Cited by 685Extracellular vesicles in diseaseNanoparticle-Based Drug DeliveryCancer Genomics and Diagnostics

Application of exosomes as liquid biopsy in clinical diagnosis

Open access
Zhou, Biting, Xu, Kailun, Zheng, Xi, Chen, Ting, Wang, Jian, Song, Yongmao, Shao, Yingkuan, Zheng, Shu·2020·Signal Transduction and Targeted Therapy

Abstract

Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small extracellular vesicles with sizes between 30-150 nm. They are secreted by multivesicular bodies through exocytosis in live cells and can participate in intercellular communication due to their contents, including nucleic acids, proteins, and lipids. Herein, we investigate publication frequencies on exosomes over the past 10 years, and review recent clinical studies on liquid biopsy of exosomes in the fields of oncology, pregnancy disorders, cardiovascular diseases, and organ transplantation. We also describe the advantages of exosomes as an effective liquid biopsy tool and the progression of exosome extraction methods. Finally, we depict the commercial development of exosome research and discuss the future role of exosomes in liquid biopsy.

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Crossref · 10.1038/s41392-020-00258-9

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  • Clinical application of exosomes is mainly used for body fluid biopsy and clinical diagnosis of diseases such as cancer, nervous system diseases, and immune diseases.

    “Thus far, the clinical application of exosomes is mainly used for body fluid biopsy and clinical diagnosis of diseases such as cancer, nervous system diseases. and immune diseases [112].”

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  1. [162]Kevin Dooley, S. C. J. et al. Developing an Engineered Exosome Therapeutic Platform for Immuno-Oncology. Keystone Symposium on Cancer Immunotherapy, Whistler, Canada (2019).
  2. [167]PureTech Health Announces Collaboration with Roche to Advance Technology for Oral Administration of Antisense Oligonucleotides. PureTech News. http://puretechhealth.com/news/23-press-releases/1029-puretech-health-announces-collaboration-with-roche-to-advance-technology-for-oral-administration-of-antisense-oligonucleotides (Accessed 20 Jul 2018).

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Authors
Zhou, B., Xu, K., Zheng, X., Chen, T., Wang, J., Song, Y., Shao, Y., & Zheng, S.
Affiliations
Second Affiliated Hospital of Zhejiang University (CN)
Corresponding author
  • Shao, Yingkuan
  • Zheng, Shu
Venue
Signal Transduction and Targeted Therapy
Published
2020-08-03
Volume
5
Issue
1
Pages
144-144
ISSN
2059-3635 (ISSN-L)
OpenAlex
W3047244309
Cited by
685
References
186
Citations by year
2026: 68 · 2025: 94 · 2024: 129 · 2023: 148 · 2022: 145 · 2021: 90 · 2020: 11
FWCI
9.45
Type
journal article
Language
en
Open access
Locations
  • Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81500115, 81672342)
  • Natural Science Foundation of Zhejiang Province (LY19H030012)
  • National Key R&D Program of China
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Keywords
exosomes, liquid biopsy, extracellular vesicles, circulating tumor cells, cancer diagnosis, pregnancy disorders, cardiovascular disease, organ transplantation, intercellular communication
MeSH terms
Liquid Biopsy, Cardiovascular Diseases, Female, Humans, Male, Neoplasms, Pregnancy, Pregnancy Complications, Transplants, Exosomes

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