The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Broad neutralization of SARS-related viruses by human monoclonal antibodies
Open accessAbstract
Seeking broad protection: As scientists develop therapeutic antibodies and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the risk of emergent coronaviruses makes it important to also identify broadly protective antibodies. Wec et al. isolated and characterized hundreds of antibodies against the viral spike protein of SARS-CoV-2 from the memory B cells of a survivor of the 2003 outbreak caused by the related coronavirus, SARS-CoV. In both of these viruses, the spike protein facilitated viral entry by binding to the angiotensin-converting enzyme 2 (ACE2) receptor on human cells. The antibodies targeted multiple sites on the spike protein, but of nine antibodies that showed strong cross-neutralization, eight targeted the domain that binds to ACE2. These eight antibodies also neutralized a bat SARS-related virus. Illuminating the epitopes on the viral spike protein that bind cross-neutralizing antibodies could guide the design of broadly protective vaccines. Science , this issue p. 731
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Metadata
- Authors
- Wec, A. Z., Wrapp, D., Herbert, A. S., Maurer, D. P., Haslwanter, D., Sakharkar, M., Jangra, R. K., Dieterle, M. E., Lilov, A., Huang, D., Tse, L. V., Johnson, N. V., Hsieh, C.-L., Wang, N., Nett, J. H., Champney, E., Burnina, I., Brown, M., Lin, S., Sinclair, M., Johnson, C., Pudi, S., Bortz, R., Wirchnianski, A. S., Laudermilch, E., Florez, C., Fels, J. M., O’Brien, C. M., Graham, B. S., Nemazee, D., Burton, D. R., Baric, R. S., Voss, J. E., Chandran, K., Dye, J. M., McLellan, J. S., & Walker, L. M.
- Venue
- Science
- Published
- 2020-08-07
- Volume
- 369
- Issue
- 6504
- Pages
- 731-736
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3034816694
- Cited by
- 539
- References
- 13
- FWCI
- 14.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wec, A. Z., Wrapp, D., Herbert, A. S., Maurer, D. P., Haslwanter, D., Sakharkar, M., Jangra, R. K., Dieterle, M. E., Lilov, A., Huang, D., Tse, L. V., Johnson, N. V., Hsieh, C.-L., Wang, N., Nett, J. H., Champney, E., Burnina, I., Brown, M., Lin, S., . . . Walker, L. M. (2020). Broad neutralization of SARS-related viruses by human monoclonal antibodies. Science. https://doi.org/10.1126/science.abc7424
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