Cited by 213Malaria Research and ControlErythrocyte Function and PathophysiologyBird parasitology and diseases

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Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax

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Gruszczyk, Jakub, Kanjee, Usheer, Chan, Li-Jin, Menant, Sébastien, Malleret, Benoit, Lim, Nicholas T. Y., Schmidt, Christoph Q., Mok, Yee-Foong, Lin, Kai-Min, Pearson, Richard D., Rangel, Gabriel, Smith, Brian J., Call, Melissa J., Weekes, Michael P., Griffin, Michael D. W., Murphy, James M., Abraham, Jonathan, Sriprawat, Kanlaya, Menezes, Maria J., Ferreira, Marcelo U., Russell, Bruce, Renia, Laurent, Duraisingh, Manoj T., Tham, Wai-Hong·2018·Science

DOI 10.1126/science.aan1078PMC PMC5788258

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Abstract

Vivax malaria host receptor Human malaria is caused by half a dozen species of Plasmodium protozoan parasites, each with distinctive biology. P. vivax , which causes relapsing malaria, specifically parasitizes immature red blood cells called reticulocytes. Gruszczyk et al. identified TfR1 (host transferrin receptor 1) as an alternative receptor for P. vivax . TfR1 binds to a specific P. vivax surface protein. However, the parasite that causes cerebral malaria, P. falciparum , does not share TfR1 as a receptor: P. falciparum could still infect cells in which TfR1 expression was knocked down, but P. vivax could not. Monoclonal antibodies to the P. vivax protein successfully hindered P. vivax infection of red blood cells. Science , this issue p. 48

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Authors: Gruszczyk, J., Kanjee, U., Chan, L.-J., Menant, S., Malleret, B., Lim, N. T. Y., Schmidt, C. Q., Mok, Y.-F., Lin, K.-M., Pearson, R. D., Rangel, G., Smith, B. J., Call, M. J., Weekes, M. P., Griffin, M. D. W., Murphy, J. M., Abraham, J., Sriprawat, K., Menezes, M. J., Ferreira, M. U., Russell, B., Renia, L., Duraisingh, M. T., & Tham, W.-H.
Affiliations: Walter and Eliza Hall Institute of Medical Research (AU)
Harvard University (US)
The University of Melbourne (AU)
Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore.
Universität Ulm (DE)
University of Cambridge (GB)
Wellcome Sanger Institute (GB)
La Trobe University (AU)
Mahidol University (TH)
Universidade de São Paulo (BR)
University of Otago (NZ)
Singapore Immunology Network, A*STAR, 138648 Singapore.
Corresponding author: Tham, Wai-Hong
ORCID: Gruszczyk, Jakub
Kanjee, Usheer
Chan, Li-Jin
Menant, Sébastien
Malleret, Benoit
Schmidt, Christoph Q.
Mok, Yee-Foong
Lin, Kai-Min
Pearson, Richard D.
Rangel, Gabriel
Smith, Brian J.
Call, Melissa J.
Weekes, Michael P.
Griffin, Michael D. W.
Murphy, James M.
Abraham, Jonathan
Sriprawat, Kanlaya
Ferreira, Marcelo U.
Russell, Bruce
Renia, Laurent
Duraisingh, Manoj T.
Tham, Wai-Hong
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2018-01-05
Volume: 359
Issue: 6371
Pages: 48-55
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aan1078
PMC: PMC5788258
OpenAlex: W2772277028
Cited by: 212
References: 81
Citations by year: 2026: 11 · 2025: 22 · 2024: 23 · 2023: 29 · 2022: 25 · 2021: 29 · 2020: 25 · 2019: 27 · 2018: 20
FWCI: 24.08
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
ANU Open Research (Australian National University) (submittedVersion)
Funders: Wellcome Trust
Canadian Institutes of Health Research
Australian Research Council
National Health and Medical Research Council (1105754)
Howard Hughes Medical Institute and Wellcome Trust
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
Keywords: transferrin receptor 1, Plasmodium vivax, reticulocytes, host cell receptors, Plasmodium falciparum, cerebral malaria, relapsing malaria, red blood cell infection, monoclonal antibodies, parasite surface proteins, host-parasite interactions
MeSH terms: Protein Domains, Host-Parasite Interactions, Humans, Membrane Proteins, Plasmodium vivax, Receptors, Transferrin, Reticulocytes, Antigens, CD, Protozoan Proteins, Malaria, Vivax, Crystallography, X-Ray, Gene Knockdown Techniques

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Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax

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