The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Cancer modeling meets human organoid technology
Open accessAbstract
Organoids are microscopic self-organizing, three-dimensional structures that are grown from stem cells in vitro. They recapitulate many structural and functional aspects of their in vivo counterpart organs. This versatile technology has led to the development of many novel human cancer models. It is now possible to create indefinitely expanding organoids starting from tumor tissue of individuals suffering from a range of carcinomas. Alternatively, CRISPR-based gene modification allows the engineering of organoid models of cancer through the introduction of any combination of cancer gene alterations to normal organoids. When combined with immune cells and fibroblasts, tumor organoids become models for the cancer microenvironment enabling immune-oncology applications. Emerging evidence indicates that organoids can be used to accurately predict drug responses in a personalized treatment setting. Here, we review the current state and future prospects of the rapidly evolving tumor organoid field.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“dynamic drug treatment was more effective than constant‐dose administration methods.”
From 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip (2023) · cites this paper as [105]
In the citing paper
“Using this system, the authors observed that significant differences in the response of individual PDOs to specific drug treatments and dynamic drug treatments could be more effective than constant‐dose therapy in vitro, indicating that this platform holds great potential to make clinical decisions for personalized therapy.”
From 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip (2023) · cites this paper as [105]
In the citing paper
“Using this system, the authors observed that significant differences in the response of individual PDOs to specific drug treatments and dynamic drug treatments could be more effective than constant‐dose therapy in vitro, indicating that this platform holds great potential to make clinical decisions for personalized therapy.”
From 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip (2023) · cites this paper as [105]
In the citing paper
“APCmin/+ mice can develop intestinal tumors around 10 weeks-old26”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [26]
In the citing paper
“Wnt/β-catenin signaling is essential to maintain intestinal organoid growth26,27”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [26]
In the citing paper
“The patient-derived tumor organoids, which recapitulate the complexity and heterogeneity of tumors, have been shown to be an ideal model for drug screening and precision medicine26.”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [26]
In the citing paper
“These tumoroid biobanks can then be used as in vitro models of tumorigenesis and offer a significant advantage over conventional 2D cell culture technology5,6.”
From One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids (2023) · cites this paper as [6]
Citations
Cites
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204
Self-citationCerebral organoids model human brain development and microcephaly
Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372
Sato, T., Stange, D. E., Ferrante, M., Vries, R. G. J., van Es, J. H., van den Brink, S., van Houdt, W. J., Pronk, A., van Gorp, J., Siersema, P. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.050 · Cited by 3,753
Self-citationDistinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162024 · Cited by 2,590
Self-citationProspective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
van de Wetering, M., Francies, H. E., Francis, J. M., Bounova, G., Iorio, F., Pronk, A., van Houdt, W., van Gorp, J., Taylor-Weiner, A., Kester, L., et al. (2015) · Cell · doi:10.1016/j.cell.2015.03.053 · Cited by 2,408
Self-citationOrganoid models of human and mouse ductal pancreatic cancer
Boj, S. F., Hwang, C.-I., Baker, L. A., Chio, I. I. C., Engle, D. D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M. S., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.021 · Cited by 2,150
Self-citationPatient-derived organoids model treatment response of metastatic gastrointestinal cancers
Vlachogiannis, G., Hedayat, S., Vatsiou, A., Jamin, Y., Fernández-Mateos, J., Khan, K., Lampis, A., Eason, K., Huntingford, I., Burke, R., et al. (2018) · Science · doi:10.1126/science.aao2774 · Cited by 2,096
A living biobank of breast cancer organoids captures disease heterogeneity
Sachs, N., de Ligt, J., Kopper, O., Gogola, E., Bounova, G., Weeber, F., Balgobind, A. V., Wind, K., Gracanin, A., Begthel, H., et al. (2018) · Cell · doi:10.1016/j.cell.2017.11.010 · Cited by 1,973
Self-citationBasal cells as stem cells of the mouse trachea and human airway epithelium
Rock, J. R., Onaitis, M. W., Rawlins, E. L., Lu, Y., Clark, C. P., Xue, Y., Randell, S. H., & Hogan, B. L. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906850106 · Cited by 1,591
Cited by
Sorted by citations
Items 201–300 of 938
Gastric Organoids: Progress and Remaining Challenges
Pang, M.-J., Burclaff, J., Jin, R. U., Adkins-Threats, M., Osaki, L. H., Han, Y., Mills, J. C., Miao, Z., & Wang, Z.-N. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.09.005 · Cited by 43
Harnessing the power of artificial intelligence for human living organoid research
Wang, H., Li, X., You, X., & Zhao, G. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.08.027 · Cited by 43
Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer
García, P., Rosa, L., Vargas-Salas, S., Weber, H. L., Espinoza, J. A., Suárez, F., Romero‐Calvo, I., Elgueta, N., Rivera, V., Nervi, B., et al. (2020) · Cancers · doi:10.3390/cancers12040778 · Cited by 43
Zhang, W., Zhang, S., Hou, Q., Qin, Y., Chen, X., Zhou, Z., Shu, Y., Xu, H., & Hu, J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01214 · Cited by 43
Characteristics and Outcome of Children with Renal Cell Carcinoma: A Narrative Review
van der Beek, J. N., Geller, J. I., de Krijger, R. R., Graf, N. M., Pritchard‐Jones, K., Drost, J., Verschuur, A. C., Murphy, D., Ray, S., Spreafico, F., et al. (2020) · Cancers · doi:10.3390/cancers12071776 · Cited by 42
Boulay, G., Cironi, L., Garcia, S. P., Rengarajan, S., Xing, Y., Lee, L., Awad, M. E., Naigles, B., Iyer, S., Broye, L. C., et al. (2020) · Life Science Alliance · doi:10.26508/lsa.202000808 · Cited by 42
Yu, Y., Yang, G., Huang, H., Fu, Z., Cao, Z., Zheng, L., You, L., & Zhang, T. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01787-5 · Cited by 42
Hou, J., He, Z., Liu, T., Chen, D., Wang, B., Wen, Q., & Zheng, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.755053 · Cited by 48
Xing, F., Liu, Y., Huang, S., Lyu, X., Su, S. M., Chan, U. I., Wu, P., Yan, Y., Ai, N., Li, J., et al. (2021) · Theranostics · doi:10.7150/thno.59533 · Cited by 41
A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer
Inglebert, M., Dettwiler, M., Hahn, K., Letko, A., Drögemüller, C., Doench, J. G., Brown, A., Memari, Y., Davies, H. R., Degasperi, A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-21706-2 · Cited by 43
Breast cancer organoids derived from patients: A platform for tailored drug screening
Tzeng, Y. T., Hsiao, J., Tseng, L., Hou, M., & Li, C. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115803 · Cited by 45
CRISPR screen in mechanism and target discovery for cancer immunotherapy
Liu, D., Zhao, X., Tang, A., Xu, X., Liu, S., Zha, L., Ma, W., Zheng, J., & Shi, M. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188378 · Cited by 44
Dhumal, D. M., Lan, W., Ding, L., Jiang, Y., Lyu, Z., Laurini, E., Marson, D., Tintaru, A., Dusetti, N., Giorgio, S., et al. (2020) · Nano Research · doi:10.1007/s12274-020-3216-8 · Cited by 46
Three-Dimensional Cell Culture Models to Investigate Oral Carcinogenesis: A Scoping Review
Suryaprakash, R. T. C., Kujan, O., Shearston, K., & Farah, C. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249520 · Cited by 42
A biomimetic tumor model of heterogeneous invasion in pancreatic ductal adenocarcinoma
Bradney, M. J., Venis, S. M., Yang, Y., Konieczny, S. F., & Han, B. (2020) · Small · doi:10.1002/smll.201905500 · Cited by 38
Tissue Biology: In Search of a New Paradigm
Adler, M., Chavan, A. R., & Medzhitov, R. (2023) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120420-113830 · Cited by 40
The application of patient-derived organoid in the research of lung cancer
Li, Y., Gao, X., Ni, C., Zhao, B. T., & Cheng, X. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00771-3 · Cited by 41
Organoid technology and applications in cancer immunotherapy and precision medicine
Homicskó, K. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.05.002 · Cited by 40
Okamoto, T., duVerle, D. A., Yaginuma, K., Natsume, Y., Yamanaka, H., Kusama, D., Fukuda, M., Yamamoto, M., Perraudeau, F., Srivastava, U., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.02.012 · Cited by 42
Wang, Y., & Hummon, A. B. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101139 · Cited by 42
Recent advances in organotypic tissue slice cultures for anticancer drug development
He, L., & Deng, C. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.78997 · Cited by 40
Organoids: opportunities and challenges of cancer therapy
Jiang, X., Oyang, L., Qiu, P., Liu, Q., Xu, X., Wu, N., Tan, S., Yang, W., Han, Y., Lin, J., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1232528 · Cited by 41
Rodríguez, E., Boelaars, K., Brown, K., Madunić, K., van Ee, T., Dijk, F., Verheij, J., Li, R. J. E., Schetters, S. T. T., Meijer, L. L., et al. (2022) · Communications Biology · doi:10.1038/s42003-021-02934-0 · Cited by 38
Self-citationPatient-derived Tumour Organoids: A Bridge between Cancer Biology and Personalised Therapy
Wu, W., Li, X., & Yu, S. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.04.050 · Cited by 40
Joshi, R. S., de Moura, M. C., Piñeyro, D., Álvarez‐Errico, D., Arribas, C., & Esteller, M. (2020) · Epigenetics · doi:10.1080/15592294.2020.1762398 · Cited by 39
Anti-GD2-IRDye800CW as a targeted probe for fluorescence-guided surgery in neuroblastoma
Wellens, L. M., Deken, M. M., Sier, C. F. M., Johnson, H. R., Ortiz, F. D. L. J., Bhairosingh, S. S., Houvast, R. D., Kholosy, W. M., Baart, V. M., Pieters, A. M. M. J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-74464-4 · Cited by 43
Lee, T. W., Lai, A., Harms, J. K., Singleton, D. C., Dickson, B. D., Macann, A., Hay, M. P., & Jamieson, S. M. F. (2020) · Cancers · doi:10.3390/cancers12123743 · Cited by 38
Brok, J. S., Mavinkurve‐Groothuis, A. M. C., Drost, J., Perotti, D., Geller, J. I., Walz, A. L., Geoerger, B., Pasqualini, C., Verschuur, A. C., Polanco, A., et al. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2020.11.012 · Cited by 35
Tanaka, H. Y., Nakazawa, T., Enomoto, A., Masamune, A., & Kano, M. R. (2023) · Cancers · doi:10.3390/cancers15030724 · Cited by 42
Alieva, M., Román, M. B., de Blank, S., Petcu, D., Zeeman, A. L., Dautzenberg, N. M. M., Cornel, A. M., van de Ven, C., Pieters, R., den Boer, M. L., et al. (2024) · Nature Protocols · doi:10.1038/s41596-024-00972-6 · Cited by 42
Self-citationPing-Pong—Tumor and Host in Pancreatic Cancer Progression
Mu, W., Wang, Z., & Zöller, M. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01359 · Cited by 37
A simple metastatic brain cancer model using human embryonic stem cell‐derived cerebral organoids
Choe, M. S., Kim, J., Yeo, H. C., Bae, C. M., Han, H. J., Baek, K.-M., Chang, W., Lim, K. S., Yun, S. P., Shin, I., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202000372r · Cited by 39
Yamawaki, K., Mori, Y., Sakai, H., Kanda, Y., Shiokawa, D., Ueda, H., Ishiguro, T., Yoshihara, K., Nagasaka, K., Onda, T., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.08.018 · Cited by 37
Baka, Z., Godier, C., Lamy, L., Mallick, A., Gribova, V., Figarol, A., Bezdetnaya, L., Chateau, A., Magne, Z., Stiefel, M., et al. (2022) · Macromolecular Bioscience · doi:10.1002/mabi.202200434 · Cited by 36
Establishment and drug screening of patient-derived extrahepatic biliary tract carcinoma organoids
Wang, Z., Guo, Y., Jin, Y., Zhang, X., Geng, H., Xie, G., Ye, D., Yu, Y., Liu, D., Zhou, D., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02219-w · Cited by 36
Designing and interpreting 4D tumour spheroid experiments
Murphy, R. J., Browning, A. P., Gunasingh, G., Haass, N. K., & Simpson, M. J. (2022) · Communications Biology · doi:10.1038/s42003-022-03018-3 · Cited by 37
Precision Medicine in Head and Neck Cancers: Genomic and Preclinical Approaches
Miserocchi, G., Spadazzi, C., Calpona, S., Rosa, F. D., Usai, A., Vita, A. D., Liverani, C., Cocchi, C., Vanni, S., Calabrese, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12060854 · Cited by 36
Patient-derived cancer models: Valuable platforms for anticancer drug testing
Genta, S., Coburn, B. A., Cescon, D. W., & Spreafico, A. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.976065 · Cited by 39
Spagnol, G., Sensi, F., Tommasi, O. D., Marchetti, M., Bonaldo, G., Xhindoli, L., Noventa, M., Agostini, M., Tozzi, R., & Saccardi, C. (2023) · Cancers · doi:10.3390/cancers15072059 · Cited by 38
Reuniting philosophy and science to advance cancer research
Pradeu, T., Daignan‐Fornier, B., Ewald, A. J., Germain, P., Okasha, S., Plutynski, A., Benzekry, S., Bertolaso, M., Bissell, M. J., Brown, J. S., et al. (2023) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12971 · Cited by 37
Self-citationProgress and promise of alternative animal and non-animal methods in biomedical research
Freires, I. A., Colón, D. F., Soares, L. F. F., Costa, I. S., de Araújo, L. P., Breseghello, I., Abdalla, H. B., Lazarini, J. G., Rosalen, P. L., Pigossi, S. C., et al. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03532-1 · Cited by 36
Optimization of Vascularized Intestinal Organoid Model
Wen, Z., Orduno, M., Liang, Z., Gong, X., & Mak, M. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400977 · Cited by 37
In vitro modelling of the physiological and diseased female reproductive system
Stejskalová, A., Vankelecom, H. E. J., Sourouni, M., Ho, M. Y., Götte, M., & Almquist, B. D. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.04.032 · Cited by 36
Dorrigiv, D., Simeone, K., Communal, L., Kendall‐Dupont, J., St‐Georges‐Robillard, A., Péant, B., Carmona, E., Mes‐Masson, A., & Gervais, T. (2021) · Cancers · doi:10.3390/cancers13164208 · Cited by 40
Xu, N.-Y., Li, J., Wang, M., Chen, X., Tang, R., & Liu, X. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c17863 · Cited by 37
The complex three-dimensional organization of epithelial tissues
Gómez‐Gálvez, P., Vicente‐Munuera, P., Anbari, S., Buceta, J., & Escudero, L. M. (2021) · Development · doi:10.1242/dev.195669 · Cited by 34
Organoids in cancer research: a review for pathologist‐scientists
Wood, L. D., & Ewald, A. J. (2021) · The Journal of Pathology · doi:10.1002/path.5684 · Cited by 35
Zheng, B., Ko, K.-P., Fang, X., Wang, X., Zhang, J., Jun, S., Kim, B.-J., Luo, W., Kim, M. J., Jung, Y., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103440 · Cited by 36
Ying, Y., Päivinen, P., Xie, C., Krup, A. L., Mäkelä, T. P., Mostov, K. E., & Reiter, J. F. (2021) · Nature Communications · doi:10.1038/s41467-021-27319-z · Cited by 36
Zhao, Y., Zhang, B., Ma, Y., Zhao, F., Chen, J., Wang, B., Jin, H., Zhou, F., Guan, J., Zhao, Q., et al. (2022) · Advanced Science · doi:10.1002/advs.202201539 · Cited by 34
Zhao, H., Li, R., Chen, Y., Yang, X. Y., & Shang, Z. (2023) · Oncogene · doi:10.1038/s41388-023-02642-5 · Cited by 37
Hausmann, A., Russo, G., Grossmann, J., Zünd, M., Schwank, G., Aebersold, R. H., Liu, Y., Sellin, M. E., & Hardt, W. (2020) · Cellular Microbiology · doi:10.1111/cmi.13191 · Cited by 33
Zeng, X., Ma, Q., Li, X., You, L., Li, J., Fu, X., You, F., & Ren, Y. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1205157 · Cited by 36
Tumour organoids and assembloids: Patient‐derived cancer avatars for immunotherapy
Mei, J., Liu, X., Tian, H., Chen, Y., Cao, Y., Zeng, J., Liu, Y., Chen, Y., Gao, Y., Yin, J., et al. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1656 · Cited by 34
On-chip modeling of tumor evolution: Advances, challenges and opportunities
Li, C., Holman, J. B., Shi, Z., Qiu, B., & Ding, W. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100724 · Cited by 33
Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model
Giovanni, C. D., Nicoletti, G., Landuzzi, L., Palladini, A., Lollini, P., & Nanni, P. (2019) · Cancers · doi:10.3390/cancers11121889 · Cited by 32
Genomics-guided pre-clinical development of cancer therapies
Francies, H. E., McDermott, U., & Garnett, M. J. (2020) · Nature Cancer · doi:10.1038/s43018-020-0067-x · Cited by 32
Modeling cancer metastasis using acoustically bio-printed patient-derived 3D tumor microtissues
Chen, H., Du, L., Li, J., Wu, Z., Gong, Z., Xia, Y., Zhou, F., Qian, Q., Ding, Z., Hu, H., et al. (2022) · Journal of Materials Chemistry B · doi:10.1039/d1tb02789a · Cited by 33
Saeki, S., Kumegawa, K., Takahashi, Y., Yang, L., Osako, T., Yasen, M., Otsuji, K., Miyata, K., Yamakawa, K., Suzuka, J., et al. (2023) · Breast Cancer Research · doi:10.1186/s13058-023-01617-4 · Cited by 33
Conti, S., Venturini, V., Cañellas-Socias, A., Cortina, C., Abenza, J. F., Attolini, C. S., Guerra, E. M., Xu, C. K., Li, J. H., Rossetti, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47227-2 · Cited by 30
Stem Cells and Organoids: A Paradigm Shift in Preclinical Models Toward Personalized Medicine
Luce, E., & Duclos‐Vallée, J. (2025) · Pharmaceuticals · doi:10.3390/ph18070992 · Cited by 34
The Progress and Clinical Application of Breast Cancer Organoids
Yu, J. S., & Huang, W. (2020) · International Journal of Stem Cells · doi:10.15283/ijsc20082 · Cited by 32
PPARγ induces PD-L1 expression in MSS+ colorectal cancer cells
Gutting, T., Hauber, V., Pahl, J. H. W., Klapproth, K., Wu, W., Dobrota, I., Herweck, F., Reichling, J., Helm, L., Schroeder, T., et al. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1906500 · Cited by 30
High-resolution positron emission microscopy of patient-derived tumor organoids
Khan, S., Shin, J. H., Ferri, V., Cheng, N., Noel, J. E., Kuo, C. J., Sunwoo, J. B., & Pratx, G. (2021) · Nature Communications · doi:10.1038/s41467-021-26081-6 · Cited by 33
Kamperman, T., Willemen, N. G. A., Kelder, C., Koerselman, M., Becker, M., Lins, L. C., Johnbosco, C., Karperien, M., & Leijten, J. (2023) · Advanced Science · doi:10.1002/advs.202205487 · Cited by 31
Implications of genetic heterogeneity in hepatocellular cancer
Suresh, A., & Dhanasekaran, R. (2022) · Advances in cancer research · doi:10.1016/bs.acr.2022.01.007 · Cited by 33
Human induced pluripotent stem cell-derived planar neural organoids assembled on synthetic hydrogels
Majumder, J., Torr, E., Aisenbrey, E. A., Lebakken, C. S., Favreau, P. F., Richards, W. D., Yin, Y., Chang, Q., & Murphy, W. L. (2024) · Journal of Tissue Engineering · doi:10.1177/20417314241230633 · Cited by 30
Liu, C., Li, K., Sui, X., Zhao, T., Zhang, T., Chen, Z., Wu, H., Li, C. R., Li, H., Yang, F., et al. (2024) · Advanced Science · doi:10.1002/advs.202400185 · Cited by 35
LGR5+ epithelial tumor stem-like cells generate a 3D-organoid model for ameloblastoma
Chang, T.-H., Shanti, R. M., Liang, Y., Zeng, J., Shi, S., Alawi, F., Carrasco, L., Zhang, Q., & Le, A. D. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2560-7 · Cited by 30
Microfluidic droplets as structural templates for Matrigel to enable 1-week large organoid modeling
Zhang, W., Li, D., Jiang, S., Galan, E. A., Zhang, Z., Huang, L., & Ma, S. (2021) · Chemical Engineering Science · doi:10.1016/j.ces.2021.116632 · Cited by 31
Lv, T., Shen, L., Xu, X., Yao, Y., Mu, P., Zhang, H., Wan, J., Wang, Y., Guan, R., Li, X., et al. (2022) · International Journal of Cancer · doi:10.1002/ijc.34302 · Cited by 31
Self-citationLeartprapun, N., & Adie, S. G. (2022) · Biomedical Optics Express · doi:10.1364/boe.468932 · Cited by 31
Are There Specific Cancer Stem Cell Markers?
Lan, L., & Behrens, A. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-2053 · Cited by 30
Wang, Y., Liu, M., Zhang, L., Liu, X., Ji, H., Wang, Y., Gui, J., Yan, Y., & Wen, Z. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06336-4 · Cited by 31
Parente, I. A., Chiara, L., & Bertoni, S. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122875 · Cited by 33
GPCRs in pancreatic adenocarcinoma: Contributors to tumour biology and novel therapeutic targets
Sriram, K., Salmerón, C., Wiley, S. Z., & Insel, P. A. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15028 · Cited by 29
Novotný, J., Strnadová, K., Dvořánková, B., Kocourková, Š., Jakša, R., Dundr, P., Pačes, V., Smetana, K., Kolář, M., & Lacina, L. (2020) · Cancers · doi:10.3390/cancers12113324 · Cited by 29
Verginelli, F., Pisacane, A. M., Gambardella, G., D’Ambrosio, A., Candiello, E., Ferrio, M., Panero, M., Casorzo, L., Benvenuti, S., Cascardi, E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22643-w · Cited by 30
Using Biosensors to Study Organoids, Spheroids and Organs-on-a-Chip: A Mechanobiology Perspective
Yousafzai, M. S., & Hammer, J. A. (2023) · Biosensors · doi:10.3390/bios13100905 · Cited by 30
Bao, D., Wang, L., Zhou, X., Yang, S., He, K., & Xu, M. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1133090 · Cited by 29
Preclinical Testing Techniques: Paving the Way for New Oncology Screening Approaches
van Rijt, A., Stefanek, E., & Valente, K. P. (2023) · Cancers · doi:10.3390/cancers15184466 · Cited by 28
Choi, S. Y., Shim, J., Gu, D., Kim, S. Y., Kim, H. J., Shin, D., & Chung, M. K. (2023) · Oral Oncology · doi:10.1016/j.oraloncology.2023.106571 · Cited by 28
Tang, F., Lu, C., He, X., Wei, L., Xie, B., Gao, X., Yang, P., Yang, D., Sun, L., & Weng, L. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113477 · Cited by 28
Zhang, Z., Chen, X., Gao, S., Fang, X., & Ren, S. (2024) · Cellular Oncology · doi:10.1007/s13402-024-00935-9 · Cited by 32
Suvilesh, K. N., Manjunath, Y., Nussbaum, Y. I., Gadelkarim, M., Raju, M., Srivastava, A., Li, G., Warren, W. C., Shyu, C., Gao, F., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3980 · Cited by 28
Organoids as models of immune-organ interaction
Harter, M. F., Recaldin, T., & Gjorevski, N. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116214 · Cited by 31
Progress in the application of organoids to breast cancer research
Yang, L., Liu, B., Chen, H., Gao, R. C., Huang, K., Guo, Q., Li, F., Chen, W., & He, J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15216 · Cited by 32
Gao, M., Harper, M. M., Lin, M., Qasem, S. A., Patel, R. A., Mardini, S. H., Gabr, M. M., Cavnar, M. J., Pandalai, P. K., & Kim, J. (2020) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2020.11.009 · Cited by 29
Primate Organoids and Gene-Editing Technologies toward Next-Generation Biomedical Research
Chen, C., Ji, W., & Niu, Y. (2021) · Trends in biotechnology · doi:10.1016/j.tibtech.2021.03.010 · Cited by 28
Pancreatic Organoids for Regenerative Medicine and Cancer Research
Casamitjana, J., Espinet, E., & Rovira, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.886153 · Cited by 29
Liver Organoids as an In Vitro Model to Study Primary Liver Cancer
Siervi, S. D., & Turato, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054529 · Cited by 30
Huang, L., Xu, Y., Wang, N., Yi, K., Xi, X., Si, H., Zhang, Q., Xiang, M., Rong, Y., Yuan, Y., et al. (2023) · Small Methods · doi:10.1002/smtd.202301009 · Cited by 30
Patient-derived organoids: a promising tool for breast cancer research
Shi, Y., Guan, Z., Cai, G., Nie, Y., Zhang, C., Luo, W., & Liu, J. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1350935 · Cited by 29
Trends in the development of human stem cell-based non-animal drug testing models
Lee, S.-J., & Lee, H. (2020) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2020.24.6.441 · Cited by 28
Morice, P., Coquan, E., Weiswald, L., Lambert, B., Vaur, D., & Poulain, L. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01295-z · Cited by 29
Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival
Gillani, R., Seong, B. K. A., Crowdis, J. P., Conway, J. R., Dharia, N. V., Alimohamed, S. I., Haas, B. J., Han, K., Park, J., Dietlein, F., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0791 · Cited by 28
Tumor organoids for cancer research and personalized medicine
Yang, H., Wang, Y., Wang, P., Zhang, N., & Wang, P. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2021.0335 · Cited by 29
Establishment of gastric signet ring cell carcinoma organoid for the therapeutic drug testing
Li, G., Ma, S., Wu, Q., Kong, D., Yang, Z., Gu, Z., Feng, L., Zhang, K., Cheng, S., Tian, Y., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-021-00803-7 · Cited by 28
Organoid: Bridging the gap between basic research and clinical practice
Weng, G., Tao, J., Liu, Y., Qiu, J., Su, D., Wang, R., Luo, W., & Zhang, T. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216353 · Cited by 29
Zhang, X., Zhao, Z., Wang, X., Zhang, S., Zhao, Z., Feng, W., Xu, L., Nie, J., Li, H., Liu, J., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06727-1 · Cited by 28
Metadata
- Authors
- Tuveson, D., & Clevers, H.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- Royal Netherlands Academy of Arts and Sciences (NL)
- Corresponding author
- Tuveson, David
- Clevers, Hans
- Venue
- Science
- Published
- 2019-06-07
- Volume
- 364
- Issue
- 6444
- Pages
- 952-955
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2948402706
- Cited by
- 935
- References
- 53
- Citations by year
- 2026: 111 · 2025: 122 · 2024: 134 · 2023: 156 · 2022: 125 · 2021: 154 · 2020: 116 · 2019: 15
- FWCI
- 42.84
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Licence
- other-oa
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- National Cancer Institute (NIH 5P30CA45508-29, 5P50CA101955-07, P20CA192996-03, U01CA210240-01A1, 1R01CA188134-01)
- Lustgarten Foundation (Dedicated Laboratory)
- European Research Council (EU-ERC-670133 Organoid)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- tumor organoids, tumor models, organoid engineering, CRISPR gene editing, tumor microenvironment, cancer immunotherapy, drug response prediction, precision oncology, stem cell-derived organoids, fibroblasts, immune cells
- MeSH terms
- Gene Editing, Humans, Models, Biological, Neoplasms, Organoids, Stem Cells, Biological Specimen Banks, Coculture Techniques, Precision Medicine, Tumor Microenvironment, Carcinogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
