The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
A single-cell atlas of the normal and malformed human brain vasculature
Open accessAbstract
Cerebrovascular diseases are a leading cause of death and neurologic disability. Further understanding of disease mechanisms and therapeutic strategies requires a deeper knowledge of cerebrovascular cells in humans. We profiled transcriptomes of 181,388 cells to define a cell atlas of the adult human cerebrovasculature, including endothelial cell molecular signatures with arteriovenous segmentation and expanded perivascular cell diversity. By leveraging this reference, we investigated cellular and molecular perturbations in brain arteriovenous malformations, which are a leading cause of stroke in young people, and identified pathologic endothelial transformations with abnormal vascular patterning and the ontology of vascularly derived inflammation. We illustrate the interplay between vascular and immune cells that contributes to brain hemorrhage and catalog opportunities for targeting angiogenic and inflammatory programs in vascular malformations.
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Fast, sensitive and accurate integration of single-cell data with Harmony
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Inference and analysis of cell-cell communication using CellChat
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Dimensionality reduction for visualizing single-cell data using UMAP
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CellChat for systematic analysis of cell–cell communication from single-cell transcriptomics
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A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Yao, Z., van Velthoven, C. T. J., Kunst, M., Zhang, M., McMillen, D., Lee, C., Jung, W., Goldy, J., Abdelhak, A., Aitken, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06812-z · Cited by 1,203
Vascular endothelial cell development and diversity
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What is a cell type and how to define it?
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Hypertension, Neurovascular Dysfunction, and Cognitive Impairment
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Metadata
- Authors
- Winkler, E. A., Kim, C. N., Ross, J. M., Garcia, J. H., Gil, E., Oh, I., Chen, L. Q., Wu, D., Catapano, J. S., Raygor, K., Narsinh, K., Kim, H., Weinsheimer, S., Cooke, D. L., Walcott, B. P., Lawton, M. T., Gupta, N., Zlokovic, B. V., Chang, E. F., Abla, A. A., Lim, D. A., & Nowakowski, T. J.
- Venue
- Science
- Published
- 2022-03-04
- Volume
- 375
- Issue
- 6584
- Pages
- eabi7377-eabi7377
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4210553032
- Cited by
- 322
- References
- 84
- FWCI
- 19.96
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Winkler, E. A., Kim, C. N., Ross, J. M., Garcia, J. H., Gil, E., Oh, I., Chen, L. Q., Wu, D., Catapano, J. S., Raygor, K., Narsinh, K., Kim, H., Weinsheimer, S., Cooke, D. L., Walcott, B. P., Lawton, M. T., Gupta, N., Zlokovic, B. V., Chang, E. F., . . . Nowakowski, T. J. (2022). A single-cell atlas of the normal and malformed human brain vasculature. Science. https://doi.org/10.1126/science.abi7377
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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