How glycan metabolism shapes the human gut microbiota
Open accessAbstract
Symbiotic microorganisms that reside in the human intestine are adept at foraging glycans and polysaccharides, including those in dietary plants (starch, hemicellulose and pectin), animal-derived cartilage and tissue (glycosaminoglycans and N-linked glycans), and host mucus (O-linked glycans). Fluctuations in the abundance of dietary and endogenous glycans, combined with the immense chemical variation among these molecules, create a dynamic and heterogeneous environment in which gut microorganisms proliferate. In this Review, we describe how glycans shape the composition of the gut microbiota over various periods of time, the mechanisms by which individual microorganisms degrade these glycans, and potential opportunities to intentionally influence this ecosystem for better health and nutrition.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Model systems show that an important function of the intestinal microbiome is metabolizing complex carbohydrates and polysaccharides, called glycans, to produce short-chain fatty acids through fermentation.
“Model systems have demonstrated that an important function of the intestinal microbiome is its ability to metabolize complex carbohydrates and polysaccharides, collectively termed glycans, which leads to production of short-chain fatty acids through fermentation34.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [34]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics
Cantarel, B. L., Coutinho, P. M., Rancurel, C., Bernard, T., Lombard, V., & Henrissat, B. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn663 · Cited by 5,947 · see citing works
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works
(1992) · PubMed · Cited by 3,809 · see citing works
Bacterial Community Variation in Human Body Habitats Across Space and Time
Costello, E. K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J. I., & Knight, R. (2009) · Science · doi:10.1126/science.1177486 · Cited by 3,231 · see citing works
Chen, L., Li, N., & Ye, H. (2012) · Hepatogastroenterology · doi:10.5754/hge12469 · Cited by 3,199 · see citing works
The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000322 · Cited by 3,058 · see citing works
Development of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877 · see citing works
Review article: the role of butyrate on colonic function
HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03562.x · Cited by 2,721 · see citing works
Succession of microbial consortia in the developing infant gut microbiome
Koenig, J. E., Spor, A., Scalfone, N., Fricker, A. D., Stombaugh, J., Knight, R., Angenent, L. T., & Ley, R. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000081107 · Cited by 2,540 · see citing works
Pectin structure and biosynthesis
MOHNEN, D. (2008) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2008.03.006 · Cited by 2,447 · see citing works
Bifidobacteria can protect from enteropathogenic infection through production of acetate
Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., et al. (2011) · Nature · doi:10.1038/nature09646 · Cited by 2,387 · see citing works
Varki, A. P., Cummings, R. D., Esko, J. D., Freeze, H. H., Stanley, P., Bertozzi, C. R., Hart, G. W., & Etzler, M. E. (1999) · Cited by 2,384 · see citing works
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200 · see citing works
Cani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R., Tuohy, K. M., Gibson, G. R., & Delzenne, N. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0791-0 · Cited by 1,770 · see citing works
The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age
Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V., Sokol, H., Doré, J., Corthier, G., & Furet, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-123 · Cited by 1,755 · see citing works
Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis
Flint, H. J., Bayer, E. A., Rincón, M. T., Lamed, R., & White, B. A. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1817 · Cited by 1,710 · see citing works
Dominant and diet-responsive groups of bacteria within the human colonic microbiota
Walker, A. W., Ince, J., Duncan, S. H., Webster, L. M., Holtrop, G., Ze, X., Brown, D., Stares, M. D., Scott, P., Bergerat, A., et al. (2011) · The ISME Journal · doi:10.1038/ismej.2010.118 · Cited by 1,632 · see citing works
Png, C. W., Lindén, S. K., Gilshenan, K. S., Zoetendal, E. G., McSweeney, C. S., Sly, L. I., McGuckin, M. A., & Florin, T. H. J. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.281 · Cited by 1,364 · see citing works
Zoetendal, E. G., Akkermans, A. D. L., & de Vos, W. M. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3854-3859.1998 · Cited by 1,360 · see citing works
A Genomic View of the Human- <i>Bacteroides thetaiotaomicron</i> Symbiosis
Xu, J., Bjursell, M. K., Himrod, J., Deng, S., Carmichael, L. K., Chiang, H. C., Hooper, L. V., & Gordon, J. I. (2003) · Science · doi:10.1126/science.1080029 · Cited by 1,353 · see citing works
Harmsen, H. J. M., Wildeboer-Veloo, A. C. M., Raangs, G. C., Wagendorp, A. A., Klijn, N., BINDELS, J. G., & Welling, G. W. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001000-00019 · Cited by 1,326 · see citing works
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
Segain, J.-P., de la Blétière, D. R., Bourreille, A., Leray, V., Gervois, N., Rosales, C., Ferrier, L., Bonnet, C., Blottière, H. M., & Galmiche, J.-P. (2000) · Gut · doi:10.1136/gut.47.3.397 · Cited by 1,325 · see citing works
The microbiology of butyrate formation in the human colon
Pryde, S. E., Duncan, S. H., Hold, G. L., Stewart, C. S., & Flint, H. J. (2002) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2002.tb11467.x · Cited by 1,320 · see citing works
Gut inflammation provides a respiratory electron acceptor for Salmonella
Winter, S., Thiennimitr, P., Winter, M. G., Butler, B. P., Huseby, D. L., Crawford, R. W., Russell, J. M., Bevins, C. L., Adams, L. G., Tsolis, R. M., et al. (2010) · Nature · doi:10.1038/nature09415 · Cited by 1,271 · see citing works
Glycan foraging in vivo by an intestine-adapted bacterial symbiont
Sonnenburg, J. L., Xu, J., Leip, D. D., Chen, C.-H., Westover, B. P., Weatherford, J., Buhler, J. D., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1109051 · Cited by 1,184 · see citing works
Moving pictures of the human microbiome
Caporaso, J. G., Lauber, C. L., Costello, E. K., Berg-Lyons, D., Gonzalez, A., Stombaugh, J., Knights, D., Gajer, P., Ravel, J., Fierer, N., et al. (2011) · Genome Biology · doi:10.1186/gb-2011-12-5-r50 · Cited by 1,138 · see citing works
Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota
Hehemann, J.-H., Correc, G., Barbeyron, T., Helbert, W., Czjzek, M., & Michel, G. (2010) · Nature · doi:10.1038/nature08937 · Cited by 1,117 · see citing works
Franks, A. H., Harmsen, H. J. M., Raangs, G. C., Jansen, G. J., Schut, F., & Welling, G. W. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.9.3336-3345.1998 · Cited by 1,055 · see citing works
Oligosaccharides in Human Milk: Structural, Functional, and Metabolic Aspects
Kunz, C., Rudloff, S., Baier, W., Klein, N. J., & Ströbel, S. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.699 · Cited by 1,037 · see citing works
Munro, S. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01855-9 · Cited by 966 · see citing works
Towards the human intestinal microbiota phylogenetic core
Tap, J., Mondot, S., Levenez, F., Pelletier, E., Caron, C., Furet, J., Ugarte, E., Muñoz‐Tamayo, R., Paslier, D. L. E., Nalin, R., et al. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01982.x · Cited by 927 · see citing works
Martens, E. C., Chiang, H. C., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.007 · Cited by 919 · see citing works
Self-citationComparative metagenomics revealed commonly enriched gene sets in human gut microbiomes
Kurokawa, K., Itoh, T., Kuwahara, T., Oshima, K., Toh, H., Toyoda, A., Takami, H., Morita, H., Sharma, V. K., Srivastava, T. P., et al. (2007) · DNA Research · doi:10.1093/dnares/dsm018 · Cited by 869 · see citing works
Molecular Monitoring of Succession of Bacterial Communities in Human Neonates
Favier, C. F., Vaughan, E. E., de Vos, W. M., & Akkermans, A. D. L. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.1.219-226.2002 · Cited by 859 · see citing works
Carbohydrate metabolism in Bifidobacteria
Pokusaeva, K., Fitzgerald, G. F., & van Sinderen, D. (2011) · Genes & Nutrition · doi:10.1007/s12263-010-0206-6 · Cited by 855 · see citing works
Recognition and Degradation of Plant Cell Wall Polysaccharides by Two Human Gut Symbionts
Martens, E. C., Lowe, E. C., Chiang, H. C., Pudlo, N. A., Wu, M., McNulty, N. P., Abbott, D. W., Henrissat, B., Gilbert, H. J., Bolam, D. N., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001221 · Cited by 847 · see citing works
Self-citationRamirez-Farias, C., Slezak, K., Fuller, Z., Duncan, A., Holtrop, G., & Louis, P. (2008) · British Journal of Nutrition · doi:10.1017/s0007114508019880 · Cited by 822 · see citing works
Garrett, W. S., Gallini, C. A., Yatsunenko, T., Michaud, M., DuBois, A., Delaney, M. L., Punit, S., Karlsson, M., Bry, L., Glickman, J. N., et al. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.08.004 · Cited by 788 · see citing works
Goodman, A. L., Kallstrom, G., Faith, J. J., Reyes, A., Moore, A. M., Dantas, G. A., & Gordon, J. I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102938108 · Cited by 779 · see citing works
Sonnenburg, E. D., Zheng, H., Joglekar, P., Higginbottom, S. K., Firbank, S. J., Bolam, D. N., & Sonnenburg, J. L. (2010) · Cell · doi:10.1016/j.cell.2010.05.005 · Cited by 745 · see citing works
Duncan, S. H., Barcenilla, A., Stewart, C. S., Pryde, S. E., & Flint, H. J. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.10.5186-5190.2002 · Cited by 743 · see citing works
Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla
Mahowald, M. A., Rey, F. E., Seedorf, H., Turnbaugh, P. J., Fulton, R. S., Wollam, A., Shah, N., Wang, C., Magrini, V. J., Wilson, R. K., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901529106 · Cited by 737 · see citing works
A Catalog of Reference Genomes from the Human Microbiome
The Human Microbiome Jumpstart Reference Strains Consortium, Nelson, K. E., Weinstock, G. M., Highlander, S. K., Worley, K. C., Creasy, H. H., Wortman, J. R., Rusch, D. B., Mitreva, M., Sodergren, E., et al. (2010) · Science · doi:10.1126/science.1183605 · Cited by 702 · see citing works
Fermentation of mucin and plant polysaccharides by strains of Bacteroides from the human colon
Salyers, A. A., Vercellotti, J. R., West, S. E. H., & Wilkins, T. D. (1977) · Applied and Environmental Microbiology · doi:10.1128/aem.33.2.319-322.1977 · Cited by 691 · see citing works
The contribution of the large intestine to energy supplies in man
N I, M. (1984) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/39.2.338 · Cited by 691 · see citing works
Complex Glycan Catabolism by the Human Gut Microbiota: The Bacteroidetes Sus-like Paradigm
Martens, E. C., Koropatkin, N. M., Smith, T. J., & Gordon, J. I. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r109.022848 · Cited by 657 · see citing works
Self-citationKhoruts, A., Dicksved, J., Jansson, J. K., & Sadowsky, M. J. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181c87e02 · Cited by 649 · see citing works
Martínez, I., Kim, J., Duffy, P. R., Schlegel, V. L., & Walter, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015046 · Cited by 645 · see citing works
Evolution of Symbiotic Bacteria in the Distal Human Intestine
Xu, J., Mahowald, M. A., Ley, R. E., Lozupone, C., Hamady, M., Martens, E. C., Henrissat, B., Coutinho, P. M., Minx, P. J., Latreille, P., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050156 · Cited by 585 · see citing works
Self-citationBacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways
Marcobal, A., Barboza, M., Sonnenburg, E. D., Pudlo, N., Martens, E. C., Desai, P., Lebrilla, C. B., Weimer, B. C., Mills, D. A., German, J. B., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.007 · Cited by 574 · see citing works
Fontes, C. M. G. A., & Gilbert, H. J. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-091208-085603 · Cited by 560 · see citing works
Butyrate production from dietary fibre and protection against large bowel cancer in a rat model.
McIntyre, A., Gibson, P. R., & Young, G. P. (1993) · Gut · doi:10.1136/gut.34.3.386 · Cited by 555 · see citing works
Predicting a Human Gut Microbiota’s Response to Diet in Gnotobiotic Mice
Faith, J. J., McNulty, N. P., Rey, F. E., & Gordon, J. I. (2011) · Science · doi:10.1126/science.1206025 · Cited by 536 · see citing works
A Strategy for Annotating the Human Milk Glycome
Niñonuevo, M. R., Park, Y., Yin, H., Zhang, J., Ward, R. E., Clowers, B. H., German, J. B., Freeman, S. L., Killeen, K., Grimm, R., et al. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0615810 · Cited by 495 · see citing works
Contribution of acetate to butyrate formation by human faecal bacteria
Duncan, S. H., Holtrop, G., Lobley, G. E., Calder, A. G., Stewart, C. S., & Flint, H. J. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041150 · Cited by 494 · see citing works
Bloom, S. M., Bijanki, V. N., Nava, G. M., Sun, L., Malvin, N. P., Donermeyer, D. L., Dunne, W. M., Allen, P. M., & Stappenbeck, T. S. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.009 · Cited by 488 · see citing works
Turnbaugh, P. J., Quince, C., Faith, J. J., McHardy, A. C., Yatsunenko, T., Niazi, F., Affourtit, J., Egholm, M., Henrissat, B., Knight, R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002355107 · Cited by 478 · see citing works
Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the human colon
Salyers, A. A., West, S. E. H., Vercellotti, J. R., & Wilkins, T. D. (1977) · Applied and Environmental Microbiology · doi:10.1128/aem.34.5.529-533.1977 · Cited by 471 · see citing works
Neyrinck, A. M., Possemiers, S., Druart, C., Van de Wiele, T., De Backer, F., Cani, P. D., Larondelle, Y., & Delzenne, N. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020944 · Cited by 465 · see citing works
Slowly Digestible Starch: Concept, Mechanism, and Proposed Extended Glycemic Index
Zhang, G., & Hamaker, B. R. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903372466 · Cited by 464 · see citing works
Genomic and Metabolic Studies of the Impact of Probiotics on a Model Gut Symbiont and Host
Sonnenburg, J. L., Chen, C. T. L., & Gordon, J. I. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040413 · Cited by 423 · see citing works
Dissecting the in Vivo Metabolic Potential of Two Human Gut Acetogens
Rey, F. E., Faith, J. J., Bain, J. R., Muehlbauer, M. J., Stevens, R. D., Newgard, C. B., & Gordon, J. I. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.117713 · Cited by 417 · see citing works
Butyrate modulates oxidative stress in the colonic mucosa of healthy humans
Hamer, H. M., Jonkers, D. M. A. E., Bast, A., Vanhoutvin, S. A. L. W., Fischer, M. A. J. G., Kodde, A., Troost, F. J., Venema, K., & Brummer, R.-J. M. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2008.11.002 · Cited by 400 · see citing works
Fallani, M., Amarri, S., Uusijärvi, A., Adam, R., Khanna, S., Aguilera, J., Gil, Á., Vieites, J. M., Norin, E. L., Young, D., et al. (2011) · Microbiology · doi:10.1099/mic.0.042143-0 · Cited by 393 · see citing works
Koropatkin, N. M., Martens, E. C., Gordon, J. I., & Smith, T. J. (2008) · Structure · doi:10.1016/j.str.2008.03.017 · Cited by 375 · see citing works
Self-citationTurroni, F., Bottacini, F., Foroni, E., Mulder, I., Kim, J.-H., Zomer, A., Sánchez, B., Bidossi, A., Ferrarini, A., Giubellini, V., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011100107 · Cited by 364 · see citing works
Bauer, M., Kube, M., Teeling, H., Richter, M., Lombardot, T., Allers, E., Würdemann, C., Quast, C., Kuhl, H., Knaust, F., et al. (2006) · Environmental Microbiology · doi:10.1111/j.1462-2920.2006.01152.x · Cited by 364 · see citing works
Bjursell, M. K., Martens, E. C., & Gordon, J. I. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606509200 · Cited by 338 · see citing works
Self-citationFrom cellulosomes to cellulosomics
Bayer, E. A., Lamed, R., White, B. A., & Flint, H. J. (2008) · The Chemical Record · doi:10.1002/tcr.20160 · Cited by 323 · see citing works
The bifidogenic effect of inulin and oligofructose and its consequences for gut health
Meyer, D., & Stasse-Wolthuis, M. (2009) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2009.64 · Cited by 322 · see citing works
Packey, C. D., & Sartor, R. B. (2009) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32832a8a5d · Cited by 319 · see citing works
Swidsinski, A. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i8.1131 · Cited by 314 · see citing works
Oligosaccharides in human milk during different phases of lactation
Coppa, G. V., Pierani, P., Zampini, L., Carloni, I., Carlucci, A., & Gabrielli, O. (1999) · Acta Paediatrica · doi:10.1111/j.1651-2227.1999.tb01307.x · Cited by 305 · see citing works
Human Milk Oligosaccharides Are Minimally Digested In Vitro
Gnoth, M. J., Kunz, C., Kinne-Saffran, E., & Rudloff, S. (2000) · Journal of Nutrition · doi:10.1093/jn/130.12.3014 · Cited by 298 · see citing works
Selective colonization of insoluble substrates by human faecal bacteria
Leitch, E. C. M., Walker, A. W., Duncan, S. H., Holtrop, G., & Flint, H. J. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2006.01186.x · Cited by 297 · see citing works
Larsson, J. M. H., Karlsson, H., Sjövall, H., & Hansson, G. C. (2009) · Glycobiology · doi:10.1093/glycob/cwp048 · Cited by 282 · see citing works
Histochemistry of the surface mucous gel layer of the human colon.
Matsuo, K., Ota, H., Akamatsu, T., Sugiyama, A., & Katsuyama, T. (1997) · Gut · doi:10.1136/gut.40.6.782 · Cited by 271 · see citing works
den Abbeele, P. V., Gérard, P., Rabot, S., Bruneau, A., Aidy, S. E., Derrien, M., Kleerebezem, M., Zoetendal, E. G., Smidt, H., Verstraete, W., et al. (2011) · Environmental Microbiology · doi:10.1111/j.1462-2920.2011.02533.x · Cited by 257 · see citing works
Alternative pathways for hydrogen disposal during fermentation in the human colon.
Gibson, G. R., Cummings, J. H., Macfarlane, G. T., Allison, C., Segal, I., Vorster, H. H., & Walker, A. R. (1990) · Gut · doi:10.1136/gut.31.6.679 · Cited by 255 · see citing works
Cell wall polysaccharide interactions in maize bran
Saulnier, L., Marot, C., Chanliaud, E., et al. (1995) · Carbohydrate Polymers · doi:10.1016/0144-8617(95)00020-8 · Cited by 255 · see citing works
McBride, M. J., Xie, G. G., Martens, E. C., Lapidus, A. L., Henrissat, B., Rhodes, R. G., Goltsman, E., Wang, W., Xu, J., Hunnicutt, D. W., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01495-09 · Cited by 252 · see citing works
Self-citationNeyrinck, A. M., Possemiers, S., Verstraete, W., Backer, F. D., Cani, P. D., & Delzenne, N. M. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.10.008 · Cited by 245 · see citing works
German, J. B., Freeman, S. L., Lebrilla, C. B., & Mills, D. A. (2008) · Nestlé Nutrition Workshop series. Pediatric program/Nestlé Nutrition Workshop series. Paediatric program · doi:10.1159/000146322 · Cited by 237 · see citing works
LoCascio, R. G., Desai, P., Sela, D. A., Weimer, B., & Mills, D. A. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00675-10 · Cited by 229 · see citing works
Furne, J. K., Springfield, J. R., Koenig, T. W., DeMaster, E. G., & Levitt, M. D. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00657-8 · Cited by 223 · see citing works
Garrido, D. A., Kim, J., German, J. B., Raybould, H. E., & Mills, D. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017315 · Cited by 218 · see citing works
Delzenne, N., Cani, P. D., & Neyrinck, A. (2007) · Journal of NutriLife · doi:10.1093/jn/137.11.2547s · Cited by 208 · see citing works
Immerseel, F. V., Ducatelle, R., Vos, M. D., Boon, N., de Wiele, T. V., Verbeke, K., Rutgeerts, P. J., Sas, B., Louis, P., & Flint, H. J. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.017541-0 · Cited by 201 · see citing works
Composition and Metabolic Activities of Bacterial Biofilms Colonizing Food Residues in the Human Gut
Macfarlane, S., & Macfarlane, G. T. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.00754-06 · Cited by 195 · see citing works
Development of bacterial and bifidobacterial communities in feces of newborn babies
Favier, C. F., de Vos, W. M., & Akkermans, A. D. L. (2003) · Anaerobe · doi:10.1016/j.anaerobe.2003.07.001 · Cited by 194 · see citing works
Sakamoto, M., Takagaki, A., Matsumoto, K., Kato, Y., Gotō, K., & Benno, Y. (2009) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.007674-0 · Cited by 163 · see citing works
Products of the Colonic Microbiota Mediate the Effects of Diet on Colon Cancer Risk ,
O’Keefe, S. J., Ou, J., Aufreiter, S., O’Connor, D. L., Sharma, S. K., Sepulveda, J. L., Fukuwatari, T., Shibata, K., & Mawhinney, T. P. (2009) · Journal of Nutrition · doi:10.3945/jn.109.104380 · Cited by 161 · see citing works
The human commensal Bacteroides fragilis binds intestinal mucin
Huang, J. Y., Lee, S. M., & Mazmanian, S. K. (2011) · Anaerobe · doi:10.1016/j.anaerobe.2011.05.017 · Cited by 160 · see citing works
Scott, K. P., Martin, J. C., Chassard, C., Clerget, M., Potrykus, J., Campbell, G., Mayer, C., Young, P., Rucklidge, G. J., Ramsay, A. G., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000091107 · Cited by 144 · see citing works
Cho, K. H., & Salyers, A. A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.24.7224-7230.2001 · Cited by 144 · see citing works
Dodd, D., Moon, Y.-H., Swaminathan, K., Mackie, R. I., & Cann, I. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.141788 · Cited by 141 · see citing works
Schwab, C., & Gänzle, M. G. (2010) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2010.02185.x · Cited by 140 · see citing works
D'Elia, J. N., & Salyers, A. A. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.24.7173-7179.1996 · Cited by 135 · see citing works
Koropatkin, N. M., & Smith, T. J. (2010) · Structure · doi:10.1016/j.str.2009.12.010 · Cited by 133 · see citing works
Self-citationMiwa, M., Horimoto, T., Kiyohara, M., Katayama, T., Kitaoka, M., Ashida, H., & Yamamoto, K. (2010) · Glycobiology · doi:10.1093/glycob/cwq101 · Cited by 127 · see citing works
Milk sialyllactose influences colitis in mice through selective intestinal bacterial colonization
Fuhrer, A. C., Sprenger, N., Kurakevich, E., Borsig, L., Chassard, C., & Hennet, T. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101098 · Cited by 125 · see citing works
Survival of Human Milk Oligosaccharides in the Intestine of Infants
Chaturvedi, P., Warren, C. D., Buescher, C., Pickering, L. K., & Newburg, D. S. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1371-1_39 · Cited by 124 · see citing works
Metabolic and Intestinal Effects of Short‐Chain Fatty Acids
Rombeau, J. L., & Kripke, S. A. (1990) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719001400507 · Cited by 118 · see citing works
How does oxygen inhibit central metabolism in the obligate anaerobe Bacteroides thetaiotaomicron
Pan, N., & Imlay, J. A. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02343.x · Cited by 111 · see citing works
Clarke, J. M., Topping, D. L., Bird, A. R., Young, G. P., & Cobiac, L. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn192 · Cited by 110 · see citing works
Bifidobacterial utilization of human milk oligosaccharides
Sela, D. A. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.01.025 · Cited by 107 · see citing works
Avivi-Green, C., Polak‐Charcon, S., Madar, Z., & Schwartz, B. (2001) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504001108747558 · Cited by 104 · see citing works
Current Concepts of the Intestinal Microbiota and the Pathogenesis of Infection
Wardwell-Scott, L., Huttenhower, C., & Garrett, W. S. (2010) · Current Infectious Disease Reports · doi:10.1007/s11908-010-0147-7 · Cited by 102 · see citing works
Rodríguez‐Díaz, J., Monedero, V., & Yebra, M. J. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.01906-10 · Cited by 101 · see citing works
Tancula, E., Feldhaus, M. J., Bedzyk, L. A., et al. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.17.5609-5616.1992 · Cited by 91 · see citing works
Larsen, I. K., & Bray, F. (2009) · International Journal of Cancer · doi:10.1002/ijc.24839 · Cited by 90 · see citing works
Renzi, F., Manfredi, P., Mally, M., Moes, S., Jenö, P., & Cornelis, G. R. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002118 · Cited by 77 · see citing works
Host genetic susceptibility, dysbiosis, and viral triggers in inflammatory bowel disease
Sun, L., Nava, G. M., & Stappenbeck, T. S. (2011) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32834661b4 · Cited by 75 · see citing works
Formation of glycoprotein degrading enzymes by Bacteroides fragilis
Macfarlane, G. T. (1991) · FEMS Microbiology Letters · doi:10.1016/0378-1097(91)90567-t · Cited by 73 · see citing works
Dronamraju, S. S., Coxhead, J., Kelly, S. B., Burn, J., & Mathers, J. C. (2008) · Gut · doi:10.1136/gut.2008.162933 · Cited by 73 · see citing works
Lührs, H., Gerke, T., Schauber, J., Dusel, G., Melcher, R., Scheppach, W. M., & Menzel, T. (2001) · International Journal of Colorectal Disease · doi:10.1007/s003840100295 · Cited by 71 · see citing works
Munjal, U., Glei, M., Pool-Zobel, B. L., & Scharlau, D. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509274770 · Cited by 64 · see citing works
Formation of glycoprotein degrading enzymes byBacteroides fragilis
Macfarlane, G. T., & Gibson, G. R. (1991) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1991.tb04363.x · Cited by 63 · see citing works
Martinez, R. C. R., Aynaou, A.-E., Albrecht, S., Schols, H. A., Martinis, E. C. P. D., Zoetendal, E. G., Venema, K., Saad, S. M. I., & Smidt, H. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.06.010 · Cited by 54 · see citing works
Singh, H., Demers, A. A., Xue, L., et al. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01726.x · Cited by 52 · see citing works
Trends in Colorectal Cancer Incidence by Subsite in Osaka, Japan
Toyoda, Y., Nakayama, T., Ito, Y., et al. (2008) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyn144 · Cited by 47 · see citing works
Hill, J. E., Fernando, W. M. U., Zello, G. A., Tyler, R. T., Dahl, W. J., & Kessel, A. G. V. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.01510-09 · Cited by 39 · see citing works
Miyazaki, K., Hirase, T., KOJIMA, Y., et al. (2005) · Microbiology · doi:10.1099/mic.0.28270-0 · Cited by 36 · see citing works
Proximal shift in the distribution of adenomatous polyps in Korea over the past ten years.
Park, S. Y., Kim, B. C., Shin, S. J., et al. (2009) · PubMed · Cited by 19 · see citing works
Gourineni, V., Verghese, M., Boateng, J. A., et al. (2011) · Journal of Nutrition and Metabolism · doi:10.1155/2011/983038 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635 · see citing works
“Numerous pathogens generate a diverse array of cell surface and secreted glycosidases that serve to remodel or destroy the host glycocalyx, sometimes then utilizing the released monosaccharides as food sources and/or providing a nutritional resource for other microorganisms in the same milieu (783) (784) (785) .”
BackgroundRole of the gut microbiota in nutrition and health
Valdes, A. M., Walter, J., Segal, E., & Spector, T. D. (2018) · BMJ · doi:10.1136/bmj.k2179 · Cited by 2,375 · see citing works
Gut biogeography of the bacterial microbiota
Donaldson, G. P., Lee, S. M., & Mazmanian, S. K. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro3552 · Cited by 2,535 · see citing works
Artificial sweeteners induce glucose intolerance by altering the gut microbiota
Suez, J., Korem, T., Zeevi, D., Zilberman-Schapira, G., Thaiss, C. A., Maza, O., Israeli, D., Zmora, N., Gilad, S., Weinberger, A., et al. (2014) · Nature · doi:10.1038/nature13793 · Cited by 2,067 · see citing works
You are what you eat: Diet, health and the gut microbiota
Zmora, N., Suez, J., & Elinav, E. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0061-2 · Cited by 1,792 · see citing works
Dietary fiber and prebiotics and the gastrointestinal microbiota
Holscher, H. D. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1290756 · Cited by 1,808 · see citing works
The abundance and variety of carbohydrate-active enzymes in the human gut microbiota
Kaoutari, A. E., Armougom, F., Gordon, J. I., Raoult, D., & Henrissat, B. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3050 · Cited by 1,683 · see citing works
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
Pickard, J. M., Zeng, M. Y., Caruso, R., & Núñez, G. (2017) · Immunological Reviews · doi:10.1111/imr.12567 · Cited by 1,699 · see citing works
Control of pathogens and pathobionts by the gut microbiota
Kamada, N., Chen, G. Y., Inohara, N., & Núñez, G. (2013) · Nature Immunology · doi:10.1038/ni.2608 · Cited by 1,625 · see citing works
Pelaseyed, T., Bergström, J. H., Gustafsson, J. K., Ermund, A., Birchenough, G. M. H., Schütte, A., van der Post, S., Svensson, F., Rodríguez‐Piñeiro, A. M., Nyström, E. E. L., et al. (2014) · Immunological Reviews · doi:10.1111/imr.12182 · Cited by 1,363 · see citing works
Potential of fecal microbiota for early-stage detection of colorectal cancer
Zeller, G., Tap, J., Voigt, A. Y., Sunagawa, S., Kultima, J. R., Costea, P. I., Amiot, A., Böhm, J., Brunetti, F., Habermann, N., et al. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145645 · Cited by 1,375 · see citing works
Chemical transformation of xenobiotics by the human gut microbiota
Koppel, N., Maini Rekdal, V., & Balskus, E. P. (2017) · Science · doi:10.1126/science.aag2770 · Cited by 1,080 · see citing works
Human Gut Microbiome and Risk for Colorectal Cancer
Ahn, J., Sinha, R., Pei, Z., Dominianni, C., Wu, J., Shi, J., Goedert, J. J., Hayes, R. B., & Yang, L. (2013) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djt300 · Cited by 947 · see citing works
Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota
Albenberg, L., Esipova, T. V., Judge, C. P., Bittinger, K., Chen, J., Laughlin, A., Grunberg, S., Baldassano, R. N., Lewis, J. D., Li, H., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.020 · Cited by 886 · see citing works
The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens
Kim, S., Covington, A., & Pamer, E. G. (2017) · Immunological Reviews · doi:10.1111/imr.12563 · Cited by 741 · see citing works
Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier
Martens, E. C., Neumann, M., & Desai, M. S. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0036-x · Cited by 711 · see citing works
Self-citationDietary fibre modulates the gut microbiota
Cronin, P., Joyce, S. A., O’Toole, P. W., & O’Connor, E. M. (2021) · Nutrients · doi:10.3390/nu13051655 · Cited by 658 · see citing works
The influence of the microbiome on respiratory health
Wypych, T. P., Wickramasinghe, L. C., & Marsland, B. J. (2019) · Nature Immunology · doi:10.1038/s41590-019-0451-9 · Cited by 611 · see citing works
Gut microbiome composition is linked to whole grain-induced immunological improvements
Martínez, I., Lattimer, J. M., Hubach, K. L., Case, J. A., Yang, J., Weber, C. G., Louk, J. A., Rose, D. J., Kyureghian, G., Peterson, D. A., et al. (2013) · The ISME Journal · doi:10.1038/ismej.2012.104 · Cited by 614 · see citing works
The evolution of cooperation within the gut microbiota
Rakoff-Nahoum, S., Foster, K. R., & Comstock, L. E. (2016) · Nature · doi:10.1038/nature17626 · Cited by 616 · see citing works
Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease
Albenberg, L. G., & Wu, G. D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.058 · Cited by 606 · see citing works
Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock
Liang, X., Bushman, F. D., & FitzGerald, G. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501305112 · Cited by 578 · see citing works
Metagenome-wide association studies: fine-mining the microbiome
Wang, J., & Jia, H. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.83 · Cited by 429 · see citing works
Role of priority effects in the early-life assembly of the gut microbiota
Sprockett, D., Fukami, T., & Relman, D. A. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.173 · Cited by 419 · see citing works
The human microbiome in evolution
Davenport, E. R., Sanders, J. G., Song, S. J., Amato, K. R., Clark, A. G., & Knight, R. (2017) · BMC Biology · doi:10.1186/s12915-017-0454-7 · Cited by 393 · see citing works
T cell-mediated regulation of the microbiota protects against obesity
Petersen, C., Bell, R., Klag, K. A., Lee, S.-H., Soto, R., Ghazaryan, A., Buhrke, K., Ekiz, H. A., Ost, K. S., Boudina, S., et al. (2019) · Science · doi:10.1126/science.aat9351 · Cited by 385 · see citing works
Wang, D. D., Nguyen, L. H., Li, Y., Yan, Y., Ma, W., Rinott, E., Ivey, K. L., Shai, I., Willett, W. C., Hu, F. B., et al. (2021) · Nature Medicine · doi:10.1038/s41591-020-01223-3 · Cited by 386 · see citing works
Karl, J. P., Margolis, L. M., Madslien, E. H., Murphy, N. E., Castellani, J. W., Gundersen, Y., Hoke, A. V., Levangie, M. W., Kumar, R., Chakraborty, N., et al. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00066.2017 · Cited by 373 · see citing works
Hughes, E. R., Winter, M. G., Duerkop, B. A., Spiga, L., Furtado de Carvalho, T., Zhu, W., Gillis, C. C., Büttner, L., Smoot, M. P., Behrendt, C. L., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.01.005 · Cited by 353 · see citing works
Faith, J. J., Ahern, P. P., Ridaura, V. K., Cheng, J., & Gordon, J. I. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008051 · Cited by 373 · see citing works
Functional metagenomic profiling of intestinal microbiome in extreme ageing
Rampelli, S., Candela, M., Turroni, S., Biagi, E., Collino, S., Franceschi, C., O'Toole, P. W., & Brigidi, P. (2013) · Aging · doi:10.18632/aging.100623 · Cited by 359 · see citing works
Cornejo-Granados, F., Lopez-Zavala, A. A., Gallardo-Becerra, L., Mendoza-Vargas, A., Sánchez, F., Vichido, R., Brieba, L. G., Viana, M. T., Sotelo-Mundo, R. R., & Ochoa-Leyva, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-11805-w · Cited by 302 · see citing works
An atlas of β-glucuronidases in the human intestinal microbiome
Pollet, R. M., D'Agostino, E. H., Walton, W. G., Xu, Y., Little, M. S., Biernat, K. A., Pellock, S. J., Patterson, L. M., Creekmore, B. C., Isenberg, H. N., et al. (2017) · Structure · doi:10.1016/j.str.2017.05.003 · Cited by 289 · see citing works
Bifidobacteria exhibit social behavior through carbohydrate resource sharing in the gut
Milani, C., Lugli, G. A., Duranti, S., Turroni, F., Mancabelli, L., Ferrario, C., Mangifesta, M., Hevia, A., Viappiani, A., Scholz, M., et al. (2015) · Scientific Reports · doi:10.1038/srep15782 · Cited by 284 · see citing works
Host-compound foraging by intestinal microbiota revealed by single-cell stable isotope probing
Berry, D., Stecher, B., Schintlmeister, A., Reichert, J., Brugiroux, S., Wild, B., Wanek, W., Richter, A., Rauch, I., Decker, T., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219247110 · Cited by 246 · see citing works
Biomass Utilization by Gut Microbiomes
White, B. A., Lamed, R., Bayer, E. A., & Flint, H. J. (2014) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092412-155618 · Cited by 217 · see citing works
Martens, E. C., Kelly, A. G., Tauzin, A. S., & Brumer, H. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.06.022 · Cited by 235 · see citing works
Self-citationDiet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints
Holmes, A. J., Chew, Y. V., Colakoglu, F., Cliff, J. B., Klaassens, E., Read, M. N., Solon-Biet, S. M., McMahon, A. C., Cogger, V. C., Ruohonen, K., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.021 · Cited by 183 · see citing works
Tailford, L. E., Owen, C. D., Walshaw, J., Crost, E. H., Hardy-Goddard, J., Le Gall, G., de Vos, W. M., Taylor, G. L., & Juge, N. (2015) · Nature Communications · doi:10.1038/ncomms8624 · Cited by 183 · see citing works
The Impact of Artificial Sweeteners on Body Weight Control and Glucose Homeostasis
Pang, M. D., Goossens, G. H., & Blaak, E. E. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.598340 · Cited by 180 · see citing works
Sugahara, H., Odamaki, T., Fukuda, S., Kato, T., Xiao, J.-Z., Abe, F., Kikuchi, J., & Ohno, H. (2015) · Scientific Reports · doi:10.1038/srep13548 · Cited by 169 · see citing works
Svartström, O., Alneberg, J., Terrapon, N., Lombard, V., de Bruijn, I., Malmsten, J., Dalin, A.-M., EL Muller, E., Shah, P., Wilmes, P., et al. (2017) · The ISME Journal · doi:10.1038/ismej.2017.108 · Cited by 161 · see citing works
Seasonality of the gut microbiota of free-ranging white-faced capuchins in a tropical dry forest
Orkin, J. D., Campos, F. A., Myers, M. S., Cheves Hernandez, S. E., Guadamuz, A., & Melin, A. D. (2019) · The ISME Journal · doi:10.1038/s41396-018-0256-0 · Cited by 140 · see citing works
Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health
Ha, C. W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i44.16498 · Cited by 137 · see citing works
Klimenko, N. S., Tyakht, A. V., Popenko, A. S., Vasiliev, A. S., Altukhov, I. A., Ischenko, D. S., Shashkova, T. I., Efimova, D. A., Nikogosov, D. A., Osipenko, D. A., et al. (2018) · Nutrients · doi:10.3390/nu10050576 · Cited by 123 · see citing works
The Gut Microbiome and Individual-Specific Responses to Diet
Leshem, A., Segal, E., & Elinav, E. (2020) · mSystems · doi:10.1128/msystems.00665-20 · Cited by 109 · see citing works
Tuncil, Y. E., Thakkar, R. D., Arioglu-Tuncil, S., Hamaker, B. R., & Lindemann, S. R. (2020) · mSphere · doi:10.1128/msphere.00180-20 · Cited by 97 · see citing works
Ruiz, A., Cerdó, T., Jáuregui, R., Pieper, D. H., Marcos, A., Clemente, A., García, F., Margolles, A., Ferrer, M., Campoy, C., et al. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13713 · Cited by 85 · see citing works
Tanca, A., Abbondio, M., Palomba, A., Fraumene, C., Marongiu, F., Serra, M., Pagnozzi, D., Laconi, E., & Uzzau, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-33100-y · Cited by 79 · see citing works
Hansen, N. W., & Sams, A. (2018) · Nutrients · doi:10.3390/nu10111590 · Cited by 65 · see citing works
Klurfeld, D. M., Davis, C. D., Karp, R. W., Allen-Vercoe, E., Chang, E. B., Chassaing, B., Fahey, G. C., Hamaker, B. R., Holscher, H. D., Lampe, J. W., et al. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00058.2018 · Cited by 61 · see citing works
Self-citationDietary Habits of 2- to 9-Year-Old American Children Are Associated with Gut Microbiome Composition
Herman, D. R., Rhoades, N., Mercado, J., Argueta, P., Lopez, U., & Flores, G. E. (2020) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2019.07.024 · Cited by 50 · see citing works
Mirror, mirror on the wall: which microbiomes will help heal them all?
Nayak, R. R., & Turnbaugh, P. J. (2016) · BMC Medicine · doi:10.1186/s12916-016-0622-6 · Cited by 36 · see citing works
Fan, S., Zhang, H., Chen, X., Lu, L., Xu, L., & Xiao, M. (2016) · Journal of Basic Microbiology · doi:10.1002/jobm.201500582 · Cited by 35 · see citing works
Tang, W., Han, S., Zhou, J., Xu, Q., Dong, M., Fan, X., Rui, X., Zhang, Q., Chen, X., Jiang, M., et al. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103952 · Cited by 31 · see citing works
Recent insight into oligosaccharide uptake and metabolism in probiotic bacteria
Abou Hachem, M., Andersen, J. M., Barrangou, R., Møller, M. S., Fredslund, F., Majumder, A., Ejby, M., Lahtinen, S. J., Jacobsen, S., Lo Leggio, L., et al. (2013) · Biocatalysis and Biotransformation · doi:10.3109/10242422.2013.828048 · Cited by 25 · see citing works
Hu, D., Liu, W., Yu, W., Huang, L., Ji, C., Liu, X., & Lu, Z. (2023) · Renal Failure · doi:10.1080/0886022x.2023.2197076 · Cited by 21 · see citing works
Different Reactions in Each Enterotype Depending on the Intake of Probiotic Yogurt Powder
Lee, S., You, H., Lee, M., Kim, D., Jung, S., Park, Y., & Hyun, S. (2021) · Microorganisms · doi:10.3390/microorganisms9061277 · Cited by 16 · see citing works
- Authors
- Koropatkin, N. M., Cameron, E. A., & Martens, E. C.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Martens, Eric C.
- Venue
- Nature Reviews Microbiology
- Published
- 2012-04-11
- Volume
- 10
- Issue
- 5
- Pages
- 323-335
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- PMC
- PMC4005082
- OpenAlex
- W2044482540
- Cited by
- 1,419
- References
- 132
- Citations by year
- 2026: 75 · 2025: 106 · 2024: 132 · 2023: 113 · 2022: 128 · 2021: 148 · 2020: 135 · 2019: 105 · 2018: 97 · 2017: 107 · 2016: 82 · 2015: 63 · 2014: 64 · 2013: 55 · 2012: 8
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (GM-07544, T32GM007544)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034933, DK 034933, DK084214, K01DK084214)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- gut microbiota, glycan metabolism, polysaccharide degradation, glycosaminoglycans, N-glycans, O-linked glycans, hemicellulose, pectin, starch, microbial ecology, microbiota modulation, nutrition
- MeSH terms
- Diet, Humans, Polysaccharides, Gastrointestinal Tract, Metagenome, Biota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review