The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Reconfigurable system for automated optimization of diverse chemical reactions
Open accessAbstract
A self-optimizing reactor: Chemists spend a great deal of time tweaking the conditions of known reactions. Small changes to temperature and concentration can have a big influence over product yield. Bédard et al. present a flow-based reaction platform that carries out this laborious task automatically. By using feedback from integrated analytics, the system converges on optimal conditions that can then be applied with high precision afterward. A series of modules with heating, cooling, mixing, and photochemical capabilities could be configured for a broad range of reactions. These include homogeneous and heterogeneous palladium-catalyzed cross-coupling, reductive amination, and the generation of sensitive intermediates under an inert atmosphere. Science , this issue p. 1220
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Cites
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On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
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Burger, B., Maffettone, P. M., Gusev, V. V., Aitchison, C. M., Bai, Y., Wang, X., Li, X., Alston, B. M., Li, B., Clowes, R., et al. (2020) · Nature · doi:10.1038/s41586-020-2442-2 · Cited by 1,516
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Attia, P. M., Grover, A., Jin, N., Severson, K. A., Markov, T. M., Liao, Y.-H., Chen, M. H., Cheong, B., Perkins, N., Yang, Z., et al. (2020) · Nature · doi:10.1038/s41586-020-1994-5 · Cited by 1,180
A robotic platform for flow synthesis of organic compounds informed by AI planning
Coley, C. W., Thomas, D. A., Lummiss, J. A. M., Jaworski, J. N., Breen, C. P., Schultz, V., Hart, T., Fishman, J. S., Rogers, L., Gao, H., et al. (2019) · Science · doi:10.1126/science.aax1566 · Cited by 1,052
Self-citationRethinking drug design in the artificial intelligence era
Schneider, P., Walters, W. P., Plowright, A. T., Sieroka, N., Listgarten, J., Goodnow, R. A., Fisher, J., Jansen, J. M., Duca, J. S., Rush, T. S., et al. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0050-3 · Cited by 894
Challenges and advances in clinical applications of mesenchymal stromal cells
Zhou, T., Yuan, Z., Weng, J., Pei, D., Du, X., He, C., & Lai, P. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01037-x · Cited by 712
Metadata
- Authors
- Bédard, A.-C., Adamo, A., Aroh, K. C., Russell, M. G., Bedermann, A. A., Torosian, J., Yue, B., Jensen, K. F., & Jamison, T. F.
- Venue
- Science
- Published
- 2018-09-21
- Volume
- 361
- Issue
- 6408
- Pages
- 1220-1225
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2891182990
- Cited by
- 482
- References
- 37
- FWCI
- 20.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bédard, A.-C., Adamo, A., Aroh, K. C., Russell, M. G., Bedermann, A. A., Torosian, J., Yue, B., Jensen, K. F., & Jamison, T. F. (2018). Reconfigurable system for automated optimization of diverse chemical reactions. Science. https://doi.org/10.1126/science.aat0650
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