IgA dominates the early neutralizing antibody response to SARS-CoV-2
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Abstract
Early specific antibody responses against SARS-CoV-2 include IgG, IgM, and IgA, but IgA may neutralize virus and control infection to a larger extent.
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Neutralization titers measured by the S-Fuse reporter assay correlate with those from a pseudovirus neutralization assay.
“Of note, we previously reported a correlation between neutralization titers obtained with the S-Fuse reporter assay and a pseudovirus neutralization assay 38 .”
From Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies (2021) · cites this paper as [38]
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- Authors
- Sterlin, D., Mathian, A., Miyara, M., Mohr, A., Anna, F., Claër, L., Quentric, P., Fadlallah, J., Devilliers, H., Ghillani, P., Gunn, C., Hockett, R., Mudumba, S., Guihot, A., Luyt, C.-E., Mayaux, J., Beurton, A., Fourati, S., Bruel, T., Schwartz, O., Lacorte, J.-M., Yssel, H., Parizot, C., Dorgham, K., Charneau, P., Amoura, Z., & Gorochov, G.
- Affiliations
- Inserm (FR)
- Institut Pasteur (FR)
- Département d’Immunologie, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Pitié-Salpêtrière, 83 boulevard de l’Hôpital, 75013 Paris, France.
- Genalyte (United States) (US)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Sterlin, Delphine
- Mathian, Alexis
- Miyara, Makoto
- Mohr, Audrey
- Anna, François
- Amoura, Zahir
- Gorochov, Guy
- ORCID
- Sterlin, Delphine
- Mathian, Alexis
- Miyara, Makoto
- Mohr, Audrey
- Anna, François
- Claër, Laetitia
- Quentric, Paul
- Fadlallah, Jehane
- Devilliers, Hervé
- Ghillani, Pascale
- Gunn, Cary
- Hockett, Rick
- Mudumba, Sasi
- Guihot, Amélie
- Luyt, Charles-Edouard
- Mayaux, Julien
- Beurton, Alexandra
- Fourati, Salma
- Bruel, Timothée
- Schwartz, Olivier
- Lacorte, Jean-Marc
- Yssel, Hans
- Parizot, Christophe
- Dorgham, Karim
- Charneau, Pierre
- Amoura, Zahir
- Gorochov, Guy
- Venue
- Science Translational Medicine
- Published
- 2021-01-20
- Volume
- 13
- Issue
- 577
- Pages
- eabd2223
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7857408
- OpenAlex
- W3112389805
- Cited by
- 1,037
- References
- 52
- Citations by year
- 2026: 39 · 2025: 69 · 2024: 116 · 2023: 169 · 2022: 286 · 2021: 317 · 2020: 39
- FWCI
- 26.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Science Translational Medicine (publishedVersion, cc-by)
- medRxiv (acceptedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- Funders
- Agence Nationale de la Recherche (ANR Flash COVID19 program, ANR-10-INSB-04-01)
- Fondation de France
- Conseil Régional, Île-de-France, DIM-1-Health
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Keywords
- SARS-CoV-2, COVID-19 pandemic, IgA, neutralizing antibodies, humoral immune response, plasmablasts, mucosal immunity, saliva, bronchoalveolar lavage fluid, IgG, IgM, antibody-secreting cells, reinfection protection, vaccine design
- MeSH terms
- COVID-19, SARS-CoV-2, Antibodies, Viral, Bronchoalveolar Lavage Fluid, Humans, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Longitudinal Studies, Saliva, Time Factors, Biomarkers, Case-Control Studies, Host-Pathogen Interactions, Immunity, Humoral, Antibodies, Neutralizing
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