Cited by 494Cerebrospinal fluid and hydrocephalusAcute Ischemic Stroke ManagementTraumatic Brain Injury and Neurovascular Disturbances

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Cerebrospinal fluid influx drives acute ischemic tissue swelling

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Mestre, Humberto, Du, Ting, Sweeney, Amanda M., Liu, Guojun, Samson, Andrew J., Peng, Weiguo, Mortensen, Kristian Nygaard, Stæger, Frederik Filip, Bork, Peter A. R., Bashford, Logan, Toro, Edna R., Tithof, Jeffrey, Kelley, Douglas H., Thomas, John H., Hjorth, Poul G., Martens, Erik A., Mehta, Rupal I., Solis, Orestes, Blinder, Pablo, Kleinfeld, David, Hirase, Hajime, Mori, Yuki, Nedergaard, Maiken·2020·Science

DOI 10.1126/science.aax7171PMC PMC7375109

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Abstract

Spreading edema after stroke: The brain is enveloped in a cushion of cerebrospinal fluid (CSF), which normally provides protection and helps to remove metabolic waste. CSF transport has also recently been shown to play unexpected roles in neurodegeneration and sleep. Mestre et al. used multimodal in vivo imaging in rodents and found that, after a stroke, an abnormally large volume of CSF rushes into the brain, causing swelling (see the Perspective by Moss and Williams). This influx of CSF is caused by constrictions of arteries triggered by a well-known propagating chemical reaction-diffusion wave called spreading depolarization. CSF transport can thus play a role in brain swelling after stroke. Science , this issue p. eaax7171 ; see also p. 1195

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Authors: Mestre, H., Du, T., Sweeney, A. M., Liu, G., Samson, A. J., Peng, W., Mortensen, K. N., Stæger, F. F., Bork, P. A. R., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Solis, O., Blinder, P., Kleinfeld, D., Hirase, H., Mori, Y., & Nedergaard, M.
Affiliations: University of Rochester Medicine (US)
University of Copenhagen (DK)
University of Rochester (US)
Technical University of Denmark (DK)
Tel Aviv University (IL)
University of California San Diego (US)
Corresponding author: Mestre, Humberto
Du, Ting
Mori, Yuki
Nedergaard, Maiken
ORCID: Mestre, Humberto
Du, Ting
Liu, Guojun
Samson, Andrew J.
Peng, Weiguo
Mortensen, Kristian Nygaard
Stæger, Frederik Filip
Bork, Peter A. R.
Bashford, Logan
Toro, Edna R.
Tithof, Jeffrey
Kelley, Douglas H.
Thomas, John H.
Hjorth, Poul G.
Martens, Erik A.
Mehta, Rupal I.
Solis, Orestes
Blinder, Pablo
Kleinfeld, David
Hirase, Hajime
Mori, Yuki
Nedergaard, Maiken
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2020-03-13
Volume: 367
Issue: 6483
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aax7171
PMC: PMC7375109
OpenAlex: W3004007615
Cited by: 494
References: 83
Citations by year: 2026: 59 · 2025: 70 · 2024: 76 · 2023: 80 · 2022: 91 · 2021: 77 · 2020: 40
FWCI: 32.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: other-oa
Locations: Science (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Lund University Publications (Lund University) (submittedVersion)
Funders: National Institute on Aging (RF1AG057575)
National Institute of Neurological Disorders and Stroke (R01NS100366, K08NS089830)
Army Research Office (MURI W911NF1910280)
Horizon 2020 Framework Programme (666881)
Fondation Leducq (16CVD05)
Lundbeckfonden
Novo Nordisk Fonden
Topics: Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: glymphatic system, vasoconstriction, perivascular spaces, stroke
MeSH terms: Glymphatic System, Animals, Brain Edema, Magnetic Resonance Imaging, Male, Mice, Inbred C57BL, Vasoconstriction, Stroke, Mice, Aquaporin 5

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