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CMV Status Drives Distinct Trajectories of CD4+ T Cell Differentiation

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Cellular heterogeneity of circulating CD4+CD8+ double-positive T cells characterized by single-cell RNA sequencing

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Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a

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Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma

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Single-cell analysis to understand the diversity of immune cell types that drive disease pathogenesis

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Single-cell transcriptomic landscape of nucleated cells in umbilical cord blood

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Cytokine profiling and transcriptomics in mononuclear cells define immune variants in Meniere Disease

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scBFA: modeling detection patterns to mitigate technical noise in large-scale single-cell genomics data

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Adaptive Immunity to Dengue Virus: Slippery Slope or Solid Ground for Rational Vaccine Design?

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Technical Advances in Single-Cell RNA Sequencing and Applications in Normal and Malignant Hematopoiesis

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EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

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Unravelling the heterogeneity and dynamic relationships of tumor-infiltrating T cells by single-cell RNA sequencing analysis

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Single-cell temporal analysis of natural dengue infection reveals skin-homing lymphocyte expansion one day before defervescence

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Cytotoxic Tph subset with low B-cell helper functions and its involvement in systemic lupus erythematosus

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Tumor infiltrating and peripheral CD4+ILT2+ T cells are a cytotoxic subset selectively inhibited by HLA-G in clear cell renal cell carcinoma patients

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SARS-CoV-2: Immunity, Challenges with Current Vaccines, and a Novel Perspective on Mucosal Vaccines

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Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort

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Cytotoxic CD4+ T-cells specific for EBV capsid antigen BORF1 are maintained in long-term latently infected healthy donors

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G Protein–Coupled Receptor 56 Characterizes CTLs and Reflects the Progression of Lung Cancer Patients

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CD4+ teff cell heterogeneity: the perspective from single-cell transcriptomics

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Transcriptomic immune profiles of human flavivirus‐specific T‐cell responses

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An ultra-sensitive T-cell receptor detection method for TCR-Seq and RNA-Seq data

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Single-Cell TCR and Transcriptome Analysis: An Indispensable Tool for Studying T-Cell Biology and Cancer Immunotherapy

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BCL11B and the NuRD complex cooperatively guard T‐cell fate and inhibit OPA1‐mediated mitochondrial fusion in T cells

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Role of CD4+ T cells in cancer immunity: a single-cell sequencing exploration of tumor microenvironment

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Single-cell transcriptomics of human gut T cells identifies cytotoxic CD4+CD8A+ T cells related to mouse CD4 cytotoxic T cells

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Memory T Cells in Flavivirus Vaccination

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Characterizing the cellular and molecular variabilities of peripheral immune cells in healthy recipients of BBIBP-CorV inactivated SARS-CoV-2 vaccine by single-cell RNA sequencing

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CD4+CTLs in Fibrosing Mediastinitis Linked to Histoplasma capsulatum

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Transfer learning between preclinical models and human tumors identifies a conserved NK cell activation signature in anti-CTLA-4 responsive tumors

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CReSCENT: CanceR Single Cell ExpressioN Toolkit

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Single-cell transcriptomic analyses of T cells in chronic HCV-infected patients dominated by DAA-induced interferon signaling changes

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Application of single-cell RNA sequencing in embryonic development

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CD4 T cells acquire Eomesodermin to modulate cellular senescence and aging

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Cytotoxic CD4+ T cells: origin, biological functions, diseases and therapeutic targets

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Human CD4 cytotoxic T lymphocytes mediate potent tumor control in humanized immune system mice

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Differential Runx3, Eomes, and T‐bet expression subdivides MS‐associated CD4 + T cells with brain‐homing capacity

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T Cell Receptor Repertoire Analysis Reveals Signatures of T Cell Responses to Human Mycobacterium tuberculosis

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Concomitant Cytotoxic Effector Differentiation of CD4+ and CD8+ T Cells in Response to EBV-Infected B Cells

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Distinct features of a peripheral T helper subset that drives the B cell response in dengue virus infection

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TransSynW: A single-cell RNA-sequencing based web application to guide cell conversion experiments

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Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus

Trzupek, D., Lee, M., Hamey, F., Wicker, L. S., Todd, J. A., & Ferreira, R. C. (2022) · Wellcome Open Research · doi:10.12688/wellcomeopenres.16883.2 · Cited by 16

VEGF-A enhances the cytotoxic function of CD4+ cytotoxic T cells via the VEGF-receptor 1/VEGF-receptor 2/AKT/mTOR pathway

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Single-cell RNA profiling of blood CD4+ T cells identifies distinct helper and dysfunctional regulatory clusters in children with SLE

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Macrophage Membrane‐Biomimetic Multi‐Layered Nanoparticles Targeting Synovial Angiogenesis for Osteoarthritis Therapy

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Centenarians—the way to healthy vascular ageing and longevity: a review from VascAgeNet

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CD4+CD8+ T-Lymphocytes in Xenogeneic and Human Graft-versus-Host Disease

Hussen, K. A., Michonneau, D., Biajoux, V., Keita, S., Dubouchet, L., Nelson, E., Setterblad, N., Buanec, H. L., Bouaziz, J., Guimiot, F., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.579776 · Cited by 14

The transcriptomics profiling of blood CD4 and CD8 T-cells in narcolepsy type I

Khajavi, L., Nguyen, X., Queriault, C., Chabod, M., Barateau, L., Dauvilliers, Y. A., Zytnicki, M., & Liblau, R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1249405 · Cited by 15

Cytotoxicity-Related Gene Expression and Chromatin Accessibility Define a Subset of CD4+ T Cells That Mark Progression to Type 1 Diabetes

Bediaga, N. G., Garnham, A. L., Naselli, G., Bandala‐Sanchez, E., Stone, N. L., Cobb, J. E., Harbison, J. E., Wentworth, J. M., Ziegler, A., Couper, J., et al. (2022) · Diabetes · doi:10.2337/db21-0612 · Cited by 13

Nectin Family Ligands Trigger Immune Effector Functions in Health and Autoimmunity

Hermans, D., van Beers, L., & Broux, B. (2023) · Biology · doi:10.3390/biology12030452 · Cited by 13

CD4 + follicular helper-like T cells are key players in anti-tumor immunityPreprint

Singh, D. K., Ganesan, A., Panwar, B., Eschweiler, S., Hanley, C. J., Madrigal, A., Ramírez-Suástegui, C., Wang, A., Clarke, J. D., Wood, O., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.08.898346 · Cited by 14

Transcriptomics of Acute DENV-Specific CD8+ T Cells Does Not Support Qualitative Differences as Drivers of Disease Severity

Grifoni, A., Voic, H., Yu, E. D., Mateus, J., Fung, K., Wang, A., Seumois, G., Silva, A. D. D., Tennekoon, R. N., Premawansa, S., et al. (2022) · Vaccines · doi:10.3390/vaccines10040612 · Cited by 12

CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells

Hao, Y., Miraghazadeh, B., Chand, R., Davies, A. R., Cardinez, C., Kwong, K., Downes, M. B., Sweet, R. A., Cañete, P. F., D'Orsogna, L. J. A., et al. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01027-8 · Cited by 12

The role of CD4+ T cells in visceral leishmaniasis; new and emerging roles for NKG7 and TGFβ

Na, J., & Engwerda, C. R. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1414493 · Cited by 13

Prognostic value of the baseline circulating T cell receptor β chain diversity in advanced lung cancer

Wang, J., Bie, Z., Zhang, Y., Li, L., Zhu, Y., Zhang, Y., Nie, X., Zhang, P., Cheng, G., Di, X., et al. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1899609 · Cited by 12

Activated CD4+ T Cells and Highly Differentiated Alloreactive CD4+ T Cells Distinguish Operationally Tolerant Liver Transplantation Recipients

Duizendstra, A. A., de Knegt, R. J., Mancham, S., Klepper, M., Roelen, D. L., Brand‐Schaaf, S. H., Boor, P. P. C., Doukas, M., de Man, R. A., Sprengers, D., et al. (2021) · Liver Transplantation · doi:10.1002/lt.26188 · Cited by 12

Molecular mechanisms of autophagic memory in pathogenic T cells in human arthritis

Kumar, P., Yao, L. J., Saidin, S., Paleja, B. S., van Loosdregt, J., Chua, C. J. H., Arkachaisri, T., Consolaro, A., Gattorno, M., Martini, A., et al. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.07.014 · Cited by 12

Single‐cell transcriptomic and T cell antigen receptor analysis of human cytomegalovirus ( hCMV )‐specific memory T cells reveals effectors and pre‐effectors of CD8 + ‐ and CD4 + ‐cytotoxic T cells

Kar, R., Chattopadhyay, S., Sharma, A., Sharma, K. M. T. K., Sinha, S., Arimbasseri, G. A., & Patil, V. S. (2024) · Immunology · doi:10.1111/imm.13783 · Cited by 11

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Lyu, M., Liu, Y., Zhou, J. F., Lai, H., Ruan, H., Wu, D., Shun, Z., Zhou, X., Ma, W., Huang, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202415678 · Cited by 12

Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children

Badolato-Corrêa, J., Carvalho, F. R., Paiva, I. A., Familiar-Macedo, D., Dias, H. G., Pauvolid‐Corrêa, A., Fernandes-Santos, C., Lima, M. D. R. Q., Gandini, M., Silva, A. A., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.610456 · Cited by 11

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus

Trzupek, D., Lee, M., Hamey, F., Wicker, L. S., Todd, J. A., & Ferreira, R. C. (2021) · Wellcome Open Research · doi:10.12688/wellcomeopenres.16883.1 · Cited by 20

High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges

Nikolaou, C., Mühle, K., Schlickeiser, S., Japp, A. S., Matzmohr, N., Kunkel, D., Frentsch, M., & Thiel, A. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00230-3 · Cited by 11

Lung cancer vaccines to enhance immune checkpoint inhibitor therapy: evidence and future perspectives

Tang, Z., Zha, L., Liang, R., & Li, T. (2026) · Journal of Hematology & Oncology · doi:10.1186/s13045-026-01778-7 · Cited by 11

Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process

Zhang, C., Ren, T., Zhao, X., Su, Y., Wang, Q., Zhang, T., He, B., Chen, Y., Wu, L., Sun, L., et al. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00479-4 · Cited by 10

Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq

Lukyanov, D. K., Kriukova, V., Ladell, K., Shagina, I. A., Staroverov, D. B., Минасян, Б. Э., Fedosova, A. S., Shelyakin, P. V., Suchalko, O. N., Komkov, A. Y., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1536302 · Cited by 9

Heterogeneity of circulating CD4+CD8+ double-positive T cells characterized by scRNA-seq analysis and trajectory inference

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Transfer learning between preclinical models and human tumors identifies conserved NK cell activation signature in anti-CTLA-4 responsive tumorsPreprint

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Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis

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Understanding and mitigating the impact of ambient mRNA contamination in single-cell RNA-sequencing analysis

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Alemtuzumab treatment exemplifies discordant immune effects of blood and cerebrospinal fluid in multiple sclerosis

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Antigen Receptor Sequence Reconstruction and Clonality Inference from scRNA-Seq Data

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Differential memory enrichment of cytotoxic CD4 T cells in Parkinson’s disease patients reactive to α-synuclein

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T cell-mediated SIV dissemination into the CNS: a single-cell transcriptomic analysis

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Landscape of Hopx expression in cells of the immune system

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Cell composition and expansion strategy can reduce the beneficial effect of AKT-inhibition on functionality of CD8+ T cells

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Cytotoxic Response of CD4 + T Cells Orchestrated by SLAMF4 in Rheumatoid Arthritis

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Distinct systemic immune responses in asymptomatic and symptomatic dengue virus infection

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A distinct subset of stem-cell memory is poised for the cytotoxicity program in CD4 + T cells in humans

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New advances in immune components mediating viral control in the CNS

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Immune responses to citrullinated and homocitrullinated peptides in healthy donors are not restricted to the HLA SE shared allele and can be selected into the memory pool

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Insights into the dynamics of memory, effector and apoptotic cytotoxic T lymphocytes in channel catfish, Ictalurus punctatus

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Single-Cell RNA Sequencing of Tocilizumab-Treated Peripheral Blood Mononuclear Cells as an in vitro Model of Inflammation

Zarinsefat, A., Hartoularos, G. C., Rychkov, D., Rashmi, P., Chandran, S., Vincenti, F. G., Yee, C. J., & Sarwal, M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.610682 · Cited by 5

TIM-3 ameliorates host responses to Salmonella infection by controlling iron driven CD4+ T cell differentiation and interleukin-10 formation

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GPR56 Outperforms CD319 as a Discriminative Marker for CD4 + Cytotoxic T Lymphocytes and Is Elevated in Primary Sjögren's Syndrome

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Hmmr Acts as a Key Regulator in the ADSCs Proliferation and Mitosis

Zhang, X., Huang, D., Li, K., Han, C., Li, H., Cai, L., & Liu, L. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10563-9 · Cited by 5

The Roles of RUNX Proteins in Lymphocyte Function and Anti-Tumor Immunity

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Expansion of a distinct cytotoxic CD4 TFH-cell cluster in lymph nodes of patients with complicated common variable immunodeficiency

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Single-cell T cell receptor sequencing of paired tissue and blood samples reveals clonal expansion of CD8+ effector T cells in patients with calcific aortic valve diseasePreprint

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Apheresis for the treatment of relapses in MS and NMOSD: reduced antibody reactivities, gene expression changes and potential clinical response indicators

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Comprehensive analysis of antiviral adaptive immunity formation and reactivation down to single-cell levelPreprint

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Correction to: High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges

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A liver-infiltrating CD4+ Tfh1 cell response predicts HCV control, hepatitis, and seroconversion during acute infection

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TNBC Spatial Transcriptomic Analysis across Clinical States Reveals Subtype-Specific Networks and Immunosuppressive Niches

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Co-expression of B7-H3 and LAG3 represents cytotoxicity of CD4+ T cells in humans

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ScRNA-Seq reveals T cell immunity in COVID-19 patients and implications for immunotherapy

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Single-cell immune profiling reveals the impact of antiretroviral therapy on HIV-1-induced immune dysfunction, T cell clonal expansion, and HIV-1 persistence in vivoPreprint

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CD28+ CD8+ TCR αβ+ peripheral T lymphocytes are cytolytic precursors for CD28− effector cells

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Identifying memory CD4+ T cell precursors

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A distinct subset of stem-cell memory is poised for the cytotoxicity program in CD4 + T cells in humans

Kar, R., Sinha, S., Khatun, Z., Sharma, A., & Patil, V. S. (2026) · Science Advances · doi:10.1126/sciadv.ady6423 · Cited by 6

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