Cited by 144Neutrophil, Myeloperoxidase and Oxidative MechanismsCell death mechanisms and regulationPhagocytosis and Immune Regulation

How neutrophils meet their end

Lawrence, Shelley M., Corriden, Ross, Nizet, Victor·2020·Trends in Immunology

Abstract

Neutrophil death can transpire via diverse pathways and is regulated by interactions with commensal and pathogenic microorganisms, environmental exposures, and cell age. At steady state, neutrophil turnover and replenishment are continually maintained via a delicate balance between host-mediated responses and microbial forces. Disruptions in this equilibrium directly impact neutrophil numbers in circulation, cell trafficking, antimicrobial defenses, and host well-being. How neutrophils meet their end is physiologically important and can result in different immunologic consequences. Whereas nonlytic forms of neutrophil death typically elicit anti-inflammatory responses and promote healing, pathways ending with cell membrane rupture may incite deleterious proinflammatory responses, which can exacerbate local tissue injury, lead to chronic inflammation, or precipitate autoimmunity. This review seeks to provide a contemporary analysis of mechanisms of neutrophil death.

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Crossref · 10.1016/j.it.2020.03.008

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Authors
Lawrence, S. M., Corriden, R., & Nizet, V.
Affiliations
University of California San Diego (US)
Corresponding author
Lawrence, Shelley M.
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2020-06
Volume
41
Issue
6
Pages
531-544
ISSN
1471-4906 (ISSN-L)
OpenAlex
W3016802219
Cited by
144
References
106
Citations by year
2026: 15 · 2025: 23 · 2024: 25 · 2023: 30 · 2022: 20 · 2021: 26 · 2020: 4 · 2012: 1
FWCI
1.95
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords
neutrophil death, neutrophil turnover, cell membrane rupture, commensal microorganisms, pathogenic microorganisms, cell age, cell trafficking, antimicrobial defense, chronic inflammation, autoimmunity, tissue damage
MeSH terms
Animals, Humans, Inflammation, Neutrophils, Apoptosis

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