Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex
Castellano, Brian M., Thelen, Ashley M., Moldavski, Ofer, Feltes, McKenna, van der Welle, Reini E. N., Mydock-McGrane, Laurel, Jiang, Xuntian, van Eijkeren, Robert J, Davis, Oliver B., Louie, Sharon M., Perera, Rushika M., Covey, Douglas F., Nomura, Daniel K., Ory, Daniel S., Zoncu, Roberto·2017·Science
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- Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunctionFannie W. Chen, Joanna P. Davies, Raul Calvo, Jagruti Chaudhari, Georgia Dolios, Mercedes K. Taylor, Samarjit Patnaik, Jean Dehdashti, Rebecca Mull, Patricia Dranchack et al. · 2022 · iScience
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- Autophagy: ‘Self-Eating’ Your Way to LongevityCharlotte J. Pattison, Viktor I. Korolchuk · 2018 · Sub-cellular biochemistry/Subcellular biochemistry
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- Finding Sugar in the Pantry: How Galectins Detect and Signal Lysosomal DamageHijai R. Shin, Roberto Zoncu · 2018 · Molecular Cell
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