The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
WDFY4 is required for cross-presentation in response to viral and tumor antigens
Open accessAbstract
Adding to the cross-presentation family: Immune responses to viral or tumor antigens are typically initiated by the process of cross-presentation. Cross-presentation is believed to be the major way that innate immune cells, such as the classical dendritic cell 1 (cDC1) subset, activate and prime immunological T cells. Theisen et al. used CRISPR-based screening to identify regulators of cross-presentation by cDC1s (see the Perspective by Barbet and Blander). One such regulator that was identified, WDFY4 (WD repeat- and FYVE domain–containing protein 4), was required for cross-presentation of cell- and bacterial-associated antigens. WDFY4 played a critical role in cDC1-mediated viral and tumor immunity yet did not seem necessary for major histocompatibility complex class II presentation or for cross-presentation by monocyte-derived DCs. Science , this issue p. 694 ; see also p. 641
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Metadata
- Authors
- Theisen, D. J., Davidson, J. T., Briseño, C. G., Gargaro, M., Lauron, E. J., Wang, Q., Desai, P., Durai, V., Bagadia, P., Brickner, J. R., Beatty, W. L., Virgin, H. W., Gillanders, W. E., Mosammaparast, N., Diamond, M. S., Sibley, L. D., Yokoyama, W., Schreiber, R. D., Murphy, T. L., & Murphy, K. M.
- Venue
- Science
- Published
- 2018-11-09
- Volume
- 362
- Issue
- 6415
- Pages
- 694-699
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2900391803
- Cited by
- 346
- References
- 86
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Theisen, D. J., Davidson, J. T., Briseño, C. G., Gargaro, M., Lauron, E. J., Wang, Q., Desai, P., Durai, V., Bagadia, P., Brickner, J. R., Beatty, W. L., Virgin, H. W., Gillanders, W. E., Mosammaparast, N., Diamond, M. S., Sibley, L. D., Yokoyama, W., Schreiber, R. D., Murphy, T. L., & Murphy, K. M. (2018). WDFY4 is required for cross-presentation in response to viral and tumor antigens. Science. https://doi.org/10.1126/science.aat5030
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