An orally available non-nucleotide STING agonist with antitumor activity

Pan, Bo-Sheng, Perera, Samanthi A., Piesvaux, Jennifer A., Presland, Jeremy P., Schroeder, Gottfried K., Cumming, Jared N., Trotter, B. Wesley, Altman, Michael D. +33 more·2020·Science

DOI 10.1126/science.aba6098

Cited by (709)

Items 201–300 of 709

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Chemical regulation of the cGAS-STING pathway
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Tatyana V. Korneenko, Nikolay Borisovich Pestov, Ivan A. Nevzorov, Alexandra A. Daks, Трачук Кирилл Николаевич, О. Н. Солопова, Nickolai A. Barlev · 2023 · Pharmaceuticals
Spatiotemporal release of non-nucleotide STING agonist and AKT inhibitor from implantable 3D-printed scaffold for amplified cancer immunotherapy
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Lipid Nanoparticles Delivering Constitutively Active STING mRNA to Stimulate Antitumor Immunity
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A DNA‐Modularized STING Agonist with Macrophage‐Selectivity and Programmability for Enhanced Anti‐Tumor Immunotherapy
Yingzhi Chen, Ruike Li, Qiao Duan, Lingling Wu, Xinyi Li, Aoxiang Luo, Yongming Zhang, Na Zhao, Kai Cui, Wenwei Wu et al. · 2024 · Advanced Science
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Li Liu, Shengxiang Fu, Haojie Gu, Yangqian Li, Guonian Zhu, Hua Ai, Weimin Li · 2025 · ACS Nano
The cGAS‒STING pathway in colorectal cancer: bridging innate immunity and therapeutic strategies
Wenjing Li, Guang-Hui Dong, Yao Bi, You-Yan Han, Longlong Sun, Tong Wang, Zhenhua Lin, Xiang-Shan Ren · 2025 · Journal of Experimental & Clinical Cancer Research
Cytosolic sensor STING in mucosal immunity: a master regulator of gut inflammation and carcinogenesis
Qiongyuan Hu, Quan Zhou, Xuefeng Xia, Lihua Shao, Meng Wang, Xiaofeng Lu, Song Liu, Wenxian Guan · 2021 · Journal of Experimental & Clinical Cancer Research
The multiple faces of cGAS-STING in antitumor immunity: prospects and challenges
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cGAS-STING: mechanisms and therapeutic opportunities
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Ancheng Shen, Xiyuan Wang, Qingxuan Chen, Yan Zhang, Fang Wang, Yuqiang Li, Zhiguo Liu, Liufu Deng, Wanli Ouyang, Meiyu Geng et al. · 2025 · Journal of Medicinal Chemistry
Unveiling the crossroads of STING signaling pathway and metabolic reprogramming: the multifaceted role of the STING in the TME and new prospects in cancer therapies
Siwei Wang, Lu Qin, Furong Liu, Zhanguo Zhang · 2025 · Cell Communication and Signaling
Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors
Ruirui Yang, Wang Bei, Zhaoming Su, Ying Song, Yingying Zhang, Yadan Liu, Yinghui Zhang, Changyu He, Yang Xi, Feisheng Zhong et al. · 2025 · Science Translational Medicine
Therapeutic Interventions Targeting Innate Immune Receptors: A Balancing Act
Xujun Cao, Anthony F. Cordova, Lingyin Li · 2021 · Chemical Reviews
A hierarchical tumor-targeting strategy for eliciting potent antitumor immunity against triple negative breast cancer
Minzhao Lin, Yujun Cai, Gengjia Chen, Huihai Zhong, Bo Li, Li Tan, Zecong Xiao, Xintao Shuai · 2023 · Biomaterials
Protein–Ligand Interactions in the STING Binding Site Probed by Rationally Designed Single-Point Mutations: Experiment and Theory
Zdeněk Vavřina, Ondrej Gutten, Miroslav Smola, Martin Zavřel, Zahra Aliakbar Tehrani, Vilém Charvát, Milan Kožíšek, Evžen Bouřa, Gabriel Birkuš, Lubomı́r Rulı́šek · 2021 · Biochemistry
Potential therapeutic strategies for colitis and colon cancer: bidirectional targeting STING pathway
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Peng Xia, Chengming Qu, Xiaolong Xu, Ming Tian, Zhifen Li, Jingbo Ma, Rui Hou, Han Li, Felix Rückert, Tianyu Zhong et al. · 2025 · Journal of Extracellular Vesicles
Bacterial Cyclic Dinucleotides and the cGAS–cGAMP–STING Pathway: A Role in Periodontitis?
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Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligence
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Structure−Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists
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Brief report: STING expressed in tumor and non-tumor compartments has distinct roles in regulating anti-tumor immunity
Kim, Jennie C., Liu, Xian, Fitzgerald, Karen, Eng, Jason S., Orf, Jessica, O’Brien, Sarah A., Belmontes, Brian, Casbon, Amy-Jo, Novitskiy, Sergey V., Tarbell, Kristin V. et al. · 2023 · Cancer Immunology, Immunotherapy
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Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth
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Activation of STING in pancreatic cancer-associated fibroblasts exerts an antitumor effect by enhancing tumor immunity
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Targeting STING signaling for the optimal cancer immunotherapy
Yan Xu, Ying Xiong · 2024 · Frontiers in Immunology
The common HAQ STING allele prevents clinical penetrance of COPA syndrome
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Nanomedicines targeting activation of STING to reshape tumor immune microenvironment and enhance immunotherapeutic efficacy
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Biomaterial-enabled therapeutic modulation of cGAS-STING signaling for enhancing antitumor immunity
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Coordinated modulation of glucose metabolism and immunity via metal-drug nanovesicles for hepatocellular carcinoma therapy
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Arabinose- and xylose-modified analogs of 2′,3′-cGAMP act as STING agonists
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Antitumor Effect of Platinum-Modified STING Agonist MSA-2
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Activated STING-containing R-EVs from iPSC-derived MSCs promote antitumor immunity
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A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement
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AND logic nanoparticle for precision immunotherapy of metastatic cancers
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Targeting the cGAS-STING pathway as an inflammatory crossroad in coronavirus disease 2019 (COVID-19)
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