Cited by 37Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

C/EBPβ/AEP Signaling Drives Alzheimer’s Disease Pathogenesis

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Xiong, Jing, Zhang, Zhentao, Ye, Keqiang·2023·Neuroscience Bulletin

Abstract

Alzheimer's disease (AD) is the most common type of dementia. Almost two-thirds of patients with AD are female. The reason for the higher susceptibility to AD onset in women is unclear. However, hormone changes during the menopausal transition are known to be associated with AD. Most recently, we reported that follicle-stimulating hormone (FSH) promotes AD pathology and enhances cognitive dysfunctions via activating the CCAAT-enhancer-binding protein (C/EBPβ)/asparagine endopeptidase (AEP) pathway. This review summarizes our current understanding of the crucial role of the C/EBPβ/AEP pathway in driving AD pathogenesis by cleaving multiple critical AD players, including APP and Tau, explaining the roles and the mechanisms of FSH in increasing the susceptibility to AD in postmenopausal females. The FSH-C/EBPβ/AEP pathway may serve as a novel therapeutic target for the treatment of AD.

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Authors
Xiong, J., Zhang, Z., & Ye, K.
Affiliations
  • Renmin Hospital of Wuhan University (CN)
  • Shenzhen Institutes of Advanced Technology (CN)
Corresponding author
Ye, Keqiang
Venue
Neuroscience Bulletin
Published
2023-02-03
Volume
39
Issue
7
Pages
1173-1185
ISSN
  • 1995-8218 (ISSN-L)
  • 1673-7067
OpenAlex
W4319057809
Cited by
37
References
135
Citations by year
2026: 7 · 2025: 20 · 2024: 10
FWCI
1.32
Type
journal article
Language
en
Open access
Locations
  • Neuroscience Bulletin (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (82271446)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, C/EBPβ, asparaginyl endopeptidase, follicle-stimulating hormone, menopause, postmenopausal women, amyloid precursor protein, tau protein, proteolytic cleavage, cognitive impairment, therapeutic target
MeSH terms
Alzheimer Disease, Female, Follicle Stimulating Hormone, Humans, Male, Signal Transduction, CCAAT-Enhancer-Binding Protein-beta, Cognitive Dysfunction

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