The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex
Open accessAbstract
Heart rate and blood pressure control: PIEZO1 and PIEZO2 are two mechanically activated ion channels that are highly expressed in lungs, bladder, and skin. Zeng et al. found that both ion channels are expressed in sensory neurons of a ganglion complex that contribute to the baroreflex, a homeostatic mechanism that helps to keep blood pressure stable (see the Perspective by Ehmke). Conditional double knockout of PIEZO1 and PIEZO2 in these neurons abolished the baroreflex and disrupted blood pressure regulation and heart rates in mice. These changes were very similar to those seen in patients with baroreflex failure. In mice, selective activation of PIEZO2-expressing ganglion neurons triggered immediate increases in heart rate and blood pressure. Science , this issue p. 464 ; see also p. 398
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Wang, S., Chennupati, R., Kaur, H., Iring, A., Wettschureck, N., & Offermanns, S. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87343 · Cited by 616
Piezos thrive under pressure: mechanically activated ion channels in health and disease
Murthy, S. E., Dubin, A. E., & Patapoutian, A. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.92 · Cited by 582
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Chesler, A. T., Szczot, M., Bharucha-Goebel, D., Čeko, M., Donkervoort, S., Laubacher, C., Hayes, L. H., Alter, K., Zampieri, C., Stanley, C., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1602812 · Cited by 462
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A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel
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Piezo1 and its inhibitors: Overview and perspectives
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Endesh, N., Chuntharpursat‐Bon, E., Revill, C., Yuldasheva, N. Y., Futers, T. S., Parsonage, G., Humphreys, N., Adamson, A., Morley, L. C., Cubbon, R. M., et al. (2023) · Liver International · doi:10.1111/liv.15646 · Cited by 44
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Metadata
- Authors
- Zeng, W.-Z., Marshall, K. L., Min, S., Daou, I., Chapleau, M. W., Abboud, F. M., Liberles, S. D., & Patapoutian, A.
- Venue
- Science
- Published
- 2018-10-26
- Volume
- 362
- Issue
- 6413
- Pages
- 464-467
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2898266525
- Cited by
- 493
- References
- 3
- FWCI
- 26.15
- Type
- journal article
- Language
- en
- Open access
- green
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