SF-1 in the ventral medial hypothalamic nucleus: A key regulator of homeostasis
Open accessAbstract
The ventral medial hypothalamic nucleus (VMH) regulates food intake and body weight homeostasis. The nuclear receptor NR5A1 (steroidogenic factor 1; SF-1) is a transcription factor whose expression is highly restricted in the VMH and is required for the development of the nucleus. Neurons expressing SF-1 in the VMH have emerged as playing important roles in the regulation of body weight and energy homeostasis. Many of these studies have used site-specific gene KO approaches, providing insights into the molecular mechanisms underlying the regulation of energy homeostasis by the SF-1 neurons of the VMH. In this brief review, we will focus on recent studies defining the molecular mechanisms regulating energy homeostasis and body weight in the VMH, particularly stressing the SF-1 expressing neurons.
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The hypothalamus is an important center for coordination of food consumption, body weight homeostasis, and energy expenditure.
“The hypothalamus is an important center in the brain for the coordination of food consumption, body weight homeostasis, and energy expenditure [83–85].”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [85]
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Brain Regulation of Feeding and Energy Homeostasis
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- Authors
- Kim, K. W., Sohn, J.-W., Kohno, D., Xu, Y., Williams, K., & Elmquist, J. K.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Elmquist, Joel K.
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 336
- Issue
- 1-2
- Pages
- 219-223
- ISSN
- 0303-7207 (ISSN-L)
- PMC
- PMC3057357
- OpenAlex
- W2020968269
- Cited by
- 76
- References
- 42
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 5 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 6 · 2012: 2
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (RL1DK081185)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- steroidogenic factor 1, energy homeostasis, body weight regulation, dietary intake, hypothalamic neurons, transcription factors, molecular mechanisms
- MeSH terms
- Animals, Homeostasis, Humans, Neurons, Ventromedial Hypothalamic Nucleus, Integrases, Leptin, Steroidogenic Factor 1
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