Cerebrospinal fluid influx drives acute ischemic tissue swelling
Open accessAbstract
Spreading edema after stroke: The brain is enveloped in a cushion of cerebrospinal fluid (CSF), which normally provides protection and helps to remove metabolic waste. CSF transport has also recently been shown to play unexpected roles in neurodegeneration and sleep. Mestre et al. used multimodal in vivo imaging in rodents and found that, after a stroke, an abnormally large volume of CSF rushes into the brain, causing swelling (see the Perspective by Moss and Williams). This influx of CSF is caused by constrictions of arteries triggered by a well-known propagating chemical reaction-diffusion wave called spreading depolarization. CSF transport can thus play a role in brain swelling after stroke. Science , this issue p. eaax7171 ; see also p. 1195
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Deletion of AQP4 reduces CSF tracer influx and solute efflux from the neuropil.
“Deletion of AQP4 channels reduces both the influx of CSF tracers and the efflux of solutes from the neuropil (24, 30, 31).”
From Glymphatic failure as a final common pathway to dementia (2020) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036 · see citing works
Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824 · see citing works
Self-citationSleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411 · see citing works
Self-citationA reproducible evaluation of ANTs similarity metric performance in brain image registration
Avants, B. B., Tustison, N. J., Song, G., Cook, P. A., Klein, A., & Gee, J. C. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.025 · Cited by 4,796 · see citing works
Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke
Manley, G. T., Fujimura, M., Ma, T., Noshita, N., Filiz, F., Bollen, A. W., Chan, P. H., & Verkman, A. S. (2000) · Nature Medicine · doi:10.1038/72256 · Cited by 1,501 · see citing works
Diffusion in Brain Extracellular Space
Syková, E., & Nicholson, C. (2008) · Physiological Reviews · doi:10.1152/physrev.00027.2007 · Cited by 1,481 · see citing works
Update on the Global Burden of Ischemic and Hemorrhagic Stroke in 1990-2013: The GBD 2013 Study
Feigin, V. L., Krishnamurthi, R., Parmar, P. G. K., Norrving, B., Mensah, G. A., Bennett, D., Barker-Collo, S. L., Moran, A. E., Sacco, R. L., Truelsen, T., et al. (2015) · Neuroepidemiology · doi:10.1159/000441085 · Cited by 1,313 · see citing works
KLATZO, I. (1967) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196701000-00001 · Cited by 1,180 · see citing works
Brain-wide pathway for waste clearance captured by contrast-enhanced MRI
Iliff, J. J., Lee, H., Yu, M., Feng, T., Logan, J., Nedergaard, M., & Benveniste, H. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67677 · Cited by 1,148 · see citing works
Self-citationDreier, J. P. (2011) · Nature Medicine · doi:10.1038/nm.2333 · Cited by 1,132 · see citing works
Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.
Mestre, H., Tithof, J., Du, T., Song, W., Peng, W., Sweeney, A. M., Olveda, G., Thomas, J. H., Nedergaard, M., & Kelley, D. H. (2018) · Nature Communications · doi:10.1038/s41467-018-07318-3 · Cited by 1,110 · see citing works
Self-citationBrain oedema in focal ischaemia: molecular pathophysiology and theoretical implications
Simard, J. M., Kent, T. A., Chen, M., Tarasov, K. V., & Gerzanich, V. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70055-8 · Cited by 799 · see citing works
Aquaporin-4-dependent glymphatic solute transport in the rodent brain
Mestre, H., Hablitz, L. M., Xavier, A. L., Feng, W., Zou, W., Pu, T., Monai, H., Murlidharan, G., Castellanos Rivera, R. M., Simon, M. J., et al. (2018) · eLife · doi:10.7554/elife.40070 · Cited by 738 · see citing works
Self-citationKnowland, D., Arac, A., Sekiguchi, K. J., Hsu, M., Lutz, S. E., Perrino, J., Steinberg, G. K., Barres, B. A., Nimmerjahn, A., & Agalliu, D. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.003 · Cited by 703 · see citing works
Thorne, R. G., & Nicholson, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509425103 · Cited by 641 · see citing works
Molecular pathophysiology of cerebral edema
Stokum, J. A., Gerzanich, V., & Simard, J. M. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15617172 · Cited by 596 · see citing works
Dreier, J. P., Major, S., Manning, A. P., Woitzik, J., Drenckhahn, C., Steinbrink, J. M., Tolias, C. M., Oliveira-Ferreira, A. I., Fabricius, M. E., Hartings, J. A., et al. (2009) · Brain · doi:10.1093/brain/awp102 · Cited by 545 · see citing works
Brain-wide glymphatic enhancement and clearance in humans assessed with MRI.
Ringstad, G., Valnes, L. M., Dale, A. M., Pripp, A. H., Vatnehol, S.-A. S., Emblem, K. E., Mardal, K.-A., & Eide, P. K. (2018) · JCI Insight · doi:10.1172/jci.insight.121537 · Cited by 533 · see citing works
A quantitative study of three-dimensional Lagrangian particle tracking algorithms
Ouellette, N. T., Xu, H., & Bodenschatz, E. (2005) · Experiments in Fluids · doi:10.1007/s00348-005-0068-7 · Cited by 478 · see citing works
Impaired Glymphatic Perfusion After Strokes Revealed by Contrast-Enhanced MRI
Gaberel, T., Gakuba, C., Goulay, R., de Lizarrondo, S. M., Hanouz, J., Emery, É., Touzé, E., Vivien, D., & Gauberti, M. (2014) · Stroke · doi:10.1161/strokeaha.114.006617 · Cited by 434 · see citing works
Karimy, J. K., Zhang, J., Kurland, D. B., Theriault, B. C., Durán, D., Stokum, J. A., Furey, C. G., Zhou, X., Mansuri, M. S., Montejo, J. D., et al. (2017) · Nature Medicine · doi:10.1038/nm.4361 · Cited by 411 · see citing works
Monai, H., Ohkura, M., Tanaka, M., Oe, Y., Konno, A., Hirai, H., Mikoshiba, K., Itohara, S., Nakai, J., Iwai, Y., et al. (2016) · Nature Communications · doi:10.1038/ncomms11100 · Cited by 410 · see citing works
Self-citationCytotoxic edema: mechanisms of pathological cell swelling
Liang, D., Bhatta, S., Gerzanich, V., & Simard, J. M. (2007) · Neurosurgical FOCUS · doi:10.3171/foc.2007.22.5.3 · Cited by 399 · see citing works
Stroke research at a crossroad: asking the brain for directions
Iadecola, C., & Anrather, J. (2011) · Nature Neuroscience · doi:10.1038/nn.2953 · Cited by 390 · see citing works
Hartings, J. A., Shuttleworth, C. W., Kirov, S. A., Ayata, C., Hinzman, J. M., Foreman, B. P., Andrew, R. D., Boutelle, M. G., Brennan, K. C., Carlson, A. P., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16654495 · Cited by 379 · see citing works
Iijima, T., Mies, G., & Hossmann, K. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.103 · Cited by 365 · see citing works
The Stroke-Migraine Depolarization Continuum
Dreier, J. P., & Reiffurth, C. (2015) · Neuron · doi:10.1016/j.neuron.2015.04.004 · Cited by 337 · see citing works
Nedergaard, M., & Astrup, J. (1986) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1986.108 · Cited by 330 · see citing works
Self-citationPathophysiological Aspects of Brain Edema
KLATZO, I. (1972) · Springer eBooks · doi:10.1007/978-3-642-65448-0_1 · Cited by 327 · see citing works
Vasoconstrictive Neurovascular Coupling during Focal Ischemic Depolarizations
Shin, H. K., Dunn, A. K., Jones, P., Boas, D. A., Moskowitz, M. A., & Ayata, C. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600252 · Cited by 320 · see citing works
Gotoh, O., Asano, T., Koide, T., & Takakura, K. (1985) · Stroke · doi:10.1161/01.str.16.1.101 · Cited by 303 · see citing works
Dreier, J. P., Körner, K., Ebert, N., Görner, A., Rubin, I., Back, T., Lindauer, U., Wolf, T., Villringer, A., Einhäupl, K. M., et al. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199809000-00007 · Cited by 289 · see citing works
The Effect of Glutamate Receptor Blockade on Anoxic Depolarization and Cortical Spreading Depression
Lauritzen, M., & Hansen, A. J. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.32 · Cited by 284 · see citing works
Pathophysiological aspects of brain edema
KLATZO, I. (1987) · Acta Neuropathologica · doi:10.1007/bf00691095 · Cited by 284 · see citing works
Gill, R., Andiné, P., Hillered, L., Persson, L., & Hagberg, H. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.54 · Cited by 281 · see citing works
The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema
Rungta, R. L., Choi, H. B., Tyson, J. R., Malik, A., Dissing‐Olesen, L., Lin, P. J. C., Cain, S. M., Cullis, P. R., Snutch, T. P., & MacVicar, B. A. (2015) · Cell · doi:10.1016/j.cell.2015.03.029 · Cited by 255 · see citing works
Schain, A. J., Melo‐Carrillo, A., Strassman, A. M., & Burstein, R. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3390-16.2017 · Cited by 254 · see citing works
Waxholm Space: An image-based reference for coordinating mouse brain research
Johnson, G. A., Badea, A., Brandenburg, J., Cofer, G. P., Fubara, B. N., Liu, S., & Nissanov, J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.067 · Cited by 253 · see citing works
Cerebral Impedance Changes After Circulatory Arrest
Harreveld, A. V., & Ochs, S. (1956) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1956.187.1.180 · Cited by 231 · see citing works
Drowning stars: reassessing the role of astrocytes in brain edema
Thrane, A. S., Thrane, V. R., & Nedergaard, M. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.08.010 · Cited by 218 · see citing works
Self-citationPropagation of cortical spreading depolarization in the human cortex after malignant stroke
Woitzik, J., Hecht, N., Pinczolits, A., Sandow, N., Major, S., Winkler, M. K. L., Weber‐Carstens, S., Dohmen, C., Graf, R., Strong, A. J., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e3182886932 · Cited by 210 · see citing works
Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex
Strong, A. J., Anderson, P. J., Watts, H. R., Virley, D. J., Lloyd, A., Irving, E. A., Nagafuji, T., Ninomiya, M., Nakamura, H., Dunn, A. K., et al. (2006) · Brain · doi:10.1093/brain/awl392 · Cited by 209 · see citing works
High-Resolution<i>In Vivo</i>Imaging of the Neurovascular Unit during Spreading Depression
Chuquet, J., Hollender, L., & Nimchinsky, E. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0721-07.2007 · Cited by 203 · see citing works
Dreier, J. P., Lemâle, C. L., Kola, V., Friedman, A., & Schoknecht, K. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.09.027 · Cited by 187 · see citing works
Ischemic Brain Edema and the Osmotic Gradient between Blood and Brain
Hatashita, S., Hoff, J. T., & Salamat, S. M. (1988) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1988.96 · Cited by 185 · see citing works
Topological basis for the robust distribution of blood to rodent neocortex
Blinder, P., Shih, A. Y., Rafie, C., & Kleinfeld, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007239107 · Cited by 182 · see citing works
Self-citationBrain edema and cerebrovascular permeability during cerebral ischemia in rats.
Hatashita, S., & Hoff, J. T. (1990) · Stroke · doi:10.1161/01.str.21.4.582 · Cited by 175 · see citing works
Brain Edema Predicts Outcome After Nonlacunar Ischemic Stroke
Battey, T. W. K., Karki, M., Singhal, A. B., Wu, O., Sadaghiani, S., Campbell, B. C. V., Davis, S. M., Donnan, G. A., Sheth, K. N., & Kimberly, W. T. (2014) · Stroke · doi:10.1161/strokeaha.114.006884 · Cited by 175 · see citing works
Dynamics of Ionic Shifts in Cortical Spreading Depression
Enger, R., Tang, W., Vindedal, G. F., Jensen, V., Helm, P. J., Sprengel, R., Looger, L. L., & Nagelhus, E. A. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv054 · Cited by 169 · see citing works
Igarashi, H., Huber, V. J., Tsujita, M., & Nakada, T. (2010) · Neurological Sciences · doi:10.1007/s10072-010-0431-1 · Cited by 160 · see citing works
Inverse neurovascular coupling to cortical spreading depolarizations in severe brain trauma
Hinzman, J. M., Andaluz, N. O., Shutter, L., Okonkwo, D. O., Pahl, C., Strong, A. J., Dreier, J. P., & Hartings, J. A. (2014) · Brain · doi:10.1093/brain/awu241 · Cited by 159 · see citing works
Young, W., Rappaport, Z. H., Chalif, D. J., & Flamm, E. S. (1987) · Stroke · doi:10.1161/01.str.18.4.751 · Cited by 152 · see citing works
Albayram, Ö., Kondo, A., Mannix, R., Smith, C., Tsai, C.-Y., Li, C., Herbert, M. K., Qiu, J., Monuteaux, M. C., Driver, J. A., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01068-4 · Cited by 152 · see citing works
Betz, A. L., Keep, R. F., Beer, M. E., & Ren, X.-D. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.5 · Cited by 145 · see citing works
Brain ion homeostasis in cerebral ischemia
Hansen, A. J., & Nedergaard, M. (1988) · Neurochemical Pathology · doi:10.1007/bf03160362 · Cited by 125 · see citing works
Self-citationSubarachnoid blood acutely induces spreading depolarizations and early cortical infarction
Hartings, J. A., York, J., Carroll, C. P., Hinzman, J. M., Mahoney, E., Krueger, B. M., Winkler, M. K. L., Major, S., Horst, V., Jahnke, P., et al. (2017) · Brain · doi:10.1093/brain/awx214 · Cited by 124 · see citing works
Cannula Implantation into the Cisterna Magna of Rodents
Xavier, A. L. R., Hauglund, N. L., von Holstein‐Rathlou, S., Li, Q., Sanggaard, S., Lou, N., Lundgaard, I., & Nedergaard, M. (2018) · Journal of Visualized Experiments · doi:10.3791/57378 · Cited by 124 · see citing works
Self-citationYao, X., Derugin, N., Manley, G. T., & Verkman, A. S. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.10.040 · Cited by 112 · see citing works
Multivariate Analysis of Structural and Diffusion Imaging in Traumatic Brain Injury
Avants, B., Duda, J., Kim, J., Zhang, H. G., Pluta, J. B., Gee, J. C., & Whyte, J. (2008) · Academic Radiology · doi:10.1016/j.acra.2008.07.007 · Cited by 111 · see citing works
The negative ultraslow potential, electrophysiological correlate of infarction in the human cortex
Lückl, J., Lemâle, C. L., Kola, V., Horst, V., Khojasteh, U., Oliveira-Ferreira, A. I., Major, S., Winkler, M. K. L., Kang, E., Schoknecht, K., et al. (2018) · Brain · doi:10.1093/brain/awy102 · Cited by 109 · see citing works
Plog, B. A., Mestre, H., Olveda, G. E., Sweeney, A. M., Kenney, H. M., Cove, A., Dholakia, K. Y., Tithof, J., Nevins, T. D., Lundgaard, I., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.120922 · Cited by 101 · see citing works
Self-citationPirici, I., Balsanu, T. A., Cătălin, B., Mărgăritescu, C., Divan, T., Văcăraș, V., Mogoantă, L., Pirici, D. N., Carare, R. O., & Muresanu, D. F. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010046 · Cited by 97 · see citing works
Using particle tracking to measure flow instabilities in an undergraduate laboratory experiment
Kelley, D. H., & Ouellette, N. T. (2011) · American Journal of Physics · doi:10.1119/1.3536647 · Cited by 94 · see citing works
Self-citationActive role of capillary pericytes during stimulation-induced activity and spreading depolarization
Khennouf, L., Gesslein, B., Brazhe, A., Octeau, J. C., Kutuzov, N. P., Khakh, B. S., & Lauritzen, M. (2018) · Brain · doi:10.1093/brain/awy143 · Cited by 89 · see citing works
Glibenclamide in Cerebral Ischemia and Stroke
Simard, J., Sheth, K. N., Kimberly, W. T., Stern, B., del Zoppo, G. D., Jacobson, S., & Gerzanich, V. (2014) · Neurocritical Care · doi:10.1007/s12028-013-9923-1 · Cited by 88 · see citing works
Brain distribution spaces of mannitol-3H, inulin-14C, and dextran-14C in the rat
Wb, S., & Oldendorf, W. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.221.1.214 · Cited by 82 · see citing works
Ito, U., Hakamata, Y., Kawakami, E., & Oyanagi, K. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.97 · Cited by 81 · see citing works
Kang, E.-J., Major, S., Jorks, D., Reiffurth, C., Offenhauser, N., Friedman, A., & Dreier, J. P. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.12.007 · Cited by 79 · see citing works
Ischaemia triggered by spreading neuronal activation is inhibited by vasodilators in rats
Dreier, J. P., Petzold, G. C., Tille, K., Lindauer, U., Arnold, G., Heinemann, U., Einhäupl, K. M., & Dirnagl, U. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0515i.x · Cited by 78 · see citing works
McBride, D. W., Klebe, D. W., Tang, J., & Zhang, J. H. (2015) · Translational Stroke Research · doi:10.1007/s12975-015-0400-3 · Cited by 71 · see citing works
A novel method to study cerebrospinal fluid dynamics in rats
Karimy, J. K., Kahle, K. T., Kurland, D. B., Yu, E., Gerzanich, V., & Simard, J. M. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.12.015 · Cited by 68 · see citing works
Changes in the Diameter of Apical Dendrites During Spreading Depression
Harreveld, A. V. (1958) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1958.192.3.457 · Cited by 67 · see citing works
Susceptibility of Primary Sensory Cortex to Spreading Depolarizations
Bogdanov, V. B., Middleton, N. A., Theriot, J. J., Parker, P. D., Abdullah, O., Ju, Y. S., Hartings, J. A., & Brennan, K. C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3694-15.2016 · Cited by 65 · see citing works
Transport of sodium from blood to brain in ischemic brain edema.
Lo, W. D., Betz, A. L., Schielke, G. P., & Hoff, J. T. (1987) · Stroke · doi:10.1161/01.str.18.1.150 · Cited by 50 · see citing works
Bere, Z., Obrenovitch, T. P., Bari, F., & Farkas, E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.12.032 · Cited by 43 · see citing works
Enger, R., Dukefoss, D. B., Tang, W., Pettersen, K. H., Bjørnstad, D. M., Helm, P. J., Jensen, V., Sprengel, R., Vervaeke, K., Ottersen, O. P., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw359 · Cited by 39 · see citing works
Thrane, A. S., Takano, T., Thrane, V. R., Wang, F., Peng, W., Ottersen, O. P., Nedergaard, M., & Nagelhus, E. A. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.63 · Cited by 29 · see citing works
Self-citationAquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice
Yao, X., Smith, A. J., Jin, B., Zador, Z. E., Manley, G. T., & Verkman, A. S. (2015) · Glia · doi:10.1002/glia.22853 · Cited by 27 · see citing works
Transitions from Trees to Cycles in Adaptive Flow Networks
Martens, E. A., & Klemm, K. (2017) · Frontiers in Physics · doi:10.3389/fphy.2017.00062 · Cited by 24 · see citing works
Self-citationPeri-infarct flow transients predict outcome in rat focal brain ischemia
Lückl, J., Dreier, J. P., Szabados, T., Wiesenthal, D., Bari, F., & Greenberg, J. H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.049 · Cited by 20 · see citing works
Front tracking for quantifying advection-reaction-diffusion
Nevins, T. D., & Kelley, D. H. (2017) · Chaos An Interdisciplinary Journal of Nonlinear Science · doi:10.1063/1.4979668 · Cited by 15 · see citing works
Self-citationInoue, Y., Aoki, I., Mori, Y., Kawai, Y., Ebisu, T., Osaka, Y., Houri, T., Mineura, K., Higuchi, T., & Tanaka, C. (2009) · NMR in Biomedicine · doi:10.1002/nbm.1464 · Cited by 9 · see citing works
Self-citationIshimaru, S., & Hossmann, K. ‐. (1990) · Springer eBooks · doi:10.1007/978-3-7091-9115-6_73 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Glymphatic failure as a final common pathway to dementia
Nedergaard, M., & Goldman, S. A. (2020) · Science · doi:10.1126/science.abb8739 · Cited by 1,145 · see citing works
Self-citationCircadian control of brain glymphatic and lymphatic fluid flow
Hablitz, L. M., Plá, V., Giannetto, M., Vinitsky, H. S., Stæger, F. F., Metcalfe, T., Nguyen, R., Benrais, A., & Nedergaard, M. (2020) · Nature Communications · doi:10.1038/s41467-020-18115-2 · Cited by 704 · see citing works
Self-citationRevisiting the neurovascular unit
Schaeffer, S. M., & Iadecola, C. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00904-7 · Cited by 654 · see citing works
The Brain’s Glymphatic System: Current Controversies
Mestre, H., Mori, Y., & Nedergaard, M. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.04.003 · Cited by 609 · see citing works
Self-citationRasmussen, M. K., Mestre, H., & Nedergaard, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00031.2020 · Cited by 622 · see citing works
Self-citationThe Glymphatic System: A Novel Component of Fundamental Neurobiology
Hablitz, L. M., & Nedergaard, M. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0619-21.2021 · Cited by 480 · see citing works
Self-citationThe glymphatic system: Current understanding and modeling
Bohr, T., Hjorth, P. G., Holst, S. C., Hrabětová, S., Kiviniemi, V. J., Lilius, T. O., Lundgaard, I., Mardal, K., Martens, E. A., Mori, Y., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104987 · Cited by 381 · see citing works
Self-citationNorepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
Hauglund, N. L., Andersen, M., Tokarska, K., Radovanovic, T., Kjærby, C., Sørensen, F., Bojarowska, Z., Untiet, V., Ballestero, S. B., Kolmos, M. G., et al. (2025) · Cell · doi:10.1016/j.cell.2024.11.027 · Cited by 341 · see citing works
Self-citationParenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid
Drieu, A., Du, S., Storck, S. E., Rustenhoven, J., Papadopoulos, Z., Dykstra, T., Zhong, F., Kim, K., Blackburn, S., Mamuladze, T., et al. (2022) · Nature · doi:10.1038/s41586-022-05397-3 · Cited by 325 · see citing works
Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis
Salman, M. M., Kitchen, P., Halsey, A., Wang, M. X., Törnroth-Horsefield, S., Conner, A. C., Badaut, J., Iliff, J. J., & Bill, R. M. (2022) · Brain · doi:10.1093/brain/awab311 · Cited by 303 · see citing works
A mesothelium divides the subarachnoid space into functional compartments
Møllgård, K., Beinlich, F. R. M., Kusk, P., Miyakoshi, L. M., Delle, C., Plá, V., Hauglund, N. L., Esmail, T., Rasmussen, M. K., Gomolka, R. S., et al. (2023) · Science · doi:10.1126/science.adc8810 · Cited by 272 · see citing works
Self-citationThe glymphatic hypothesis: the theory and the evidence
Hladky, S. B., & Barrand, M. A. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-021-00282-z · Cited by 271 · see citing works
The glymphatic system: implications for drugs for central nervous system diseases
Lohela, T. J., Lilius, T. O., & Nedergaard, M. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00500-9 · Cited by 246 · see citing works
Self-citationAstrocyte Endfeet in Brain Function and Pathology: Open Questions
Díaz-Castro, B., Robel, S., & Mishra, A. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-091922-031205 · Cited by 238 · see citing works
Glymphatic influx and clearance are accelerated by neurovascular coupling
von Holstein‐Rathlou, S., Gan, Y., Giannetto, M. J., Rasmussen, M. K., Sigurdsson, B., Beinlich, F. R. M., Rose, L., Untiet, V., Hablitz, L. M., Kelley, D. H., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01327-2 · Cited by 244 · see citing works
Self-citationMolecular mechanisms of ischemia and glutamate excitotoxicity
Neves, D., Salazar, I. L., Almeida, R. D., & Silva, R. M. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121814 · Cited by 219 · see citing works
The Glymphatic System (En)during Inflammation
Mogensen, F. L., Delle, C., & Nedergaard, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147491 · Cited by 214 · see citing works
Self-citationZhu, X., Huang, Q., DiSpirito, A., Vu, T., Rong, Q., Peng, X., Sheng, H., Shen, X., Zhou, Q., Jiang, L., et al. (2022) · Light Science & Applications · doi:10.1038/s41377-022-00836-2 · Cited by 190 · see citing works
Brain edema formation and therapy after intracerebral hemorrhage
Wan, Y., Holste, K. G., Hua, Y., Keep, R. F., & Xi, G. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105948 · Cited by 194 · see citing works
Multiphoton fluorescence microscopy for in vivo imaging
Xu, C., Nedergaard, M., Fowell, D. J., Friedl, P., & Ji, N. (2024) · Cell · doi:10.1016/j.cell.2024.07.036 · Cited by 172 · see citing works
Self-citationPotentiating glymphatic drainage minimizes post-traumatic cerebral oedema
Hussain, R., Tithof, J., Wang, W., Cheetham-West, A., Song, W., Peng, W., Sigurdsson, B., Kim, D., Sun, Q., Peng, S., et al. (2023) · Nature · doi:10.1038/s41586-023-06737-7 · Cited by 168 · see citing works
Self-citationThe future of neuroprotection in stroke
Chamorro, Á., Lo, E. H., Renú, A., van Leyen, K., & Lyden, P. D. (2020) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-324283 · Cited by 156 · see citing works
Bojarskaite, L., Vallet, A., Bjørnstad, D. M., Gullestad Binder, K. M., Cunen, C., Heuser, K., Kuchta, M., Mardal, K.-A., & Enger, R. (2023) · Nature Communications · doi:10.1038/s41467-023-36643-5 · Cited by 149 · see citing works
Imaging perivascular space structure and function using brain MRI
Barisano, G., Lynch, K. M., Sibilia, F., Lan, H., Shih, N., Sepehrband, F., & Choupan, J. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119329 · Cited by 149 · see citing works
Chen, S., Shao, L., & Ma, L. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.716825 · Cited by 150 · see citing works
Neuroimmune mechanisms and therapies mediating post-ischaemic brain injury and repair
Shichita, T., Ooboshi, H., & Yoshimura, A. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00690-0 · Cited by 145 · see citing works
The choroid plexus: a missing link in our understanding of brain development and function
Saunders, N. R., Dzięgielewska, K. M., Fame, R. M., Lehtinen, M. K., & Liddelow, S. A. (2022) · Physiological Reviews · doi:10.1152/physrev.00060.2021 · Cited by 141 · see citing works
Cerebral edema after ischemic stroke: Pathophysiology and underlying mechanisms
Gu, Y., Zhou, C., Piao, Z. H., Yuan, H., Jiang, H., Wei, H., Zhou, Y., Nan, G., & Ji, X. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.988283 · Cited by 134 · see citing works
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
Duperron, M., Knol, M. J., Grand, Q. L., Evans, T. E., Mishra, A., Tsuchida, A., Roshchupkin, G. V., Konuma, T., Trégouët, D., Romero, J. R., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02268-w · Cited by 130 · see citing works
Neurovascular Coupling in Development and Disease: Focus on Astrocytes
Stackhouse, T. L., & Mishra, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.702832 · Cited by 124 · see citing works
Klostranec, J. M., Vucevic, D., Bhatia, K. D., Kortman, H. G. J., Krings, T., Murphy, K., terBrugge, K. G., & Mikulis, D. J. (2021) · Radiology · doi:10.1148/radiol.2021202043 · Cited by 130 · see citing works
Klostranec, J. M., Vucevic, D., Bhatia, K. D., Kortman, H. G. J., Krings, T., Murphy, K., terBrugge, K. G., & Mikulis, D. J. (2021) · Radiology · doi:10.1148/radiol.2021204088 · Cited by 119 · see citing works
Perivascular Spaces, Glymphatic System and MR
Yu, L., Hu, X., Li, H., & Zhao, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.844938 · Cited by 114 · see citing works
Glymphatic Dysfunction in Patients With Ischemic Stroke
Toh, C., & Siow, T. Y. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.756249 · Cited by 115 · see citing works
Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury
Mastorakos, P., Mihelson, N., Luby, M., Burks, S. R., Johnson, K., Hsia, A. W., Witko, J., Frank, J. A., Latour, L., & McGavern, D. B. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00773-6 · Cited by 113 · see citing works
Body mass index, time of day and genetics affect perivascular spaces in the white matter
Barisano, G., Sepehrband, F., Sheikh‐Bahaei, N., Law, M., & Toga, A. W. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20972856 · Cited by 112 · see citing works
Shah, T., Leurgans, S. E., Mehta, R. I., Yang, J., Galloway, C. A., Bentley, K. L. D. M., Schneider, J. A., & Mehta, R. I. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220618 · Cited by 108 · see citing works
Self-citationElectrical Impedance Tomography for Biomedical Applications: Circuits and Systems Review
Wu, Y., Hanzaee, F. F., Jiang, D., Bayford, R. H., & Demosthenous, A. (2021) · IEEE Open Journal of Circuits and Systems · doi:10.1109/ojcas.2021.3075302 · Cited by 107 · see citing works
The Glymphatic System: A Novel Therapeutic Target for Stroke Treatment
Lv, T., Zhao, B., Hu, Q., & Zhang, X. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.689098 · Cited by 105 · see citing works
Kelley, D. H., & Thomas, J. H. (2022) · Annual Review of Fluid Mechanics · doi:10.1146/annurev-fluid-120720-011638 · Cited by 106 · see citing works
Self-citationGlymphatic Cerebrospinal Fluid and Solute Transport Quantified by MRI and PET Imaging
Benveniste, H., Lee, H., Ozturk, B., Chen, X., Koundal, S., Vaska, P., Tannenbaum, A., & Volkow, N. D. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.014 · Cited by 104 · see citing works
Christensen, J., Yamakawa, G. R., Shultz, S. R., & Mychasiuk, R. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101917 · Cited by 105 · see citing works
Kaur, J., Fahmy, L. M., Davoodi‐Bojd, E., Zhang, L., Ding, G., Hu, J., Zhang, Z., Chopp, M., & Jiang, Q. (2021) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2021.665803 · Cited by 104 · see citing works
The glymphatic system and meningeal lymphatics of the brain: new understanding of brain clearance
Yankova, G., Bogomyakova, O. B., & Тулупов, А. А. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0106 · Cited by 104 · see citing works
The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention
Andrew, R. D., Hartings, J. A., Ayata, C., Brennan, K. C., Dawson-Scully, K. D., Farkas, E., Herreras, Ó., Kirov, S. A., Müller, M., Ollen‐Bittle, N., et al. (2022) · Neurocritical Care · doi:10.1007/s12028-021-01431-w · Cited by 101 · see citing works
A clinical primer for the glymphatic system
Carlstrom, L. P., Eltanahy, A. M., Perry, A., Rabinstein, A. A., Elder, B. D., Morris, J. M., Meyer, F. B., Graffeo, C. S., Lundgaard, I., & Burns, T. C. (2021) · Brain · doi:10.1093/brain/awab428 · Cited by 100 · see citing works
Li, G., Cao, Y., Tang, X., Huang, J., Cai, L., & Zhou, L. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221098145 · Cited by 99 · see citing works
Astrocytes in the regulation of cerebrovascular functions
Cohen‐Salmon, M., Slaoui, L., Mazaré, N., Gilbert, A., Oudart, M., Alvear‐Perez, R., Elorza‐Vidal, X., Chever, O., & Boulay, A. (2021) · Glia · doi:10.1002/glia.23924 · Cited by 93 · see citing works
Spreading depolarizations in ischaemia after subarachnoid haemorrhage, a diagnostic phase III study
Dreier, J. P., Winkler, M. K. L., Major, S., Horst, V., Lublinsky, S., Kola, V., Lemâle, C. L., Kang, E., Maslarova, A., Salur, I., et al. (2021) · Brain · doi:10.1093/brain/awab457 · Cited by 97 · see citing works
Glymphatic system: an emerging therapeutic approach for neurological disorders
Gao, Y., Liu, K., & Zhu, J. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1138769 · Cited by 104 · see citing works
Mestre, H., Verma, N., Greene, T. D., Lin, L. A., Ladrón-de-Guevara, A., Sweeney, A. M., Liu, G., Thomas, V. K., Galloway, C. A., Bentley, K. L. D. M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31257-9 · Cited by 94 · see citing works
Self-citationAquaporin 4 and glymphatic flow have central roles in brain fluid homeostasis
Salman, M. M., Kitchen, P., Iliff, J. J., & Bill, R. M. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00514-z · Cited by 95 · see citing works
Zhou, H., Yan, L., Huang, H., Li, X., Xia, Q., Zheng, L., Shao, B., Gao, Q., Sun, N., & Shi, J. (2023) · Theranostics · doi:10.7150/thno.85390 · Cited by 94 · see citing works
Lo, E. H., Albers, G. W., Dichgans, M., Donnan, G. A., Esposito, E., Foster, R., Howells, D. W., Huang, Y.-G., Ji, X., Klerman, E. B., et al. (2021) · Stroke · doi:10.1161/strokeaha.120.031742 · Cited by 93 · see citing works
Vasciaveo, V., Iadarola, A., Casile, A., Dante, D., Morello, G., Minotta, L., Tamagno, E., Cicolin, A., & Guglielmotto, M. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01498-2 · Cited by 96 · see citing works
Zhang, D., Ruan, J., Peng, S., Li, J., Hu, X., Zhang, Y., Zhang, T., Ge, Y., Zhu, Z., Xiao, X., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01515-0 · Cited by 102 · see citing works
Glymphatic System Impairment Contributes to the Formation of Brain Edema After Ischemic Stroke
Zhu, J., Mo, J., Liu, K., Chen, Q., Li, Z., He, Y., Chang, Y., Lin, C., Yu, M., Xu, Y., et al. (2024) · Stroke · doi:10.1161/strokeaha.123.045941 · Cited by 94 · see citing works
Sun, C., Lin, L., Yin, L., Hao, X., Tian, J., Zhang, X., Ren, Y., Li, C., & Yang, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.870029 · Cited by 91 · see citing works
Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model
Rasmussen, M. K., Møllgård, K., Bork, P. A. R., Weikop, P., Esmail, T., Drici, L., Albrechtsen, N. J. W., Carlsen, J. F., Huynh, N. P. T., Ghitani, N., et al. (2024) · Science · doi:10.1126/science.adl0544 · Cited by 95 · see citing works
Self-citationGlymphatic system: a gateway for neuroinflammation
Zou, K., Deng, Q., Zhang, H., & Huang, C. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.391312 · Cited by 98 · see citing works
High-altitude cerebral edema: its own entity or end-stage acute mountain sickness?
Turner, R., Gatterer, H., Falla, M., & Lawley, J. S. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00861.2019 · Cited by 91 · see citing works
Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal
Keil, S. A., Jansson, D., Braun, M., & Iliff, J. J. (2025) · Science · doi:10.1126/science.adv8269 · Cited by 96 · see citing works
Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework
Mentis, A. A., Dardiotis, E., & Chrousos, G. P. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0731-7 · Cited by 82 · see citing works
Zhu, J., Li, Z., Ji, Z., Wu, Y., He, Y., Liu, K., Chang, Y., Peng, Y., Lin, Z., Wang, S., et al. (2021) · Brain Pathology · doi:10.1111/bpa.13006 · Cited by 84 · see citing works
Sepsis-associated encephalopathy: From pathophysiology to clinical management
Hong, Y., Chen, P., Gao, J., Lin, Y., Chen, L., & Shang, X. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110800 · Cited by 89 · see citing works
No‐reflow after stroke reperfusion therapy: An emerging phenomenon to be explored
Jia, M., Jin, F., Li, S., Ren, C., Mangal, R., Ding, Y., Zhao, W., & Ji, X. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14631 · Cited by 83 · see citing works
The role of glymphatic system in the cerebral edema formation after ischemic stroke
Ji, C., Yu, X., Xu, W., Lenahan, C., Tu, S., & Shao, A. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113685 · Cited by 82 · see citing works
DAMPs and RAGE Pathophysiology at the Acute Phase of Brain Injury: An Overview
Balança, B., Desmurs, L., Grelier, J., Perret‐Liaudet, A., & Lukaszewicz, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052439 · Cited by 82 · see citing works
Meningeal Lymphatics in Central Nervous System Diseases
Salvador, A. F., Abduljawad, N., & Kipnis, J. (2024) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-113023-103045 · Cited by 87 · see citing works
Kim, S. H., Ahn, J. H., Yang, H. J., Lee, P., Koh, G. Y., & Jeong, Y. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01042-0 · Cited by 76 · see citing works
The glymphatic system: a new perspective on brain diseases
Ding, Z., Fan, X., Zhang, Y., Yao, M., Wang, G., Dong, Y., Liu, J., & Song, W. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1179988 · Cited by 104 · see citing works
Basal lamina changes in neurodegenerative disorders
Nguyen, B., Bix, G., & Yao, Y. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00502-y · Cited by 75 · see citing works
Stevens, K. A., Cai, S., Ladrón-de-Guevara, A., Sun, J., Zheng, X., Du, T., Thomas, J. H., Nedergaard, M., Karniadakis, G. E., & Kelley, D. H. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2217744120 · Cited by 74 · see citing works
Self-citationDirect imaging of glymphatic transport using H217O MRI
Alshuhri, M. S., Gallagher, L., Work, L. M., & Holmes, W. M. (2021) · JCI Insight · doi:10.1172/jci.insight.141159 · Cited by 74 · see citing works
Electrochemically Probing Dynamics of Ascorbate during Cytotoxic Edema in Living Rat Brain
Jin, J., Ji, W., Li, L., Zhao, G., Wu, W., Wei, H., Ma, F., Jiang, Y. Y., & Mao, L. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c09011 · Cited by 72 · see citing works
Fanelli, G. N., Grassini, D., Ortenzi, V., Pasqualetti, F., Montemurro, N., Perrini, P., Naccarato, A. G., & Scatena, C. (2021) · Genes · doi:10.3390/genes12030445 · Cited by 69 · see citing works
Xiao, M., Wu, T., Liu, Y., Hu, P., Zhai, S., Feng, W., Zhang, R., Li, Q., & Marshall, C. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335169 · Cited by 68 · see citing works
A network model of glymphatic flow under different experimentally-motivated parametric scenarios
Tithof, J., Boster, K. A. S., Bork, P. A. R., Nedergaard, M., Thomas, J. H., & Kelley, D. H. (2022) · iScience · doi:10.1016/j.isci.2022.104258 · Cited by 67 · see citing works
Self-citationIschemic brain edema: Emerging cellular mechanisms and therapeutic approaches
Han, W., Song, Y., Rocha, M., & Shi, Y. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106029 · Cited by 65 · see citing works
Licastro, E., Pignataro, G., Iliff, J. J., Xiang, Y., Lo, E. H., Hayakawa, K., & Esposito, E. (2024) · Communications Biology · doi:10.1038/s42003-024-05911-5 · Cited by 69 · see citing works
Factors Associated With Dysfunction of Glymphatic System in Patients With Glioma
Toh, C., & Siow, T. Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.744318 · Cited by 64 · see citing works
Astrocytes in functional recovery following central nervous system injuries
Alhadidi, Q., Bahader, G. A., Arvola, O., Kitchen, P., Shah, Z. A., & Salman, M. M. (2023) · The Journal of Physiology · doi:10.1113/jp284197 · Cited by 64 · see citing works
Fang, Y., Shi, H. R., Ren, R., Huang, L., Okada, T., Lenahan, C., Gamdzyk, M., Travis, Z. D., Lu, Q., Tang, L., et al. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00925-3 · Cited by 61 · see citing works
Yang, D., Sun, Z., Yu, M., Zou, Q., Li, P., Zhang, J., Wu, X., Li, Y., & Wang, M. (2023) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28797 · Cited by 62 · see citing works
Liu, K., Zhu, J., Chang, Y., Lin, Z., Shi, Z., Li, X., Chen, X., Lin, C., Pan, S., & Huang, K. (2021) · JCI Insight · doi:10.1172/jci.insight.151835 · Cited by 59 · see citing works
Lemâle, C. L., Lückl, J., Horst, V., Reiffurth, C., Major, S., Hecht, N., Woitzik, J., & Dreier, J. P. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.837650 · Cited by 60 · see citing works
Molecular Mechanisms of Neuroimmune Crosstalk in the Pathogenesis of Stroke
Choi, Y. H., Laaker, C. J., Hsu, M., Cismaru, P., Sándor, M., & Fábry, Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179486 · Cited by 57 · see citing works
Stokum, J. A., Shim, B., Negoita, S., Tsymbalyuk, N., Tsymbalyuk, O., Ivanova, S., Keledjian, K. M., Bryan, J., Blaustein, M. P., Jha, R. M., et al. (2023) · Science Signaling · doi:10.1126/scisignal.add6364 · Cited by 57 · see citing works
Kirov, S. A., Fomitcheva, I. V., & Sword, J. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa134 · Cited by 57 · see citing works
MRI detection of impairment of glymphatic function in rat after mild traumatic brain injury
Li, L., Chopp, M., Ding, G., Davoodi‐Bojd, E., Zhang, L., Li, Q., Zhang, Y., Xiong, Y., & Jiang, Q. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147062 · Cited by 58 · see citing works
The lymphatic drainage systems in the brain: a novel target for ischemic stroke?
Wang, Y.-J., Sun, Y., Pei, Y., Ma, H.-W., Ma, H., Qin, L., & Yan, J.-H. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.346484 · Cited by 58 · see citing works
Liao, J., Duan, Y., Liu, Y., Chen, H., An, Z., Chen, Y., Su, Z., Usman, A. M., & Xiao, G. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111045 · Cited by 55 · see citing works
Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review
Jha, R. M., Rani, A., Desai, S. M., Raikwar, S. P., Mihaljević, S., Munoz-Casabella, A., Kochanek, P. M., Catapano, J. S., Winkler, E. A., Citerio, G., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111899 · Cited by 57 · see citing works
Andrew, R. D., Farkas, E., Hartings, J. A., Brennan, K. C., Herreras, Ó., Müller, M., Kirov, S. A., Ayata, C., Ollen‐Bittle, N., Reiffurth, C., et al. (2022) · Neurocritical Care · doi:10.1007/s12028-021-01429-4 · Cited by 53 · see citing works
The glymphatic system and cerebral small vessel disease
Ang, P. S., Zhang, D. M., Azizi, S., de Matos, S. N., & Brorson, J. R. (2024) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2024.107557 · Cited by 56 · see citing works
Fang, Y., Huang, L., Wang, X., Si, X., Lenahan, C., Shi, H., Shao, A., Tang, J., Chen, S., Zhang, J., et al. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x211045748 · Cited by 52 · see citing works
Li, M., Kitamura, A., Beverley, J., Koudelka, J., Duncombe, J., Lennen, R. J., Jansen, M. A., Marshall, I., Platt, B., Wiegand, U. K., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.788519 · Cited by 52 · see citing works
CSF transport at the brain–meningeal border: effects on neurological health and disease
Pinho-Correia, L. M., McCullough, S. J. C., Ghanizada, H., Nedergaard, M., Rustenhoven, J., & Mesquita, S. D. (2025) · The Lancet Neurology · doi:10.1016/s1474-4422(25)00115-2 · Cited by 52 · see citing works
Self-citationJavierre‐Petit, C., Schneider, J. A., Kapasi, A., Makkinejad, N., Tamhane, A. A., Leurgans, S. E., Mehta, R. I., Barnes, L. L., Bennett, D. A., & Arfanakis, K. (2020) · Stroke · doi:10.1161/strokeaha.120.029388 · Cited by 52 · see citing works
Self-citationKe, Z., Mo, Y., Li, J., Yang, D., Huang, L., Yang, Z., Qin, R., Mao, C., Lv, W., Huang, Y., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12121611 · Cited by 51 · see citing works
- Authors
- Mestre, H., Du, T., Sweeney, A. M., Liu, G., Samson, A. J., Peng, W., Mortensen, K. N., Stæger, F. F., Bork, P. A. R., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Solis, O., Blinder, P., Kleinfeld, D., Hirase, H., Mori, Y., & Nedergaard, M.
- Affiliations
- University of Rochester Medicine (US)
- University of Copenhagen (DK)
- University of Rochester (US)
- Technical University of Denmark (DK)
- Tel Aviv University (IL)
- University of California San Diego (US)
- Corresponding author
- Mestre, Humberto
- Du, Ting
- Mori, Yuki
- Nedergaard, Maiken
- ORCID
- Mestre, Humberto
- Du, Ting
- Liu, Guojun
- Samson, Andrew J.
- Peng, Weiguo
- Mortensen, Kristian Nygaard
- Stæger, Frederik Filip
- Bork, Peter A. R.
- Bashford, Logan
- Toro, Edna R.
- Tithof, Jeffrey
- Kelley, Douglas H.
- Thomas, John H.
- Hjorth, Poul G.
- Martens, Erik A.
- Mehta, Rupal I.
- Solis, Orestes
- Blinder, Pablo
- Kleinfeld, David
- Hirase, Hajime
- Mori, Yuki
- Nedergaard, Maiken
- Venue
- Science
- Published
- 2020-03-13
- Volume
- 367
- Issue
- 6483
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7375109
- OpenAlex
- W3004007615
- Cited by
- 494
- References
- 83
- Citations by year
- 2026: 59 · 2025: 70 · 2024: 76 · 2023: 80 · 2022: 91 · 2021: 77 · 2020: 40
- FWCI
- 32.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- other-oa
- Locations
- Science (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- National Institute on Aging (RF1AG057575)
- National Institute of Neurological Disorders and Stroke (R01NS100366, K08NS089830)
- Army Research Office (MURI W911NF1910280)
- Horizon 2020 Framework Programme (666881)
- Fondation Leducq (16CVD05)
- Lundbeckfonden
- Novo Nordisk Fonden
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- glymphatic system, vasoconstriction, perivascular spaces, stroke
- MeSH terms
- Glymphatic System, Animals, Brain Edema, Magnetic Resonance Imaging, Male, Mice, Inbred C57BL, Vasoconstriction, Stroke, Mice, Aquaporin 5
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review