The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Host DNases prevent vascular occlusion by neutrophil extracellular traps
Open accessAbstract
Blood DNases hack the NET: Neutrophil extracellular traps (NETs) are lattices of processed chromatin decorated with select secreted and cytoplasmic proteins that trap and neutralize microbes. However, their inappropriate release may do more harm than good by promoting inflammation and thrombosis. Jiménez-Alcázar et al. report that two deoxyribonucleases (DNases), DNASE1 and DNASE1L3, have partially redundant roles in degrading NETs in the circulation (see the Perspective by Gunzer). Knockout mice lacking these enzymes were unable to tolerate chronic neutrophilia, quickly dying after blood vessels were occluded by NET clots. Furthermore, the damage unleashed by clots during septicemia was enhanced when these DNases were absent. Science , this issue p. 1202 ; see also p. 1126
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Neutrophil Extracellular Traps Kill Bacteria
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Novel cell death program leads to neutrophil extracellular traps
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Self-citationExtracellular DNA traps promote thrombosis
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Self-citationPlatelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
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Stark, K., & Massberg, S. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00552-1 · Cited by 1,033
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Castanheira, F. V. S., & Kubes, P. (2019) · Blood · doi:10.1182/blood-2018-11-844530 · Cited by 792
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Lawrence, S. M., Corriden, R., & Nizet, V. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.03.008 · Cited by 144
Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils
Huerga Encabo, H., Aramburu, I. V., Garcia-Albornoz, M., Piganeau, M., Wood, H., Song, A., Ferrelli, A., Sharma, A., Minutti, C. M., Domart, M.-C., et al. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.05.004 · Cited by 81
Metadata
- Authors
- Jiménez-Alcázar, M., Rangaswamy, C., Panda, R., Bitterling, J., Simsek, Y. J., Long, A. T., Bilyy, R., Krenn, V., Renné, C., Renné, T., Kluge, S., Panzer, U., Mizuta, R., Mannherz, H. G., Kitamura, D., Herrmann, M., Napirei, M., & Fuchs, T. A.
- Venue
- Science
- Published
- 2017-12
- Volume
- 358
- Issue
- 6367
- Pages
- 1202-1206
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2773766732
- Cited by
- 594
- References
- 27
- FWCI
- 18.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jiménez-Alcázar, M., Rangaswamy, C., Panda, R., Bitterling, J., Simsek, Y. J., Long, A. T., Bilyy, R., Krenn, V., Renné, C., Renné, T., Kluge, S., Panzer, U., Mizuta, R., Mannherz, H. G., Kitamura, D., Herrmann, M., Napirei, M., & Fuchs, T. A. (2017). Host DNases prevent vascular occlusion by neutrophil extracellular traps. Science. https://doi.org/10.1126/science.aam8897
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