Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

Castellano, Brian M., Thelen, Ashley M., Moldavski, Ofer, Feltes, McKenna, van der Welle, Reini E. N., Mydock-McGrane, Laurel, Jiang, Xuntian, van Eijkeren, Robert J +7 more·2017·Science
DOI 10.1126/science.aag1417

Cited by (562)

Items 101–200 of 562

  1. The lysosomal membrane—export of metabolites and beyond
    Sönke Rudnik, Markus Daμμe · 2020 · FEBS Journal
  2. Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis
    Brandon Chen, Costas Andreas Lyssiotis, Yatrik Madhukar Shah · 2025 · Molecular Cell
  3. Cholesterol and bile acid-mediated regulation of autophagy in fatty liver diseases and atherosclerosis
    Yifeng Wang, Wen‐Xing Ding, Tiangang Li · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  4. Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells
    Elsa Meneses‐Salas, Ana García-Melero, Kristiina Kanerva, Patricia Blanco‐Muñoz, Frederic Morales-Paytuví, Júlia Bonjoch, Josefina Casas, Antonia Egert, Syed Sultan Beevi, Jaimy Jose et al. · 2019 · Cellular and Molecular Life Sciences
  5. Mechanisms and function of autophagy in intestinal disease
    Kara G. Lassen, Ramnik J. Xavier · 2017 · Autophagy
  6. Recent advances in lysosome-targeting luminescent transition metal complexes
    Kangqiang Qiu, Hongyi Zhu, Thomas W. Rees, Liang‐Nian Ji, Qianling Zhang, Hui Chao · 2019 · Coordination Chemistry Reviews
  7. Annexins—Coordinators of Cholesterol Homeostasis in Endocytic Pathways
    Carles Rentero, Patricia Blanco‐Muñoz, Elsa Meneses‐Salas, Thomas Grewal, Carlos Enrich · 2018 · International Journal of Molecular Sciences
  8. Maintenance of CD4 T cell fitness through regulation of Foxo1
    Ryan H. Newton, Sharad Shrestha, Jenna M. Sullivan, Kathleen B. Yates, Ewoud Bernardus Compeer, Noga Ron‐Harel, Bruce R. Blazar, Steven J. Bensinger, W. Nicholas Haining, Michael Loran Dustin et al. · 2018 · Nature Immunology
  9. Super-resolution observation of lysosomal dynamics with fluorescent gold nanoparticles
    Kangqiang Qiu, Yang Du, Jiyan Liu · 2020 · Theranostics
  10. Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells
    Yao Yao, E. Jones, K. Inoki · 2017 · Biomolecules
  11. The mTOR–lysosome axis at the centre of ageing
    Julian M. Carosi, Célia Fourrier, Julien Bensalem, Timothy J. Sargeant · 2021 · FEBS Open Bio
  12. mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species
    Aaron M. Hosios, Meghan E. Wilkinson, Molly C. McNamara, Krystle C. Kalafut, Margaret E. Torrence, John M. Asara, Brendan D. Manning · 2022 · Nature Metabolism
  13. The Extending Spectrum of NPC1-Related Human Disorders: From Niemann–Pick C1 Disease to Obesity
    Amel Lamri, Marie Pigeyre, William Sherman Garver, David Meyre · 2018 · Endocrine Reviews
  14. Mechanisms of cellular cholesterol compartmentalization: recent insights
    Elina Ikonen · 2018 · Current Opinion in Cell Biology
  15. Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state
    Hsiang‐Ting Lei, Jinming Ma, Silvia Sanchez Martinez, Tamir Gonen · 2018 · Nature Structural & Molecular Biology
  16. Cholesterol depletion sensitizes gallbladder cancer to cisplatin by impairing DNA damage response
    Yonglong Zhang, Yanfeng Liu, Jinlin Duan, Hui Wang, Yuchen Zhang, Ke Qiao, Jian Wang · 2019 · Cell Cycle
  17. The complex network of mTOR signalling in the heart
    Sebastiano Sciarretta, Maurizio Forte, Giacomo Frati, Junichi Sadoshima · 2021 · Cardiovascular Research
  18. The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability
    Qiang Pan‐Hammarström, Shanshan Zhong, Hanling Wang, Xuege Wang, Ni Li, Yaqi Li, Guoying Zhang, Huairui Yuan, Yannan Lian, Qilong Chen et al. · 2021 · Molecular Cell
  19. Cholesterol homeostasis and cancer: a new perspective on the low-density lipoprotein receptor
    Jia Gu, Neng Zhu, Hongfang Li, Tanjun Zhao, Chanjuan Zhang, Duan-Fang Liao, Qin Li · 2022 · Cellular Oncology
  20. Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation
    Xing Chen, Chunyu Yu, Xin-Hua Liu, Bei-bei Liu, Xiao-Di Wu, Jia-Jing Wu, Dong Yan, Lu-Lu Han, Zifan Tang, Xinyi Yuan et al. · 2022 · Nature Communications
  21. Lysosomal nanotoxicity: Impact of nanomedicines on lysosomal function
    Mariia Uzhytchak, Barbora Smolková, Mariia Lunová, Adam Frtús, Milan Jirsa, Alexandr Dejneka, Oleg Lunov · 2023 · Advanced Drug Delivery Reviews
  22. Metformin: A Dual-Role Player in Cancer Treatment and Prevention
    Mariam Ahmed Galal, Mohammed Al-Rimawi, Abdurrahman Hajeer, Huda Dahman, Samhar Samer Alouch, Ahmad Aljada · 2024 · International Journal of Molecular Sciences
  23. UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
    Jiandong Sun, Yan Liu, Yousheng Jia, Jennifer Tran, Xiaoning Hao, Weiju Lin, GARY S. LYNCH, Michel Baudry, Xiaoning Bi · 2018 · eLife
  24. The complexity of a monogenic neurodegenerative disease: More than two decades of therapeutic driven research into Niemann-Pick type C disease
    Natalie Hammond, Andrew B. Munkacsi, Stephen L. Sturley · 2019 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  25. Cholesterol: An important actor on the cancer immune scene
    Hossein Halimi, Shirin Farjadian · 2022 · Frontiers in Immunology
  26. Crystal structure of human ORP1-ORD in complex with cholesterol at 2.6 A resolution
    Jiangqing Dong, J. Wang, J.W. Wu · 2018 · Worldwide Protein Data Bank
  27. Lysosome (Dys)function in Atherosclerosis—A Big Weight on the Shoulders of a Small Organelle
    André R. A. Marques, Cristiano Ramos, Gisela Machado-Oliveira, Otília V. Vieira · 2021 · Frontiers in Cell and Developmental Biology
  28. Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability
    Oscar Vivas, Scott A. Tiscione, Rose Ellen Dixon, Daniel S. Ory, Eamonn James Dickson · 2019 · Cell Reports
  29. Lipid Metabolism at Membrane Contacts: Dynamics and Functions Beyond Lipid Homeostasis
    Jiesi Xu, Xun Huang · 2020 · Frontiers in Cell and Developmental Biology
  30. Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover
    Nikki L. Raftopulos, Tinashe C. Washaya, Andreas Niederprüm et al. · 2022 · Cancer & Metabolism
  31. Nutrient Sensing in Cancer
    Margaret E. Torrence, Brendan D. Manning · 2017 · Annual Review of Cancer Biology
  32. The Niemann-Pick type diseases – A synopsis of inborn errors in sphingolipid and cholesterol metabolism
    Frank W. Pfrieger · 2023 · Progress in Lipid Research
  33. PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer
    Gilles Rademaker, Grace A. Hernandez, Yurim Seo, Sumena Dahal, Lisa Miller‐Phillips, Alexander L. Li, Xianlu L. Peng, Changfei Luan, Longhui Qiu, Maude A. Liegeois et al. · 2025 · Nature
  34. Regulation of mTORC1 by the Rag GTPases
    Tshering D. Lama-Sherpa, Mi‐Hyeon Jeong, Jenna L. Jewell · 2023 · Biochemical Society Transactions
  35. Lysosome-Mitochondrial Crosstalk in Cellular Stress and Disease
    Szilvia Kiraly, Jack Stanley, Emily R. Eden · 2025 · Antioxidants
  36. Emerging roles of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate as regulators of multiple steps in autophagy
    Takashi Baba, Tamás Balla · 2020 · The Journal of Biochemistry
  37. The Consequences of GBA Deficiency in the Autophagy–Lysosome System in Parkinson’s Disease Associated with GBA
    Eddie Pradas, Marta Martínez‐Vicente · 2023 · Cells
  38. The Lysosome and Intracellular Signalling.
    G. Hesketh, L. Wartosch, Luther J. Davis, Nicholas A. Bright, J. P. Luzio · 2018 · Progress in molecular and subcellular biology
  39. mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars
    Gemma Sangüesa, Núria Roglans, Miguel Baena, Ana Magdalena Velázquez, Juan Carlos Laguna, Marta Alegret · 2019 · International Journal of Molecular Sciences
  40. And three’s a party: lysosomes, lipid droplets, and the ER in lipid trafficking and cell homeostasis
    W. Mike Henne · 2019 · Current Opinion in Cell Biology
  41. The anti-tubercular activity of simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis
    Natalie Bruiners, Noton Kumar Dutta, Valentina Guerrini, Hugh Salamon, Ken D Yamaguchi, Petros C. Karakousis, Maria Laura Gennaro · 2020 · Journal of Lipid Research
  42. Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes
    Ling Li, Zhifen Chen, Moritz von Scheidt, Shuangyue Li, Andrea Steiner, Ulrich Güldener, Simon Koplev, Angela Ma, Ke Hao, Calvin Pan et al. · 2022 · Basic Research in Cardiology
  43. mTORC2–NDRG1–CDC42 axis couples fasting to mitochondrial fission
    Nuria Martínez-López, Pamela Mattar, Míriam Toledo, Henrietta Bains, Manu Kalyani, Marie Louise Aoun, Mridul Sharma, Laura Beth McIntire, Leslie Gunther-Cummins, Frank Macaluso et al. · 2023 · Nature Cell Biology
  44. Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis
    Fabrizia Bonacina, Xiangyu Zhang, Nicolas Manel, Laurent Yvan‐Charvet, Babak Razani, Giuseppe Danilo Norata · 2024 · Nature Reviews Cardiology
  45. Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress
    Abigail L. Buchwalter, Roberta J. Schulte, Hsiao Tsai, Juliana S. Capitanio, Martin W. Hetzer · 2019 · eLife
  46. Rapid affinity purification of intracellular organelles using a twin strep tag
    Jian Xiong, Jingquan He, Wendy P. Xie, Ezekiel Hinojosa, Chandrashekar R. Ambati, Nagireddy Putluri, Hyun-Eui Kim, Michael X. Zhu, Guangwei Du · 2019 · Journal of Cell Science
  47. atherosclerosis: gone with the Wnt?
    Philippe Boucher, Rachel L. Matz, Jérôme Terrand · 2020 · Atherosclerosis
  48. Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells
    Matsuda, Jun, Takahashi, Atsushi, Takabatake, Yoshitsugu, Sakai, Shinsuke, Minami, Satoshi, Yamamoto, Takeshi, Fujimura, Ryuta, Namba-Hamano, Tomoko, Yonishi, Hiroaki, Nakamura, Jun et al. · 2020 · Autophagy
  49. Fine‐Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation
    Zhiyuan Lu, Lixia Huang, Yanxia Li, Yan Xu, Ruihao Zhang, Qian Zhou, Qi Sun, Yi Lu, Junjie Chen, Yuemao Shen et al. · 2021 · Advanced Science
  50. The role of metabolic ecosystem in cancer progression — metabolic plasticity and mTOR hyperactivity in tumor tissues
    Anna Réka Sebestyén, Titanilla Dankó, Dániel Sztankovics, Dorottya Moldvai, Regina Eszter Raffay, Catherine Cervi, Ildikó Krencz, Viktória Zsiros, András Jeney, Gábor Petővári · 2021 · Cancer and Metastasis Reviews
  51. ATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease
    Qian Ma, Qiuhua Yang, Jiean Xu, Xiaoyu Zhang, David S. Kim, Zhiping Liu, Qingen Da, Xiaoxiao Mao, Yaqi Zhou, Yongfeng Cai et al. · 2022 · Circulation
  52. On the structure and mechanism of two‐pore channels
    Alexander F. Kintzer, Robert Michael Stroud · 2017 · FEBS Journal
  53. Phosphoinositides in the control of lysosome function and homeostasis
    Michael Ebner, Philipp Alexander Koch, Volker Haucke · 2019 · Biochemical Society Transactions
  54. c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder
    Pablo S. Contreras, Pablo Tapía, Lila González-Hódar, Ivana Peluso, Chiara Soldati, Gennaro Napolitano, Maria Matarese, Macarena Las Heras, Cristian Valls, Alexis N. Martinez et al. · 2020 · iScience
  55. Mechanisms and functions of lysosomal lipid homeostasis
    Michael Ebner, Florian Fröhlich, Volker Haucke · 2025 · Cell chemical biology
  56. Tumor Cell Glycolysis—At the Crossroad of Epithelial–Mesenchymal Transition and Autophagy
    Fabrizio Marcucci, Cristiano Rumio · 2022 · Cells
  57. Mechanistic Target of Rapamycin Complex 1: From a Nutrient Sensor to a Key Regulator of Metabolism and Health
    Guoyan Wang, Lei Chen, Senlin Qin, Tingting Zhang, Junhu Yao, Yanglei Yi, Lu Deng · 2022 · Advances in Nutrition
  58. The Central Role of mTORC1 in Amino Acid Sensing
    Shusheng Yue, Guanya Li, Shanping He, Tingting Li · 2022 · Cancer Research
  59. Recent Data on Cellular Component Turnover: Focus on Adaptations to Physical Exercise
    Anthony M. J. Sanchez, Robin B. Candau, Henri Bernardi · 2019 · Cells
  60. Targeting Cancer Lysosomes with Good Old Cationic Amphiphilic Drugs
    Anne‐Marie Ellegaard, Peter Brian Bach, Marja Jäättelä · 2020 · Reviews of physiology, biochemistry and pharmacology
  61. Lipid metabolism, inflammation, and foam cell formation in health and metabolic disorders: targeting mTORC1
    So Yeong Cheon, Kyoungjoo Cho · 2021 · Journal of Molecular Medicine
  62. Photoaffinity labeling approaches to elucidate lipid–protein interactions
    Weizhi Yu, Jeremy M. Baskin · 2022 · Current Opinion in Chemical Biology
  63. Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization
    Marine Berquez, Zhiyong Chen, Beatrice Paola Festa, Patrick Krohn, Svenja Aline Keller, Silvia Parolo, Mikhail Korzinkin, Anna V. Gaponova, Endre Laczkó, Enrico Domenici et al. · 2023 · Nature Communications
  64. Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor
    Raffaele Nicastro, Laura Brohée, Josephine Alba, Julian Nüchel, Gianluca Figlia, Stefanie Kipschull, Peter Gollwitzer, Jesús Romero‐Pozuelo, Stephanie Fernandes, Andreas A. Lamprakis et al. · 2023 · Nature Cell Biology
  65. Stay in touch with the endoplasmic reticulum
    Sha Sun, Zhao Gan, Mingkang Jia, Qing Jiang, Shulin Li, Haibin Wang, Wenjing Li, Yunyun Wang, Xin Bian, Yan G. Zhao et al. · 2024 · Science China Life Sciences
  66. Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity
    Scott A. Tiscione, Oscar Vivas, Kenneth S. Ginsburg, Donald M. Bers, Daniel S. Ory, Luis Fernando Santana, Rose Ellen Dixon, Eamonn James Dickson · 2019 · The Journal of Cell Biology
  67. Elevated Glucosylsphingosine in Gaucher Disease induced Pluripotent Stem Cell Neurons Deregulates Lysosomal Compartment through Mammalian Target of Rapamycin Complex 1
    Manasa P. Srikanth, Jace W. Jones, Maureen A. Kane, Ola Awad, Tea Soon Park, Elias T. Zambidis, Ricardo A. Feldman · 2021 · Stem Cells Translational Medicine
  68. Association between abnormal lipid metabolism and tumor
    Chunyu Li, Fei Wang, Lili Cui, Shaoxin Li, Junyu Zhao, Lin Liao · 2023 · Frontiers in Endocrinology
  69. PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy
    Mohd Shariq, Mohammad Firoz Khan, Reshmi Raj, Nuzhat Ahsan, Pramod Kumar · 2024 · Journal of Molecular Medicine
  70. Nutritional Considerations for the Vegan Athlete
    West, Sam, Monteyne, Alistair J., van der Heijden, Ino, Stephens, Francis B., Wall, Benjamin T. · 2023 · Advances in Nutrition
  71. Cholesterol confers ferroptosis resistance onto myeloid-biased hematopoietic stem cells and prevents irradiation-induced myelosuppression
    Chaonan Liu, Weinian Liao, Jun Chen, Kuan Yu, Yiding Wu, Shuzhen Zhang, Mo Chen, Fang Chen, Song Wang, Tianmin Cheng et al. · 2023 · Redox Biology
  72. Age‐associated cholesterol reduction triggers brain insulin resistance by facilitating ligand‐independent receptor activation and pathway desensitization
    Adrián Martín‐Segura, Tariq Ahmed, Álvaro Casadomé‐Perales, Irene Palomares-Pérez, Ernest Palomer, Axelle Kerstens, Sebastian Munck, Detlef Balschun, Carlos G. Dotti · 2019 · Aging Cell
  73. Pathogens MenTORing Macrophages and Dendritic Cells: Manipulation of mTOR and Cellular Metabolism to Promote Immune Escape
    Lonneke V. Nouwen, Bart Everts · 2020 · Cells
  74. The Pivotal Role of the Dysregulation of Cholesterol Homeostasis in Cancer: Implications for Therapeutic Targets
    Etienne Ho Kit Mok, Terence K. Lee · 2020 · Cancers
  75. Lysosomes at the Crossroads of Cell Metabolism, Cell Cycle, and Stemness
    A. Nowosad, A. Besson · 2022 · International Journal of Molecular Sciences
  76. The low-density lipoprotein receptor–mTORC1 axis coordinates CD8+ T cell activation
    Fabrizia Bonacina, Annalisa Moregola, Monika Svecla, David Coe, Patrizia Uboldi, Sara Fraire, Simona Beretta, Giangiacomo Beretta, Fabio Pellegatta, Alberico Luigi Catapano et al. · 2022 · The Journal of Cell Biology
  77. GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway
    Nick Hoppe, Simone Harrison, Sun‐Hee Hwang, Zi-Wei Chen, Masha Karelina, Ishan Deshpande, Carl‐Mikael Suomivuori, Vivek Reddy Palicharla, Samuel P. Berry, Philipp Tschaikner et al. · 2024 · Nature Structural & Molecular Biology
  78. Structural Insights into TOR Signaling
    L. Tafur, Jennifer M. Kefauver, R. Loewith · 2020 · Genes
  79. Cellular cholesterol and how to find it
    Valentin Schoop, Andrea Martello, Emily R. Eden, Doris Höglinger · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  80. Restoration of mitophagy ameliorates cardiomyopathy in Barth syndrome
    Jun Zhang, Xueling Liu, Jia Nie, Yuguang Shi · 2022 · Autophagy
  81. Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
    Shaowei Wang, Boyang Li, Jie Li, Zhiheng Cai, Cristelle Hugo, Yi Eve Sun, Lu Qian, Julia TCW, Helena Chang Chui, Dante Dikeman et al. · 2025 · Molecular Neurodegeneration
  82. Whole egg, but not egg white, ingestion induces mTOR colocalization with the lysosome after resistance exercise
    Sidney Abou Sawan, Stephan van Vliet, Daniel W. D. West, Joseph W. Beals, Scott A. Paluska, Nicholas A. Burd, Daniel R. Moore · 2018 · American Journal of Physiology-Cell Physiology
  83. Sensors for the mTORC1 pathway regulated by amino acids
    Xiu-zhi Li, Xianghua Yan · 2019 · Journal of Zhejiang University SCIENCE B
  84. Diet-induced dyslipidemia induces metabolic and migratory adaptations in regulatory T cells
    Jacob Amersfoort, Frank H. Schaftenaar, Hidde Douna, Peter J. van Santbrink, Gijs H.M. van Puijvelde, Bram Slütter, Amanda C. Foks, Amy C. Harms, Estefanía Moreno-Gordaliza, Yanyan Wang et al. · 2020 · Cardiovascular Research
  85. Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity
    Yu, Yong, Gao, Shihong M, Guan, Youchen, Hu, Pei-Wen, Zhang, Qinghao, Liu, Jiaming, Jing, Bentian, Zhao, Qian, Sabatini, David M, Abu-Remaileh, Monther et al. · 2024 · eLife
  86. A conformational change in the N terminus of SLC38A9 signals mTORC1 activation
    Hsiang‐Ting Lei, Xuelang Mu, Johan Hattne, Tamir Gonen · 2020 · Structure
  87. Systematic Comparison of Strategies for the Enrichment of Lysosomes by Data Independent Acquisition
    Jasjot Singh, Edgar Kaade, Jan Muntel, Roland Bruderer, Lukas Reiter, Melanie Thelen, Dominic Winter · 2019 · Journal of Proteome Research
  88. Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport
    John-Paul Andersen, Jun Zhang, Haoran Sun, Xuyun Liu, Jiankang Liu, Jia Nie, Yuguang Shi · 2020 · Molecular Metabolism
  89. Functional Peroxisomes Are Essential for Efficient Cholesterol Sensing and Synthesis
    Charles, Khanichi N., Shackelford, Janis E., Faust, Phyllis L., Fliesler, Steven J., Stangl, Herbert, Kovacs, Werner J. · 2020 · Frontiers in Cell and Developmental Biology
  90. The LKB1‐AMPK and mTORC1 Metabolic Signaling Networks in Schwann Cells Control Axon Integrity and Myelination
    Bogdan Beirowski · 2018 · BioEssays
  91. Molecular Regulation of Skeletal Muscle Growth and Organelle Biosynthesis: Practical Recommendations for Exercise Training
    Robert Solsona, Laura Pavlin, Henri Bernardi, Anthony M. J. Sanchez · 2021 · International Journal of Molecular Sciences
  92. S ‑Palmitoylation and Sterol Interactions Mediate Antiviral Specificity of IFITMs
    Tandrila Das, Xinglin Yang, Hwa-Young Lee, Emma H. Garst, Estefania Valencia, Kartik Chandran, Wonpil Im, Howard C. Hang · 2022 · ACS Chemical Biology
  93. Exploring Pro-Inflammatory Immunological Mediators: Unraveling the Mechanisms of Neuroinflammation in Lysosomal Storage Diseases
    Manoj K. Pandey · 2023 · Biomedicines
  94. Survival strategies of cancer cells: the role of macropinocytosis in nutrient acquisition, metabolic reprogramming, and therapeutic targeting
    Guoshuai Xu, Qinghong Zhang, Renjia Cheng, Jun Qu, Wenqiang Li · 2025 · Autophagy
  95. Staying in touch with the endocytic network: The importance of contacts for cholesterol transport
    Andrea Martello, Frances M. Platt, Emily R. Eden · 2020 · Traffic
  96. Insulin signaling couples growth and early maturation to cholesterol intake in Drosophila
    Michael James Texada, Mette Lassen, Lisa Hedegaard Pedersen, Takashi Koyama, Alina Malita, Kim Rewitz · 2022 · Current Biology
  97. A SPLICS reporter reveals $${{{{{\boldsymbol{\alpha }}}}}}$$-synuclein regulation of lysosome-mitochondria contacts which affects TFEB nuclear translocation
    Flavia Giamogante, Lucia Barazzuol, Francesca Maiorca, Elena Poggio, Alessandra Esposito, Anna Masato, Gennaro Napolitano, Alessio Vagnoni, Tito Calí, Marisa Brini · 2024 · Nature Communications
  98. Regulation of Adipocyte and Macrophage Functions by mTORC1 and 2 in Metabolic Diseases
    William T. Festuccia · 2020 · Molecular Nutrition & Food Research
  99. Understanding and Treating Niemann–Pick Type C Disease: Models Matter
    Valentina Pallottini, Frank W. Pfrieger · 2020 · International Journal of Molecular Sciences
  100. Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup
    Francesc Xavier Guix, Ana Dácil Marrero, Álvaro Casadomé‐Perales, Irene Palomares-Pérez, Inés Lopez Del Castillo, Verónica Miguel, Leigh Goedeke, Mauricio G. Martín, Santiago Lamas, Héctor Peinado et al. · 2021 · Life Science Alliance