Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

Fujimoto, A., Furuta, M., Totoki, Y., Tsunoda, T., Kato, M., Shiraishi, Y., Tanaka, H., Taniguchi, H., Kawakami, Y., Ueno, M., et al. (2016) · Nature Genetics · doi:10.1038/ng.3547 · Cited by 696 · see citing works

Timing, rates and spectra of human germline mutation

Rahbari, R., Wüster, A., Lindsay, S., Hardwick, R. J., Alexandrov, L. B., Turki, S. H. A., Dominiczak, A. F., Morris, A. D., Porteous, D. J., Smith, B. H., et al. (2015) · Nature Genetics · doi:10.1038/ng.3469 · Cited by 632 · see citing works

Cigarette smoking and lung cancer—relative risk estimates for the major histological types from a pooled analysis of case–control studies

Pesch, B., Kendzia, B., Gustavsson, P., Jöckel, K., Johnen, G., Pohlabeln, H., Olsson, A., Ahrens, W., Gross, I. M., Brüske, I., et al. (2012) · International Journal of Cancer · doi:10.1002/ijc.27339 · Cited by 509 · see citing works

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes

Alexandrov, L. B., & Stratton, M. R. (2014) · Current Opinion in Genetics &amp; Development · doi:10.1016/j.gde.2013.11.014 · Cited by 488 · see citing works

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

Ju, Y. S., Alexandrov, L. B., Gerstung, M., Martin, S., Nik‐Zainal, S., Ramakrishna, M., Davies, H. R., Papaemmanuil, E., Gundem, G., Shlien, A., et al. (2014) · eLife · doi:10.7554/elife.02935 · Cited by 481 · see citing works

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity

Swanton, C., McGranahan, N., Starrett, G. J., & Harris, R. S. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0344 · Cited by 480 · see citing works

Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions

Roberts, S. A., Sterling, J. F., Thompson, C., Harris, S. F., Mav, D., Shah, R., Klimczak, L. J., Kryukov, G. V., Malc, E. P., Mieczkowski, P. A., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.03.030 · Cited by 414 · see citing works

Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors

Kim, J., Mouw, K. W., Polak, P. P., Braunstein, L. Z., Kamburov, A., Tiao, G., Kwiatkowski, D. J., Rosenberg, J. E., Allen, E. M. V., D’Andrea, A. D., et al. (2016) · Nature Genetics · doi:10.1038/ng.3557 · Cited by 402 · see citing works

Only three driver gene mutations are required for the development of lung and colorectal cancers

Tomasetti, C., Marchionni, L., Nowak, M. A., Parmigiani, G., & Vogelstein, B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421839112 · Cited by 395 · see citing works

A Note on Computing Robust Regression Estimates Via Iteratively Reweighted Least Squares

Street, J. O., Carroll, R. J., & Ruppert, D. (1988) · The American Statistician · doi:10.1080/00031305.1988.10475548 · Cited by 380 · see citing works

Genome sequencing of normal cells reveals developmental lineages and mutational processes

Behjati, S., Huch, M., van Boxtel, R., Karthaus, W., Wedge, D., Tamuri, A. U., Martincorena, I., Petljak, M., Alexandrov, L., Gundem, G., et al. (2014) · Nature · doi:10.1038/nature13448 · Cited by 342 · see citing works

Targeting of Lung Cancer Mutational Hotspots by Polycyclic Aromatic Hydrocarbons

Smith, L. E., Denissenko, M. F., Bennett, W. P., Li, H., Amin, S., Tang, M., & Pfeifer, G. P. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.10.803 · Cited by 307 · see citing works

Smoking-related DNA and protein adducts in human tissues

Phillips, D. H. (2002) · Carcinogenesis · doi:10.1093/carcin/23.12.1979 · Cited by 296 · see citing works

Epidemiology of Bladder Cancer

Silverman, D. T., Hartge, P. A., Morrison, A. S., & Devesa, S. S. (1992) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(18)30360-5 · Cited by 288 · see citing works

Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer

Nik-Zainal, S., Wedge, D. C., Alexandrov, L. B., Petljak, M., Butler, A. P., Bolli, N., Davies, H. R., Knappskog, S., Martin, S., Papaemmanuil, E., et al. (2014) · Nature Genetics · doi:10.1038/ng.2955 · Cited by 277 · see citing works

<i>TP53</i> and <i>KRAS</i> Mutation Load and Types in Lung Cancers in Relation to Tobacco Smoke: Distinct Patterns in Never, Former, and Current Smokers

Le Calvez, F., Mukeria, A., Hunt, J. D., Kelm, O., Hung, R. J., Tanière, P., Brennan, P., Boffetta, P., Zaridze, D. G., & Hainaut, P. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0551 · Cited by 273 · see citing works

The genome as a record of environmental exposure

Nik‐Zainal, S., Kucab, J. E., Morganella, S., Głodzik, D., Alexandrov, L. B., Arlt, V. M., Weninger, A., Hollstein, M. C., Stratton, M. R., & Phillips, D. H. (2015) · Mutagenesis · doi:10.1093/mutage/gev073 · Cited by 215 · see citing works

Correlation of Smoking-Associated DNA Methylation Changes in Buccal Cells With DNA Methylation Changes in Epithelial Cancer

Teschendorff, A. E., Yang, Z., Wong, A., Pipinikas, C., Jiao, Y., Jones, A., Anjum, S., Hardy, R., Salvesen, H. B., Thirlwell, C., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.1053 · Cited by 204 · see citing works

Transmissible Dog Cancer Genome Reveals the Origin and History of an Ancient Cell Lineage

Murchison, E. P., Wedge, D. C., Alexandrov, L. B., Fu, B., Martincorena, I., Ning, Z., Tubío, J. M. C., Werner, E., Allen, J., Nardi, A. B. D., et al. (2014) · Science · doi:10.1126/science.1247167 · Cited by 187 · see citing works

A mutational signature in gastric cancer suggests therapeutic strategies

Alexandrov, L. B., Nik‐Zainal, S., Siu, H. C., Leung, S. Y., & Stratton, M. R. (2015) · Nature Communications · doi:10.1038/ncomms9683 · Cited by 178 · see citing works

Impact of Cigarette Smoking on Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study

Agudo, A., Bonet, C., Travier, N., Gonzalez, C. A., Vineis, P., Bueno-de-Mesquita, H. B., Trichopoulos, D., Boffetta, P., Clavel‐Chapelon, F., Boutron‐Ruault, M., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.41.0183 · Cited by 159 · see citing works

DNA and protein adducts in human tissues resulting from exposure to tobacco smoke

Phillips, D. H., & Venitt, S. (2012) · International Journal of Cancer · doi:10.1002/ijc.27827 · Cited by 144 · see citing works

On a Robust Correlation Coefficient

Abdullah, M. B. (1990) · Journal of the Royal Statistical Society Series D (The Statistician) · doi:10.2307/2349088 · Cited by 98 · see citing works

Formation and repair of DNA lesions in thep53 gene: Relation to cancer mutations?

Pfeifer, G. P., & Denissenko, M. F. (1998) · Environmental and Molecular Mutagenesis · doi:10.1002/(sici)1098-2280(1998)31:3 · Cited by 63 · see citing works

Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesis

Rubin, H. (2002) · Oncogene · doi:10.1038/sj.onc.1205800 · Cited by 44 · see citing works

Understanding the origins of human cancer

Alexandrov, L. B. (2015) · Science · doi:10.1126/science.aad7363 · Cited by 34 · see citing works

Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma

Wagener, R., Alexandrov, L. B., Montesinos‐Rongen, M., Schlesner, M., Haake, A., Drexler, H. G., Richter, J., Bignell, G. R., McDermott, U., & Siebert, R. (2015) · Leukemia · doi:10.1038/leu.2015.22 · Cited by 28 · see citing works

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

Chalmers, Z. R., Connelly, C. F., Fabrizio, D., Gay, L., Ali, S. M., Ennis, R., Schrock, A., Campbell, B., Shlien, A., Chmielecki, J., et al. (2017) · Genome Medicine · doi:10.1186/s13073-017-0424-2 · Cited by 3,519 · see citing works

Pan-cancer analysis of whole genomes

The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Aaltonen, L. A., Abascal, F., Abeshouse, A., Aburatani, H., Adams, D. J., Agrawal, N., Ahn, K. S., Ahn, S.-M., Aikata, H., et al. (2020) · Nature · doi:10.1038/s41586-020-1969-6 · Cited by 3,064 · see citing works

Putting p53 in context

Kastenhuber, E. R., & Lowe, S. W. (2017) · Cell · doi:10.1016/j.cell.2017.08.028 · Cited by 1,906 · see citing works

A compendium of mutational cancer driver genes

Martínez-Jiménez, F., Muiños, F., Sentís, I., Deu-Pons, J., Reyes-Salazar, I., Arnedo-Pac, C., Mularoni, L., Pich, O., Bonet, J., Kranas, H., et al. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0290-x · Cited by 1,278 · see citing works

The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker

Jardim, D. L., Goodman, A., de Melo Gagliato, D., & Kurzrock, R. (2021) · Cancer Cell · doi:10.1016/j.ccell.2020.10.001 · Cited by 1,192 · see citing works

Small-cell lung cancer: what we know, what we need to know and the path forward

Gazdar, A. F., Bunn, P. A., & Minna, J. D. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.87 · Cited by 897 · see citing works

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

Gettinger, S., Choi, J., Hastings, K., Truini, A., Datar, I., Sowell, R., Wurtz, A., Dong, W., Cai, G., Melnick, M. A., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0593 · Cited by 787 · see citing works

Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer

Caliri, A. W., Tommasi, S., & Nia, A. B. (2021) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2021.108365 · Cited by 689 · see citing works

DNA Damage and Repair Biomarkers of Immunotherapy Response

Mouw, K. W., Goldberg, M. S., Konstantinopoulos, P. A., & D’Andrea, A. D. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0226 · Cited by 652 · see citing works

MutationalPatterns: comprehensive genome-wide analysis of mutational processes

Blokzijl, F., Janssen, R., van Boxtel, R., & Cuppen, E. (2018) · Genome Medicine · doi:10.1186/s13073-018-0539-0 · Cited by 660 · see citing works

Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics

Chamoli, A., Gosavi, A., Shirwadkar, U. P., Wangdale, K. V., Behera, S. K., Kurrey, N. K., Kalia, K., & Mandoli, A. (2021) · Oral Oncology · doi:10.1016/j.oraloncology.2021.105451 · Cited by 616 · see citing works

The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti–Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC

Jin, Y., Dong, H., Xia, L., Yang, Y., Zhu, Y., Shen, Y., Zheng, H., Yao, C., Wang, Y., & Lu, S. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2019.04.007 · Cited by 573 · see citing works

Advances in molecular classification and precision oncology in hepatocellular carcinoma

Rebouissou, S., & Nault, J. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2019.08.017 · Cited by 580 · see citing works

Tobacco smoking and somatic mutations in human bronchial epithelium

Yoshida, K., Gowers, K. H. C., Lee-Six, H., Chandrasekharan, D. P., Coorens, T. H. H., Maughan, E. F., Beal, K. M., Menzies, A. H., Millar, F. R., Anderson, E. L., et al. (2020) · Nature · doi:10.1038/s41586-020-1961-1 · Cited by 532 · see citing works

Signatures of copy number alterations in human cancer

Steele, C. D., Abbasi, A., Islam, S. M. A., Bowes, A. L., Khandekar, A., Haase, K., Hames-Fathi, S., Ajayi, D., Verfaillie, A., Dhami, P., et al. (2022) · Nature · doi:10.1038/s41586-022-04738-6 · Cited by 487 · see citing works

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J. E., van Wezel, T., et al. (2017) · Science · doi:10.1126/science.aao3130 · Cited by 461 · see citing works

Environmental chemicals and breast cancer: An updated review of epidemiological literature informed by biological mechanisms

Rodgers, K. M., Udesky, J. O., Rudel, R. A., & Brody, J. G. (2017) · Environmental Research · doi:10.1016/j.envres.2017.08.045 · Cited by 451 · see citing works

Tumor Mutational Burden as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors: A Review of Current Evidence

Klempner, S. J., Fabrizio, D. A., Bane, S., Reinhart, M. L., Peoples, T., Ali, S. M., Sokol, E. S., Frampton, G. M., Schrock, A. B., Anhorn, R., et al. (2019) · The Oncologist · doi:10.1634/theoncologist.2019-0244 · Cited by 398 · see citing works

The mutational landscape of human somatic and germline cells

Moore, L., Cagan, A., Coorens, T. H. H., Neville, M. D. C., Sanghvi, R., Sanders, M. A., Oliver, T. R. W., Leongamornlert, D., Ellis, P., Noorani, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03822-7 · Cited by 379 · see citing works

Whole genome sequencing analysis for cancer genomics and precision medicine

Nakagawa, H., & Fujita, M. (2018) · Cancer Science · doi:10.1111/cas.13505 · Cited by 376 · see citing works

Improving radiotherapy in cancer treatment: Promises and challenges

Chen, H. H. W., & Kuo, M. T. (2017) · Oncotarget · doi:10.18632/oncotarget.18409 · Cited by 376 · see citing works

Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations

Wardell, C. P., Fujita, M., Yamada, T., Simbolo, M., Fassan, M., Karlić, R., Polak, P. P., Kim, J., Hatanaka, Y., Maejima, K., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.01.009 · Cited by 374 · see citing works

Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor

Islam, S. M. A., Díaz‐Gay, M., Wu, Y., Barnes, M. D., Vangara, R., Bergstrom, E. N., He, Y., Vella, M., Wang, J., Teague, J. W., et al. (2022) · Cell Genomics · doi:10.1016/j.xgen.2022.100179 · Cited by 350 · see citing works

Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification

Leader, A. M., Grout, J. A., Maier, B. B., Nabet, B. Y., Park, M. D., Tabachnikova, A., Chang, C., Walker, L. A., Lansky, A., Bérichel, J. L., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.10.009 · Cited by 356 · see citing works

Electrochemical biosensors for the detection of lung cancer biomarkers: A review

Khanmohammadi, A., Aghaie, A. B. G., Vahedi, E., Qazvini, A., Ghanei, M., Afkhami, A., Hajian, A., & Bagheri, H. (2019) · Talanta · doi:10.1016/j.talanta.2019.120251 · Cited by 358 · see citing works

Cigarette smoking and telomere length: A systematic review of 84 studies and meta-analysis

Astuti, Y., Wardhana, A. P., Watkins, J. A., & Wulaningsih, W. (2017) · Environmental Research · doi:10.1016/j.envres.2017.06.038 · Cited by 329 · see citing works

SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events

Bergstrom, E. N., Huang, M. N., Mahto, U., Barnes, M. D., Stratton, M. R., Rozen, S., & Alexandrov, L. B. (2019) · BMC Genomics · doi:10.1186/s12864-019-6041-2 · Cited by 301 · see citing works

Extensive heterogeneity in somatic mutation and selection in the human bladder

Lawson, A. R. J., Abascal, F., Coorens, T. H. H., Hooks, Y., O’Neill, L., Latimer, C., Raine, K., Sanders, M. A., Warren, A. Y., Mahbubani, K. T. A., et al. (2020) · Science · doi:10.1126/science.aba8347 · Cited by 311 · see citing works

The mutational footprints of cancer therapies

Pich, O., Muiños, F., Lolkema, M. P., Steeghs, N., Gonzalez-Perez, A., & Lopez-Bigas, N. (2019) · Nature Genetics · doi:10.1038/s41588-019-0525-5 · Cited by 309 · see citing works

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Inman, G. J., Wang, J., Nagano, A., Alexandrov, L. B., Purdie, K. J., Taylor, R. G., Sherwood, V., Thomson, J., Hogan, S., Spender, L. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06027-1 · Cited by 301 · see citing works

Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

Lee, J. S., Adler, L. N., Karathia, H., Carmel, N. N., Rabinovich, S., Auslander, N., Keshet, R., Stettner, N., Silberman, A., Agemy, L., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.019 · Cited by 297 · see citing works

What is new in the exposome?

Vineis, P., Robinson, O., Chadeau‐Hyam, M., Dehghan, A., Mudway, I., & Dagnino, S. (2020) · Environment International · doi:10.1016/j.envint.2020.105887 · Cited by 303 · see citing works

Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis

Letouzé, É., Shinde, J., Renault, V., Couchy, G., Blanc, J., Tubacher, E., Bayard, Q., Bacq, D., Meyer, V., Semhoun, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01358-x · Cited by 290 · see citing works

Lung cancer in patients who have never smoked — an emerging disease

LoPiccolo, J., Gusev, A., Christiani, D. C., & Janne, P. A. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00844-0 · Cited by 307 · see citing works

The Promises and Challenges of Tumor Mutation Burden as an Immunotherapy Biomarker: A Perspective from the International Association for the Study of Lung Cancer Pathology Committee

Sholl, L. M., Hirsch, F. R., Hwang, D. M., Botling, J., López‐Ríos, F., Bubendorf, L., Mino-Kenudson, M. A., Roden, A. C., Beasley, M. B., Borczuk, A., et al. (2020) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2020.05.019 · Cited by 284 · see citing works

Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention

Hecht, S. S., & Hatsukami, D. K. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-021-00423-4 · Cited by 300 · see citing works

Identification of cancer driver genes based on nucleotide context

Dietlein, F., Weghorn, D., Taylor-Weiner, A. N., Richters, A., Reardon, B. M., Liu, D., Lander, E. S., Allen, E. M. V., & Sunyaev, S. R. (2020) · Nature Genetics · doi:10.1038/s41588-019-0572-y · Cited by 241 · see citing works

Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients

Lin, D., Wang, M., & Koeffler, H. P. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.06.066 · Cited by 249 · see citing works

Diverse EGFR Exon 20 Insertions and Co-Occurring Molecular Alterations Identified by Comprehensive Genomic Profiling of NSCLC

Riess, J. W., Gandara, D. R., Frampton, G. M., Madison, R., Peled, N., Bufill, J. A., Dy, G. K., Ou, S.-H. I., Stephens, P. J., McPherson, J. D., et al. (2018) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2018.06.019 · Cited by 240 · see citing works

Human papillomavirus and the landscape of secondary genetic alterations in oral cancersPreprint

Gillison, M. L., Akagi, K., Xiao, W., Jiang, B., Pickard, R. K. L., Li, J., Swanson, B. J., Agrawal, A. D., Zucker, M., Stache-Crain, B., et al. (2018) · Genome Research · doi:10.1101/gr.241141.118 · Cited by 237 · see citing works

A Decade of GWAS Results in Lung Cancer

Bossé, Y., & Amos, C. I. (2017) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0794 · Cited by 229 · see citing works

Enter the Matrix: Factorization Uncovers Knowledge from Omics

Stein-O’Brien, G., Arora, R., Culhane, A. C., Favorov, A. V., Garmire, L. X., Greene, C. S., Goff, L. A., Li, Y., Ngom, A., Ochs, M. F., et al. (2018) · Trends in Genetics · doi:10.1016/j.tig.2018.07.003 · Cited by 235 · see citing works

Mutational signatures are jointly shaped by DNA damage and repair

Volkova, N. V., Meier, B., González‐Huici, V., Bertolini, S., González, S., Vöhringer, H. S., Abascal, F., Martincorena, I., Campbell, P. J., Gartner, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15912-7 · Cited by 223 · see citing works

The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy

Wang, G.-Z., Zhang, L., Zhao, X.-C., Gao, S.-H., Qu, L.-W., Yu, H., Fang, W.-F., Zhou, Y.-C., Liang, F., Zhang, C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08887-7 · Cited by 213 · see citing works

Clustered Mutation Signatures Reveal that Error-Prone DNA Repair Targets Mutations to Active Genes

Supek, F., & Lehner, B. (2017) · Cell · doi:10.1016/j.cell.2017.07.003 · Cited by 192 · see citing works

Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer

Falcomatà, C., Bärthel, S., Schneider, G., Rad, R., Schmidt‐Supprian, M., & Saur, D. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0876 · Cited by 213 · see citing works

Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer

Rodrigues, D. N., Rescigno, P., Liu, D., Yuan, W., Carreira, S., Lambros, M. B. K., Seed, G., Mateo, J., Riisnaes, R., Mullane, S. A., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci121924 · Cited by 204 · see citing works

Causal Inference in Cancer Epidemiology: What Is the Role of Mendelian Randomization?

Yarmolinsky, J., Wade, K. H., Richmond, R. C., Langdon, R., Bull, C. J., Tilling, K. M., Relton, C. L., Lewis, S. J., Smith, G. D., & Martin, R. M. (2018) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-17-1177 · Cited by 186 · see citing works

Tumour predisposition and cancer syndromes as models to study gene–environment interactions

Carbone, M., Arron, S. T., Beutler, B., Bononi, A., Cavenee, W. K., Cleaver, J. E., Croce, C. M., D’Andrea, A. D., Foulkes, W. D., Gaudino, G., et al. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0265-y · Cited by 195 · see citing works

Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence

Moody, S., Senkin, S., Islam, S. M. A., Wang, J., Nasrollahzadeh, D., Penha, R. C. C., Fitzgerald, S. F., Bergstrom, E. N., Atkins, J. R., He, Y., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00928-6 · Cited by 193 · see citing works

The hazards of smoking and the benefits of cessation: A critical summation of the epidemiological evidence in high-income countries

Jha, P. (2020) · eLife · doi:10.7554/elife.49979 · Cited by 191 · see citing works

Molecular events in neuroendocrine prostate cancer development

Wang, Y., Wang, Y., Ci, X., Choi, S. Y. C., Crea, F., Lin, D., & Wang, Y. Z. (2021) · Nature Reviews Urology · doi:10.1038/s41585-021-00490-0 · Cited by 186 · see citing works

Limitations in predicting the space radiation health risk for exploration astronauts

Chancellor, J. C., Blue, R. S., Cengel, K. A., Auñón-Chancellor, S. M., Rubins, K. H., Katzgraber, H. G., & Kennedy, A. R. (2018) · npj Microgravity · doi:10.1038/s41526-018-0043-2 · Cited by 183 · see citing works

Tobacco Smoking-Associated Alterations in the Immune Microenvironment of Squamous Cell Carcinomas

Desrichard, A., Kuo, F., Chowell, D., Lee, K.-W., Riaz, N., Wong, R. J., Chan, T. A.-T., & Morris, L. G. T. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy060 · Cited by 176 · see citing works

Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4

Wang, Z.-Y., Wu, V. H., Allevato, M., Gilardi, M., He, Y., Callejas-Valera, J. L., Vitale-Cross, L., Martin, D., Amornphimoltham, P., Mcdermott, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13471-0 · Cited by 144 · see citing works

Limitations in predicting the space radiation health risk for exploration astronauts

Chancellor, J. C., Blue, R. S., Cengel, K. A., Auñón-Chancellor, S. M., Rubins, K., Katzgraber, H. G., & Kennedy, A. R. (2018) · Civil War Book Review · Cited by 174 · see citing works

Lung Adenocarcinoma Tumor Origin: A Guide for Personalized Medicine

Seguin, L., Durandy, M., & Féral, C. C. (2022) · Cancers · doi:10.3390/cancers14071759 · Cited by 174 · see citing works

A biobank of small cell lung cancer CDX models elucidates inter- and intratumoral phenotypic heterogeneity

Simpson, K., Stoney, R., Frese, K. K., Simms, N., Rowe, W., Pearce, S. P., Humphrey, S., Booth, L., Morgan, D., Dynowski, M., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-0046-2 · Cited by 173 · see citing works

Local Determinants of the Mutational Landscape of the Human Genome

González-Pérez, A., Sabarinathan, R., & López-Bigas, N. (2019) · Cell · doi:10.1016/j.cell.2019.02.051 · Cited by 162 · see citing works

The mutational signature profile of known and suspected human carcinogens in mice

Riva, L., Pandiri, A. R., Li, Y. R., Droop, A., Hewinson, J., Quail, M. A., Iyer, V., Shepherd, R., Herbert, R. A., Campbell, P. J., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-0692-4 · Cited by 162 · see citing works

A practical guide for mutational signature analysis in hematological malignancies

Maura, F., Degasperi, A., Nadeu, F., Leongamornlert, D., Davies, H., Moore, L., Royo, R., Ziccheddu, B., Puente, X. S., Avet-Loiseau, H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11037-8 · Cited by 184 · see citing works

Association between Smoking History and Tumor Mutation Burden in Advanced Non–Small Cell Lung Cancer

Wang, X., Ricciuti, B., Nguyen, T. T., Li, X., Rabin, M. S., Awad, M. M., Lin, X., Johnson, B. E., & Christiani, D. C. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3991 · Cited by 163 · see citing works

The Underlying Tumor Genomics of Predominant Histologic Subtypes in Lung Adenocarcinoma

Caso, R., Sánchez-Vega, F., Tan, K. S., Mastrogiacomo, B., Zhou, J. H., Jones, G. D., Nguyen, B., Schultz, N. D., Connolly, J. G., Brandt, W. S., et al. (2020) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2020.08.005 · Cited by 158 · see citing works

Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation

Park, J. S., Lee, J., Jung, E. S., Kim, M.-H., Kim, I. B., Son, H., Kim, S., Kim, S., Park, Y. M., Mook-Jung, I., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11000-7 · Cited by 155 · see citing works

PD-L1 expression testing in non-small cell lung cancer

Teixidó, C., Vilariño, N., Reyes, R., & Reguart, N. (2018) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835918763493 · Cited by 155 · see citing works

Epidemiology and Molecular Biology of Head and Neck Cancer

Jou, A., & Heß, J. (2017) · Oncology Research and Treatment · doi:10.1159/000477127 · Cited by 154 · see citing works

Molecular mechanisms of the preventable causes of cancer in the United StatesPreprint

Golemis, E. A., Scheet, P. A., Beck, T. N., Scolnick, E. M., Hunter, D. J., Hawk, E. T., & Hopkins, N. H. (2018) · Genes & Development · doi:10.1101/gad.314849.118 · Cited by 156 · see citing works

Validating the concept of mutational signatures with isogenic cell models

Zou, X., Owusu, M., Harris, R., Jackson, S. P., Loizou, J. I., & Nik‐Zainal, S. (2018) · Nature Communications · doi:10.1038/s41467-018-04052-8 · Cited by 142 · see citing works

Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System

Yachida, S., Totoki, Y., Noë, M., Nakatani, Y., Horie, M., Kawasaki, K., Nakamura, H., Saito-Adachi, M., Suzuki, M., Takai, E., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0669 · Cited by 119 · see citing works

Genomic characterization of malignant progression in neoplastic pancreatic cysts

Noë, M., Niknafs, N., Fischer, C. G., Hackeng, W. M., Guthrie, V. B., Hosoda, W., Debeljak, M., Papp, E., Adleff, V., White, J. R., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17917-8 · Cited by 144 · see citing works

Clonal dynamics in early human embryogenesis inferred from somatic mutation

Park, S., Mali, N. M., Kim, R., Choi, J., Lee, J., Lim, J., Park, J. M., Park, J. W., Kim, D., Kim, T., et al. (2021) · Nature · doi:10.1038/s41586-021-03786-8 · Cited by 142 · see citing works

Impact of risk factors on early cancer evolution

Weeden, C. E., Hill, W., Lim, E. L., Gronroos, E. C., & Swanton, C. (2023) · Cell · doi:10.1016/j.cell.2023.03.013 · Cited by 143 · see citing works

Molecular profiles of small cell lung cancer subtypes: Therapeutic implications

Solta, A., Megyesfalvi, Z., Bárány, N., Valkó, Z., Bugyik, E., Lang, C., Ferencz, B., Paku, S., Lantos, A., Fillinger, J., et al. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.02.004 · Cited by 140 · see citing works

Dancing with the DNA damage response: next-generation anti-cancer therapeutic strategies

Minchom, A. R., Aversa, C., & Lopez, J. S. (2018) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835918786658 · Cited by 137 · see citing works

Precision oncology in the age of integrative genomics

Kumar‐Sinha, C., & Chinnaiyan, A. M. (2018) · Nature Biotechnology · doi:10.1038/nbt.4017 · Cited by 137 · see citing works

Correlate the TP53 Mutation and the HRAS Mutation with Immune Signatures in Head and Neck Squamous Cell Cancer

Lyu, H., Li, M., Jiang, Z., Liu, Z., & Wang, X. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.07.009 · Cited by 134 · see citing works

Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment

Widman, A. J., Shah, M. J., Frydendahl, A., Halmos, D., Khamnei, C. C., Øgaard, N., Rajagopalan, S., Arora, A., Deshpande, A. S., Hooper, W. F., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03040-4 · Cited by 143 · see citing works

Stress, epigenetics, and aging: Unraveling the intricate crosstalk

Wu, Z., Qu, J. T., Zhang, W., & Liu, G. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.10.006 · Cited by 142 · see citing works

Evolutionary trajectories of small cell lung cancer under therapy

George, J., Maas, L., Abedpour, N., Cartolano, M., Kaiser, L., Fischer, R. N., Scheel, A. H., Weber, J.-P., Hellmich, M., Bosco, G., et al. (2024) · Nature · doi:10.1038/s41586-024-07177-7 · Cited by 137 · see citing works

Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution

Venkatesan, S., Angelova, M., Puttick, C., Zhai, H.-R., Caswell, D. R., Lu, W.-T., Dietzen, M., Galanos, P., Evangelou, K., Bellelli, R., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0725 · Cited by 134 · see citing works

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking

Huang, Z., Sun, S., Lee, M., Maslov, A. Y., Shi, M., Waldman, S., Marsh, A., Siddiqui, T., Dong, X., Peter, Y., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01035-w · Cited by 125 · see citing works

A systematic assessment of statistics, risk factors, and underlying features involved in pancreatic cancer

Aier, I., Semwal, R., Sharma, A., & Varadwaj, P. K. (2018) · Cancer Epidemiology · doi:10.1016/j.canep.2018.12.001 · Cited by 134 · see citing works

Exome Sequencing of Oral Squamous Cell Carcinoma Reveals Molecular Subgroups and Novel Therapeutic Opportunities

Su, S., Lin, C., Liu, Y., Fan, W., Chen, M., Yu, C.-P., Yang, W., Su, C., Chuang, C., Li, W., et al. (2017) · Theranostics · doi:10.7150/thno.18551 · Cited by 132 · see citing works

Heated Tobacco Products: A Review of Current Knowledge and Initial Assessments

Mallock, N., Pieper, E., Hutzler, C., Henkler, F., & Luch, A. (2019) · Frontiers in Public Health · doi:10.3389/fpubh.2019.00287 · Cited by 130 · see citing works

Precancer Atlas to Drive Precision Prevention Trials

Spira, A. E., Yurgelun, M. B., Alexandrov, L. B., Rao, A., Bejar, R., Polyák, K., Giannakis, M., Shilatifard, A., Finn, O. J., Dhodapkar, M., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2346 · Cited by 130 · see citing works

Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis

Weng, M.-W., Lee, H., Park, S., Hu, Y., Wang, H.-T., Chen, L., Rom, W. N., Huang, W. C. W., Lepor, H., Wu, X., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1804869115 · Cited by 128 · see citing works

APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa

Cho, R. J., Alexandrov, L. B., den Breems, N. Y., Atanasova, V. S., Farshchian, M., Purdom, E. A., Nguyen, T., Coarfa, C., Rajapakshe, K., di Prisco, M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aas9668 · Cited by 126 · see citing works

Non-Genetic Intra-Tumor Heterogeneity Is a Major Predictor of Phenotypic Heterogeneity and Ongoing Evolutionary Dynamics in Lung Tumors

Sharma, A., Merritt, E., Hu, X., Cruz, A., Jiang, C., Sarkodie, H., Zhou, Z. M., Malhotra, J. D., Riedlinger, G., & De, S. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.045 · Cited by 126 · see citing works

Specific Gut Microbiome and Serum Metabolome Changes in Lung Cancer Patients

Zhao, F., An, R., Wang, L., Shan, J., & Wang, X. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.725284 · Cited by 127 · see citing works

An integrative analysis of the age-associated multi-omic landscape across cancers

Chatsirisupachai, K., Lesluyes, T., Paraoan, L., Loo, P. V., & de Magalhães, J. P. (2021) · Nature Communications · doi:10.1038/s41467-021-22560-y · Cited by 122 · see citing works

Identification of distinct mutational patterns and new driver genes in oesophageal squamous cell carcinomas and adenocarcinomas

Lin, D., Dinh, H. Q., Xie, J., Mayakonda, A., Silva, T. C., Jiang, Y., Ding, L., He, J., Xu, X., Hao, J., et al. (2017) · Gut · doi:10.1136/gutjnl-2017-314607 · Cited by 124 · see citing works

Somatic and Germline Mutation Periodicity Follow the Orientation of the DNA Minor Groove around Nucleosomes

Pich, O., Muiños, F., Sabarinathan, R., Reyes-Salazar, I., Gonzalez-Perez, A., & Lopez-Bigas, N. (2018) · Cell · doi:10.1016/j.cell.2018.10.004 · Cited by 123 · see citing works

The clinical utility of tumor mutational burden in non-small cell lung cancer

Greillier, L., Tomasini, P., & Barlési, F. (2018) · Translational Lung Cancer Research · doi:10.21037/tlcr.2018.10.08 · Cited by 123 · see citing works

Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure

Akdemir, K. C., Le, V. T., Kim, J. M., Killcoyne, S., King, D. A., Lin, Y., Tian, Y., Inoue, A., Amin, S. B., Robinson, F. S., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-0708-0 · Cited by 112 · see citing works

Alterations of fecal bacterial communities in patients with lung cancer.

Zhang, W., Zhao, S., Luo, J., Dong, X., Hao, Y., Li, H., Shan, L., Zhou, Y., Shi, H., Zhang, Z.-Y., et al. (2018) · Europe PMC (PubMed Central) · Cited by 119 · see citing works

PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

Piberger, A. L., Bowry, A., Kelly, R. D., Walker, A. K., González‐Acosta, D., Bailey, L. J., Doherty, A. J., Méndez, J., Morris, J. R., Bryant, H. E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19570-7 · Cited by 119 · see citing works

Tumor mutational burden as a predictor of immunotherapy response in breast cancer

O’Meara, T. A., & Tolaney, S. M. (2021) · Oncotarget · doi:10.18632/oncotarget.27877 · Cited by 118 · see citing works

Portrait of a cancer: mutational signature analyses for cancer diagnostics

Van Hoeck, A., Tjoonk, N. H., van Boxtel, R., & Cuppen, E. (2019) · BMC Cancer · doi:10.1186/s12885-019-5677-2 · Cited by 107 · see citing works

Effects of tobacco smoking on the tumor immune microenvironment in head and neck squamous cell carcinoma

de la Iglesia, J. V., Slebos, R., Martín-Gómez, L., Wang, X.-F., Teer, J. K., Tan, A., Gerke, T., Aden-Buie, G., van Veen, T., Masannat, J., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-1769 · Cited by 90 · see citing works

Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRASG12D-mutated non-small-cell lung cancer

Ricciuti, B., Alessi, J. V., Elkrief, A., Wang, X., Cortellini, A., Li, Y. Y., Vaz, V. R., Gupta, H., Pecci, F., Barrichello, A., et al. (2022) · Annals of Oncology · doi:10.1016/j.annonc.2022.07.005 · Cited by 112 · see citing works

Assessing smoke damage in cancer genomes

Kiberstis, P. A. (2016) · Science · doi:10.1126/science.354.6312.593-d

Mutational spectra and mutational signatures: Insights into cancer aetiology and mechanisms of DNA damage and repair

Phillips, D. H. (2018) · DNA repair · doi:10.1016/j.dnarep.2018.08.003 · Cited by 78 · see citing works

Mutational Signature Mark Cancer’s Smoking Gun

Alexandrov, L. B. (2016) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)

Abstract 836: From tobacco smoking to mutation signature: The role of epigenetic changes in human cancers

Chen, Z., Wen, W., Cai, Q., Long, J., Shu, X., Zheng, W., & Guo, X. (2019) · Cancer Research · doi:10.1158/1538-7445.am2019-836

From tobacco smoking to mutational signature: the role of epigenetic changes in human cancersPreprint

Chen, Z., Wen, W., Cai, Q., Long, J., Wang, Y., Lin, W., Shu, X., Zheng, W., & Guo, X. (2020) · doi:10.21203/rs.2.21105/v1