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Cited by 227Embodied and Extended CognitionPsychosomatic Disorders and Their TreatmentsHeart Rate Variability and Autonomic Control

Computational Models of Interoception and Body Regulation

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Petzschner, Frederike H., Garfinkel, Sarah N., Paulus, Martin P., Koch, Christof, Khalsa, Sahib S.·2021·Trends in Neurosciences
DOI 10.1016/j.tins.2020.09.012PMC PMC8109616
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Abstract

To survive, organisms must effectively respond to the challenge of maintaining their physiological integrity in the face of an ever-changing environment. Preserving this homeostasis critically relies on adaptive behavior. In this review, we consider recent frameworks that extend classical homeostatic control via reflex arcs to include more flexible forms of adaptive behavior that take interoceptive context, experiences, and expectations into account. Specifically, we define a landscape for computational models of interoception, body regulation, and forecasting, address these models' unique challenges in relation to translational research efforts, and discuss what they can teach us about cognition as well as physical and mental health.

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  • Allostatic regulations can be expressed in an extended predictive coding framework, where the brain constantly generates and updates not only a model of the external environment, but also of the organism state.

    “Allostatic regulations can be expressed in an extended predictive coding framework, where the brain constantly generates and updates not only a model of the external environment, but also of the organism state 207 (Figure 4C).”

    From Interoceptive rhythms in the brain (2023) · cites this paper as [207]

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Cited by

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Authors
Petzschner, F. H., Garfinkel, S. N., Paulus, M. P., Koch, C., & Khalsa, S. S.
Affiliations
  • University of Zurich (CH)
  • Brighton and Sussex Medical School (GB)
  • Laureate Institute for Brain Research (US)
Corresponding author
Petzschner, Frederike H.
ORCID
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2021-01
Volume
44
Issue
1
Pages
63-76
ISSN
0166-2236 (ISSN-L)
DOI
10.1016/j.tins.2020.09.012
PMC
PMC8109616
OpenAlex
W3114806425
Cited by
227
References
35
Citations by year
2026: 42 · 2025: 44 · 2024: 49 · 2023: 31 · 2022: 35 · 2021: 20 · 2020: 6
FWCI
3.11
Type
journal article
Language
en
Open access
Licence
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (K23MH112949)
  • National Institute of General Medical Sciences (1P20GM121312)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Embodied and Extended Cognition
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
interoception, body regulation, homeostasis, computational model, adaptive behavior, expectations, forecasting, reflex arc, cognition, mental health, physical health
MeSH terms
Cognition, Computer Simulation, Forecasting, Humans, Interoception

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