The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS
Open accessAbstract
Organized for action: It is becoming increasingly clear that biomolecular condensates, which are concentrations of macromolecules not surrounded by a membrane, are a key organizational structure in eukaryotic cells (see the Perspective by Martin and Mittag). Now, two papers show how such condensates function in actin assembly or in a Ras signaling pathway. In both cases, the condensates form at the plasma membrane and increase the activity of signaling proteins by increasing their membrane dwell times. Case et al. show that the dwell time is dependent on cluster stoichiometry, so that stoichiometry of regulatory proteins can control actin assembly. Huang et al. demonstrate that the longer dwell time allows kinetic proofreading in receptor-mediated activation of Ras. Science , this issue p. 1093 , p. 1098 ; see also p. 1036
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Cites
Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases
Vadas, O., Burke, J. E., Zhang, X., Berndt, A., & Williams, R. L. (2011) · Science Signaling · doi:10.1126/scisignal.2002165 · Cited by 299
Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics
Iversen, L., Tu, H.-L., Lin, W.-C., Christensen, S. M., Abel, S. M., Iwig, J., Wu, H.-J., Gureasko, J., Rhodes, C., Petit, R. S., et al. (2014) · Science · doi:10.1126/science.1250373 · Cited by 154
Self-citationExtein Residues Play an Intimate Role in the Rate-Limiting Step of Protein Trans -Splicing
Shah, N. H., Eryilmaz, E., Cowburn, D., & Muir, T. W. (2013) · Journal of the American Chemical Society · doi:10.1021/ja401015p · Cited by 84
Methods in Statistical Kinetics
Moffitt, J. R., Chemla, Y. R., & Bustamante, C. (2010) · Methods in Enzymology · doi:10.1016/s0076-6879(10)75010-2 · Cited by 66
Cited by
A framework for understanding the functions of biomolecular condensates across scales
Lyon, A. S., Peeples, W. B., & Rosen, M. K. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00303-z · Cited by 895
Stoichiometry controls activity of phase-separated clusters of actin signaling proteins
Case, L. B., Zhang, X., Ditlev, J. A., & Rosen, M. K. (2019) · Science · doi:10.1126/science.aau6313 · Cited by 499
Regulation of Transmembrane Signaling by Phase Separation
Case, L. B., Ditlev, J. A., & Rosen, M. K. (2019) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-052118-115534 · Cited by 303
Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation
Zhu, G., Xie, J., Kong, W., Xie, J., Li, Y., Du, L., Zheng, Q., Sun, L., Guan, M., Li, H., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.002 · Cited by 267
Targeting RAS–RAF–MEK–ERK signaling pathway in human cancer: Current status in clinical trials
Song, Y., Bi, Z., Liu, Y., Qin, F., Wei, Y., & Wei, X. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.05.006 · Cited by 212
Metadata
- Authors
- Huang, W. Y. C., Alvarez, S., Kondo, Y., Lee, Y. K., Chung, J. K., Lam, H. Y. M., Biswas, K. H., Kuriyan, J., & Groves, J. T.
- Venue
- Science
- Published
- 2019-03-08
- Volume
- 363
- Issue
- 6431
- Pages
- 1098-1103
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2921733160
- Cited by
- 347
- References
- 4
- FWCI
- 13.18
- Type
- journal article
- Language
- en
- Open access
- green
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