How neutrophils meet their end
Abstract
Neutrophil death can transpire via diverse pathways and is regulated by interactions with commensal and pathogenic microorganisms, environmental exposures, and cell age. At steady state, neutrophil turnover and replenishment are continually maintained via a delicate balance between host-mediated responses and microbial forces. Disruptions in this equilibrium directly impact neutrophil numbers in circulation, cell trafficking, antimicrobial defenses, and host well-being. How neutrophils meet their end is physiologically important and can result in different immunologic consequences. Whereas nonlytic forms of neutrophil death typically elicit anti-inflammatory responses and promote healing, pathways ending with cell membrane rupture may incite deleterious proinflammatory responses, which can exacerbate local tissue injury, lead to chronic inflammation, or precipitate autoimmunity. This review seeks to provide a contemporary analysis of mechanisms of neutrophil death.
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Pathogen-induced cell death is dependent on NOX activity.
“This process is called pathogen-induced cell death and is also dependent on NOx activity [180].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [180]
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- Authors
- Lawrence, S. M., Corriden, R., & Nizet, V.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Lawrence, Shelley M.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 41
- Issue
- 6
- Pages
- 531-544
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W3016802219
- Cited by
- 144
- References
- 106
- Citations by year
- 2026: 15 · 2025: 23 · 2024: 25 · 2023: 30 · 2022: 20 · 2021: 26 · 2020: 4 · 2012: 1
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- neutrophil death, neutrophil turnover, cell membrane rupture, commensal microorganisms, pathogenic microorganisms, cell age, cell trafficking, antimicrobial defense, chronic inflammation, autoimmunity, tissue damage
- MeSH terms
- Animals, Humans, Inflammation, Neutrophils, Apoptosis
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