The m 6 A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis
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The m6A “reader” IMP2 promotes cytokine-induced kidney autoimmunity by posttranscriptional control of C/EBPβ/δ transcription factors.
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In AGN, IMP2 stabilized mRNAs encoding the transcription factors C/EBPβ and C/EBPδ, driving the expression of inflammatory genes such as Lipocalin-2 (LCN2).
“Similarly, in AGN, IMP2 stabilized mRNAs encoding the transcription factors C/EBPβ and C/EBPδ, driving the expression of inflammatory genes such as Lipocalin-2 (LCN2) [119].”
From IMPlications of IMP2 in RNA Biology and Disease (2025) · cites this paper as [119]
The Results section (“IMP2 binds Cebpd and Cebpb mRNAs”; page unavailable) reports that IMP2 helps stabilize Cebpd mRNA and promotes translation of both C/EBPδ and C/EBPβ. It explicitly says Cebpb mRNA stability was unaffected by IMP2 deficiency. The Introduction and Abstract link this C/EBP pathway to Lcn2 expression and AGN, but the claim incorrectly says IMP2 stabilized both transcription-factor mRNAs. (LLM, conf=0.91)
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- Authors
- Bechara, R., Amatya, N., Bailey, R. D., Li, Y., Aggor, F. E. Y., Li, D.-D., Jawale, C. V., Coleman, B. M., Dai, N., Gokhale, N. S., Taylor, T. C., Horner, S. M., Poholek, A. C., Bansal, A., Biswas, P. S., & Gaffen, S. L.
- Affiliations
- University of Pittsburgh (US)
- Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
- Massachusetts General Hospital (US)
- Duke Medical Center (US)
- Corresponding author
- Gaffen, Sarah L.
- ORCID
- Venue
- Science Immunology
- Published
- 2021-07-29
- Volume
- 6
- Issue
- 61
- ISSN
- 2470-9468 (ISSN-L)
- PMC
- PMC8404281
- OpenAlex
- W3174569344
- Cited by
- 89
- References
- 120
- Citations by year
- 2026: 15 · 2025: 16 · 2024: 15 · 2023: 19 · 2022: 17 · 2021: 6
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- National Institutes of Health (AI107825, DE022550, AI147383, DK104680, AI142354, AI125416)
- National Institute of Allergy and Infectious Diseases (AI147383, AI125416, AI142354)
- Wellcome
- Center for Research Computing, University of Pittsburgh
- Burroughs Wellcome Fund
- National Institute of Diabetes and Digestive and Kidney Diseases (DK104680)
- Rheumatology Research Foundation (N/A)
- National Institute of Dental and Craniofacial Research (DE022550)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- m6A RNA methylation, IGF2BP2, C/EBPβ, C/EBPδ, IL-17, TNF-α, post-transcriptional regulation, kidney autoimmunity, autoimmune inflammation
- MeSH terms
- Adenosine, Animals, Cell Line, Female, Humans, Inflammation, Male, Mice, Inbred C57BL, Tumor Necrosis Factor-alpha, Autoimmunity, RNA-Binding Proteins, Mice, Knockout, Interleukin-17, CCAAT-Enhancer-Binding Proteins, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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