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Identification of a T follicular helper cell subset that drives anaphylactic IgE
Open accessAbstract
Thirteen is the charm in anaphylaxis: Immunoglobulin E (IgE) is a type of antibody associated with allergies and response to parasites such as worms. When high-affinity, allergen-specific IgE binds its target, it can cross-link receptors on mast cells that induce anaphylaxis. It remains unclear, however, how B cells are instructed to generate high-affinity IgE. Gowthaman et al. discovered a subset of T follicular helper cells (T FH 13) that direct B cells to do just that. T FH 13 cells are induced by allergens but not during parasite infection. Transgenic mice lacking these cells show impaired production of high-affinity, anaphylactic IgE. T FH 13 cells, which are elevated in patients with food and aeroallergies, may be targeted in future antianaphylaxis therapies. Science , this issue p. eaaw6433
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The role of allergen‐specific IgE, IgG and IgA in allergic disease
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Metadata
- Authors
- Gowthaman, U., Chen, J. S., Zhang, B., Flynn, W. F., Lu, Y., Song, W., Joseph, J., Gertie, J. A., Xu, L., Collet, M. A., Grassmann, J. D. S., Simoneau, T., Chiang, D., Berin, M. C., Craft, J. E., Weinstein, J. S., Williams, A., & Eisenbarth, S. C.
- Venue
- Science
- Published
- 2019-08-30
- Volume
- 365
- Issue
- 6456
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2965364009
- Cited by
- 477
- References
- 72
- FWCI
- 18.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Gowthaman, U., Chen, J. S., Zhang, B., Flynn, W. F., Lu, Y., Song, W., Joseph, J., Gertie, J. A., Xu, L., Collet, M. A., Grassmann, J. D. S., Simoneau, T., Chiang, D., Berin, M. C., Craft, J. E., Weinstein, J. S., Williams, A., & Eisenbarth, S. C. (2019). Identification of a T follicular helper cell subset that drives anaphylactic IgE. Science. https://doi.org/10.1126/science.aaw6433
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