The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Cancer modeling meets human organoid technology
Open accessAbstract
Organoids are microscopic self-organizing, three-dimensional structures that are grown from stem cells in vitro. They recapitulate many structural and functional aspects of their in vivo counterpart organs. This versatile technology has led to the development of many novel human cancer models. It is now possible to create indefinitely expanding organoids starting from tumor tissue of individuals suffering from a range of carcinomas. Alternatively, CRISPR-based gene modification allows the engineering of organoid models of cancer through the introduction of any combination of cancer gene alterations to normal organoids. When combined with immune cells and fibroblasts, tumor organoids become models for the cancer microenvironment enabling immune-oncology applications. Emerging evidence indicates that organoids can be used to accurately predict drug responses in a personalized treatment setting. Here, we review the current state and future prospects of the rapidly evolving tumor organoid field.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“dynamic drug treatment was more effective than constant‐dose administration methods.”
From 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip (2023) · cites this paper as [105]
In the citing paper
“Using this system, the authors observed that significant differences in the response of individual PDOs to specific drug treatments and dynamic drug treatments could be more effective than constant‐dose therapy in vitro, indicating that this platform holds great potential to make clinical decisions for personalized therapy.”
From 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip (2023) · cites this paper as [105]
In the citing paper
“Using this system, the authors observed that significant differences in the response of individual PDOs to specific drug treatments and dynamic drug treatments could be more effective than constant‐dose therapy in vitro, indicating that this platform holds great potential to make clinical decisions for personalized therapy.”
From 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip (2023) · cites this paper as [105]
In the citing paper
“APCmin/+ mice can develop intestinal tumors around 10 weeks-old26”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [26]
In the citing paper
“Wnt/β-catenin signaling is essential to maintain intestinal organoid growth26,27”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [26]
In the citing paper
“The patient-derived tumor organoids, which recapitulate the complexity and heterogeneity of tumors, have been shown to be an ideal model for drug screening and precision medicine26.”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [26]
In the citing paper
“These tumoroid biobanks can then be used as in vitro models of tumorigenesis and offer a significant advantage over conventional 2D cell culture technology5,6.”
From One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids (2023) · cites this paper as [6]
Citations
Cites
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204
Self-citationCerebral organoids model human brain development and microcephaly
Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372
Sato, T., Stange, D. E., Ferrante, M., Vries, R. G. J., van Es, J. H., van den Brink, S., van Houdt, W. J., Pronk, A., van Gorp, J., Siersema, P. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.050 · Cited by 3,753
Self-citationDistinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162024 · Cited by 2,590
Self-citationProspective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
van de Wetering, M., Francies, H. E., Francis, J. M., Bounova, G., Iorio, F., Pronk, A., van Houdt, W., van Gorp, J., Taylor-Weiner, A., Kester, L., et al. (2015) · Cell · doi:10.1016/j.cell.2015.03.053 · Cited by 2,408
Self-citationOrganoid models of human and mouse ductal pancreatic cancer
Boj, S. F., Hwang, C.-I., Baker, L. A., Chio, I. I. C., Engle, D. D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M. S., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.021 · Cited by 2,150
Self-citationPatient-derived organoids model treatment response of metastatic gastrointestinal cancers
Vlachogiannis, G., Hedayat, S., Vatsiou, A., Jamin, Y., Fernández-Mateos, J., Khan, K., Lampis, A., Eason, K., Huntingford, I., Burke, R., et al. (2018) · Science · doi:10.1126/science.aao2774 · Cited by 2,096
A living biobank of breast cancer organoids captures disease heterogeneity
Sachs, N., de Ligt, J., Kopper, O., Gogola, E., Bounova, G., Weeber, F., Balgobind, A. V., Wind, K., Gracanin, A., Begthel, H., et al. (2018) · Cell · doi:10.1016/j.cell.2017.11.010 · Cited by 1,973
Self-citationBasal cells as stem cells of the mouse trachea and human airway epithelium
Rock, J. R., Onaitis, M. W., Rawlins, E. L., Lu, Y., Clark, C. P., Xue, Y., Randell, S. H., & Hogan, B. L. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906850106 · Cited by 1,591
Flagged first, then by citations
Cited by
Sorted by citations
Items 601–700 of 938
Hanitrarimalala, V., Prgomet, Z., Hedhammar, M., Tassidis, H., & Wingren, A. G. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1545017 · Cited by 6
Organoid models derived from patients with malignant phyllodes tumor of the breast
Chu, X., Wu, M., Yang, J., Fu, Y., Wang, X., Wang, H., Yang, X., Chen, D., & He, J. (2023) · Breast Cancer Research and Treatment · doi:10.1007/s10549-023-06973-5 · Cited by 6
Research Update on Bioreactors Used in Tissue Engineering
Wang, W., Deng, Q. F., Li, T., Liu, Y., Liu, Y., Sun, Y., Deng, C., Zhou, X., Ma, Z., Qiang, L., et al. (2021) · Journal of Shanghai Jiaotong University (Science) · doi:10.1007/s12204-021-2293-5 · Cited by 6
Camargo, S., Gofrit, O. N., Assis, A., & Mitrani, E. (2021) · Cancers · doi:10.3390/cancers13122972 · Cited by 6
Construction of 3D hierarchical tissue platforms for modeling diabetes
Kim, M., & Jang, J. (2021) · APL Bioengineering · doi:10.1063/5.0055128 · Cited by 7
Conditionally Reprogrammed Cells and Robotic High-Throughput Screening for Precision Cancer Therapy
Alkhilaiwi, F. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.761986 · Cited by 6
Repositioned Drugs for COVID-19—the Impact on Multiple Organs
Chan, C., Foster, S. T., Chan, K. G., Cacace, M. J., Ladd, S., Sandum, C. T., Wright, P. T., Volmert, B. D., Yang, W., Aguirre, A., et al. (2021) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-021-00874-8 · Cited by 5
Ibáñez, J. J. R., & Montojo, V. M. (1998) · Dialnet (Universidad de la Rioja) · Cited by 6
Lü, J., Cao, L., Xu, Y., Huang, X., Cho, S., Ashktorab, H., Smoot, D. T., Li, P., Zheng, C., Kim, J., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.09.009 · Cited by 6
RetractedOrganoid technology in cervical cancer research
Ye, H. (2025) · American Journal of Cancer Research · doi:10.62347/fntd1712 · Cited by 7
Recent advances in applications of nanoparticles and decellularized ECM for organoid engineering
Lee, S.-J., Cho, J., Heo, T.-H., Yang, D. H., Chun, H. J., Yoon, J., & Jeong, G. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102274 · Cited by 6
Suppressing protein damage response to overcome multidrug resistance in cancer therapy
Shao, F., Li, Z., Xiao, H., Chen, Y., Zhang, Y., Li, L., Peng, Y., Li, X., Hou, Y., Li, B., et al. (2025) · Cell Discovery · doi:10.1038/s41421-025-00826-9 · Cited by 5
Renal cell carcinoma organoids for precision medicine: bridging the gap between models and patients
Gao, J., Luo, H., Wang, S., Zhou, C., Li, Z., Kimhoy, C., Liang, G., & Chen, S. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06949-7 · Cited by 8
Anderko, R. R., Bowman, A. E., Murthy, P., Murthy, P., Chopra, A., Tirukkovalur, N. V., Ceuppens, S., Paniccia, A., Lee, K. K. W., Mailliard, R. B., et al. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-25-1110 · Cited by 5
Intelligent image-activated sorting of large cells enabled by elasto-inertial focusing
Nagasaka, Y., Isozaki, A., Matsumura, H., Ishii, N. T., Roels, N., Rassuli, M., Lee, K. C. M., Peterson, W., Ding, T., & Goda, K. (2026) · Lab on a Chip · doi:10.1039/d5lc01143d · Cited by 5
A dependency map enhanced with next-generation 3D cancer models
Neiswender, J. V., Maffa, S., Brenan, L., ElHarouni, D., Yun, Y., Boyle, I., Wienand, K., Inam, H., Bertea, T., Anderson, A., et al. (2026) · Nature · doi:10.1038/s41586-026-10843-7 · Cited by 9
A Self-Assembling Peptide as a Model for Detection of Colorectal Cancer
Wan, Y., Luo, R., Chen, J., Luo, X., Liu, G., Su, D., Lu, N., Liu, Q., & Luo, Z. (2022) · Gels · doi:10.3390/gels8120770 · Cited by 5
Progress in patient-derived liver cancer cell models: a step forward for precision medicine
Zhang, Z., & Hui, L. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023224 · Cited by 5
Cellulose nanofibril matrix drives the dynamic formation of spheroids
Lü, Y., Guo, L., Li, Y., & Yao, Y. (2023) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b23d0003 · Cited by 5
Yoon, Y., Kim, C. W., Kim, M. Y., Baik, S. K., Jung, P. Y., & Eom, Y. W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021325 · Cited by 5
Yang, J., Zhang, J., Gu, J., Gao, M., Zheng, M.-Y., Guo, S.-X., & Zhang, T. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i42.4532 · Cited by 5
Bai, M., Wang, R., Huang, C., Zhong, R., Jiang, N., Fu, W., Mi, N., Gao, L., Jin, Y., Ma, H., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-81392-0 · Cited by 5
Emerging Prospects for the Study of Colorectal Cancer Stem Cells using Patient-derived Organoids
Ding, L., Yang, Y., Lu, Q., Cao, Z., & Weygant, N. (2022) · Current Cancer Drug Targets · doi:10.2174/1568009622666220117124546 · Cited by 5
A hepatoprotective role of peritumoral non-parenchymal cells in early liver tumorigenesis
Tian, C. L., Li, L., Fan, L., Brown, A. R., Norris, E. J., Morrison, M., Glazer, E. S., & Zhu, L. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.049750 · Cited by 6
Research progress on platelets in glioma
Zuo, M., Li, T., Wang, Z., Xiang, Y., Chen, S., & Liu, Y. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003282 · Cited by 5
Research progress and application status of organoid in breast cancer subtypes
Zhang, Q., Wang, M., Li, Y., Chen, C., Feng, J., Song, M., Yang, K., Liu, X., Li, G., & Liu, J. (2024) · Biomolecules and Biomedicine · doi:10.17305/bb.2024.11450 · Cited by 5
Synthetic scaffold for pancreatic organoids
Khan, S., & Tiriac, H. (2021) · Nature Materials · doi:10.1038/s41563-021-01177-y · Cited by 5
Wang, X., Lu, X., Cai, B., Li, X., Zou, D., Lei, S., Xu, L., Wang, G., Wang, L., & Wang, Z. (2022) · Advanced Therapeutics · doi:10.1002/adtp.202200093 · Cited by 5
Advances in breast cancer organoid for individualized treatment
Li, X., & Zhu, D. (2023) · Organs-on-a-Chip · doi:10.1016/j.ooc.2023.100028 · Cited by 5
Spatially controlled construction of assembloids using bioprintingPreprint
Roth, J. G., Brunel, L. G., Huang, M. S., Cai, B., Liu, Y., Sinha, S., Yang, F., Pașca, S. P., Shin, S., & Heilshorn, S. C. (2023) · Research Square · doi:10.21203/rs.3.rs-2389192/v1 · Cited by 5
Lung organoids and microplastic fibers: a new exposure model for emerging contaminantsPreprint
Winkler, A., Santo, N., Madaschi, L., Cherubini, A., Rusconi, F., Rosso, L., Tremolada, P., Lazzari, L., & Bacchetta, R. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.07.434247 · Cited by 5
Xue, Z., Wang, Z., Liu, D., Li, B., Sun, Z., Zhao, J., Li, H., Wang, X., & Sun, Y. (2025) · Immunologic Research · doi:10.1007/s12026-025-09628-3 · Cited by 4
Protocol for high-content drug screening using tumor organoids on a 384-pillar plate platform
Choi, J. S., Lee, M. S., Song, M. J., & Jeong, K. (2025) · STAR Protocols · doi:10.1016/j.xpro.2025.104250 · Cited by 4
Du, L., Zheng, Z., Wang, Y., Zhang, K., Lü, Y., Sun, M., Pang, M., Jiang, S., He, Y., Du, S., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03934-6 · Cited by 4
Wang, J. Q., Peng, Y., Miao, T., Li, Y., Li, Y., He, Z., Zhao, J., & Huang, B. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb01845e · Cited by 4
Li, R., Wu, Y., Zheng, Z., Zhou, F., Xu, K., & Su, J. (2026) · MedComm · doi:10.1002/mco2.70575 · Cited by 4
Wang, Y., Diao, P., Lv, P., Qi, N., Wang, Z., Yan, E., Li, J., Wang, Y., Wang, D., Wu, Y., et al. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.102622 · Cited by 6
PAUL, S., & SARKAR, A. (2024) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2024v17i8.51398 · Cited by 4
A biobank of patient derived glioma organoids
Wen, Y., Bai, H., Li, Q., Huang, S., Jia, X., Pan, G., & Yao, H. (2024) · Science China Life Sciences · doi:10.1007/s11427-024-2632-0 · Cited by 4
Global Literature Analysis of Tumor Organoid and Tumor-on-Chip Research
Shoji, J., Davis, R. P., Mummery, C. L., & Krauss, S. J. K. (2025) · Cancers · doi:10.3390/cancers17010108 · Cited by 4
Microfluidic and organ-on-a-chip approaches to model the tumor microenvironment
Bonnet, V., Angelidakis, E., Sart, S., & Baroud, C. N. (2025) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2025.100606 · Cited by 7
Advancing Preclinical Biology for Ewing Sarcoma: An International Effort
Cruz, F. S. D., Stewart, E. A., Surdez, D., Daley, J. D., Soragni, A., Tomazou, E. M., Alvarez-Perez, J., Feinberg, T. Y., Amatruda, J. F., Ganapathi, S. S., et al. (2025) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-25-0428 · Cited by 6
Engineering dense tumor constructs via cellular contraction of extracellular matrix hydrogels
McKee, J. A., Olsen, E. A., Kpeli, G. W., Brooks, M. R., Beitollahpoor, M., Pesika, N. S., Burow, M. E., & Mondrinos, M. J. (2023) · Biotechnology and Bioengineering · doi:10.1002/bit.28561 · Cited by 4
Research Progress in the Field of Tumor Model Construction Using Bioprinting: A Review
Yu, J., Zhang, Y., Ran, R., Kong, Z., Zhao, D., Zhao, W., Yang, Y., Gao, L., & Zhang, Z. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s460387 · Cited by 6
Abolins-Thompson, H., Henare, K. L., Simonson, B., Chaffin, M. D., Ellinor, P. T., Henry, C., Haimona, M., Aitken, J., Parai, T., Elkington, B., et al. (2024) · Frontiers in Research Metrics and Analytics · doi:10.3389/frma.2024.1468400 · Cited by 7
Research Progress on Neural Cell Culture Systems
Li, T., Qin, X., & Ao, Q. (2025) · Current Neuropharmacology · doi:10.2174/011570159x360193250219082312 · Cited by 4
Zhang, J., Sun, M., Zhang, F., Xuanyuan, T., Liu, X., Yu, D., & Liu, W. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501105 · Cited by 4
Current Status and Perspectives of Patient-Derived Models for Ewing’s Sarcoma
Kondo, T. (2020) · Cancers · doi:10.3390/cancers12092520 · Cited by 4
Targeting tumor resistance mechanisms
Gerard, L., Duvivier, L., & Gillet, J. (2021) · Faculty Reviews · doi:10.12703/r/10-6 · Cited by 4
Organoid research on human early development and beyond
Wen, L., & Tang, F. (2022) · Medical Review · doi:10.1515/mr-2022-0028 · Cited by 6
Cornelius, S. L., Colonnetta, M. M., Lake, K. E., Smith, C. A., Zhang, Y., Torres, E. T. R., Reddy, S. M., Chen, E. H., & Chan, I. S. (2022) · Journal of Visualized Experiments · doi:10.3791/64626 · Cited by 4
Es, H. A., Aref, A. R., Granpayeh, L., Ebrahimi, M., & Baharvand, H. (2021) · medRxiv · doi:10.1101/2021.05.19.21257378 · Cited by 4
Botrugno, O. A., Bianchi, E., Bruno, J. M., Gallo, G. F. M., Felici, C., Sommella, E., Stefano, P. D., Giansanti, V., Rossella, V., Merciai, F., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.28.630600 · Cited by 4
Kim, Y., Park, D., Lee, D. H., & Chung, C. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114642 · Cited by 3
The application of liver cancer organoids in tumour precision medicine: A comprehensive review
Mo, J., Gong, D., Zhai, M., Yang, J., Li, Z., Wu, M., Deng, X., & Dai, X. (2025) · iLiver · doi:10.1016/j.iliver.2025.100179 · Cited by 3
Joo, S., Bae, Y., Yoon, B. K., Je, Y., Kim, Y., Kim, M., Shin, S., Fang, S., & Kim, J. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02704-5 · Cited by 3
Rebuilding the Marrow In Vitro: Translational Advances in the 3D Modeling of Blood Cancers
Silvestri, G., & Chatterjee, A. (2025) · Onco · doi:10.3390/onco5040051 · Cited by 3
Chondrosarcoma organoids reveal SHH pathway activation driven by PTCH1 and BCOR alterations
Takami, H., Yoshida, K., Matsuoka, Y., Sasagawa, S., Nagamine, N., Kukita, Y., Kiyotani, K., Yoshimura, Y., Suzuki, R., Tamiya, H., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-33061-z · Cited by 3
Wakamatsu, T., Yamada, Y., Yoshida, K., Matsuoka, Y., Sasagawa, S., Nagamine, N., Shizuma, K., Suzuki, R., Tamiya, H., Imura, Y., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-32030-w · Cited by 3
Re, O. L., Corti, C., Cerrito, L., Cesari, E., Creta, E., Maio, F. D., Prima, A. D., Facciuto, V., Ferraro, C., Huqi, E., et al. (2026) · Cells · doi:10.3390/cells15020125 · Cited by 3
Vázquez‐Aristizabal, P., Arriola-Alvarez, I., Henriksen‐Lacey, M., Alonso‐Martín, S., van den Broek, L., Liz‐Marzán, L. M., & Izeta, A. (2026) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c02329 · Cited by 4
Zhao, Y., Sui, J.-F., Wu, D., Chen, M., Ni, J., Zhang, Y., Xin, S.-Y., & Fan, M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1682356 · Cited by 4
Tumor organoid-immune cell co-culture systems for precision oncology
Cai, L., Xiao, Y., Xie, F., & Yang, Z. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1865487 · Cited by 3
Can Pancreatic Organoids Help in the Treatment of Pancreatic Cancer?
Seppälä, T. T., & Burkhart, R. A. (2021) · Advances in Surgery · doi:10.1016/j.yasu.2021.05.015 · Cited by 3
Progressing Towards a Human-Centric Approach in Cancer Research
Parekh, A., Das, S., Das, C. K., & Mandal, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.896633 · Cited by 4
Sundaramoorthy, S., Colombo, D., Sanalkumar, R., Broye, L. C., Bourloud, K. B., Boulay, G., Cironi, L., Stamenkovic, I., Renella, R., Kuttler, F., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.169647 · Cited by 3
Landscape of Noncoding RNA in the Hypoxic Tumor Microenvironment
Gong, L., Zou, C., Zhang, H., Yang, F., Qi, G., & Ma, Z. (2025) · Genes · doi:10.3390/genes16020140 · Cited by 3
Liu, Y., Johnson, J., Zhang, H., Huang, P., & Li, L. (2025) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-025-05843-x · Cited by 3
Klima, S., Hurrell, T., Goolam, M., Gouws, C., Engelbrecht, A., Kaur, M., & van den Bout, I. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102391 · Cited by 4
Duan, Y., Jin, Y., Jia, Y., Zhao, M., Bai, L., Zhu, S., Wei, Z., Zhang, S., Yang, B., & Li, Y. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123723 · Cited by 3
Brown, D. (2021) · Georgetown Scientific Research Journal · doi:10.48091/gsr.v1i2.20 · Cited by 3
CRISPR screening in cancer stem cells
Wang, B., & Wong, A. S. L. (2022) · Essays in Biochemistry · doi:10.1042/ebc20220009 · Cited by 4
The Cutting-edge of CRISPR for Cancer Treatment and its Future Prospects
Liau, K. M., Ooi, A. G., Mah, C. H., Yong, P., Kee, L. S., Loo, C. Z., Tay, M. Y., Foo, J. B., & Hamzah, S. B. (2023) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010258617231020062637 · Cited by 3
Chen, J., Liu, L., Yang, Y., Luo, J., & Liu, S. (2025) · Journal of drug targeting · doi:10.1080/1061186x.2025.2473010 · Cited by 3
Tran, B. M., Flanagan, D. J., Phesse, T. J., & Vincan, E. (2021) · Handbook of experimental pharmacology · doi:10.1007/164_2021_524 · Cited by 4
Kanda, Y., Ohata, H., Miyazaki, T., Sakai, H., Mori, Y., Shiokawa, D., Yokoi, A., Owa, T., Ochiai, A., & Okamoto, K. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.11.063 · Cited by 3
The role of molecular genetic diagnosis in clinical oncology
Imyanitov, I. (2019) · Practical oncology · doi:10.31917/2004261 · Cited by 4
A living biobank of canine mammary tumor organoids as a comparative model for human breast cancerPreprint
Inglebert, M., Dettwiler, M., Hahn, K., Letko, A., Drögemüller, C., Doench, J. G., Brown, A., Memari, Y., Davies, H. R., Degasperi, A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.02.505845 · Cited by 3
Zuo, M., Zhang, S., Chen, S., Xiang, Y., Yuan, Y., Li, T., Yang, W., Wang, Z., He, Y., Li, W., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.05.581575 · Cited by 3
Popova, L. V., Garfinkle, E. A. R., Chopyk, D. M., Navarro, J. B., Rivaldi, A., Shu, Y., Lomonosova, E. E., Phay, J. E., Miller, B. S., Sattuwar, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.30.615695 · Cited by 3
Nakahashi, H., Oda, T., Shimomura, O., Akashi, Y., Takahashi, K., Miyazaki, Y., Furuta, T., Kuroda, Y., Louphrasitthiphol, P., Mathis, B. J., et al. (2024) · Journal of Oncology · doi:10.1155/2024/1529449 · Cited by 2
Anandi, L., V, Garcia, J., Ros, M., Janská, L., Liu, J., & Carmona‐Fontaine, C. (2024) · Life Science Alliance · doi:10.26508/lsa.202403053 · Cited by 2
Hamada, A., Kita, Y., Sakatani, T., Nakamura, K. D., Takada, H., Ikeuchi, R., Koike, S., Masuda, N., Murakami, K., Sano, T., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03311-5 · Cited by 2
Arcieri, M., Capezzali, E., Restaino, S., Pregnolato, S., Mariuzzi, L., Mangogna, A., Orsaria, M., Tulisso, A., Tonon, S., Martino, M. D., et al. (2025) · Cancer Reports · doi:10.1002/cnr2.70242 · Cited by 2
Deep manifold learning reveals hidden developmental dynamics of a human embryo model
Chen, K., Qin, K., Na, J., Gao, G., Yang, C., & Fu, J. (2025) · Science Advances · doi:10.1126/sciadv.adr8901 · Cited by 2
Gastric Cancer Treatment New Chapter: Organoid Models Leading Personalized Medicine
Meng, Y., Zhang, L., Yang, J., Wang, X., Zhu, M., & Kong, F. (2025) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-025-00808-3 · Cited by 2
Zhang, X., Zhang, Z., Chen, Y., Xu, Y., & Sun, M. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1630761 · Cited by 2
Zhao, M., Guo, H., Kuang, L., Dai, J., Cao, X., Yu, K., Wang, Y., Wang, Z., & Peng, C. Y. (2026) · International Journal of Surgery · doi:10.1097/js9.0000000000004634 · Cited by 2
Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors
Boni, L. D., Claridge, S. E., Nath, S., Tofani, K., Stein, B. D., Park, E., Steiner, S., Elemento, O., Pauli, C., & Hopkins, B. D. (2026) · iScience · doi:10.1016/j.isci.2026.114954 · Cited by 2
Yadav, R., Singh, S., Kumar, S., Kolay, A., Sharma, H., Dorai, R., Sharma, A. K., Singh, R. P., & Yadav, M. K. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1822764 · Cited by 2
Hu, Z., Liao, Y., Niu, M., Kong, Z., Vankelecom, H. E. J., Cheng, J., Deleidi, M., Li, C., Jiang, Z., Bian, S., et al. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.05.032 · Cited by 2
Wu, M., Xu, D., Dou, X., Zhou, Y., Lu, J., & Ge, Q. (2026) · Cell Signaling Inflammation & Disease · doi:10.1186/s44505-026-00004-y · Cited by 2
Three-dimensional in vitro models of angiogenesis
di Blasio, L., Vara-Messler, M., & Primo, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818128-7.00008-3 · Cited by 2
Skin Organoid Research Progress and Potential Applications
Li, H., Ren, K., Wang, C., & Bu, W.-B. (2021) · International Journal of Dermatology and Venereology · doi:10.1097/jd9.0000000000000201 · Cited by 5
A platform for modular assembly and feeding of micro-organoids on standard Petri dishes
Nebuloni, F., Morgan, J., Walsh, E. J., & Cook, P. R. (2023) · Biology Open · doi:10.1242/bio.059825 · Cited by 2
Kim, B., Park, J., Na, H. Y., Park, S., Jin, J., Jung, K., Lee, J.-C., Hwang, J., Seo, M., & Kim, J. (2024) · Cellular Oncology · doi:10.1007/s13402-024-01026-5 · Cited by 2
Du, L., Wang, D., Yue, Y., Yang, R., Zhang, H., Chen, M., Ma, X., Xu, H., Zhu, H., Liu, Y., et al. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108610 · Cited by 2
Ancillary Studies for Serous Fluids
Bubendorf, L., Fırat, P., Kulaç, İ., Pisapia, P., Savic-Prince, S., Santos, G. D. C., & Troncone, G. (2020) · Springer eBooks · doi:10.1007/978-3-030-53908-5_8 · Cited by 2
Novel Drug Screening Platform: Tumor Organoid
Maeng, J. E., Seo, H., Kim, S., & Ku, J. (2021) · The Korean Journal of Pancreas and Biliary Tract · doi:10.15279/kpba.2021.26.4.233 · Cited by 2
How has CRISPR Transformed Therapeutic Drug Discovery?
Parker, J. (2023) · BioTechniques · doi:10.2144/btn-2023-0020 · Cited by 2
Metadata
- Authors
- Tuveson, D., & Clevers, H.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- Royal Netherlands Academy of Arts and Sciences (NL)
- Corresponding author
- Tuveson, David
- Clevers, Hans
- Venue
- Science
- Published
- 2019-06-07
- Volume
- 364
- Issue
- 6444
- Pages
- 952-955
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2948402706
- Cited by
- 935
- References
- 53
- Citations by year
- 2026: 111 · 2025: 122 · 2024: 134 · 2023: 156 · 2022: 125 · 2021: 154 · 2020: 116 · 2019: 15
- FWCI
- 42.84
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Licence
- other-oa
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- National Cancer Institute (NIH 5P30CA45508-29, 5P50CA101955-07, P20CA192996-03, U01CA210240-01A1, 1R01CA188134-01)
- Lustgarten Foundation (Dedicated Laboratory)
- European Research Council (EU-ERC-670133 Organoid)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- tumor organoids, tumor models, organoid engineering, CRISPR gene editing, tumor microenvironment, cancer immunotherapy, drug response prediction, precision oncology, stem cell-derived organoids, fibroblasts, immune cells
- MeSH terms
- Gene Editing, Humans, Models, Biological, Neoplasms, Organoids, Stem Cells, Biological Specimen Banks, Coculture Techniques, Precision Medicine, Tumor Microenvironment, Carcinogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
