Linking smell to metabolism and aging
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The olfactory system can have direct effects on energy homeostasis
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Olfactory GPCRs appear to attract less interest from drug discovery programmes despite links to metabolism and ageing.
“The exception among druggable families are olfactory GPCRs, which appear to attract less interest from drug discovery programmes, despite some of these GPCRs being linked to metabolism and ageing47.”
From Unexplored therapeutic opportunities in the human genome (2018) · cites this paper as [47]
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Unexplored therapeutic opportunities in the human genome
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- Authors
- Garrison, J. L., & Knight, Z. A.
- Affiliations
- Buck Institute for Research on Aging (US)
- University of California, San Francisco (US)
- Venue
- Science
- Published
- 2017-11-10
- Volume
- 358
- Issue
- 6364
- Pages
- 718-719
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5937531
- OpenAlex
- W2767439881
- Cited by
- 38
- References
- 15
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 3
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1dp2dk109533-01)
- National Institute of General Medical Sciences (R35GM119828)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP2-DK109533, P30DK098722, R01DK106399)
- National Institute of Neurological Disorders and Stroke (R01NS094781)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- olfaction, energy homeostasis, metabolism, aging, olfactory system
- MeSH terms
- Aging, Animals, Eating, Energy Metabolism, Humans, Smell, Olfactory Receptor Neurons, Mice, Agouti-Related Protein
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