The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges
Open accessAbstract
Flexible spikes: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein enables viral entry into host cells by binding to the angiotensin-converting enzyme 2 (ACE2) receptor and is a major target for neutralizing antibodies. About 20 to 40 spikes decorate the surface of virions. Turoňová et al. now show that the spike is flexibly connected to the viral surface by three hinges that are well protected by glycosylation sites. The flexibility imparted by these hinges may explain how multiple spikes act in concert to engage onto the flat surface of a host cell. Science , this issue p. 203
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Ng, K. W., Faulkner, N., Cornish, G. H., Rosa, A., Harvey, R., Hussain, S., Ulferts, R., Earl, C., Wrobel, A. G., Benton, D. J., et al. (2020) · Science · doi:10.1126/science.abe1107 · Cited by 886
SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography
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Metadata
- Authors
- Turoňová, B., Sikora, M., Schürmann, C., Hagen, W. J. H., Welsch, S., Blanc, F. E. C., von Bülow, S., Gecht, M., Bagola, K., Hörner, C., van Zandbergen, G., Landry, J., de Azevedo, N. T. D., Mosalaganti, S., Schwarz, A., Covino, R., Mühlebach, M. D., Hummer, G., Krijnse Locker, J., & Beck, M.
- Venue
- Science
- Published
- 2020-10-09
- Volume
- 370
- Issue
- 6513
- Pages
- 203-208
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3058836816
- Cited by
- 652
- References
- 8
- FWCI
- 14.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Turoňová, B., Sikora, M., Schürmann, C., Hagen, W. J. H., Welsch, S., Blanc, F. E. C., von Bülow, S., Gecht, M., Bagola, K., Hörner, C., van Zandbergen, G., Landry, J., de Azevedo, N. T. D., Mosalaganti, S., Schwarz, A., Covino, R., Mühlebach, M. D., Hummer, G., Krijnse Locker, J., & Beck, M. (2020). In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges. Science. https://doi.org/10.1126/science.abd5223
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
