An orally available non-nucleotide STING agonist with antitumor activity

Features and development of Coot

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MolProbity : all-atom structure validation for macromolecular crystallography

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Overview of the CCP 4 suite and current developments

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MOLREP : an Automated Program for Molecular Replacement

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MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

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Dysregulated pH: a perfect storm for cancer progression

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Data processing and analysis with the autoPROC toolbox

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Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

Corrales, L., Glickman, L. H., McWhirter, S. M., Kanne, D. B., Sivick, K. E., Katibah, G. E., Woo, S.-R., Lemmens, E., Banda, T., Leong, J. J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.031 · Cited by 1,560

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

Estrella, V. C., Chen, T., Lloyd, M. C., Wojtkowiak, J. W., Cornnell, H. H., Ibrahim‐Hashim, A., Bailey, K. M., Balagurunathan, Y., Rothberg, J. M., Sloane, B. F., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2796 · Cited by 1,404

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

Zhang, X., Shi, H., Wu, J., Zhang, X., Sun, L., Chen, C., & Chen, Z. J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.05.022 · Cited by 1,118

Pharmacological Polarization of Tumor‐Associated Macrophages Toward a CXCL9 Antitumor Phenotype

Enbergs, N., Halabi, E. A., Goubet, A., Schleyer, K. A., Fredrich, I. R., Köhler, R. H., Garris, C., Pittet, M. J., & Weissleder, R. (2024) · Advanced Science · doi:10.1002/advs.202309026 · Cited by 14

Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti‐tumor efficacy

Yu, Y., Jagannathan‐Bogdan, M., Noman, M. Z., Parpal, S., Bartolini, E., Moer, K. V., Kleinendorst, S. C., Sæther, K. B., Tresaugues, L., Silvander, C., et al. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13619 · Cited by 14

STING‐Activating Small Molecular Therapeutics for Cancer Immunotherapy

Huang, C., Tong, T., Ren, L., & Wang, H. (2024) · ChemBioChem · doi:10.1002/cbic.202400255 · Cited by 15

Tandem‐Controlled Dynamic DNA Assembly Enables Temporally‐Selective Orthogonal Regulation of cGAS–STING Stimulation

Li, X., Yu, F., & Li, L. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202417916 · Cited by 15

An oral tricyclic STING agonist suppresses tumor growth through remodeling of the immune microenvironment

Zhao, H., Liu, Z., Tao, J., Mao, S., Wang, M., He, M., Wen, B., Gao, W., & Sun, D. (2025) · Cell chemical biology · doi:10.1016/j.chembiol.2025.01.004 · Cited by 15

Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration

Niu, J., Bai, H., Li, Z., Gao, Y., Zhang, Y., Wang, X., Yang, Y., Xu, Y., Geng, M., Xie, Z., et al. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114482 · Cited by 15

Stimulator of Interferon Genes Agonist Synergistically Amplifies Programmed Cell Death Protein-1 Blockade and Radiation-Induced Systemic Antitumor Responses via Tumor Microenvironment Enrichment

Zheng, Y., Zhou, P., Wang, H., Liao, S., Guo, L., Kang, K., Luo, R., Peng, Z., Liu, S., Yi, L., et al. (2025) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2025.04.011 · Cited by 14

Emerging therapeutics targeting tumor-associated macrophages for the treatment of solid organ cancers

Li, D., & Rudloff, U. (2025) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2025.2504376 · Cited by 15

GALNT6 dual regulates innate immunity STING signaling and PD-L1 expression to promote immune evasion in pancreatic ductal adenocarcinoma

Chong, S., Liu, Y., Bian, Z., Hu, D., Guo, S., Dong, C., Zeng, J., Fan, S., & Chen, X. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111942 · Cited by 14

Biodegradable MnO2-x sensitized hollow prussian blue for enhanced sono-immunotherapy through cascade amplification of ROS generation and activation of cGAS-STING pathway

Tao, R., Cai, J., Duan, H., Hua, Y., Geng, B., & Qin, J. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.165530 · Cited by 14

cGAS-agonistic spherical nucleic acids reprogram the glioblastoma immune microenvironment and promote antitumor immunity

Mahajan, A. S., Dussold, C., Kim, S., Jarvis, R., Hurley, L., Tommasini-Ghelfi, S., Park, J., Forsyth, C. M., Zhang, B., Miska, J. M., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2409557122 · Cited by 14

Cell-type specific activation of the cGAS-STING pathway in tumor immunotherapy: mechanisms and therapeutic implications

Wang, L., Zhu, S., Ding, Z., Hong, J., Zheng, L., Sun, J., Tang, Y., Chen, X., Yong, X., Hu, M., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-025-07645-2 · Cited by 16

Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor

Chen, N., Zhang, H., Zhu, Q., Zeng, T., Dai, W., Zhou, Y.-L., Xin, G.-F., Wu, B.-D., Gong, S.-J., Jiang, Z., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c02046 · Cited by 15

STING controls opioid-induced itch and chronic itch via spinal tank-binding kinase 1-dependent type I interferon response in mice

Li, N., Wang, C., Zhao, Y., Wang, Y., Gao, T., Yu, Y., Wang, G., & Zhang, L. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02783-0 · Cited by 15

M335, a novel small-molecule STING agonist activates the immune response and exerts antitumor effects

Zhao, M., Fan, W., Wang, Y., Qiang, P., Zheng, Z., Shan, H., Zhang, M., Liu, P., Wang, Y., Li, G., et al. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.116018 · Cited by 14

Recent Progress in Photothermal, Photodynamic and Sonodynamic Cancer Therapy: Through the cGAS-STING Pathway to Efficacy-Enhancing Strategies

Fang, K., Zhang, H., Kong, Q., Ma, Y., Xiong, T., Qin, T., Li, S., & Zhu, X. (2024) · Molecules · doi:10.3390/molecules29153704 · Cited by 15

STimulator of INterferon Genes Agonism Accelerates Antitumor Activity in Poorly Immunogenic Tumors

Perera, S. A., Kopinja, J. E., Ma, Y., Muise, E. S., Laskey, J., Chakravarthy, K., Chen, Y., Cui, L., Presland, J. P., Sathe, M., et al. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-21-0136 · Cited by 14

Distinct oligomeric assemblies of STING induced by non-nucleotide agonists

Gharpure, A., Sulpizio, A., Loeffler, J. R., Fernández‐Quintero, M. L., Tran, A. S., Lairson, L. L., & Ward, A. B. (2025) · Nature Communications · doi:10.1038/s41467-025-58641-5 · Cited by 16

Precision targeting of STING: Challenges, innovations, and clinical outlook for cancer therapy

Shi, J., Zhang, Y., Zhao, N., Seki, E., Ma, L., Kocic, G. M., Li, X., Terzić, J., & Zheng, T. (2025) · The Innovation · doi:10.1016/j.xinn.2025.101074 · Cited by 16

Co-delivery of SN38 and SR717 activates cGAS–STING for near-infrared II image-guided chemoimmunotherapy

Hou, X., Ren, C., Zeng, X., Hu, Y., Zhao, Y., Cheng, Y., Luo, Q., Ding, T., Qiao, X., Liao, Y., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114129 · Cited by 13

Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform

Zhao, J., Tang, Z., Selvaraju, M., Johnson, K. A., Douglas, J. T., Gao, P. F., Petrassi, H. M., Wang, M. Z., & Wang, J. (2022) · ACS Central Science · doi:10.1021/acscentsci.2c00609 · Cited by 12

Potentiating the Systemic Immunity by Bacteria‐Delivered Sting Activation in a Tumor Microenvironment

Chen, W., Zhu, Y., Chen, J., Jing, X., Xiong, Y., Zou, L., Li, J., Liu, Q., Li, Y., Huang, Y., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202307001 · Cited by 13

The curious case of type I interferon signaling in cancer

Chhipa, A. S., Boscaro, V., Gallicchio, M., & Patel, S. S. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189204 · Cited by 13

A Single‐Atom Mn/MoO 3− x Nanoagonist for Cascade cGAS/STING Activation in Tumor‐Specific Catalytic Metalloimmunotherapy

Hu, X., Ma, Z., Zhang, B., Wang, J., Zhou, Y., Li, J., Liu, T., Zhang, J., Hong, B., Zhu, M., et al. (2024) · Small · doi:10.1002/smll.202407214 · Cited by 13

Engineering Autologous Cell‐Derived Exosomes to Boost Melanoma‐Targeted Radio‐Immunotherapy by Cascade cGAS‐STING Pathway Activation

Zhang, F., Zhang, Z., Yang, W., Peng, Z., Sun, J., Li, G., Wei, Y., Wang, X., Zhao, L., & Xie, W. (2024) · Small · doi:10.1002/smll.202408769 · Cited by 14

TAX1BP1-dependent autophagic degradation of STING1 impairs anti-tumor immunity

Zhang, R., Yu, C., Zeh, H. J., Kroemer, G., Klionsky, D. J., Tang, D., & Kang, R. (2025) · Autophagy · doi:10.1080/15548627.2025.2471736 · Cited by 14

STING agonists: a range of eminent mediators in cancer immunotherapy

Wen, Z., Sun, F., Wang, R., Wang, W., Zhang, H., Yang, F., Wang, M., Wang, Y., & Li, B. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111914 · Cited by 14

Strengthening the sting of immunotherapy

Crunkhorn, S. (2020) · Nature Reviews Drug Discovery · doi:10.1038/d41573-020-00148-3 · Cited by 13

Small molecule approaches to treat autoimmune and inflammatory diseases (Part II): Nucleic acid sensing antagonists and inhibitors

Wang, X., Liu, Y., Han, X., Zou, G., Zhu, W., Shen, H. C., & Liu, H. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.128101 · Cited by 13

Neural Spectral Prediction for Structure Elucidation with Tandem Mass SpectrometryPreprint

Wang, R., Manjrekar, M., Mahjour, B. A., Ávila-Pacheco, J., Provenzano, J., Reynolds, E. E., Lederbauer, M., Mashin, E., Goldman, S., Wang, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.28.656653 · Cited by 16

Targeting the cGAS-STING Pathway for Cancer Immunotherapy: From Small-Molecule Agonists to Advanced Nanomaterials

Guo, Z., Liu, T., Gao, Q., Wang, C., Wang, Q., Du, R., Liu, Y., Li, H., Huang, Y., Liu, Y., et al. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c01263 · Cited by 12

A sequential scheme including PTT and 2′3′-cGAMP/CQ-LP reveals the antitumor immune function of PTT through the type I interferon pathway

Song, X., Wang, M., Liu, S., Liu, H., Jiang, A., Zou, Y., Deng, Y., Qin, Q., Song, Y., & Zheng, Y. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106939 · Cited by 12

Sulfonated Perylene as Three‐in‐One STING Agonist for Cancer Chemo‐Immunotherapy

Zhao, X., Zheng, R., Zhang, B., Zhao, Y., Xue, W., Fang, Y., Huang, Y., & Yin, M. (2024) · Angewandte Chemie · doi:10.1002/ange.202318799 · Cited by 12

STING pathway as a cancer immunotherapy: Progress and challenges in activating anti-tumor immunity

Tabar, M. M. M., Fathi, M., Kazemi, F., Bazregari, G., & Ghasemian, A. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09418-4 · Cited by 14

The First GMP Synthesis of MK-2118, a Small Molecule Agonist for Stimulator of Interferon Genes

Lyons, T. W., Thaisrivongs, D. A., Kuhl, N., Chung, C. K., Angeles, A. R., Steinhuebel, D. P., Guetschow, E. D., Brunskill, A. P. J., Henderson, T. J., Cash, B. M., et al. (2024) · Organic Process Research & Development · doi:10.1021/acs.oprd.4c00102 · Cited by 12

Facile integration of a binary nano-prodrug with αPD-L1 as a translatable technology for potent immunotherapy of TNBC

Zhou, Z., Guo, F., Zhang, J., Liao, L., Jiang, M., Huang, Y., Liu, Y., Lei, L., Tao, Z., Yu, C., et al. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.01.038 · Cited by 12

Enhancing tumor immunotherapy with smart nanoparticles for reprogramming macrophages and blocking the CD47/Sirpα pathway

Hussain, Z., Gou, S., Liu, X., Li, M., Zhang, H., Ren, S., Han, R., Liu, F., Zhou, X., Qiu, L., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101826 · Cited by 14

Combination immunotherapy targeting LAG-3, PD-1 and STING suppresses hepatocellular carcinoma as monitored by LAG-3 targeted PET imaging

Quan, Z., Gao, Y., Sun, B., Guo, Y., Jin, Z., Hao, N., Jiang, D., Zheng, C., Li, X., & Chen, Q. (2025) · Biomarker Research · doi:10.1186/s40364-025-00820-z · Cited by 12

Molecular dynamics simulations provide structural insight into binding of cyclic dinucleotides to human STING protein

Tehrani, Z. A., Rulı́šek, L., & Černý, J. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1942213 · Cited by 12

New Strategies and Combinations to Improve Outcomes in Immunotherapy in Metastatic Non-Small-Cell Lung Cancer

Corke, L., & Sacher, A. G. (2021) · Current Oncology · doi:10.3390/curroncol29010004 · Cited by 15

Emerging therapeutic strategies for enhancing sensitivity and countering resistance to programmed cell death protein 1 or programmed death‐ligand 1 inhibitors in non–small cell lung cancer

Villaruz, L. C., Blumenschein, G. R., Otterson, G. A., & Leal, T. A. B. (2023) · Cancer · doi:10.1002/cncr.34683 · Cited by 12

Cell-based relay delivery strategy in biomedical applications

Chen, Y., Pal, S., & Hu, Q. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114871 · Cited by 12

TTK inhibition activates STING signal and promotes anti-PD1 immunotherapy in breast cancer

Hu, X., Li, G., Li, S., Wang, Q., Wang, Y., Zhang, P., Yang, T., Yang, B., Yu, L., & Liu, Z. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149388 · Cited by 12

Nanomaterials Application for STING Pathway-Based Tumor Immunotherapy

Zhao, W., Tang, X., Qin, Y., Wang, X., Zhong, K., Gong, N., & Li, T. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s535460 · Cited by 11

Dual‐Locked Polymeric STING Nano‐Agonist/Sonosensitizer Augments Spatiotemporally Controlled Cancer Sono‐Immunotherapy

Jia, Y., Jia, W., Tang, Z., Wu, Y., Yang, W., Ye, W., Ren, H., Xie, Y., Chen, Y., & Yu, M. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202514516 · Cited by 12

Tumour-specific STING agonist synthesis via a two-component prodrug system

Hsu, N., Tang, C., Mendes, R. V., Labão‐Almeida, C., dos Reis, C. V., Coelho, A. R., Marques, M. C., Cabeza-Cabrerizo, M., Misteli, R., Rooney, T. P. C., et al. (2025) · Nature Chemistry · doi:10.1038/s41557-025-01930-9 · Cited by 11

MTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonists

Hsu, J.-M., Liu, C., Xia, W., Chen, C., Cheng, W., Hou, J., & Hung, M. (2025) · Science · doi:10.1126/science.adl4089 · Cited by 15

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

Zhao, S., Qu, R., Dai, Z., Jiang, X., & Zhen, X. (2026) · BMEMat · doi:10.1002/bmm2.70062 · Cited by 13

Harnessing cGAS‐STING Pathway for Cancer Immunotherapy: From Bench to Clinic

Lee, D., Huntoon, K. M., Kang, M., Lü, Y., Gallup, T. D., Jiang, W., & Kim, B. Y. S. (2022) · Advanced Therapeutics · doi:10.1002/adtp.202200040 · Cited by 10

Astaxanthin Inhibits STING Carbonylation and Enhances Antiviral Responses

Li, Q., Jia, M., Song, H., Peng, J., Zhao, W., & Zhang, W. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2300306 · Cited by 11

Advances in the prerequisite and consequence of STING downstream signalosomes

Lu, X., Li, X., Li, L., Han, C., & Li, S. (2024) · Medical Review · doi:10.1515/mr-2024-0016 · Cited by 11

Novel Modifications and Delivery Modes of Cyclic Dinucleotides for STING Activation in Cancer Treatment

Lu, Y., Li, Z., Zhu, X., Zeng, Q., Liu, S., & Guan, W. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s503780 · Cited by 11

NOTCH1 reverses immune suppression in small cell lung cancer through reactivation of STING

Kim, Y. S., Nabet, B. Y., Cortez, B. N., Sun, N.-Y., Sebastian, R., Redon, C. E., Ray, A., Liu, L., Ishola, A. A., Löw, S., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci185423 · Cited by 11

Strengthening the sting of immunotherapy

Crunkhorn, S. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-00447-1 · Cited by 11

Agonist of stimulator of interferon genes as antitumor agents: a patent review (2008-2020)

Chen, N., Zhang, H., You, Q., & Xu, X. (2021) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2021.1877660 · Cited by 11

Development of Small-Molecule STING Activators for Cancer Immunotherapy

Jung, H. R., Jo, S., Jeon, M. J., Lee, H., Chu, Y., Lee, J., Kim, E., Song, G., Jung, C., Kim, H., et al. (2021) · Biomedicines · doi:10.3390/biomedicines10010033 · Cited by 11

Icaritin ameliorates extracellular microparticles‐induced inflammatory pre‐metastatic niche via modulating the cGAS‐STING signaling

Tu, S., Mao, D., Shi, M., Zhang, H., Liu, C., Li, X., Zhao, Y., Chen, Y., & Liu, Y. (2022) · Phytotherapy Research · doi:10.1002/ptr.7433 · Cited by 12

Identification of new benzofuran derivatives as STING agonists with broad-spectrum antiviral activity

Paulis, A., Onali, A., Vidalain, P., Lotteau, V., Jaquemin, C., Corona, A., Distinto, S., Delogu, G., & Tramontano, E. (2024) · Virus Research · doi:10.1016/j.virusres.2024.199432 · Cited by 12

Novel classes of immunotherapy for breast cancer

Hernando‐Calvo, A., Cescon, D. W., & Bedard, P. L. (2021) · Breast Cancer Research and Treatment · doi:10.1007/s10549-021-06405-2 · Cited by 11

A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity

Wang, X., Yin, X., Zhang, B., Liu, C., Lin, Y., Huang, X., Li, Y., Shen, C., Zheng, W., Fu, G., et al. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2050951 · Cited by 10

Personalized Vaccination of Tumor‐Derived Antigens and STING Agonists for Specific Cancer Immunotherapy

Wang, N., Zhang, X., Gao, Z., Jiang, X., Li, J., Hao, J., & Cui, J. (2025) · Advanced Materials · doi:10.1002/adma.202420325 · Cited by 10

Fangchinoline induces antiviral response by suppressing STING degradation

Wang, J., Xie, F., Jia, X., Wang, X., Kong, L., Li, Y., Liang, X., Zhang, M., He, Y., Feng, W.-D., et al. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.100972 · Cited by 10

Nanoparticle targeting cGAS-STING signaling in disease therapy

Zhou, L., Huang, Y., Wu, Y., & Tang, S. (2024) · Nano Research · doi:10.1007/s12274-024-6714-x · Cited by 11

Immune amplifying hydrogel microspheres with STING activation improve tumor retention for photoimmunotherapy

Luo, H., Chen, J., Gao, T., Ma, J., Zhang, X., Xu, Z., Xu, Z., Liu, J., Xu, H., Guan, H., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.153346 · Cited by 10

Oncogenic RAS in Cancers from the DNA Replication Stress and Senescence Perspective

Técher, H., Kemiha, S., Xieraili, A., & Kolinjivadi, A. M. (2024) · Cancers · doi:10.3390/cancers16233993 · Cited by 11

Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effect

Wang, X., Zhan, Z., Wang, Z., Zhang, Y., Zhao, K., Han, L., Zhou, X., Guo, Y., Fan, F., Ding, J., et al. (2024) · MedComm · doi:10.1002/mco2.70001 · Cited by 10

Tumor Metastasis: Mechanistic Insights and Therapeutic Intervention

Tang, L., Peng, S., Zhuang, X., He, Y., Song, Y., Nie, H., Zheng, C., Pan, Z., Lam, A. K.-Y., He, M., et al. (2025) · MedComm – Oncology · doi:10.1002/mog2.70012 · Cited by 11

Targeting USP1 Potentiates Radiation‐Induced Type I IFN‐Dependent Antitumor Immunity by Enhancing Oligo‐Ubiquitinated SAR1A‐Mediated STING Trafficking and Activation

Zhou, W., Zhao, Y., Qin, W., Wu, W., Liao, C.-Y., Zhang, Y., Yang, X., Chen, X., Wang, Y., Kang, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202412687 · Cited by 11

An engineered viral protein activates STAT5 to prevent T cell suppression

Zheng, Y., Gu, Z., Shudde, C. E., Piper, T. L., Wang, X., Aleck, G. A., Zhou, J., King, D., Chanda, M. K., Trinch, L., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adn9633 · Cited by 10

A cGAS-STING pathway activating cobalt(III) cyclam prodrug for combined chemotherapy and immunotherapy of breast cancer

Song, H., Montesdeoca, N., Efanova, E., Li, X., Karges, J., Xiao, H., Shang, K., & Zhang, H. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113942 · Cited by 13

The cGAS-STING signaling pathway in the regulation of pulmonary infections: a systematic review

Xu, Q., & Zhu, J. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1628481 · Cited by 11

Chemically Inducible Cyclic Dinucleotides as Self-Deliverable STING Agonists with Enhanced Antitumor Immunity

Hai, Y., Xun, Z., Yang, L., Cai, Z., Wu, Z., & Jiang, J. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c09626 · Cited by 10

NIR-Switched DNA Shutter Enables Reversible Intermittent cGAS-STING Activation for Enhanced Antitumor Immunity

Bi, S., Yang, R., Cong, Y., Ju, H., & Liu, Y. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c08583 · Cited by 11

18F-FDG PET Visualizes Systemic STING Agonist-Induced Lymphocyte Activation in Preclinical Models

Le, T. M., Lee, H. R., Abt, E. R., Rashid, K., Creech, A. L., Liang, K., Cui, J., Cho, A. E.-H., Liu, W., Labora, A. N., et al. (2022) · Journal of Nuclear Medicine · doi:10.2967/jnumed.122.264121 · Cited by 10

AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer

Yeo, S. K., Haas, M., Manupati, K., Hao, M., Yang, F., Chen, S., & Guan, J. (2023) · Autophagy · doi:10.1080/15548627.2023.2259775 · Cited by 11

DNA sensing of dendritic cells in cancer immunotherapy

Qian, W. P., Ye, J., & Xia, S. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1391046 · Cited by 10

Activation of Stimulator of Interferon Genes (STING): Promising Strategy to Overcome Immune Resistance in Prostate Cancer

Alnukhali, M., Altabbakh, O., Farooqı, A. A., Pollack, A. S., Daunert, S., Deo, S. K., & Tao, W. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673273303231208071403 · Cited by 9

Discovery of orally bioavailable phosphonate prodrugs of potent ENPP1 inhibitors for cancer treatment

Gao, S., Hou, Y., Xu, Y., Li, J., Zhang, C., Jiang, S., Tu, W., Liu, L., Tu, W., Yu, B., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116853 · Cited by 9

Small molecule innate immune modulators in cancer therapy

Goswami, A., Goyal, S., Khurana, P., Singh, K., Deb, B., & Kulkarni, A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1395655 · Cited by 10

Suppressing Pancreatic Cancer Survival and Immune Escape via Nanoparticle-Modulated STING/STAT3 Axis Regulation

Li, R., Liu, R., Xu, Y., Zhang, S., Yang, P., Zeng, W., Wang, H., Liu, Y., Yang, H., Yue, X., et al. (2024) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00379 · Cited by 9

Low-Intensity Focused Ultrasound-Responsive Phase-Transitional Liposomes Loaded with STING Agonist Enhances Immune Activation for Breast Cancer Immunotherapy

Hu, C., Jiang, Y., Chen, Y., Wang, Y., Wu, Z., Zhang, Q., & Wu, M. (2024) · Cancers · doi:10.3390/cancers16213657 · Cited by 9

Design of an Oral STING Agonist through Intramolecular Hydrogen Bond Ring Mimicking to Achieve Complete Tumor Regression

Zhao, H., Tao, J., Zhang, L., Li, Q., He, M., Wen, B., Liu, Z., Myatt, H., & Sun, D. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00296 · Cited by 9

Macromolecular Diamidobenzimidazole Conjugates Can Activate Stimulator of Interferon Genes

Arora, K., Sheehy, T. L., Schulman, J. A., Loken, J. R., Lehmann, Z., Kimmel, B. R., McAtee, C., Bharti, V., Stone, P. T., Weaver, A. M., et al. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c13195 · Cited by 9

Peptide vaccine formulations with structurally distinct STING agonist drugamers induce discrete, efficacious antitumor responses

Song, K., Nguyen, D. C., Wang, Y., Jokonya, S., Yazdani, O., Sellers, D. L., Stayton, P. S., & Pun, S. H. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2409978122 · Cited by 9

STING Agonist‐Modified Tumor Targeting Photosensitizer Remodels Cancer‐Associated Fibroblasts to Potentiate Photoimmunotherapy in Pancreatic Cancer

Zhang, Y., Yao, S., Zhao, Y., Zhu, S., Fang, W., Yu, R., Shi, N., Zhang, R., Zhang, Y., Liang, J., et al. (2025) · Advanced Science · doi:10.1002/advs.202520547 · Cited by 9

The Crucial Roles and Research Advances of cGAS-STING Pathway in Cutaneous Disorders

Huang, C., Li, W., Ren, X., Tang, M., Zhang, K., Zhuo, F., Dou, X., & Yu, B. (2023) · Inflammation · doi:10.1007/s10753-023-01812-7 · Cited by 9

SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression

Liang, B., Zhang, E. H., Ye, Z., Storts, H., Wei, J., Zheng, X., Hylton, H., Zaleski, O., Xing, X., Miles, W. O., et al. (2023) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0265 · Cited by 9

STINGing Viral Tumors: What We Know from Head and Neck Cancers

Saulters, E. L., Woolley, J. F., Varadarajan, S., Jones, T. M., & Dahal, L. N. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0785 · Cited by 9

Stimulator of interferon response cGAMP interactor overcomes ERBB2-mediated apatinib resistance in head and neck squamous cell carcinoma

Ye, G., Zhang, J., & Zhang, C. (2021) · Aging · doi:10.18632/aging.203475 · Cited by 9

How Fragile We Are: Influence of Stimulator of Interferon Genes (STING) Variants on Pathogen Recognition and Immune Response Efficiency

Morere, J., Hognon, C., Miclot, T., Jiang, T., Dumont, E. E., Barone, G., Monari, A., & Bignon, E. (2022) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.2c00315 · Cited by 10

Development of 18F-Labeled Acridone Analogue for Tumor Imaging via Stimulator of Interferon Genes Targeting

Liu, H., Sun, Y., Li, J., Chen, Y., Liu, J., Fang, J., Yang, H., Feng, L., Peng, S., Zhuang, R., et al. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00137 · Cited by 9

Intratumoral STING activation causes durable immunogenic tumor eradication in the KP soft tissue sarcoma model

Marritt, K., Hildebrand, K. M., Hildebrand, K., Singla, A. K., Zemp, F. J., Mahoney, D. J., Jirik, F. R., & Monument, M. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1087991 · Cited by 12

Lycorine Suppresses Non‐Small‐Cell Lung Cancer Progression Through Activating STING Pathway and Stimulating an Antitumor Immune Response

Jiang, Z., Xu, C., Xu, P., Huang, D., & Kang, L. (2024) · Chemical Biology & Drug Design · doi:10.1111/cbdd.70036 · Cited by 8

Advances in nanoplatform-based multimodal combination therapy activating STING pathway for enhanced anti-tumor immunotherapy

Zhang, H., Xu, X., Li, S., Huang, H., Zhang, K., Li, W., Wang, X., Yang, J., Yin, X., Qu, C., et al. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114573 · Cited by 9

MYC controls STING levels to downregulate inflammatory signaling in breast cancer cells upon DNA damage

Linstra, R., Stappenbelt, C., Bakker, F. J., Everts, M., Bhattacharya, A., Yu, S., van Bergen, S. D., van der Vegt, B., Wisman, G. B. A., Fehrmann, R. S. N., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108560 · Cited by 8

Discovery of 3-(Fluoro-imidazolyl)pyridazine Derivatives as Potent STING Agonists with Antitumor Activity

Hou, H., Zhou, J., Sui, Q., Zhang, C., Su, Z., Cui, R., Shan, B., Xu, P., Chen, Z., Jiang, B., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01873 · Cited by 8

Orthosteric STING inhibition elucidates molecular correction of SAVI STING

Xie, T., Ruzanov, M., Critton, D., Merselis, L. C., Naglich, J. G., Sack, J. S., Zhang, P., Xie, C., Tredup, J. A., Stine, L. B., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60632-5 · Cited by 8

STING agonists drive recruitment and intrinsic type I interferon responses in monocytic lineage cells for optimal anti-tumor immunity

Girard, M., Yu, T., Batista, N. V., Yeung, K. K. M., Lamorte, S., Gao, W., Liu, M., McGaha, T. L., & Watts, T. H. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf131 · Cited by 8

Restoration of cGAS in cancer cells promotes antitumor immunity via transfer of cancer cell–generated cGAMP

Cryer, A. M., Dosta, P., Dion, M. Z., Soto, L. D. L. P., Amar‐Lewis, E., Carmona, G. G. D. L., Perez, A. A. E., Aguilar, D. F. R., Sanchez-Huerta, T. M., Ruiz, B. N., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2409556122 · Cited by 8

Silencing PCSK9 reshapes the spatiotemporal activation of STING for safe and effective cancer immunotherapy

Sun, P., Han, F., Li, X., Wu, C., Deng, T., He, J., Zhang, C., & Kuai, R. (2025) · Nature Communications · doi:10.1038/s41467-025-66630-x · Cited by 8

Identification of MSA-2: An oral antitumor non-nucleotide STING agonist

Liu, J., Huang, X., & Ding, J. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00459-2 · Cited by 35

A next-generation STING agonist MSA-2: From mechanism to application

Yang, J., Luo, Z., Ma, J., Wang, Y., & Cheng, N. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.05.042 · Cited by 41

A novel STING agonist with systemic and durable anti‐tumour activity

Wang, X., Shen, A., Zhang, Y., Chen, X., Ding, J., Zhang, A., Geng, M., Ding, C., & Xie, Z. (2023) · Clinical and Translational Discovery · doi:10.1002/ctd2.231 · Cited by 4

STimulator of INterferon Genes Agonism Accelerates Antitumor Activity in Poorly Immunogenic Tumors

Perera, S. A., Kopinja, J. E., Ma, Y., Muise, E. S., Laskey, J., Chakravarthy, K., Chen, Y., Cui, L., Presland, J. P., Sathe, M., et al. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-21-0136 · Cited by 14

Highlights from Recent Cancer Literature

(2020) · Cancer Research · doi:10.1158/0008-5472.4303.80.20