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Prevotella histicola ameliorates DSS-induced colitis by inhibiting IRE1α-JNK pathway of ER stress and NF-κB signaling

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Endoplasmic Reticulum Stress in Cancer

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Goblet cells need some stress

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Endoplasmic reticulum stress in the pathogenesis of chemotherapy‐induced mucositis: Physiological mechanisms and therapeutic implications

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Gut microbiota modulate intestinal inflammation by endoplasmic reticulum stress-autophagy-cell death signaling axis

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Unfolded protein response transcription factor XBP1 suppresses necroptosis-induced colitis by reinforcing the mucus barrier

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Bacillus subtilis HW2 enhances growth performance and alleviates gut injury via attenuation of endoplasmic reticulum stress and regulation of gut microbiota in broilers under necrotic enteritis challenge

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Essential roles of the unfolded protein response in intestinal physiology

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Integrin αVβ6: Autoantigen and Driver of Epithelial Remodeling in Colon and Bile Ducts in Primary Sclerosing Cholangitis and Inflammatory Bowel Disease

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Nanoparticles alleviate non-alcoholic steatohepatitis via ER stress sensor-mediated intestinal barrier damage and gut dysbiosis

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Endoplasmic reticulum stress in gut inflammation: Implications for ulcerative colitis and Crohn’s disease

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Nur77 as a novel regulator of Paneth cell differentiation and function

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Coated sodium butyrate and vitamin D3 supplementation improve gut health through influencing intestinal immunity, barrier, and microflora in early‐stage broilers

Gao, H., Zhao, X., Guo, Y., Li, Z., & Zhou, Z. (2024) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.13288 · Cited by 11 · see citing works

Cigarette Smoke Extract Induces MUC5AC Expression Through the ROS/ IP3R/Ca2+ Pathway in Calu-3 Cells

Wu, X., Zhang, G., & Du, X. (2024) · International Journal of COPD · doi:10.2147/copd.s469866 · Cited by 11 · see citing works

Galactooligosaccharides ameliorate dietary advanced glycation end product-induced intestinal barrier damage in C57BL/6 mice by modulation of the intestinal microbiome

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Oregano essential oil modulates colonic homeostasis and intestinal barrier function in fattening bulls

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Cross-kingdom-mediated detection of intestinal protozoa through NLRP6

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Adolescent social isolation decreases colonic goblet cells and impairs spatial cognition through the reduction of cystine

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The interplay between gut microbiota and the unfolded protein response: Implications for intestinal homeostasis preservation and dysbiosis-related diseases.

Mattia, M. D., Sallese, M., & Lopetuso, L. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107279 · Cited by 11 · see citing works

Sorafenib induces intestinal toxicity by disturbing gut microbiota and activating the LPS/TLR4/NF-κB signaling pathway in mice

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Targeting the unfolded protein response for cancer therapy: mitigating tumor adaptation and immune suppression

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Butyrate Protects against SARS-CoV-2-Induced Tissue Damage in Golden Hamsters

Yu, H., Yuan, L., Yan, Z., Zhou, M., Ye, J., Wu, K., Chen, W.-J., Chen, R., Xia, N., Guan, Y., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814191 · Cited by 9 · see citing works

IL-20 Activates ERK1/2 and Suppresses Splicing of X-Box Protein-1 in Intestinal Epithelial Cells but Does Not Improve Pathology in Acute or Chronic Models of Colitis

Moniruzzaman, M., Wong, K. Y., Wang, R., Symon, H., Mueller, A., Rahman, M. A., & Hasnain, S. Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010174 · Cited by 8 · see citing works

Tributyltin (TBT) toxicity: Effects on enteric neuronal plasticity and intestinal barrier of rats' duodenum

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Unfolded protein response: An essential element of intestinal homeostasis and a potential therapeutic target for inflammatory bowel disease

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Goblet cell-expressed microprotein FXYD3 determines gut homeostasis by maintaining mucus barrier integrity.

Yang, W., Xue, Y., Zhu, P., Jiang, Z.-N., He, R., Tian, H., Wang, T., Xiao, P., Lian, W., Cao, Q., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116502 · Cited by 9 · see citing works

IRE1β evolves to be a guardian of respiratory and gastrointestinal mucosa

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IRE1α recognizes a structural motif in cholera toxin to activate an unfolded protein response

Simpson, M. S., Luca, H. E. D., Cauthorn, S., Luong, P., Udeshi, N. D., Svinkina, T., Schmieder, S. S., Carr, S. A., Grey, M. J., & Lencer, W. I. (2024) · The Journal of Cell Biology · doi:10.1083/jcb.202402062 · Cited by 7 · see citing works

From mucus secretion to immune surveillance: the evolving roles of goblet cells in intestinal homeostasis and inflammation

Du, N., Zhang, K., Guo, J., Yan, W., & Xu, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1735230 · Cited by 6 · see citing works

CD73 mediated host purinergic metabolism in intestine contributes to the therapeutic efficacy of a novel mesenchymal-like endometrial regenerative cells against experimental colitis

Shao, B., Ren, S., Wang, Z.-B., Wang, H.-D., Zhang, J., Qin, H., Zhu, Y., Sun, C., Xu, Y., Li, X., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1155090 · Cited by 6 · see citing works

KDELR2 is necessary for chronic obstructive pulmonary disease airway Mucin5AC hypersecretion via an IRE1α/XBP‐1s‐dependent mechanism

Wu, X., Du, F., Zhang, A., Zhang, G., Xu, R., & Du, X. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70125 · Cited by 6 · see citing works

Synergy of secoisolariciresinol diglucoside and fructooligosaccharide in enhancement of the intestinal mucus barrier by relieving ER stress and regulating the gut microbiome

Zhang, L., Ji, M., Li, N., Yu, J., Yan, G., Yan, D., Zhang, Y., Liu, Q., Sun, L., Liu, X., et al. (2025) · Food & Function · doi:10.1039/d5fo01526j · Cited by 4 · see citing works

High-fat diet, intestinal microecology and bone loss

Wang, N., Xue, T., & Li, Y. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-01013-z · Cited by 4 · see citing works

Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Yuan, Z., Xia, Z., Ling, L., Xie, J., & Zhang, F. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13728 · Cited by 4 · see citing works

Nanoscale Viscometry Reveals an Inherent Mucus Defect in Cystic Fibrosis

Ponomarchuk, O., Boudreault, F., Gryczyński, I., Lee, B. H., Dzyuba, S. V., Fudala, R., Gryczynski, Z. K., Hanrahan, J. W., & Grygorczyk, R. (2025) · ACS Nano · doi:10.1021/acsnano.4c14927 · Cited by 4 · see citing works

ER stress-related mRNA-lncRNA co-expression gene signature predicts the prognosis and immune implications of esophageal cancer.

Li, F., Ma, J., Yan, C., & Qi, Y. (2022) · PubMed Central · Cited by 4 · see citing works

The Role of Crosstalk Between the Unfolded Protein Response and Autophagy in Diseases Associated with Sympathetic Nervous System Imbalance: Mechanisms and Therapeutic Perspectives

Xu, B., Yang, Y., & Wang, R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031282 · Cited by 3 · see citing works

High-fat diet-induced obesity disrupts the gut microbiome and mucus secretion to aggravate experimental colitis

Wang, Y., Zhao, L., Huang, S., Peng, J., Wu, K., & Wu, M. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117245 · Cited by 2 · see citing works

Impacts of trichothecene mycotoxins on human colonic epithelial cells: molecular mechanisms and signaling pathways

Li, S., Chun-min, Y., & Ou, S. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.11.024 · Cited by 2 · see citing works

Rhubarb extract rebuilding the mucus homeostasis and regulating mucin-associated flora to relieve constipation

Gao, H., He, C., Xin, S., Hua, R., Du, Y., Wang, B., Gong, F., Yu, X., Pan, L., Liang, C., et al. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702231211859 · Cited by 1 · see citing works

Coordinated transcriptional networks program organelle expansion and metabolic flows for high endothelial morphology and function

Bi, Y., Brulois, K., Ayesha, A., Xiang, M., Ballet, R., Ocón, B., Dinh, T. T., Lazarus, N. H., Kunte, M., Ramos, G., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.07.014 · Cited by 1 · see citing works

IRE1α and IRE1β Protect Intestinal Epithelium and Suppress Colorectal Tumorigenesis through Distinct MechanismsPreprint

Deng, R., Wang, M., Promlek, T., Druelle-Cedano, C., Murad, R., Davidson, N., & Kaufman, R. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.01.651751 · Cited by 1 · see citing works

An RNA regulates iron homeostasis and host mucus colonization in Bacteroides thetaiotaomicronPreprint

Prezza, G., Fansler, R. T., Guest, T., Mädler, G., Schlauch, H., Zhu, W., & Westermann, A. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.08.672848 · Cited by 1 · see citing works

Structural basis for recognition of unfolded proteins by the ER stress sensor ERN1/IRE1αPreprint

Simpson, M. S., Luca, H. E. D., Cauthorn, S., Luong, P., Udeshi, N. D., Svinkina, T., Schmieder, S. S., Carr, S. A., Grey, M. J., & Lencer, W. I. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.20.545791

A Mouse Model of SARS-CoV-2-Driven Acute Maladaptive Responses and Chronic Systemic DiseasesPreprint

Kenney, D., Unali, G., Tseng, A. E., Léger, J., Matsuo, M., O’Connell, A. K., McConney, C., Good, S., Norton, J., Feitosa-Suntheimer, F., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.13.670105

Research Progress on the Secretion of MUC2 and Its Influence on the Pathogenesis of Colorectal Cancer

刘, 钰. (2025) · Hans Journal of Biomedicine · doi:10.12677/hjbm.2025.155105

Fortilin binds IRE1β to facilitate mucin 5AC expression via the IRE1β/XBP1 signaling pathway

Pinkaew, D., Pal, U., Fujise, K., Dellis, C., & Folz, R. J. (2025) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2025-0065oc

Mapping intestinal microenvironment heterogeneity in Hirschsprung's disease by spatial transcriptomics: Role of THBS1 in macrophage polarization and neural stem cell regulation

Li, J., Du, J., Hou, L., Luo, Q., & Kang, Q. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102254

Cell surface GRP78 and the UPR pathway as novel promising therapeutic targets in cancer: an insight into the treatment of acute leukemia by using GRP78-CART cells

Román-Anguiano, N. G., Gutiérrez-Muñoz, P. A., Ángeles-Floriano, T., Martínez‐Rodríguez, N., Gutiérrez‐Kobeh, L., Martínez, M. D. C. J., & Valle‐Rios, R. (2026) · Clinical & Translational Oncology · doi:10.1007/s12094-026-04413-6

Endoplasmic reticulum stress in the logic of ulcerative colitis development

Московцев, А. А., Zaichenko, D. M., Astafeva, I. R., Morozov, S. G., Папышева, О. В., Харитонова, Л. А., & Babayan, M. L. (2026) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-245-1-99-108

Endoplasmic reticulum stress as a mechanistic link between nutrition and inflammatory bowel disease

Seylan, M., Arslan, Ş., & Besler, H. T. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1915419

Codonopsis pilosula inulin-type fructan CPA ameliorates diarrhea-predominant irritable bowel syndrome via regulation of ER stress-induced autophagy and modulation of gut microbiota

Tian, L., Bai, Y., Wang, S., Wang, C., Gao, J., Zhou, J., & Xiang, W. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1715972

From Monomer to Mesh: The Biochemical Maturation of Gel-Forming Mucin Glycoproteins

Bendek, M., & Fass, D. (2026) · Biochemistry · doi:10.1021/acs.biochem.6c00607

The epithelial-specific ER stress sensor IRE1β enables host-microbiota crosstalk to affect colon goblet cell development [preprint]

Grey, M. J., Luca, H. E. D., Ward, D. V., Kreulen, I. A. M., Foley, S. E., Thiagarajah, J. R., McCormick, B. A., Turner, J. R., & Lencer, W. I. (2021) · The Journal of the American Medical Association (JAMA) Network (American Medical Association)

The Epithelial‐Specific ER Stress Sensor IRE1β Enables Host‐Microbiota Crosstalk to Affect Colon Goblet Cell Development

Grey, M. J., Luca, H. E. D., Ward, D. V., Kreulen, I. A. M., Foley, S. E., Thiagarajah, J. R., McCormick, B. A., Turner, J. R., & Lencer, W. I. (2022) · The FASEB Journal · doi:10.1096/fasebj.2022.36.s1.r1937 · Cited by 1 · see citing works

Goblet cells need some stress

Johansson, M., & Hansson, G. C. (2022) · Journal of Clinical Investigation · doi:10.1172/jci162030 · Cited by 29 · see citing works

Microbes and microbial products that induce ERN2 expression in colonic goblet cells

Vitti, H. (2025) · OpenBU (Boston University)

Su1479: THE EPITHELIAL-SPECIFIC ER STRESS SENSOR IRE1β ENABLES HOSTMICROBIOTA CROSSTALK TO AFFECT COLON GOBLET CELL DEVELOPMENT

Grey, M. J., Luca, H. E. D., Ward, D. V., Thiagarajah, J. R., McCormick, B. A., Turner, J. R., & Lencer, W. I. (2022) · Gastroenterology · doi:10.1016/s0016-5085(22)61401-x