Application of exosomes as liquid biopsy in clinical diagnosis
Open accessAbstract
Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small extracellular vesicles with sizes between 30-150 nm. They are secreted by multivesicular bodies through exocytosis in live cells and can participate in intercellular communication due to their contents, including nucleic acids, proteins, and lipids. Herein, we investigate publication frequencies on exosomes over the past 10 years, and review recent clinical studies on liquid biopsy of exosomes in the fields of oncology, pregnancy disorders, cardiovascular diseases, and organ transplantation. We also describe the advantages of exosomes as an effective liquid biopsy tool and the progression of exosome extraction methods. Finally, we depict the commercial development of exosome research and discuss the future role of exosomes in liquid biopsy.
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Clinical application of exosomes is mainly used for body fluid biopsy and clinical diagnosis of diseases such as cancer, nervous system diseases, and immune diseases.
“Thus far, the clinical application of exosomes is mainly used for body fluid biopsy and clinical diagnosis of diseases such as cancer, nervous system diseases. and immune diseases [112].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [112]
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Liu, T., Zhang, X., Du, L., Wang, Y., Liu, X., Tian, H., Wang, L., Li, P., Zhao, Y., Duan, W., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0981-7 · Cited by 264 · see citing works
RetractedHan, M., Hu, J., Lu, P., Cao, H., Yu, C., Li, X., Qian, X., Yang, X. F., Yang, Y., Han, N., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2250-5 · Cited by 138 · see citing works
RetractedThéry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099 · see citing works
Standards of Medical Care in Diabetes
Power, D. V. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1593 · Cited by 8,672 · see citing works
Biological properties of extracellular vesicles and their physiological functions
Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926 · see citing works
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766 · see citing works
Tumour exosome integrins determine organotropic metastasis
Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101 · see citing works
Standards of medical care in diabetes—2014
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s014 · Cited by 4,572 · see citing works
(2013) · doi:10.1097/01.aog.0000437382.03963.88 · Cited by 3,961 · see citing works
Membrane vesicles as conveyors of immune responses
Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,869 · see citing works
Mathieu, M., Jaular, L. M., Lavieu, G., & Théry, C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0250-9 · Cited by 3,776 · see citing works
Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis
Bellamy, L., Casas, J.-P., Hingorani, A. D., & Williams, D. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60731-5 · Cited by 3,253 · see citing works
Reassessment of exosome composition
Jeppesen, D. K., Fenix, A. M., Franklin, J. L., Higginbotham, J. N., Zhang, Q., Zimmerman, L. J., Liebler, D. C., Ping, J., Liu, Q., Evans, R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.029 · Cited by 2,975 · see citing works
Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48095-7 · Cited by 2,931 · see citing works
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880 · see citing works
Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Chen, G., Huang, A. C., Zhang, W., Zhang, G., Wu, M., Xu, W., Yu, Z., Yang, J., Wang, B., Sun, H., et al. (2018) · Nature · doi:10.1038/s41586-018-0392-8 · Cited by 2,813 · see citing works
Elective induction versus spontaneous labor after sonographic diagnosis of fetal macrosomia.
Combs, C. A., Singh, N. B., & Khoury, J. C. (1993) · PubMed · Cited by 2,462 · see citing works
Identification and proteomic profiling of exosomes in human urine
Pisitkun, T., Shen, R., & Knepper, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403453101 · Cited by 2,162 · see citing works
Optimized exosome isolation protocol for cell culture supernatant and human plasma
Lobb, R. J., Becker, M., Wen, S., Wong, C. S. F., Wiegmans, A. P., Leimgruber, A., & Möller, A. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27031 · Cited by 1,725 · see citing works
Mol, B. W., Roberts, C. T., Thangaratinam, S., Magee, L. A., de Groot, C. J. M., & Hofmeyr, G. J. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00070-7 · Cited by 1,619 · see citing works
Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis
Zhou, W., Fong, M. Y., Min, Y., Somlo, G., Liu, L., Palomares, M. R., Yu, Y., Chow, A., O’Connor, S. T. F., Chin, A. R., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.007 · Cited by 1,476 · see citing works
Exosomal-like vesicles are present in human blood plasma
Caby, M.-P., Lankar, D., Vincendeau-Scherrer, C., Raposo, G., & Bonnerot, C. (2005) · International Immunology · doi:10.1093/intimm/dxh267 · Cited by 1,348 · see citing works
Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance
Mashouri, L., Yousefi, H., Aref, A., Ahadi, A., Molaei, F., & Alahari, S. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0991-5 · Cited by 1,345 · see citing works
EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research
EV-TRACK Consortium, Van Deun, J., Mestdagh, P., Agostinis, P., Akay, Ö., Anand, S., Anckaert, J., Martinez, Z. A., Baetens, T., Beghein, E., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4185 · Cited by 1,284 · see citing works
Exosomes with Immune Modulatory Features Are Present in Human Breast Milk
Admyre, C., Johansson, S. M., Qazi, K. R., Filén, J., Lahesmaa, R., Norman, M., Neve, E. P. A., Scheynius, A., & Gabrielsson, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1969 · Cited by 1,222 · see citing works
Qu, L., Ding, J., Chen, C. Y., Wu, Z., Liu, B., Gao, Y., Chen, W., Liu, F., Sun, W. C., Li, X., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.03.004 · Cited by 1,116 · see citing works
Maternal Obesity and Risk of Gestational Diabetes Mellitus
Chu, S. Y., Callaghan, W. M., Kim, S. Y., Schmid, C. H., Lau, J., England, L. J., & Dietz, P. M. (2007) · Diabetes Care · doi:10.2337/dc06-2559a · Cited by 1,114 · see citing works
Gardiner, C., Vizio, D. D., Sahoo, S., Théry, C., Witwer, K. W., Wauben, M. H. M., & Hill, A. F. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.32945 · Cited by 1,075 · see citing works
Zeng, Z., Li, Y., Pan, Y., Lan, X.-L., Song, F., Sun, J., Zhou, K., Liu, X., Ren, X., Wang, F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07810-w · Cited by 995 · see citing works
Brennan, K., Martin, K., Fitzgerald, S. P., O’Sullivan, J., Wu, Y., Blanco, A., Richardson, C., & Gee, M. M. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-57497-7 · Cited by 900 · see citing works
Extracellular vesicle isolation and characterization: toward clinical application
Xu, R., Greening, D. W., Zhu, H., Takahashi, N., & Simpson, R. J. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81129 · Cited by 879 · see citing works
Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy
Ibrahim, A., Cheng, K., & Marbán, E. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.04.006 · Cited by 821 · see citing works
Webber, J., & Clayton, A. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.19861 · Cited by 817 · see citing works
Cellular Mechanisms for Insulin Resistance in Normal Pregnancy and Gestational Diabetes
Barbour, L. A., McCurdy, C. E., Hernandez, T. L., Kirwan, J. P., Catalano, P. M., & Friedman, J. E. (2007) · Diabetes Care · doi:10.2337/dc07-s202 · Cited by 811 · see citing works
Hu, J. L., Wang, W., Lan, X. L., Zeng, Z. C., Liang, Y. S., Yan, Y. R., Song, F. Y., Wang, F. F., Zhu, X. H., Liao, W. J., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1019-x · Cited by 773 · see citing works
Metabolic Changes in Pregnancy
Lain, K. Y., & Catalano, P. M. (2007) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e31815a5494 · Cited by 765 · see citing works
Barile, L., Lionetti, V., Cervio, E., Matteucci, M., Gherghiceanu, M., Popescu, L. M., Torre, T., Siclari, F., Moccetti, T., & Vassalli, G. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu167 · Cited by 733 · see citing works
Mateescu, B., Kowal, E. J. K., van Balkom, B. W. M., Bartel, S., Bhattacharyya, S. N., Buzás, E. I., Buck, A. H., de Candia, P., Chow, F. W., Das, S., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1286095 · Cited by 729 · see citing works
A Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer at Initial Biopsy
McKiernan, J., Donovan, M. J., O’Neill, V., Bentink, S., Noerholm, M., Belzer, S. K., Skog, J., Kattan, M. W., Partin, A. W., Andriole, G. L., et al. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.0097 · Cited by 679 · see citing works
Tian, Y., Gong, M., Hu, Y., Liu, H., Zhang, W., Zhang, M., Hu, X., Aubert, D., Zhu, S., Wu, L., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1697028 · Cited by 643 · see citing works
Zheng, P., Chen, L., Yuan, X., Luo, Q., Liu, Y., Xie, G., Ma, Y., & Shen, L. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0528-y · Cited by 630 · see citing works
Clinical Significance of PD-L1+ Exosomes in Plasma of Head and Neck Cancer Patients
Theodoraki, M.-N., Yerneni, S. S., Hoffmann, T. K., Gooding, W. E., & Whiteside, T. L. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2664 · Cited by 624 · see citing works
Plasma exosome microRNAs are indicative of breast cancer
Hannafon, B. N., Trigoso, Y. D., Calloway, C. L., Zhao, Y. D., Lum, D. H., Welm, A. L., Zhao, Z. J., Blick, K. E., Dooley, W. C., & Ding, W. (2016) · Breast Cancer Research · doi:10.1186/s13058-016-0753-x · Cited by 603 · see citing works
Kuwabara, Y., Ono, K., Horie, T., Nishi, H., Nagao, K., Kinoshita, M., Watanabe, S., Baba, O., Kojima, Y., Shizuta, S., et al. (2011) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.110.958975 · Cited by 590 · see citing works
Sódar, B. W., Kittel, Á., Pálóczi, K., Vukman, K. V., Osteikoetxea, X., Szabó-Taylor, K., Nemeth, A. H., Sperlágh, B., Baranyai, T., Giricz, Z., et al. (2016) · Scientific Reports · doi:10.1038/srep24316 · Cited by 557 · see citing works
Milk-derived exosomes for oral delivery of paclitaxel
Agrawal, A. K., Aqil, F., Jeyabalan, J., Spencer, W. A., Beck, J., Gachuki, B. W., Alhakeem, S. S., Oben, K. Z., Munagala, R., Bondada, S., et al. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.03.001 · Cited by 544 · see citing works
exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes
Li, S., Li, Y., Chen, B., Zhao, J., Yu, S., Tang, Y., Zheng, Q., Li, Y., Wang, P., He, X., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx891 · Cited by 539 · see citing works
Zarovni, N., Corrado, A., Guazzi, P., Zocco, D., Lari, E., Radano, G., Muhhina, J., Fondelli, C., Gavrilova, J., & Chiesi, A. (2015) · Methods · doi:10.1016/j.ymeth.2015.05.028 · Cited by 535 · see citing works
Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models
Keklikoglou, I., Cianciaruso, C., Güç, E., Squadrito, M. L., Spring, L. M., Tazzyman, S. J., Lambein, L., Poissonnier, A., Ferraro, G. B., Baer, C., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0256-3 · Cited by 533 · see citing works
MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy
Halkein, J., Tabruyn, S. P., Ricke‐Hoch, M., Haghikia, A., Nguyen, N.-Q.-N., Scherr, M., Castermans, K., Malvaux, L., Lambert, V., Thiry, M., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64365 · Cited by 499 · see citing works
Madhavan, B. K., Yue, S., Galli, U., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.29324 · Cited by 496 · see citing works
Allenson, K., Castillo, J., San Lucas, F. A., Scelo, G., Kim, D. U., Bernard, V., Davis, G., Kumar, T., Katz, M., Overman, M. J., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx004 · Cited by 493 · see citing works
Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer
Matsumura, T., Sugimachi, K., Iinuma, H., Takahashi, Y., Kurashige, J., Sawada, G., Ueda, M., Uchi, R., Ueo, H., Takano, Y., et al. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.201 · Cited by 491 · see citing works
Identification and proteomic profiling of exosomes in human cerebrospinal fluid
Street, J. M., Barran, P. E., Mackay, C. L., Weidt, S. K., Balmforth, C., Walsh, T. S., Chalmers, R. T. A., Webb, D. J., & Dear, J. W. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-5 · Cited by 491 · see citing works
MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression
Teng, Y., Ren, Y., Hu, X., Mu, J., Samykutty, A. K., Zhuang, X., Deng, Z., Kumar, A., Zhang, L., Merchant, M. L., et al. (2017) · Nature Communications · doi:10.1038/ncomms14448 · Cited by 479 · see citing works
Phosphoproteins in extracellular vesicles as candidate markers for breast cancer
Chen, I.-H., Xue, L., Hsu, C., Paez, S. J., Pan, L., Aguilar, H. A., Wendt, M. K., Iliuk, A. B., Zhu, J., & Tao, W. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618088114 · Cited by 472 · see citing works
Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultrafiltration concentrator
Cheruvanky, A., Zhou, H., Pisitkun, T., et al. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00434.2006 · Cited by 461 · see citing works
Lakkis, F. G., Arakelov, A., Konieczny, B. T., & Inoue, Y. (2000) · Nature Medicine · doi:10.1038/76267 · Cited by 446 · see citing works
Takov, K., Yellon, D. M., & Davidson, S. M. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1560809 · Cited by 419 · see citing works
Proteomic Analysis of Exosomes Isolated from Human Malignant Pleural Effusions
Bard, M. P., Hegmans, J. P., Hemmes, A., Luider, T. M., Willemsen, R., Severijnen, L.-A. A., van Meerbeeck, J. P., Burgers, S. A., Hoogsteden, H. C., & Lambrecht, B. N. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0238oc · Cited by 416 · see citing works
Salomón, C., Torres, M. J., Kobayashi, M., Scholz‐Romero, K., Sobrevía, L., Dobierzewska, A., Illanes, S. E., Mitchell, M. D., & Rice, G. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098667 · Cited by 402 · see citing works
Malignant ascites-derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM
Runz, S., Keller, S., Rupp, C., Stoeck, A., Issa, Y., Koensgen, D., Mustea, A., Sehouli, J., Kristiansen, G., & Altevogt, P. (2007) · Gynecologic Oncology · doi:10.1016/j.ygyno.2007.08.064 · Cited by 400 · see citing works
The Exosome Total Isolation Chip
Liu, F., Vermesh, O., Mani, V., Ge, T. J., Madsen, S. J., Sabour, A. F., Hsu, E., Gowrishankar, G., Kanada, M., Jokerst, J. V., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b04878 · Cited by 398 · see citing works
Shedden, K., Xie, X. T., Chandaroy, P., Chang, Y., & Rosania, G. R. (2003) · PubMed · Cited by 385 · see citing works
A lipase-independent pathway of lipid release and immune modulation by adipocytes
Flaherty, S. E., Grijalva, A., Xu, X., Ables, E. V., Nomani, A., & Ferrante, A. W. (2019) · Science · doi:10.1126/science.aaw2586 · Cited by 378 · see citing works
Matsumoto, S., Sakata, Y., Suna, S., Nakatani, D., Usami, M., Hara, M., Kitamura, T., Hamasaki, T., Nanto, S., Kawahara, Y., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.301209 · Cited by 374 · see citing works
CD24 is a marker of exosomes secreted into urine and amniotic fluid
Keller, S., Rupp, C., Stoeck, A., Runz, S., Fogel, M., Lugert, S., Hager, H. D., Abdel‐Bakky, M. S., Gutwein, P., & Altevogt, P. (2007) · Kidney International · doi:10.1038/sj.ki.5002486 · Cited by 372 · see citing works
Exosome isolation from distinct biofluids using precipitation and column-based approaches
Martins, T. S., Catita, J. A. M., Rosa, I. M., Silva, O. A. B. D. C. E., & Henriques, A. G. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198820 · Cited by 369 · see citing works
Placental exosomes in normal and complicated pregnancy
Mitchell, M. D., Peiris, H. N., Kobayashi, M., Koh, Y. Q., Duncombe, G. J., Illanes, S. E., Rice, G. E., & Salomón, C. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.07.001 · Cited by 364 · see citing works
Circulating Nucleic Acids Are Associated With Outcomes of Patients With Pancreatic Cancer
Bernard, V., Kim, D. U., Lucas, F. A. S., Castillo, J., Allenson, K., Mulu, F. C., Stephens, B. M., Huang, J. H., Semaan, A., Guerrero, P. A., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.09.022 · Cited by 364 · see citing works
Chen, L., Wang, Y., Pan, Y., Zhang, L., Shen, C., Qin, G., Ashraf, M., Weintraub, N. L., Ma, G., & Tang, Y. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.01.015 · Cited by 359 · see citing works
Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells
Wei, Y., Lai, X., Yu, S., Chen, S., Ma, Y., Zhang, Y., Li, H., Zhu, X., Yao, L., & Zhang, J. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3037-0 · Cited by 355 · see citing works
Serum Levels of microRNAs in Patients with Heart Failure
Goren, Y., Kushnir, M., Zafrir, B., et al. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfr155 · Cited by 354 · see citing works
What Are We Looking At? Extracellular Vesicles, Lipoproteins, or Both?
Simonsen, J. B. (2017) · Circulation Research · doi:10.1161/circresaha.117.311767 · Cited by 353 · see citing works
Nanostructural and Transcriptomic Analyses of Human Saliva Derived Exosomes
Palanisamy, V., Sharma, S., Deshpande, A., Zhou, H., Gimzewski, J. K., & Wong, D. T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008577 · Cited by 352 · see citing works
Binenbaum, Y., Fridman, E., Yaari, Z. A., Milman, N., Schroeder, A., David, G. B., Shlomi, T., & Gil, Z. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0124 · Cited by 339 · see citing works
Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes
Cheng, Y., Zeng, Q., Han, Q., & Xia, W. (2019) · Protein & Cell · doi:10.1007/s13238-018-0529-4 · Cited by 336 · see citing works
Exosomal Annexin II Promotes Angiogenesis and Breast Cancer Metastasis
Maji, S., Chaudhary, P., Akopova, I., Nguyen, P. M., Hare, R. J., Gryczyński, I., & Vishwanatha, J. K. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0163 · Cited by 331 · see citing works
Salomón, C., Guanzon, D., Scholz‐Romero, K., Longo, S. A., Correa, P. J., Illanes, S. E., & Rice, G. E. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00672 · Cited by 322 · see citing works
Exosomal Proteins as Diagnostic Biomarkers in Lung Cancer
Sandfeld‐Paulsen, B., Jakobsen, K. R., Bæk, R., Folkersen, B. H., Rasmussen, T. R., Meldgaard, P., Varming, K., Jørgensen, M. M., & Sørensen, B. S. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.05.034 · Cited by 311 · see citing works
Contributions of Direct and Indirect T Cell Alloreactivity During Allograft Rejection in Mice
Bénichou, G., Valujskikh, A., & Heeger, P. S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.1.352 · Cited by 309 · see citing works
Howard, B. V., Robbins, D. C., Sievers, M. L., Lee, E. T., Rhoades, D. A., Devereux, R. B., Cowan, L. D., Gray, R. S., Welty, T. K., Go, O. T., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.3.830 · Cited by 302 · see citing works
Salomón, C., Scholz‐Romero, K., Sarker, S., Sweeney, E. L., Kobayashi, M., Correa, P. J., Longo, S. A., Duncombe, G. J., Mitchell, M. D., Rice, G. E., et al. (2015) · Diabetes · doi:10.2337/db15-0966 · Cited by 302 · see citing works
Donor dendritic cell–derived exosomes promote allograft-targeting immune response
Liu, Q., Rojas-Canales, D. M., Divito, S. J., Shufesky, W. J., Stolz, D. B., Erdos, G., Sullivan, M. L. G., Gibson, G. A., Watkins, S. C., Larregina, A. T., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84577 · Cited by 302 · see citing works
Mechanisms of nuclear content loading to exosomes
Yokoi, A., Villar‐Prados, A., Oliphint, P. A., Zhang, J., Song, X., Hoff, P. L. D., Morey, R. E., Liu, J., Roszik, J., Clise-Dwyer, K., et al. (2019) · Science Advances · doi:10.1126/sciadv.aax8849 · Cited by 291 · see citing works
Arbelaiz, A., Azkargorta, M., Krawczyk, M. J., Santos‐Laso, Á., Lapitz, A., Perugorria, M. J., Erice, O., González, E., Jiménez-Agüero, R., Casta, A. L., et al. (2017) · Hepatology · doi:10.1002/hep.29291 · Cited by 289 · see citing works
McKiernan, J., Donovan, M. J., Margolis, E., Partin, A. W., Carter, B., Brown, G. A., Torkler, P., Noerholm, M., Skog, J., Shore, N. D., et al. (2018) · European Urology · doi:10.1016/j.eururo.2018.08.019 · Cited by 286 · see citing works
Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21
Wang, K., Jiang, Z., Webster, K. A., Chen, J., Hu, H., Zhou, Y., Zhao, J., Wang, L., Wang, Y., Zhong, Z., et al. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0386 · Cited by 274 · see citing works
Self-citationKrug, A. K., Enderle, D., Karlovich, C., Priewasser, T., Bentink, S., Spiel, A., Brinkmann, K., Emenegger, J., Grimm, D. G., Castellanos-Rizaldos, E., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx765 · Cited by 272 · see citing works
Exosomes and exosomal miRNAs in cardiovascular protection and repair
Emanueli, C., Shearn, A. I. U., Angelini, G. D., & Sahoo, S. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.02.008 · Cited by 269 · see citing works
Proinflammatory role of epithelial cell–derived exosomes in allergic airway inflammation
Kulshreshtha, A., Ahmad, T., Agrawal, A., & Ghosh, B. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.1565 · Cited by 267 · see citing works
New evidence that a large proportion of human blood plasma cell-free DNA is localized in exosomes
Fernando, M. R., Jiang, C. Y., Krzyzanowski, G. D., & Ryan, W. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183915 · Cited by 266 · see citing works
Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment
Tian, X., Shen, H., Li, Z., Wang, T., & Wang, S. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0772-z · Cited by 261 · see citing works
Exosomal proteins as prognostic biomarkers in non‐small cell lung cancer
Sandfeld‐Paulsen, B., Pedersen, N. A., Bæk, R., Jakobsen, K. R., Meldgaard, P., Folkersen, B. H., Rasmussen, T. R., Varming, K., Jørgensen, M. M., & Sørensen, B. S. (2016) · Molecular Oncology · doi:10.1016/j.molonc.2016.10.003 · Cited by 250 · see citing works
Wei, F., Ma, C., Zhou, T., Dong, X., Luo, Q., Geng, L., Ding, L., Zhang, Y., Zhang, L., Li, N., et al. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0694-8 · Cited by 245 · see citing works
Shao, Y., Chen, T., Zheng, X. E., Yang, S., Xu, K., Chen, X., Xu, F., Wang, L., Shen, Y., Wang, T., et al. (2018) · Carcinogenesis · doi:10.1093/carcin/bgy115 · Cited by 244 · see citing works
Self-citationIncreased Brain-Specific MiR-9 and MiR-124 in the Serum Exosomes of Acute Ischemic Stroke Patients
Ji, Q., Ji, Y., Peng, J., Zhou, X., Chen, X., Zhao, H., Xu, T., Chen, L., & Xu, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163645 · Cited by 236 · see citing works
Clinical significance of PD-L1 expression in serum-derived exosomes in NSCLC patients
Li, C., Li, C., Zhi, C., Liang, W., Wang, X., Chen, X., Lv, T., Shen, Q., Song, Y., Lin, D., et al. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-2101-2 · Cited by 236 · see citing works
Self-citationFang, S., Tian, H., Li, X., Jin, D., Li, X., Kong, J., Yang, C., Yang, X., Lu, Y., Luo, Y., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175050 · Cited by 234 · see citing works
Ready‐made chromatography columns for extracellular vesicle isolation from plasma
Welton, J. L., Webber, J. P., Botos, L.-A., Jones, M. H., & Clayton, A. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27269 · Cited by 226 · see citing works
Dong, L., Lin, W., Qi, P., Xu, M., Wu, X., Ni, S., Huang, D., Weng, W., Tan, C., Sheng, W., et al. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0006 · Cited by 224 · see citing works
Exosome-Based Detection of EGFR T790M in Plasma from Non–Small Cell Lung Cancer Patients
Castellanos-Rizaldos, E., Grimm, D. G., Tadigotla, V. R., Hurley, J. D., Healy, J., Neal, P. L., Sher, M., Venkatesan, R., Karlovich, C., Raponi, M., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-3369 · Cited by 218 · see citing works
Fu, F., Jiang, W., Zhou, L., & Chen, Z. (2018) · Translational Oncology · doi:10.1016/j.tranon.2017.12.012 · Cited by 216 · see citing works
Cross Talk of Combined Gene and Cell Therapy in Ischemic Heart Disease
Ong, S., Lee, W. H., Huang, M., Dey, D., Kodo, K., Sánchez-Freire, V., Gold, J. D., & Wu, J. C. (2014) · Circulation · doi:10.1161/circulationaha.113.007917 · Cited by 213 · see citing works
Update of syncytiotrophoblast derived extracellular vesicles in normal pregnancy and preeclampsia
Tannetta, D., Masliukaitė, I., Vatish, M., Redman, C. W. G., & Sargent, I. L. (2016) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2016.08.008 · Cited by 209 · see citing works
Figueroa, J. M., Skog, J., Akers, J. C., Li, H., Komotar, R. J., Jensen, R. L., Ringel, F. A., Yang, I., Kalkanis, S. N., Thompson, R. C., et al. (2017) · Neuro-Oncology · doi:10.1093/neuonc/nox085 · Cited by 206 · see citing works
MicroRNA molecular profiling from matched tumor and bio-fluids in bladder cancer
Armstrong, D. A., Green, B. B., Seigne, J. D., Schned, A. R., & Marsit, C. J. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0466-2 · Cited by 198 · see citing works
Li, J., Chen, Y., Guo, X., Zhou, L., Jia, Z., Peng, Z., Tang, Y., Liu, W., Zhu, B., Wang, L., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12941 · Cited by 194 · see citing works
Dragovic, R., Collett, G. P., Hole, P., Ferguson, D. J. P., Redman, C. W. G., Sargent, I. L., & Tannetta, D. (2015) · Methods · doi:10.1016/j.ymeth.2015.03.028 · Cited by 191 · see citing works
Hypoxia-Induced Changes in the Bioactivity of Cytotrophoblast-Derived Exosomes
Salomón, C., Kobayashi, M., Ashman, K., Sobrevía, L., Mitchell, M. D., & Rice, G. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079636 · Cited by 186 · see citing works
Ghosh, A., Davey, M., Chute, I. C., Griffiths, S. G., Lewis, S. A., Chacko, S. M., Barnett, D. A., Crapoulet, N., Fournier, S., Joy, A. P., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110443 · Cited by 184 · see citing works
Hisey, C. L., Dorayappan, K. D. P., Cohn, D. E., Selvendiran, K., & Hansford, D. J. (2018) · Lab on a Chip · doi:10.1039/c8lc00834e · Cited by 182 · see citing works
Liu, Y., Li, Q., Hosen, M. R., Zietzer, A., Flender, A., Levermann, P., Schmitz, T., Frühwald, D., Goody, P. R., Nickenig, G., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314010 · Cited by 182 · see citing works
Martínez, A. R., de Miguel‐Pérez, D., Ortega, F. G., García-Puche, J. L., Robles‐Fernandez, I., Expósito, J., Martorell‐Marugán, J., Carmona‐Sáez, P., Garrido-Navas, M. C., Rolfo, C. D., et al. (2019) · Breast Cancer Research · doi:10.1186/s13058-019-1109-0 · Cited by 180 · see citing works
Pillay, P., Maharaj, N. R., Moodley, J., & Mackraj, I. (2016) · Placenta · doi:10.1016/j.placenta.2016.08.078 · Cited by 176 · see citing works
Isolation and Visible Detection of Tumor-Derived Exosomes from Plasma
Chen, J., Xu, Y., Lü, Y., & Xing, W. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b03031 · Cited by 171 · see citing works
Differential protein profiling of renal cell carcinoma urinary exosomes
Raimondo, F., Morosi, L., Corbetta, S., Chinello, C., Brambilla, P., Mina, P. D., Villa, A., Albo, G., Battaglia, C., Bòsari, S., et al. (2013) · Molecular BioSystems · doi:10.1039/c3mb25582d · Cited by 169 · see citing works
Möhrmann, L., Huang, H. J., Hong, D. S., Tsimberidou, A. M., Fu, S., Piha-Paul, S. A., Subbiah, V., Karp, D. D., Naing, A., Krug, A., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2007 · Cited by 168 · see citing works
c-Met and PD-L1 on Circulating Exosomes as Diagnostic and Prognostic Markers for Pancreatic Cancer
Lux, A., Kahlert, C., Grützmann, R., & Pilarsky, C. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133305 · Cited by 168 · see citing works
Bijnsdorp, I. V., Geldof, A. A., Lavaei, M., Piersma, S. R., van Moorselaar, R. J. A., & Jiménez, C. R. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.22097 · Cited by 167 · see citing works
Vallabhajosyula, P., Korutla, L., Habertheuer, A., Yu, M., Rostami, S. Y., Yuan, C., Reddy, S., Liu, C., Korutla, V., Koeberlein, B., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci87993 · Cited by 163 · see citing works
Street, J. M., Koritzinsky, E. H., Glispie, D. M., Star, R. A., & Yuen, P. S. T. (2016) · Advances in clinical chemistry · doi:10.1016/bs.acc.2016.07.003 · Cited by 162 · see citing works
Li, L., Li, W., Chen, N., Zhao, H., Xu, G., Zhao, Y., Pan, X., Zhang, X., Zhou, L., Yu, D., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1447 · Cited by 160 · see citing works
Circulating melanoma exosomes as diagnostic and prognosis biomarkers
Alegre, E., Zubiri, L., Perez‐Gracia, J. L., González‐Cao, M., Soria, L., Martín‐Algarra, S., & González, Á. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.12.031 · Cited by 157 · see citing works
Accessing Genetic Information with Liquid Biopsies
Cai, X., Jankú, F., Zhan, Q., & Fan, J. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.06.001 · Cited by 155 · see citing works
Taverna, S., Pucci, M., Giallombardo, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03460-y · Cited by 155 · see citing works
Circulating Exosomal miRNA Profile During Term and Preterm Birth Pregnancies: A Longitudinal Study
Menon, R., Debnath, C., Lai, A., Guanzon, D., Bhatnagar, S., Kshetrapal, P., Sheller‐Miller, S., Salomón, C., & The Garbhini Study Team (2018) · Endocrinology · doi:10.1210/en.2018-00836 · Cited by 153 · see citing works
Different exosome cargo from plasma/bronchoalveolar lavage in non‐small‐cell lung cancer
Rodríguez, M., Silva, J., López‐Alfonso, A., et al. (2014) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22181 · Cited by 148 · see citing works
Miranda, J., Paulés, C., Nair, S., Lai, A., Palma, C., Scholz‐Romero, K., Rice, G. E., Gratacós, E., Crispi, F., & Salomón, C. (2018) · Placenta · doi:10.1016/j.placenta.2018.02.006 · Cited by 148 · see citing works
Zheng, X. E., Xu, K., Zhou, B., Chen, T., Huang, Y., Li, Q., Wen, F., Ge, W., Wang, J., Yu, S., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1750202 · Cited by 145 · see citing works
Self-citationCirculating exosomal CPNE3 as a diagnostic and prognostic biomarker for colorectal cancer
Sun, B., Li, Y., Zhou, Y., Ng, T. K., Zhao, C., Gan, Q., Gu, X., & Xiang, J. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26936 · Cited by 143 · see citing works
Study of Circulating MicroRNA-125b Levels in Serum Exosomes in Advanced Melanoma
Alegre, E., Sanmamed, M. F., Rodriguez, C., et al. (2014) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2013-0134-oa · Cited by 141 · see citing works
Integrated Kidney Exosome Analysis for the Detection of Kidney Transplant Rejection
Park, J., Lin, H.-Y., Assaker, J. P., Jeong, S., Huang, C.-H., Kurdi, A. T., Lee, K., Fraser, K. B., Min, C., Eskandari, S. K., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b05083 · Cited by 141 · see citing works
Tumor‐derived exosomal proteins as diagnostic biomarkers in non‐small cell lung cancer
Niu, L., Song, X., Wang, N., et al. (2018) · Cancer Science · doi:10.1111/cas.13862 · Cited by 141 · see citing works
Li, H. R., Liao, Y., Gao, L., Zhuang, T., Huang, Z., Zhu, H., & Ge, J. (2018) · Theranostics · doi:10.7150/thno.21895 · Cited by 137 · see citing works
Kimura, H., Yamamoto, H., Harada, T., Fumoto, K., Osugi, Y., Sada, R., Maehara, N., Hikita, H., Mori, S., Eguchi, H., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2124 · Cited by 135 · see citing works
Cheow, E. S. H., Cheng, W. C., Lee, C. N., de Kleijn, D. P. V., Sorokin, V. A., & Sze, S. K. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.055731 · Cited by 128 · see citing works
Donor-Derived Exosomes With Lung Self-Antigens in Human Lung Allograft Rejection
Gunasekaran, M., Xu, Z., Nayak, D. K., Sharma, M., Hachem, R. R., Walia, R., Bremner, R. M., Smith, M. A., & Mohanakumar, T. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13915 · Cited by 126 · see citing works
CTC-Derived Models: A Window into the Seeding Capacity of Circulating Tumor Cells (CTCs)
Tayoun, T., Faugeroux, V., Oulhen, M., Aberlenc, A., Pawlikowska, P., & Farace, F. (2019) · Cells · doi:10.3390/cells8101145 · Cited by 125 · see citing works
Methods for extracellular vesicles isolation in a hospital setting
Sáenz-Cuesta, M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00050 · Cited by 120 · see citing works
High-Sensitivity Troponin T and Mortality After Elective Percutaneous Coronary Intervention
Ndrepepa, G., Colleran, R., Braun, S., Cassese, S., Hieber, J., Fusaro, M., Kufner, S., Ott, I., Byrne, R. A., Hüsser, O., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.08.059 · Cited by 113 · see citing works
Dorayappan, K. D. P., Gardner, M. L., Hisey, C. L., Zingarelli, R. A., Smith, B. Q., Lightfoot, M. D. S., Gogna, R., Flannery, M. M., Hays, J. L., Hansford, D. J., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3538 · Cited by 109 · see citing works
Yokoyama, S., Takeuchi, A., Yamaguchi, S., Mitani, Y., Watanabe, T., Matsuda, K., Hotta, T., Shively, J. E., & Yamaue, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183337 · Cited by 108 · see citing works
Exosomal protein CD82 as a diagnostic biomarker for precision medicine for breast cancer
Wang, X., Zhong, W., Bu, J., et al. (2019) · Molecular Carcinogenesis · doi:10.1002/mc.22960 · Cited by 107 · see citing works
MiR-21-5p in urinary extracellular vesicles is a novel biomarker of urothelial carcinoma
Matsuzaki, K., Fujita, K., Jingushi, K., Kawashima, A., Ujike, T., Nagahara, A., Ueda, Y., Tanigawa, G., Yoshioka, I., Ueda, K., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14969 · Cited by 105 · see citing works
Peng, Z., Gu, R., & Yan, B. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27291 · Cited by 105 · see citing works
Kanhai, D. A., Visseren, F. L. J., van der Graaf, Y., et al. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.01.231 · Cited by 103 · see citing works
Wan, Y., Liu, B., Lei, H., Zhang, B., Wang, Y., Huang, H. J., Chen, S., Feng, Y., Zhu, L., Gu, Y., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy458 · Cited by 103 · see citing works
Self-citationVandergriff, A. C., de Andrade, J. B. M., Tang, J., et al. (2015) · Stem Cells International · doi:10.1155/2015/960926 · Cited by 96 · see citing works
Serum exosomal protein profiling for the non-invasive detection of cardiac allograft rejection
Kennel, P. J., Saha, A., Maldonado, D. A., Givens, R. C., Brunjes, D. L., Castillero, E., Zhang, X., Ji, R., Yahi, A., George, I., et al. (2017) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2017.07.012 · Cited by 95 · see citing works
Dewi, I. S., Celik, S., Karlsson, A., Hollander, Z., Lam, K., McManus, J. E. W., Tebbutt, S. J., Ng, R. T., Keown, P. A., McMaster, R., et al. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw244 · Cited by 94 · see citing works
Lin, Y., Dong, H., Deng, W., Lin, W., Li, K., Xiong, X., Guo, Y. Z., Zhou, F., Ma, C., Chen, Y., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3169 · Cited by 93 · see citing works
Saha, P., Sharma, S., Korutla, L., Datla, S. R., Shoja‐Taheri, F., Mishra, R., Bigham, G. E., Sarkar, M., Morales, D., Bittle, G. J., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau1168 · Cited by 92 · see citing works
Exosomal Release of L-Plastin by Breast Cancer Cells Facilitates Metastatic Bone Osteolysis
Tiedemann, K., Sadvakassova, G., Mikolajewicz, N., Juhas, M., Sabirova, Z., Tabariès, S., Gettemans, J., Siegel, P. M., & Komarova, S. V. (2018) · Translational Oncology · doi:10.1016/j.tranon.2018.11.014 · Cited by 88 · see citing works
Biró, O., Alasztics, B., Molvarec, A., Joó, J. G., Nagy, B., & Rigó, J. J. (2017) · Pregnancy Hypertension · doi:10.1016/j.preghy.2017.09.002 · Cited by 87 · see citing works
Lim, J., Lee, C., Kim, K. Y., Jung, H., Choi, J., Cho, J., Park, S.-H., Kim, Y.-L., Baek, M., Park, J. B., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204204 · Cited by 84 · see citing works
Isolation and Identification of miRNAs in exosomes derived from serum of colon cancer patients
Zhao, L., Yu, J., Wang, J., Li, H., Che, J., & Cao, B. (2017) · Journal of Cancer · doi:10.7150/jca.18026 · Cited by 83 · see citing works
Self-citationWoo, H., Park, J., Ku, J. Y., Lee, C. H., Sunkara, V., Ha, H. K., & Cho, Y. (2018) · Lab on a Chip · doi:10.1039/c8lc01185k · Cited by 83 · see citing works
Chemoresistance in Cancer Cells: Exosomes As Potential Regulators of Therapeutic Tumor Heterogeneity
Sharma, A. (2017) · Nanomedicine · doi:10.2217/nnm-2017-0184 · Cited by 81 · see citing works
Keserű, J. S., Soltész, B., Lukács, J., Márton, É., Szilágyi, M., Penyige, A., Póka, R., & Nagy, B. (2019) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2019.04.015 · Cited by 79 · see citing works
Altered Exosomal RNA Profiles in Bronchoalveolar Lavage from Lung Transplants with Acute Rejection
Gregson, A. L., Hoji, A., Injean, P. A., Poynter, S. T., Briones, C., Palchevskiy, V., Weigt, S. S., Shino, M. Y., Derhovanessian, A., Sayah, D. M., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201503-0558oc · Cited by 77 · see citing works
Bijnsdorp, I. V., Maxouri, O., Kardar, A., Schelfhorst, T., Piersma, S. R., Pham, T. V., Vis, A. N., van Moorselaar, R. J. A., & Jiménez, C. R. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1313091 · Cited by 71 · see citing works
Liquid Biopsy: From Basic Research to Clinical Practice
Macías, M., Alegre, E., Díaz‐Lagares, Á., Patiño‐García, A., Perez‐Gracia, J. L., Sanmamed, M. F., López‐López, R., Varo, N., & González, Á. (2017) · Advances in clinical chemistry · doi:10.1016/bs.acc.2017.10.003 · Cited by 68 · see citing works
Circulating Exosomal miR-141-3p and miR-375 in Metastatic Progression of Rectal Cancer
Meltzer, S., Bjørnetrø, T., Lyckander, L. G., Flatmark, K., Dueland, S., Samiappan, R., Johansen, C., Kalanxhi, E., Ree, A. H., & Redalen, K. R. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.04.014 · Cited by 68 · see citing works
Chiva‐Blanch, G., Suades, R., Crespo, J., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.01.211 · Cited by 65 · see citing works
Zhang, H., Huang, E., Kahwaji, J. M., Nast, C. C., Li, P., Mirocha, J., Thomas, D. L., Ge, S., Vo, A. A., Jordan, S. C., et al. (2017) · Transplantation · doi:10.1097/tp.0000000000001834 · Cited by 61 · see citing works
Emerging role of exosomes in allorecognition and allograft rejection
Gonzalez-Nolasco, B., Wang, M., Prunevieille, A., & Benichou, G. (2018) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000489 · Cited by 59 · see citing works
Morelli, A. E., Bracamonte‐Baran, W., & Burlingham, W. J. (2016) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000372 · Cited by 56 · see citing works
Berezin, A. Е., Kremzer, A. A., Samura, T. A., Martovitskaya, Y. V., Malinovskiy, Y. V., Oleshko, S. V., & Berezina, T. A. (2014) · Journal of Cardiology · doi:10.1016/j.jjcc.2014.06.014 · Cited by 52 · see citing works
Krug, A. K., Enderle, D., Karlovich, C., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy261 · Cited by 52 · see citing works
Microparticles during long-term follow-up after acute myocardial infarction
Christersson, C., Thulin, Å., & Siegbahn, A. (2017) · Thrombosis and Haemostasis · doi:10.1160/th16-11-0837 · Cited by 47 · see citing works
Schmelter, C., Funke, S., Treml, J., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123847 · Cited by 44 · see citing works
Wang, H., Yan, H., Tang, M., Wang, Z., Zhong, M., Zhang, Y., Deng, J., & Zhang, W. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.07.005 · Cited by 36 · see citing works
Noninvasive diagnosis of recurrent autoimmune type 1 diabetes after islet cell transplantation
Korutla, L., Rickels, M. R., Hu, R. W., Freas, A., Reddy, S., Habertheuer, A., Harmon, J., Korutla, V., Ram, C., Naji, A., et al. (2019) · American Journal of Transplantation · doi:10.1111/ajt.15322 · Cited by 35 · see citing works
Nielsen, M. R., Frederiksen‐Møller, B., Zachar, R., Jørgensen, J. S., Hansen, M. R., Ydegaard, R., Svenningsen, P., Buhl, K. B., & Jensen, B. L. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1977-z · Cited by 34 · see citing works
Arbelaiz, A., Azkargorta, M., Santos‐Laso, Á., et al. (2017) · Journal of Hepatology · doi:10.1016/s0168-8278(17)30712-2 · Cited by 34 · see citing works
The relationship between amniotic fluid miRNAs and congenital obstructive nephropathy.
Xie, J., Zhou, Y., Gao, W., et al. (2017) · PubMed · Cited by 32 · see citing works
Knol, J. C., de Reus, I., Schelfhorst, T., Beekhof, R., de Wit, M., Piersma, S. R., Pham, T. V., Smit, E. F., Verheul, H. M. W., & Jiménez, C. R. (2016) · EuPA Open Proteomics · doi:10.1016/j.euprot.2016.02.001 · Cited by 30 · see citing works
Ghafarian, F., Pashirzad, M., Khazaei, M., Rezayi, M., Hassanian, S. M., Ferns, G. A., & Avan, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27964 · Cited by 29 · see citing works
Stokman, M. F., Bijnsdorp, I. V., Schelfhorst, T., Pham, T. V., Piersma, S. R., Knol, J. C., Giles, R. H., Bongers, E. M. H. F., Knoers, N. V. A. M., Liliën, M. R., et al. (2018) · Journal of Proteomics · doi:10.1016/j.jprot.2018.07.008 · Cited by 28 · see citing works
Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer
Liu, T., Zhang, X., Du, L., et al. (2019) · Figshare · doi:10.6084/m9.figshare.c.4440026 · Cited by 26 · see citing works
Quantitative Analysis of Exosomes From Murine Lung Cancer Cells by Flow Cytometry
Rim, K.-T., & Kim, S. (2016) · Journal of Cancer Prevention · doi:10.15430/jcp.2016.21.3.194 · Cited by 24 · see citing works
Jiang, P., Zhu, X., Jiang, R., et al. (2019) · PubMed · Cited by 22 · see citing works
Kasner, M., Gast, M., Galuszka, O., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.04.018 · Cited by 19 · see citing works
Toxicity of oxaliplatin rechallenge in metastatic colorectal cancer
Mauri, G., Bencardino, K. B., Bianchi, A. S., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy306 · Cited by 15 · see citing works
Schmelter, C., Funke, S., Treml, J., et al. (2018) · Advanced Techniques in Biology & Medicine · doi:10.4172/2379-1764.1000262 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [162]Kevin Dooley, S. C. J. et al. Developing an Engineered Exosome Therapeutic Platform for Immuno-Oncology. Keystone Symposium on Cancer Immunotherapy, Whistler, Canada (2019).
- [167]PureTech Health Announces Collaboration with Roche to Advance Technology for Oral Administration of Antisense Oligonucleotides. PureTech News. http://puretechhealth.com/news/23-press-releases/1029-puretech-health-announces-collaboration-with-roche-to-advance-technology-for-oral-administration-of-antisense-oligonucleotides (Accessed 20 Jul 2018).
Cited by
Sorted by citations
Clinical applications of stem cell-derived exosomes
Tan, F., Li, X., Wang, Z., Li, J., Shahzad, K., & Zheng, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01704-0 · Cited by 708 · see citing works
Exosome Processing and Characterization Approaches for Research and Technology Development
Lai, J. J., Chau, Z. L., Chen, S., Hill, J. J., Korpany, K. V., Liang, N., Lin, L., Lin, Y., Liu, J. K., Liu, Y., et al. (2022) · Advanced Science · doi:10.1002/advs.202103222 · Cited by 623 · see citing works
Recent Advances in Exosome-Based Drug Delivery for Cancer Therapy
Kim, H., Jang, H., Cho, H., Choi, J., Hwang, K. Y., Choi, Y., Kim, S. H., & Yang, Y. (2021) · Cancers · doi:10.3390/cancers13174435 · Cited by 152 · see citing works
The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System
Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110 · see citing works
Soliman, H. M., Ghonaim, G. A., Gharib, S. M., Chopra, H., Farag, A. K., Hassanin, M. H., Nagah, A., Emad-Eldin, M., Hashem, N. E., Yahya, G., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910794 · Cited by 81 · see citing works
Sheikhi, K., Ghaderi, S., Firouzi, H., Rahimibarghani, S., Shabani, E., Afkhami, H., & Yarahmadi, A. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1517369 · Cited by 20 · see citing works
- Authors
- Zhou, B., Xu, K., Zheng, X., Chen, T., Wang, J., Song, Y., Shao, Y., & Zheng, S.
- Affiliations
- Second Affiliated Hospital of Zhejiang University (CN)
- Corresponding author
- Shao, Yingkuan
- Zheng, Shu
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2020-08-03
- Volume
- 5
- Issue
- 1
- Pages
- 144-144
- ISSN
- 2059-3635 (ISSN-L)
- PMC
- PMC7400738
- OpenAlex
- W3047244309
- Cited by
- 685
- References
- 186
- Citations by year
- 2026: 68 · 2025: 94 · 2024: 129 · 2023: 148 · 2022: 145 · 2021: 90 · 2020: 11
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81500115, 81672342)
- Natural Science Foundation of Zhejiang Province (LY19H030012)
- National Key R&D Program of China
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- exosomes, liquid biopsy, extracellular vesicles, circulating tumor cells, cancer diagnosis, pregnancy disorders, cardiovascular disease, organ transplantation, intercellular communication
- MeSH terms
- Liquid Biopsy, Cardiovascular Diseases, Female, Humans, Male, Neoplasms, Pregnancy, Pregnancy Complications, Transplants, Exosomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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