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Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax
Open accessAbstract
Vivax malaria host receptor Human malaria is caused by half a dozen species of Plasmodium protozoan parasites, each with distinctive biology. P. vivax , which causes relapsing malaria, specifically parasitizes immature red blood cells called reticulocytes. Gruszczyk et al. identified TfR1 (host transferrin receptor 1) as an alternative receptor for P. vivax . TfR1 binds to a specific P. vivax surface protein. However, the parasite that causes cerebral malaria, P. falciparum , does not share TfR1 as a receptor: P. falciparum could still infect cells in which TfR1 expression was knocked down, but P. vivax could not. Monoclonal antibodies to the P. vivax protein successfully hindered P. vivax infection of red blood cells. Science , this issue p. 48
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“Of special interest for the pathophysiology of P. vivax infection is the fact that this species uses mammalian TFR1 to infect reticulocytes (Gruszczyk et al., 2018).”
From Iron in infection and immunity (2020) · cites this paper as Gruszczyk et al., 2018
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Metadata
- Authors
- Gruszczyk, J., Kanjee, U., Chan, L.-J., Menant, S., Malleret, B., Lim, N. T. Y., Schmidt, C. Q., Mok, Y.-F., Lin, K.-M., Pearson, R. D., Rangel, G., Smith, B. J., Call, M. J., Weekes, M. P., Griffin, M. D. W., Murphy, J. M., Abraham, J., Sriprawat, K., Menezes, M. J., Ferreira, M. U., Russell, B., Renia, L., Duraisingh, M. T., & Tham, W.-H.
- Affiliations
- Walter and Eliza Hall Institute of Medical Research (AU)
- Harvard University (US)
- The University of Melbourne (AU)
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore.
- Universität Ulm (DE)
- University of Cambridge (GB)
- Wellcome Sanger Institute (GB)
- La Trobe University (AU)
- Mahidol University (TH)
- Universidade de São Paulo (BR)
- University of Otago (NZ)
- Singapore Immunology Network, A*STAR, 138648 Singapore.
- Corresponding author
- Tham, Wai-Hong
- ORCID
- Gruszczyk, Jakub
- Kanjee, Usheer
- Chan, Li-Jin
- Menant, Sébastien
- Malleret, Benoit
- Schmidt, Christoph Q.
- Mok, Yee-Foong
- Lin, Kai-Min
- Pearson, Richard D.
- Rangel, Gabriel
- Smith, Brian J.
- Call, Melissa J.
- Weekes, Michael P.
- Griffin, Michael D. W.
- Murphy, James M.
- Abraham, Jonathan
- Sriprawat, Kanlaya
- Ferreira, Marcelo U.
- Russell, Bruce
- Renia, Laurent
- Duraisingh, Manoj T.
- Tham, Wai-Hong
- Venue
- Science
- Published
- 2018-01-05
- Volume
- 359
- Issue
- 6371
- Pages
- 48-55
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5788258
- OpenAlex
- W2772277028
- Cited by
- 212
- References
- 81
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 23 · 2023: 29 · 2022: 25 · 2021: 29 · 2020: 25 · 2019: 27 · 2018: 20
- FWCI
- 24.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Funders
- Wellcome Trust
- Canadian Institutes of Health Research
- Australian Research Council
- National Health and Medical Research Council (1105754)
- Howard Hughes Medical Institute and Wellcome Trust
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
- Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
- Keywords
- transferrin receptor 1, Plasmodium vivax, reticulocytes, host cell receptors, Plasmodium falciparum, cerebral malaria, relapsing malaria, red blood cell infection, monoclonal antibodies, parasite surface proteins, host-parasite interactions
- MeSH terms
- Protein Domains, Host-Parasite Interactions, Humans, Membrane Proteins, Plasmodium vivax, Receptors, Transferrin, Reticulocytes, Antigens, CD, Protozoan Proteins, Malaria, Vivax, Crystallography, X-Ray, Gene Knockdown Techniques
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