The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
Open accessAbstract
The COVID-19 RNA-synthesizing machine: Many in the scientific community have mobilized to understand the virus that is causing the global coronavirus disease 2019 (COVID-19) pandemic. Gao et al. focused on a complex that plays a key role in the replication and transcription cycle of the virus. They used cryo–electron microscopy to determine a 2.9-angstrom-resolution structure of the RNA-dependent RNA polymerase nsp12, which catalyzes the synthesis of viral RNA, in complex with two cofactors, nsp7 and nsp8. nsp12 is a target for nucleotide analog antiviral inhibitors such as remdesivir, and the structure may provide a basis for designing new antiviral therapeutics. Science , this issue p. 779
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Features and development of Coot
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Coronavirus biology and replication: implications for SARS-CoV-2
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Fast and accurate protein structure search with Foldseek
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Fast and accurate protein structure search with Foldseek
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“6W9C (16)], RNA-dependent RNA polymerase [RdRPNsp7/Nsp82/Nsp12, 6M71 (17)], RNA helicase [∼99% identical SARS-CoV Nsp13, 6JYT (18)], endoribonuclease [Nsp15, 6VWW (19)] and 2′-O-methyltransferase [Nsp16, 6WVN (20)].”
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Yin, W., Mao, C., Luan, X., Shen, D.-D., Shen, Q., Su, H., Wang, X., Zhou, F., Zhao, W., Gao, M., et al. (2020) · Science · doi:10.1126/science.abc1560 · Cited by 1,219
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Metadata
- Authors
- Gao, Y., Yan, L., Huang, Y., Liu, F., Zhao, Y., Cao, L., Wang, T., Sun, Q., Ming, Z., Zhang, L., Ge, J., Zheng, L., Zhang, Y., Wang, H., Zhu, Y., Zhu, C., Hu, T., Hua, T., Zhang, B., Yang, X., Li, J., Yang, H., Liu, Z., Xu, W., Guddat, L. W., Wang, Q., Lou, Z., & Rao, Z.
- Venue
- Science
- Published
- 2020-05-15
- Volume
- 368
- Issue
- 6492
- Pages
- 779-782
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3015429854
- Cited by
- 1,609
- References
- 25
- FWCI
- 40.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gao, Y., Yan, L., Huang, Y., Liu, F., Zhao, Y., Cao, L., Wang, T., Sun, Q., Ming, Z., Zhang, L., Ge, J., Zheng, L., Zhang, Y., Wang, H., Zhu, Y., Zhu, C., Hu, T., Hua, T., Zhang, B., . . . Rao, Z. (2020). Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science. https://doi.org/10.1126/science.abb7498
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