The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Open accessAbstract
Promising antiviral protease inhibitors: With no vaccine or proven effective drug against the virus that causes coronavirus disease 2019 (COVID-19), scientists are racing to find clinical antiviral treatments. A promising drug target is the viral main protease M pro , which plays a key role in viral replication and transcription. Dai et al. designed two inhibitors, 11a and 11b, based on analyzing the structure of the M pro active site. Both strongly inhibited the activity of M pro and showed good antiviral activity in cell culture. Compound 11a had better pharmacokinetic properties and low toxicity when tested in mice and dogs, suggesting that this compound is a promising drug candidate. Science , this issue p. 1331
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Metadata
- Authors
- Dai, W., Zhang, B., Jiang, X.-M., Su, H., Li, J., Zhao, Y., Xie, X., Jin, Z., Peng, J., Liu, F., Li, C., Li, Y., Bai, F., Wang, H., Cheng, X., Cen, X., Hu, S., Yang, X., Wang, J., Liu, X., Xiao, G., Jiang, H., Rao, Z., Zhang, L.-K., Xu, Y., Yang, H., & Liu, H.
- Venue
- Science
- Published
- 2020-06-19
- Volume
- 368
- Issue
- 6497
- Pages
- 1331-1335
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3020300207
- Cited by
- 1,478
- References
- 8
- FWCI
- 35.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Dai, W., Zhang, B., Jiang, X.-M., Su, H., Li, J., Zhao, Y., Xie, X., Jin, Z., Peng, J., Liu, F., Li, C., Li, Y., Bai, F., Wang, H., Cheng, X., Cen, X., Hu, S., Yang, X., Wang, J., . . . Liu, H. (2020). Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science. https://doi.org/10.1126/science.abb4489
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