The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Vinculin forms a directionally asymmetric catch bond with F-actin
Open accessAbstract
Making the right catch: Tension reveals cryptic vinculin-binding sites on α-catenin and talin at cadherin-based cell-cell and integrin-based cell-matrix adhesions, respectively. The enrichment of vinculin at cellular adhesions is thus an indicator of load-induced reinforcement of the cytoskeletal linkage. Huang et al. used a single-molecule optical trap assay to measure the binding lifetimes of vinculin to single actin filaments under load. The vinculin-F-actin interaction formed a directional catch bond—one that is very weak at low force but that greatly increases in lifetime with increasing force. This explains vinculin's role as a reinforcing linker at both cell-cell and cell-matrix adhesions. Science , this issue p. 703
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Adherens junctions as molecular regulators of emergent tissue mechanics
Campàs, O., Noordstra, I., & Yap, A. S. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00688-7 · Cited by 149
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Metadata
- Authors
- Huang, D. L., Bax, N. A., Buckley, C. D., Weis, W. I., & Dunn, A. R.
- Venue
- Science
- Published
- 2017-08-18
- Volume
- 357
- Issue
- 6352
- Pages
- 703-706
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2749092846
- Cited by
- 283
- References
- 64
- FWCI
- 12.55
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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