Cited by 76Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNuclear Receptors and Signaling

SF-1 in the ventral medial hypothalamic nucleus: A key regulator of homeostasis

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Kim, Ki Woo, Sohn, Jong-Woo, Kohno, Daisuke, Xu, Yong, Williams, Kevin, Elmquist, Joel K.·2011·Molecular and Cellular Endocrinology

Abstract

The ventral medial hypothalamic nucleus (VMH) regulates food intake and body weight homeostasis. The nuclear receptor NR5A1 (steroidogenic factor 1; SF-1) is a transcription factor whose expression is highly restricted in the VMH and is required for the development of the nucleus. Neurons expressing SF-1 in the VMH have emerged as playing important roles in the regulation of body weight and energy homeostasis. Many of these studies have used site-specific gene KO approaches, providing insights into the molecular mechanisms underlying the regulation of energy homeostasis by the SF-1 neurons of the VMH. In this brief review, we will focus on recent studies defining the molecular mechanisms regulating energy homeostasis and body weight in the VMH, particularly stressing the SF-1 expressing neurons.

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Crossref · 10.1016/j.mce.2010.11.019

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  • The hypothalamus is an important center for coordination of food consumption, body weight homeostasis, and energy expenditure.

    “The hypothalamus is an important center in the brain for the coordination of food consumption, body weight homeostasis, and energy expenditure [83–85].”

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Authors
Kim, K. W., Sohn, J.-W., Kohno, D., Xu, Y., Williams, K., & Elmquist, J. K.
Affiliations
The University of Texas Southwestern Medical Center (US)
Corresponding author
Elmquist, Joel K.
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2011-04
Volume
336
Issue
1-2
Pages
219-223
ISSN
0303-7207 (ISSN-L)
OpenAlex
W2020968269
Cited by
76
References
42
Citations by year
2026: 6 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 5 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 6 · 2012: 2
FWCI
0.32
Type
journal article
Language
en
Open access
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (RL1DK081185)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
steroidogenic factor 1, energy homeostasis, body weight regulation, dietary intake, hypothalamic neurons, transcription factors, molecular mechanisms
MeSH terms
Animals, Homeostasis, Humans, Neurons, Ventromedial Hypothalamic Nucleus, Integrases, Leptin, Steroidogenic Factor 1

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