Cited by 494Cerebrospinal fluid and hydrocephalusAcute Ischemic Stroke ManagementTraumatic Brain Injury and Neurovascular Disturbances

Cerebrospinal fluid influx drives acute ischemic tissue swelling

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Mestre, Humberto, Du, Ting, Sweeney, Amanda M., Liu, Guojun, Samson, Andrew J., Peng, Weiguo, Mortensen, Kristian Nygaard, Stæger, Frederik Filip +15 more·2020·Science

Abstract

Spreading edema after stroke: The brain is enveloped in a cushion of cerebrospinal fluid (CSF), which normally provides protection and helps to remove metabolic waste. CSF transport has also recently been shown to play unexpected roles in neurodegeneration and sleep. Mestre et al. used multimodal in vivo imaging in rodents and found that, after a stroke, an abnormally large volume of CSF rushes into the brain, causing swelling (see the Perspective by Moss and Williams). This influx of CSF is caused by constrictions of arteries triggered by a well-known propagating chemical reaction-diffusion wave called spreading depolarization. CSF transport can thus play a role in brain swelling after stroke. Science , this issue p. eaax7171 ; see also p. 1195

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  • Deletion of AQP4 reduces CSF tracer influx and solute efflux from the neuropil.

    “Deletion of AQP4 channels reduces both the influx of CSF tracers and the efflux of solutes from the neuropil (24, 30, 31).”

    From Glymphatic failure as a final common pathway to dementia (2020) · cites this paper as [31]

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Authors
Mestre, H., Du, T., Sweeney, A. M., Liu, G., Samson, A. J., Peng, W., Mortensen, K. N., Stæger, F. F., Bork, P. A. R., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Solis, O., Blinder, P., Kleinfeld, D., Hirase, H., Mori, Y., & Nedergaard, M.
Affiliations
  • University of Rochester Medicine (US)
  • University of Copenhagen (DK)
  • University of Rochester (US)
  • Technical University of Denmark (DK)
  • Tel Aviv University (IL)
  • University of California San Diego (US)
Corresponding author
  • Mestre, Humberto
  • Du, Ting
  • Mori, Yuki
  • Nedergaard, Maiken
Venue
Science
Published
2020-03-13
Volume
367
Issue
6483
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W3004007615
Cited by
494
References
83
Citations by year
2026: 59 · 2025: 70 · 2024: 76 · 2023: 80 · 2022: 91 · 2021: 77 · 2020: 40
FWCI
32.98
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Science (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Funders
  • National Institute on Aging (RF1AG057575)
  • National Institute of Neurological Disorders and Stroke (R01NS100366, K08NS089830)
  • Army Research Office (MURI W911NF1910280)
  • Horizon 2020 Framework Programme (666881)
  • Fondation Leducq (16CVD05)
  • Lundbeckfonden
  • Novo Nordisk Fonden
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
glymphatic system, vasoconstriction, perivascular spaces, stroke
MeSH terms
Glymphatic System, Animals, Brain Edema, Magnetic Resonance Imaging, Male, Mice, Inbred C57BL, Vasoconstriction, Stroke, Mice, Aquaporin 5

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