Cited by 263T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesSingle-cell and spatial transcriptomics

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Precursors of human CD4 + cytotoxic T lymphocytes identified by single-cell transcriptome analysis

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Patil, Veena S., Madrigal, Ariel, Schmiedel, Benjamin J., Clarke, James, O’Rourke, Patrick, de Silva, Aruna D., Harris, Eva, Peters, Bjoern, Seumois, Gregory, Weiskopf, Daniela, Sette, Alessandro, Vijayanand, Pandurangan·2018·Science Immunology

DOI 10.1126/sciimmunol.aan8664PMC PMC5931334

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Abstract

Human CD4 + cytotoxic T lymphocytes that play a vital role in antiviral immunity are highly heterogeneous.

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Result
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Additional file 10 of Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection
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Additional file 11 of Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection
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Additional file 6 of Evaluation of novel Epstein-Barr virus-derived antigen formulations for monitoring virus-specific T cells in pediatric patients with infectious mononucleosis
Fischer, F., Mücke, J., Werny, L., Gerrer, K., Mihatsch, L., Zehetmaier, S., Riedel, I., Geisperger, J., Bodenhausen, M., Schulte-Hillen, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26734032
Additional file 1 of Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection
Ryan, F. J., Hope, C. M., Masavuli, M. G., Lynn, M. A., Mekonnen, Z. A., Yeow, A. E. L., García-Valtanen, P., Al-Delfi, Z., Gummow, J., Ferguson, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18393537
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Additional file 4 of Evaluation of novel Epstein-Barr virus-derived antigen formulations for monitoring virus-specific T cells in pediatric patients with infectious mononucleosis
Fischer, F., Mücke, J., Werny, L., Gerrer, K., Mihatsch, L., Zehetmaier, S., Riedel, I., Geisperger, J., Bodenhausen, M., Schulte-Hillen, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26734026
Additional file 1 of Evaluation of novel Epstein-Barr virus-derived antigen formulations for monitoring virus-specific T cells in pediatric patients with infectious mononucleosis
Fischer, F., Mücke, J., Werny, L., Gerrer, K., Mihatsch, L., Zehetmaier, S., Riedel, I., Geisperger, J., Bodenhausen, M., Schulte-Hillen, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26734017
Additional file 2 of Evaluation of novel Epstein-Barr virus-derived antigen formulations for monitoring virus-specific T cells in pediatric patients with infectious mononucleosis
Fischer, F., Mücke, J., Werny, L., Gerrer, K., Mihatsch, L., Zehetmaier, S., Riedel, I., Geisperger, J., Bodenhausen, M., Schulte-Hillen, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26734020
Additional file 5 of Evaluation of novel Epstein-Barr virus-derived antigen formulations for monitoring virus-specific T cells in pediatric patients with infectious mononucleosis
Fischer, F., Mücke, J., Werny, L., Gerrer, K., Mihatsch, L., Zehetmaier, S., Riedel, I., Geisperger, J., Bodenhausen, M., Schulte-Hillen, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26734029
Additional file 7 of Evaluation of novel Epstein-Barr virus-derived antigen formulations for monitoring virus-specific T cells in pediatric patients with infectious mononucleosis
Fischer, F., Mücke, J., Werny, L., Gerrer, K., Mihatsch, L., Zehetmaier, S., Riedel, I., Geisperger, J., Bodenhausen, M., Schulte-Hillen, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26734035
Additional file 2 of VEGF-A enhances the cytotoxic function of CD4+ cytotoxic T cells via the VEGF-receptor 1/VEGF-receptor 2/AKT/mTOR pathway
Chen, Z., Zhang, M., Liu, Y., Chen, Z., Wang, L., Wang, W., Wang, J., He, M., Shi, B., & Wang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26566088
Additional file 2 of Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection
Ryan, F. J., Hope, C. M., Masavuli, M. G., Lynn, M. A., Mekonnen, Z. A., Yeow, A. E. L., García-Valtanen, P., Al-Delfi, Z., Gummow, J., Ferguson, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18393540
Additional file 1 of High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges
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Additional file 3 of Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection
Ryan, F. J., Hope, C. M., Masavuli, M. G., Lynn, M. A., Mekonnen, Z. A., Yeow, A. E. L., García-Valtanen, P., Al-Delfi, Z., Gummow, J., Ferguson, C., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18393543
Additional file 3 of Evaluation of novel Epstein-Barr virus-derived antigen formulations for monitoring virus-specific T cells in pediatric patients with infectious mononucleosis
Fischer, F., Mücke, J., Werny, L., Gerrer, K., Mihatsch, L., Zehetmaier, S., Riedel, I., Geisperger, J., Bodenhausen, M., Schulte-Hillen, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26734023
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Sette, A., Weiskopf, D., & Grifoni, A. (2022) · ImmPort · doi:10.21430/m3zqi9uohm
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Authors: Patil, V. S., Madrigal, A., Schmiedel, B. J., Clarke, J., O’Rourke, P., de Silva, A. D., Harris, E., Peters, B., Seumois, G., Weiskopf, D., Sette, A., & Vijayanand, P.
Affiliations: La Jolla Institute for Immunology (US)
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
University of California, Berkeley (US)
Corresponding author: Vijayanand, Pandurangan
ORCID: Patil, Veena S.
Madrigal, Ariel
Schmiedel, Benjamin J.
Clarke, James
O’Rourke, Patrick
de Silva, Aruna D.
Harris, Eva
Peters, Bjoern
Seumois, Gregory
Weiskopf, Daniela
Sette, Alessandro
Vijayanand, Pandurangan
Venue: Science Immunology
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2018-01-26
Volume: 3
Issue: 19
ISSN: 2470-9468 (ISSN-L)
DOI: 10.1126/sciimmunol.aan8664
PMC: PMC5931334
OpenAlex: W2783929588
Cited by: 262
References: 74
Citations by year: 2026: 23 · 2025: 26 · 2024: 25 · 2023: 21 · 2022: 37 · 2021: 42 · 2020: 46 · 2019: 24 · 2018: 18
FWCI: 13.96
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Science Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
ePrints Soton (University of Southampton) (acceptedVersion)
Funders: NIH Office of the Director (award317527, U19AI118626, award317529, U19AI118610, award360682, R01HL114093, award360683, R24AI108564)
William K. Bowes Jr Foundation (award317531)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
Keywords: cytotoxic CD4+ T cells, T cell differentiation, TCR clonotypes, CD127, single-cell transcriptomics, T cell subsets
MeSH terms: Humans, Immunologic Memory, Leukocytes, Mononuclear, Lymphocyte Activation, Receptors, Antigen, T-Cell, T-Lymphocytes, Cytotoxic, CD4-Positive T-Lymphocytes, Gene Expression Profiling, Single-Cell Analysis, Transcriptome

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Precursors of human CD4 + cytotoxic T lymphocytes identified by single-cell transcriptome analysis

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