The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function
Open accessAbstract
Goblet cell diversity: An adult human has a gut surface area averaging 30 square meters that is bombarded daily by xenobiotics and microorganisms. Mucus synthesized by goblet cells supplies a protective barrier coating. Nyström et al. discovered that goblet cells are not all the same along the length of the gut; rather, they form different functional populations depending on location. Small-intestine mucus is laced with antimicrobial peptides and is permeable to small molecules; downstream, thicker mucus is generated that excludes bacteria and xenobiotics. Mucus oozes in thick plumes from goblet cells within the crypts to shield the stem cell niche. Between the crypts lie highly differentiated goblet cells producing permeable mucus. Together, both types of mucus form a network that shelters the gut epithelium. If, however, the intercrypt goblet cells become dysfunctional, the exposed epithelium is exposed to bacteria and vulnerable to developing colitis. Science , this issue p. eabb1590
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Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2
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Metadata
- Authors
- Nyström, E. E. L., Martinez-Abad, B., Arike, L., Birchenough, G. M. H., Nonnecke, E. B., Castillo, P. A., Svensson, F., Bevins, C. L., Hansson, G. C., & Johansson, M. E. V.
- Venue
- Science
- Published
- 2021-04-16
- Volume
- 372
- Issue
- 6539
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3153812969
- Cited by
- 348
- References
- 72
- FWCI
- 25.18
- Type
- journal article
- Language
- en
- Open access
- green
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