Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

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  3. Cholesterol signaling in single cells: lessons from STAR and sm-FISH
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  18. Cholesterol transport in the late endocytic pathway: Roles of ORP family proteins
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  30. Cholesterol trafficking, lysosomal function, and atherosclerosis
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  45. Niemann-Pick C2 protein regulates sterol transport between plasma membrane and late endosomes in human fibroblasts
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  52. Lipid–Protein Interactions in Niemann–Pick Type C Disease: Insights from Molecular Modeling
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  58. SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation
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  78. Secretory production of 7‐dehydrocholesterol by engineered Saccharomyces cerevisiae
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  79. Association between serum high-density lipoprotein cholesterol and lung function in adults: three cross-sectional studies from US and Korea National Health and Nutrition Examination Survey
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  80. NPC1 deficiency impairs cerebellar postnatal development of microglia and climbing fiber refinement in a mouse model of Niemann–Pick disease type C
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  81. Mechanically induced solvent-free esterification method at room temperature
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  82. Lyso-IP: Uncovering Pathogenic Mechanisms of Lysosomal Dysfunction
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  83. Cardiac mTORC1 Dysregulation Impacts Stress Adaptation and Survival in Huntington’s Disease
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  87. Experimental Approaches in Delineating mTOR Signaling
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