Cited by 89RNA modifications and cancerSystemic Lupus Erythematosus ResearchT-cell and B-cell Immunology

The m 6 A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis

Open access
Bechara, Rami, Amatya, Nilesh, Bailey, Rachel D., Li, Yang, Aggor, Felix E. Y., Li, De-Dong, Jawale, Chetan V., Coleman, Bianca M. +8 more·2021·Science Immunology

Abstract

The m6A “reader” IMP2 promotes cytokine-induced kidney autoimmunity by posttranscriptional control of C/EBPβ/δ transcription factors.

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Registry

Crossref · 10.1126/sciimmunol.abd1287

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119 of 119 references verified0 citation errors · 0 not checkable

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  • In AGN, IMP2 stabilized mRNAs encoding the transcription factors C/EBPβ and C/EBPδ, driving the expression of inflammatory genes such as Lipocalin-2 (LCN2).

    “Similarly, in AGN, IMP2 stabilized mRNAs encoding the transcription factors C/EBPβ and C/EBPδ, driving the expression of inflammatory genes such as Lipocalin-2 (LCN2) [119].”

    From IMPlications of IMP2 in RNA Biology and Disease (2025) · cites this paper as [119]

    The Results section (“IMP2 binds Cebpd and Cebpb mRNAs”; page unavailable) reports that IMP2 helps stabilize Cebpd mRNA and promotes translation of both C/EBPδ and C/EBPβ. It explicitly says Cebpb mRNA stability was unaffected by IMP2 deficiency. The Introduction and Abstract link this C/EBP pathway to Lcn2 expression and AGN, but the claim incorrectly says IMP2 stabilized both transcription-factor mRNAs. (LLM, conf=0.91)

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1 of the 120 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. [60]Gokhale NS, Altered m(6)A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection. Mol Cell 77, 542– 555 (2020). 31810760 PMC7007864

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Authors
Bechara, R., Amatya, N., Bailey, R. D., Li, Y., Aggor, F. E. Y., Li, D.-D., Jawale, C. V., Coleman, B. M., Dai, N., Gokhale, N. S., Taylor, T. C., Horner, S. M., Poholek, A. C., Bansal, A., Biswas, P. S., & Gaffen, S. L.
Affiliations
  • University of Pittsburgh (US)
  • Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Massachusetts General Hospital (US)
  • Duke Medical Center (US)
Corresponding author
Gaffen, Sarah L.
Venue
Science Immunology
Published
2021-07-29
Volume
6
Issue
61
ISSN
2470-9468 (ISSN-L)
OpenAlex
W3174569344
Cited by
89
References
120
Citations by year
2026: 15 · 2025: 16 · 2024: 15 · 2023: 19 · 2022: 17 · 2021: 6
FWCI
4.47
Type
journal article
Language
en
Open access
Locations
  • Science Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion)
Funders
  • National Institutes of Health (AI107825, DE022550, AI147383, DK104680, AI142354, AI125416)
  • National Institute of Allergy and Infectious Diseases (AI147383, AI125416, AI142354)
  • Wellcome
  • Center for Research Computing, University of Pittsburgh
  • Burroughs Wellcome Fund
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK104680)
  • Rheumatology Research Foundation (N/A)
  • National Institute of Dental and Craniofacial Research (DE022550)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
m6A RNA methylation, IGF2BP2, C/EBPβ, C/EBPδ, IL-17, TNF-α, post-transcriptional regulation, kidney autoimmunity, autoimmune inflammation
MeSH terms
Adenosine, Animals, Cell Line, Female, Humans, Inflammation, Male, Mice, Inbred C57BL, Tumor Necrosis Factor-alpha, Autoimmunity, RNA-Binding Proteins, Mice, Knockout, Interleukin-17, CCAAT-Enhancer-Binding Proteins, Mice

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