An orally available non-nucleotide STING agonist with antitumor activity

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Items 101–200 of 709

1. STING-induced noncanonical autophagy regulates endolysosomal homeostasis
   Tuozhi Huang, Chenglong Sun, Fenghe Du, Zhijian J. Chen · 2025 · Proceedings of the National Academy of Sciences
2. TAK1 is an essential kinase for STING trafficking
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3. Targeting STING for cancer immunotherapy: From mechanisms to translation
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4. CFI-402257, a TTK inhibitor, effectively suppresses hepatocellular carcinoma
   Cerise Yuen‐Ki Chan, David Kung‐Chun Chiu, Vincent Wai‐Hin Yuen, Cheuk‐Ting Law, Bowie Po‐Yee Wong, Kelsie L. Thu, David W. Cescon, Isabel Soria‐Bretones, Jacinth Wing‐Sum Cheu, Derek Lee et al. · 2022 · Proceedings of the National Academy of Sciences
5. STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy
   Laura Gehrcken, Christophe Deben, Evelien Smits, Jonas R.M. Van Audenaerde · 2025 · Advanced Science
6. ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockade
   Xiao‐Lan Liu, Xufeng Cen, Ronghai Wu, Ziyan Chen, Yanqi Xie, Fengqi Wang, Bing Shan, Linghui Zeng, Jichun Zhou, Bojian Xie et al. · 2023 · Nature Communications
7. Nanoparticle‐Mediated STING Activation for Cancer Immunotherapy
   Yongjuan Li, Xinyan Li, Jinmeng Yi, Yongjian Cao, Zhihai Qin, Zhiyuan Zhong, Weijing Yang · 2023 · Advanced Healthcare Materials
8. Hyperbaric oxygen facilitates teniposide-induced cGAS-STING activation to enhance the antitumor efficacy of PD-1 antibody in HCC
   Li, Kun, Gong, Yihang, Qiu, Dongbo, Tang, Hui, Zhang, Jian, Yuan, Zenan, Huang, Yingqi, Qin, Yunfei, Ye, Linsen, Yang, Yang · 2022 · Journal for ImmunoTherapy of Cancer
9. STING Agonists/Antagonists: Their Potential as Therapeutics and Future Developments
   Danilo Guerini · 2022 · Cells
10. A General Biomineralization Strategy to Synthesize Autologous Cancer Vaccines with cGAS-STING Activating Capacity for Postsurgical Immunotherapy
    Quguang Li, Ziliang Dong, Zhiqin Cao, Huali Lei, Chunjie Wang, Yu Hao, Liangzhu Feng, Zhuang Liu · 2023 · ACS Nano
11. STING agonist-based hydrogel enhances immune activation in synergy with radiofrequency ablation for hepatocellular carcinoma treatment
    Feng Ao, Xi Li, Yan Zhi Tan, Zebo Jiang, Fan Yang, Jingpei Guo, Qiancheng Zhu, Zhongguo Chen, Bin Zhou, Ke Zhang et al. · 2024 · Journal of Controlled Release
12. Delivery of mRNA Encoding Interleukin-12 and a Stimulator of Interferon Genes Agonist Potentiates Antitumor Efficacy through Reversing T Cell Exhaustion
    Bin Wang, Maoping Tang, Qijing Chen, William Ho, Yilong Teng, Xiaojian Xiong, Zhitong Jia, Xiuling Li, Xiaoyang Xu, Xue‐Qing Zhang · 2024 · ACS Nano
13. A novel STING agonist for cancer immunotherapy and a SARS-CoV-2 vaccine adjuvant
    Jun Wu, Lang Zhao, Bei-Bei Han, Hong‐Guo Hu, Bo-Dou Zhang, Wen-Hao Li, Yong‐Xiang Chen, Yanmei Li · 2020 · Chemical Communications
14. Mannosylated STING Agonist Drugamers for Dendritic Cell-Mediated Cancer Immunotherapy
    Dinh Chuong Nguyen, Kefan Song, Simbarashe Jokonya, Omeed Yazdani, Drew L. Sellers, Yonghui Wang, ABM Zakaria, Suzie Hwang Pun, Patrick S. Stayton · 2024 · ACS Central Science
15. Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
    Sarah T. Diepstraten, Yin Yuan, John E. La Marca, Savannah Young, Catherine W.T. Chang, Lauren Whelan, Aisling M. Ross, Karla C. Fischer, Giovanna Pomilio, Rhiannon Morris et al. · 2024 · Cancer Cell
16. Dissecting FAP+ Cell Diversity in Pancreatic Cancer Uncovers an Interferon-Response Subtype of Cancer-Associated Fibroblasts with Tumor-Restraining Properties
    Joshua Cumming, Parniyan Maneshi, Mitesh Dongre, Tala Alsaed, Mohammad Javad Dehghan-Nayeri, Agnes Ling, Kristian Pietras, Cédric Patthey, Daniel Öhlund · 2025 · Cancer Research
17. Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy
    Yaling Dou, Rui Chen, Siyao Liu, Yi‐Tsang Lee, Jing Ji, Xiaoxuan Liu, Yuepeng Ke, Rui Wang, Yubin Zhou, Yun Huang · 2023 · Nature Communications
18. Targeting STING in cancer: Challenges and emerging opportunities
    Kexin Zhao, Jiaojiao Huang, Yue Zhao, Shengjun Wang, Juan Xu, Kai Yin · 2023 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
19. Polymeric Micelles in Cancer Immunotherapy
    Zhuoya Wan, Ruohui Zheng, Pearl Moharil, Yuzhe Liu, Jing Chen, Runzi Sun, Xu Song, Qiang Ao · 2021 · Molecules
20. Structure–Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists
    Zilan Song, Xiyuan Wang, Yan Zhang, Wangting Gu, Ancheng Shen, Chunyong Ding, Li Han, Ruoxuan Xiao, Meiyu Geng, Zuoquan Xie et al. · 2021 · Journal of Medicinal Chemistry
21. Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route
    Štěpán Vyskočil, David Cardin, Jeffrey P. Ciavarri, Joe Conlon, Courtney A. Cullis, Dylan B. England, Rachel E. Gershman, Kenneth M. Gigstad, Krista Gipson, Alexandra E. Gould et al. · 2021 · Journal of Medicinal Chemistry
22. STING agonism enhances anti-tumor immune responses and therapeutic efficacy of PARP inhibition in BRCA-associated breast cancer
    Constantia Pantelidou, Heta Jadhav, Aditi Kothari, Renyan Liu, Gerburg M. Wulf, Jennifer L. Guerriero, Geoffrey Ira Shapiro · 2022 · npj Breast Cancer
23. STING inhibitors sensitize platinum chemotherapy in ovarian cancer by inhibiting the CGAS-STING pathway in cancer-associated fibroblasts (CAFs)
    Jiale Liu, Chenmian Liu, Yana Ma, Xiyu Pan, Ran Chu, Shu Yao, Junyu Chen, Chang Liu, Zhongshao Chen, Chenchen Sheng et al. · 2024 · Cancer Letters
24. The abscopal effect: a sense of DNA damage is in the air
    Timothy P. Lippert, Roger A. Greenberg · 2021 · Journal of Clinical Investigation
25. Considerations for the delivery of STING ligands in cancer immunotherapy
    Marija Petrovic, Gerrit Borchard, Olivier Jordan · 2021 · Journal of Controlled Release
26. Cancer Nanovaccines: Mechanisms, Design Principles, and Clinical Translation
    Gabriel de Camargo Zaccariotto, Maria Julia Bistaffa, Angelica Maria Mazuera Zapata, Camila Fernanda Rodero, Fernanda Matos Coelho, João Victor Brandão Quitiba, Lorena Letícia Peixoto de Lima, Raquel González Sterman, Valéria Maria de Oliveira Cardoso, Valtencir Zucolotto · 2025 · ACS Nano
27. Tumor-targeting nanocarriers amplified immunotherapy of cold tumors by STING activation and inhibiting immune evasion
    Jinhua Zhao, Aiping Tong, Jing Liu, Mingxia Xu, Peng Mi · 2025 · Science Advances
28. Enhancing anti-tumour innate immunity by targeting the DNA damage response and pattern recognition receptors in combination with radiotherapy
    Charleen Chan Wah Hak, Antonio Rullan, Emmanuel Christian Patin, Malin Pedersen, Alan A. Melcher, Kevin Joseph Harrington · 2022 · Frontiers in Oncology
29. Discovery of Selenium-Containing STING Agonists as Orally Available Antitumor Agents
    Xi Feng, Lixia Pan, Zhiyu Qian, Dongyu Liu, Xin‐Yuan Guan, Feng Li, Bin Song, Xi Jin Xu, Ning‐Hua Tan, Yi Ma et al. · 2022 · Journal of Medicinal Chemistry
30. Unlocking the promise of systemic STING agonist for cancer immunotherapy
    Xiaoqi Sun, Xingwu Zhou, Yu L. Lei, James Jaehyun Moon · 2023 · Journal of Controlled Release
31. Hypoxia Reversion and STING Pathway Activation through Large Mesoporous Nanozyme for Near-Infrared-II Light Amplified Tumor Polymetallic-Immunotherapy
    Chang F. Qu, Xinyue Shao, Ran Jia, Guoqiang Song, Donghong Shi, Hui Wang, Jinping Wang, Hailong An · 2024 · ACS Nano
32. Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer
    Qiumei Li, Shuoran Tian, Jiadi Liang, Jiqiang Fan, Junzhong Lai, Qi Chen · 2021 · Frontiers in Pharmacology
33. Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system
    Qingyuan Zhu, Yaling Zhang, Li Wang, Xiangyu Yao, Daitze Wu, Junjun Cheng, Xiaoyu Pan, Haixia Liu, Zhipeng Yan, Lu Gao · 2021 · Antiviral Research
34. Regulation and function of the cGAS-MITA/STING axis in health and disease
    Zhi-Dong Zhang, Bo Zhong · 2022 · Cell Insight
35. PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages
    Winson S. Ho, Isha Mondal, Beisi Xu, Oishika Das, Raymond Sun, Pochin Chiou, Xiaomin Cai, Foozhan Tahmasebinia, Elizabeth McFadden, Caren Yu-Ju Wu et al. · 2023 · Journal of Clinical Investigation
36. Discovery of a photoactivatable dimerized STING agonist based on the benzo[ b ]selenophene scaffold
    Dongyu Liu, Bin Yu, Xin Guan, Bin Song, Huikai Pan, Renbing Wang, Xi Feng, Lixia Pan, Huidan Huang, Zhe Wang et al. · 2023 · Chemical Science
37. IUPHAR ECR review: The cGAS-STING pathway: Novel functions beyond innate immune and emerging therapeutic opportunities
    He Xu, Abdalla M. Wedn, Jian Wang, Yanlun Gu, Hongjin Liu, Juqi Zhang, Zhiqiang Lin, Renpeng Zhou, Xiaocong Pang, Yimin Cui · 2024 · Pharmacological Research
38. Sulfonated Perylene as Three‐in‐One STING Agonist for Cancer Chemo‐Immunotherapy
    Xue‐Jie Zhao, Rijie Zheng, Bianbian Zhang, Ying Zhao, Wanli Xue, Yingfei Fang, Yongwei Huang, Meizhen Yin · 2024 · Angewandte Chemie International Edition
39. New opportunities for immunomodulation of the tumour microenvironment using chemical tools
    Jingyun Su, Wenhao Li, Yanmei Li · 2022 · Chemical Society Reviews
40. SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis
    Chunying Song, Dong Liu, Suxing Liu, Di Li, Ivana Horecny, Xinzhu Zhang, Puhui Li, Lei Chen, Matthew Miller, Rasheduzzaman Chowdhury et al. · 2022 · Scientific Reports
41. Advances in plant-derived natural products for antitumor immunotherapy
    Yi Yang, Qin-Ying Liu, Xia-Nai Shi, Qiu-Hong Zheng, Li Chen, Yang Sun · 2021 · Archives of pharmacal research
42. Activation of the cGAS-STING pathway by a mitochondrial DNA-targeted emissive rhodium( iii ) metallointercalator
    Yue Zheng, Xiaoxiao Chen, Dongyang Zhang, Wenjin Wang, Kun Peng, Zhiyuan Li, Zong‐Wan Mao, Cai‐Ping Tan · 2023 · Chemical Science
43. Activating STING/TBK1 suppresses tumor growth via degrading HPV16/18 E7 oncoproteins in cervical cancer
    Xiaodan Huang, Lanqing Huo, Bei-Bei Xiao, Yi Qin Ouyang, Fo‐Ping Chen, Junyun Li, Xueping Zheng, Denghui Wei, Yuanzhong Wu, Ruhua Zhang et al. · 2023 · Cell Death and Differentiation
44. Therapeutic synthetic and natural materials for immunoengineering
    Anna Slezak, Kevin Chang, Samir Hossainy, Aslan Mansurov, Stuart J. Rowan, Jeffrey A. Hubbell, Mustafa Ozgur Guler · 2024 · Chemical Society Reviews
45. STINGing the Tumor Microenvironment to Promote Therapeutic Tertiary Lymphoid Structure Development
    Jessica N. Filderman, Mark Appleman, Manoj Chelvanambi, Jennifer L. Taylor, Walter J. Storkus · 2021 · Frontiers in Immunology
46. Targeting STING Activation by Antigen‐Inspired MnO2 Nanovaccines Optimizes Tumor Radiotherapy
    Yuan Gu, Subin Lin, Yanxian Wu, Pei Xu, Wen Zhu, Yangyun Wang, Xiaju Cheng, Leshuai W. Zhang, Roland H. Stauber, Yong Wang et al. · 2023 · Advanced Healthcare Materials
47. Metal coordination‐driven assembly of stimulator of interferon genes‐activating nanoparticles for tumor chemo‐immunotherapy
    Guiqiang Zhang, Ning Wang, Yuan Ma, Shumei Zhai, To Ngai, Shilei Ni, Xinyi Jiang, Jianwei Jiao, Jiwei Cui · 2024 · BMEMat
48. TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro
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49. STING agonist inflames the cervical cancer immune microenvironment and overcomes anti-PD-1 therapy resistance
    Tianye Li, Weijiang Zhang, Mengke Niu, Yuze Wu, Xinyue Deng, Jianwei Zhou · 2024 · Frontiers in Immunology
50. Ionizable STING-Activating Nanoadjuvants Enhance Tumor Immunogenicity and Potentiate Immunotherapy Efficacy in Solid Tumors
    Shiyun Xian, Xiaona Chen, Sihang Ren, Xiaolong Chen, Hangxiang Wang · 2024 · Cancer Research
51. Cascaded immunotherapy with implantable dual-drug depots sequentially releasing STING agonists and apoptosis inducers
    Kai Li, Xuan Yu, Yanteng Xu, Haixia Wang, Zheng Liu, Chong Wu, Xing Luo, Jiancheng Xu, Youqiang Fang, Enguo Ju et al. · 2025 · Nature Communications
52. Zr‐Based Metal–Organic Framework Dual‐Sensitized by Carbon Dot Sonosensitizers and MnO 2−x Nanozymes for cGAS‐STING Activation Enhanced Sonocatalytic‐Immunotherapy
    Longfei Xiao, Jinming Cai, Yang Wang, Jinyan Hu, Hongjing Dou, Dengyu Pan, Bijiang Geng, Pengfei Cheng, Longxiang Shen · 2025 · Advanced Functional Materials
53. Immunotherapy Advances for Epithelial Ovarian Cancer
    Erin G. Hartnett, Julia C. Knight, Mackenzy Radolec, Ronald J. Buckanovich, Robert P. Edwards, Anda Vlad · 2020 · Cancers
54. Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases
    Jin Kyung Seok, Minhyuk Kim, Han Chang Kang, Yong‐Yeon Cho, Hye Suk Lee, Joo Young Lee · 2023 · Archives of Pharmacal Research
55. A next-generation STING agonist MSA-2: From mechanism to application
    Junhan Yang, Zhenyu Luo, Jingyi Ma, Yi Wang, Ningtao Cheng · 2024 · Journal of Controlled Release
56. Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors
    Congying Pu, Hui Fang Cui, Huaxing Yu, Xin Cheng, Man Zhang, Luoheng Qin, Zhilin Ning, Wen Zhang, Shan Chen, Yuhang Qian et al. · 2025 · Nature Communications
57. Development of small molecule inhibitors/agonists targeting STING for disease
    Kaifeng Liu, Yongqi Lan, Xiaoling Li, Mingyue Li, Liao Cui, Hui Luo, Lianxiang Luo · 2020 · Biomedicine & Pharmacotherapy
58. If small molecules immunotherapy comes, can the prime be far behind?
    Jingyu Zhang, Yu Zhang, Bingxue Qu, Haiyan Yang, Shengquan Hu, Xiaowu Dong · 2021 · European Journal of Medicinal Chemistry
59. Biodegradable hollow MnO2 decorated by carbon dots with cholesterol depletion capability for cascaded amplification of sono-immunotherapy
    Jingru Zhao, Jinming Cai, Jinyan Hu, Zhenlin Zhang, Yuanyuan Liu, Dengyu Pan, Longxiang Shen, Bijiang Geng · 2025 · Biomaterials
60. Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer
    Zhen Feng Lu, Jinyun Chen, Pengfei Yu, Matthew J. Atherton, Jun Gui, Vivek S. Tomar, Justin D. Middleton, Neil T. Sullivan, Sunil Kumar Singhal, Subin S. George et al. · 2022 · Nature Communications
61. Perspectives on Nuclear Magnetic Resonance Spectroscopy in Drug Discovery Research
    Janet Caceres‐Cortes, Bradley T. Falk, Luciano Mueller, T. G. Murali Dhar · 2024 · Journal of Medicinal Chemistry
62. Advances in polymer nanomaterials targeting cGAS-STING pathway for enhanced cancer immunotherapy
    Shiyu Peng, Xiaoxue Hou, Jianfeng Liu, Fan Huang · 2025 · Journal of Controlled Release
63. Mitochondrial DNA release and cGAS-STING activation: Emerging insights into anti-tumor immunity
    Ghfren S. Aloraini · 2025 · Pathology - Research and Practice
64. The Role of cGAS-STING in Age-Related Diseases from Mechanisms to Therapies
    Weitao Zheng, Dechao Feng, Xingyu Xiong, Xinyang Liao, Sheng Wang, Hang Xu, Weizhen Le, Qiang Wei, Lu Yang · 2023 · Aging and Disease
65. Signal strength of STING activation determines cytokine plasticity and cell death in human monocytes
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66. Design, Synthesis, and Metabolism Studies of N-1,4-Diketophenyltriazinones as Protoporphyrinogen IX Oxidase Inhibitors
    Hongyun Liu, Liang-Kun Yu, Sheng-Nan Qin, Huang-Ze Yang, Dawei Wang, Zhen Xi · 2023 · Journal of Agricultural and Food Chemistry
67. Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A
    Xiaohui Zhao, Kathryn R. Stein, Victor Chen, Matthew E. Griffin, Luke L. Lairson, Howard C. Hang · 2023 · Nature Chemical Biology
68. Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization
    Emily C. Cherney, Liping Zhang, Julian B. Lo, Tram Huynh, Donna D. Wei, Vijay T. Ahuja, Claude A. Quesnelle, Gary L. Schieven, Alan S. Futran, Gregory A. Locke et al. · 2022 · Journal of Medicinal Chemistry
69. Identification of MSA-2: An oral antitumor non-nucleotide STING agonist
    Jianhua Liu, Xu Huang, Jianxun Ding · 2021 · Signal Transduction and Targeted Therapy
70. Nanodelivery of STING agonists against cancer and infectious diseases
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71. Targeting the loss of cGAS / STING signaling in cancer
    Nobunari Sasaki, Mizuki Homme, Shunsuke Kitajima · 2023 · Cancer Science
72. Oscillatory shear stress promotes endothelial senescence and atherosclerosis via STING activation
    Mengdie Dong, Minghong Chen, Yunjia Zhang, Xian He, Jiao Min, Yongkang Tan, Huiyuan Wei, Xinyu Li, Xiang Chen, Longbin Zheng et al. · 2024 · Biochemical and Biophysical Research Communications
73. Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy
    Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu · 2025 · 癌症：英文版
74. Targeting STING to generate therapeutic anti-tumor immunity
    Caroline G. Fahey, Anthony F. Cordova, Patrick C. Gedeon, David Allen Barbie · 2025 · Cancer Cell
75. Immune Regulation of the cGAS-STING Signaling Pathway in the Tumor Microenvironment and Its Clinical Application
    Feifei Pu, Fengxia Chen, Jianxiang Liu, Zhicai Zhang, Zengwu Shao · 2021 · OncoTargets and Therapy
76. Targeting tumor-associated macrophages with STING agonism improves the antitumor efficacy of osimertinib in a mouse model of EGFR-mutant lung cancer
    Ziying Lin, Qiwei Wang, Tao Jiang, Weihua Wang, Jean J. Zhao · 2023 · Frontiers in Immunology
77. Anti-triple-negative breast cancer metastasis efficacy and molecular mechanism of the STING agonist for innate immune pathway
    Xing Qiang Lü, Xiang Wang, Hao Cheng, Xiaoqing Wang, Chang Liu, Xiangshi Tan · 2023 · Annals of Medicine
78. Targeting DNA Repair, Cell Cycle, and Tumor Microenvironment in B Cell Lymphoma
    Paul Jan Bröckelmann, Mathilde R. W. de Jong, Ron Daniel Jachimowicz · 2020 · Cells
79. Intrinsic strategies for the evasion of cGAS-STING signaling-mediated immune surveillance in human cancer: How therapy can overcome them
    Shan-Shan Zou, Yuan Qiao, Shan Zhu, Bao Gao, Ning Yang, Yong-Jun Liu, Jingtao Chen · 2021 · Pharmacological Research
80. Discovery of Podofilox as a Potent cGAMP–STING Signaling Enhancer with Antitumor Activity
    Jing Han, Shuiqing Hu, Yawei Hu, Yifang Xu, Yanfei Hou, Yinlong Yang, Huili Su, Zhengyin Zhang, Peng Liu, Xuxu Sun et al. · 2023 · Cancer Immunology Research
81. Nanomaterial-mediated modulation of the cGAS-STING signaling pathway for enhanced cancer immunotherapy
    Yaxin Wang, Yunmeng Liu, Jincheng Zhang, Qikai Peng, Xingdong Wang, Xiyue Xiao, Kai Shi · 2024 · Acta Biomaterialia
82. Intratumoral or Subcutaneous MK-2118, a Noncyclic Dinucleotide STING Agonist, with or without Pembrolizumab, for Advanced or Metastatic Solid Tumors or Lymphomas
    Jason J. Luke, Randy F. Sweis, Joel Randolph Hecht, Reva Schneider, Mark N. Stein, Talia Golan, Timothy Anthony Yap, Anuradha D. Khilnani, Mo Chao Huang, Runchen Zhao et al. · 2025 · Clinical Cancer Research
83. Discovery of an Orally Bioavailable STING Inhibitor with In Vivo Anti-Inflammatory Activity in Mice with STING-Mediated Inflammation
    Xi Qin Han, Guangcai Ma, Rui-Kun Peng, Xu Ju, Lixin Sheng, Haohao Liu, Qibang Sui, Jiaxin Li, Yuhao Gu, Jinhua Yu et al. · 2025 · Journal of Medicinal Chemistry
84. Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells
    DaeYong Lee, Kristin Michelle Huntoon, Yifan Wang, Minjeong Kang, Yifei Lü, Seong Dong Jeong, Todd M Link, Thomas D. Gallup, Yaqing Qie, Xuefeng Li et al. · 2024 · Nature Biomedical Engineering
85. High-density lipoprotein modulates tumor-associated macrophage for chemoimmunotherapy of hepatocellular carcinoma
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86. The Microtubule Destabilizer Eribulin Synergizes with STING Agonists to Promote Antitumor Efficacy in Triple-Negative Breast Cancer Models
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87. Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists
    Bin Shan, Hui Hou, Keke Zhang, Rui Li, Chang Shen, Zhengyang Chen, Peijia Xu, Rongrong Cui, Zhaoming Su, Changfa Zhang et al. · 2023 · Journal of Medicinal Chemistry
88. The pleiotropic roles of cGAS–STING signaling in the tumor microenvironment
    Jun Li, Samuel F. W. Bakhoum · 2022 · Journal of Molecular Cell Biology
89. Unleashing the efficacy of immune checkpoint inhibitors for advanced hepatocellular carcinoma: factors, strategies, and ongoing trials
    Jiahui Yu, Mengnan Li, Boxu Ren, Le Cheng, Xiaoxiao Wang, Zhaowu Ma, Wei Peng Yong, Xiaoguang Chen, Lingzhi Wang, Boon Cher Goh · 2023 · Frontiers in Pharmacology
90. Targeting the cGAS‐STING Pathway Inhibits Peripheral T‐cell Lymphoma Progression and Enhances the Chemotherapeutic Efficacy
    Xueying Lü, Shunan Wang, Xin Hua, Xiao Chen, Mengtao Zhan, Qiaoyun Hu, Lei Cao, Zijuan Wu, Wei Zhang, Xiaoling Zuo et al. · 2023 · Advanced Science
91. STING Agonist Delivered by Neutrophil Membrane-Coated Gold Nanoparticles Exerts Synergistic Tumor Inhibition with Radiotherapy
    Dehua Lu, Wenhua Li, Jingyun Tan, Ying Li, Wei Mao, Yuanyuan Zheng, Muwen Yang, Jin Wang, Weihu Wang, Shubin Wang et al. · 2024 · ACS Applied Materials & Interfaces
92. Hydrogel systems for spatiotemporal controlled delivery of immunomodulators: engineering the tumor immune microenvironment for enhanced cancer immunotherapy
    Yanting Liu, Fang Liu, Yan Zeng, Liangbin Lin, Hui Yu, Sunfu Zhang, Wenyong Yang · 2024 · Frontiers in Cell and Developmental Biology
93. Unleashing the Power of Covalent Drugs for Protein Degradation
    Meng‐Jie Fu, Hang Jin, Shao‐Peng Wang, Liang Shen, Hong‐Min Liu, Ying Liu, Yi‐Chao Zheng, Xing‐Jie Dai · 2025 · Medicinal Research Reviews
94. Bioengineering strategies to optimize STING agonist therapy
    Pere Dosta, Alexander M. Cryer, Michaela Prado, Natalie Artzi · 2025 · Nature Reviews Bioengineering
95. Viral and cellular oncogenes promote immune evasion
    Jessica J. Roetman, Minna K.I. Apostolova, Mary Philip · 2022 · Oncogene
96. Development of Potent Immune Modulators Targeting Stimulator of Interferon Genes Receptor
    Min Jae Jeon, Hyelim Lee, Jeehee Lee, Soo Yeon Baek, Dong-Hee Lee, Seongman Jo, Joo‐Youn Lee, Miso Kang, Hee Ra Jung, Soo Bong Han et al. · 2022 · Journal of Medicinal Chemistry
97. Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists
    Zdeněk Vavřina, Pavla Perlíková, Nemanja Milisavljevič, Florian Chevrier, Miroslav Smola, Joshua Smith, Milan Dejmek, Vojtěch Havlíček, Miloš Buděšı́nský, Radek Liboska et al. · 2022 · Journal of Medicinal Chemistry
98. Nanobody‐Engineered Biohybrid Bacteria Targeting Gastrointestinal Cancers Induce Robust STING‐Mediated Anti‐Tumor Immunity
    Xiaolong Xu, Youbin Ding, Yafang Dong, Haitao Yuan, Peng Xia, Chengming Qu, Jingbo Ma, Huifang Wang, Xiaodong Zhang, Liang Zhao et al. · 2024 · Advanced Science
99. A dual-STING-activating nanosystem expands cancer immunotherapeutic temporal window
    Jian Wang, Xiaohu Wang, Qingqing Xiong, Shan Gao, Shihao Wang, Siqi Zhu, Shuting Xiang, Mingxi Li, Haitang Xie, Suxin Li · 2024 · Cell Reports Medicine
100. Endothelial STING-JAK1 interaction promotes tumor vasculature normalization and antitumor immunity
     Huanling Zhang, Zining Wang, Jiaxin Wu, Yongqiang Zheng, Qi Zhao, Shuai He, Hang Jiang, Chang Jiang, Tiantian Wang, Yongxiang Liu et al. · 2025 · Journal of Clinical Investigation