The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling
Open accessAbstract
Cancer drivers converge on NOTCH: Cancer genome–sequencing projects have emphasized the handful of genes mutated at high frequency in patients. Less attention has been directed to the hundreds of genes mutated in only a few patients—the so-called “long tail” mutations. Although rare, these mutations may nonetheless inform patient care. Loganathan et al. developed a reverse genetic CRISPR screen that allowed them to functionally assess in mice nearly 500 long tail gene mutations that occur in human head and neck squamous cell carcinoma (HNSCC). They identified 15 tumor-suppressor genes with activities that converged on the NOTCH signaling pathway. Given that NOTCH itself is mutated at high frequency in HNSCC, these results suggest that the growth of these tumors is largely driven by NOTCH inactivation. Science , this issue p. 1264
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Metadata
- Authors
- Loganathan, S. K., Schleicher, K., Malik, A., Quevedo, R., Langille, E., Teng, K., Oh, R. H., Rathod, B., Tsai, R., Samavarchi-Tehrani, P., Pugh, T. J., Gingras, A.-C., & Schramek, D.
- Venue
- Science
- Published
- 2020-03-13
- Volume
- 367
- Issue
- 6483
- Pages
- 1264-1269
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3011660632
- Cited by
- 283
- References
- 49
- FWCI
- 42.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- Funders
- Human Frontier Science Program (CDA00080/2015)
- Canadian Institutes of Health Research (365252)
- Canadian Breast Cancer Foundation (BC-F-16#31919)
- Canada Research Chairs
- Krembil Foundation (N/A)
- Terry Fox Research Institute (Terry Fox Research Institute Program Grant)
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- Loganathan, S. K., Schleicher, K., Malik, A., Quevedo, R., Langille, E., Teng, K., Oh, R. H., Rathod, B., Tsai, R., Samavarchi-Tehrani, P., Pugh, T. J., Gingras, A.-C., & Schramek, D. (2020). Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling. Science. https://doi.org/10.1126/science.aax0902
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