Cited by 570Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex

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Toy, Dean, Kugler, David, Wolfson, Martin, Bos, Tim Vanden, Gurgel, Jesse, Derry, Jonathan, Tocker, Joel, Peschon, Jacques·2006·The Journal of Immunology

Abstract

IL-17 is an inflammatory cytokine produced primarily by a unique lineage of CD4 T cells that plays critical roles in the pathogenesis of multiple autoimmune diseases. IL-17RA is a ubiquitously expressed receptor that is essential for IL-17 biologic activity. Despite widespread receptor expression, the activity of IL-17 is most classically defined by its ability to induce the expression of inflammatory cytokines, chemokines, and other mediators by stromal cells. The lack of IL-17 responsiveness in mouse stromal cells genetically deficient in IL-17RA is poorly complemented by human IL-17RA, suggesting the presence of an obligate ancillary component whose activity is species specific. This component is IL-17RC, a distinct member of the IL-17R family. Thus, the biologic activity of IL-17 is dependent on a complex composed of IL-17RA and IL-17RC, suggesting a new paradigm for understanding the interactions between the expanded family of IL-17 ligands and their receptors.

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Crossref · 10.4049/jimmunol.177.1.36

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  • IL-17A signaling is mediated through IL-17 receptor A (IL-17RA) and IL-17RC.

    “IL-17A signaling is mediated through IL-17 receptor A (IL-17RA) and IL-17RC,74,75”

    From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [75]

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Authors
Toy, D., Kugler, D., Wolfson, M., Bos, T. V., Gurgel, J., Derry, J., Tocker, J., & Peschon, J.
Affiliations
Amgen (United States) (US)
Venue
The Journal of Immunology
Published
2006-07-01
Volume
177
Issue
1
Pages
36-39
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
OpenAlex
W2114180142
Cited by
570
References
30
Citations by year
2026: 9 · 2025: 13 · 2024: 14 · 2023: 20 · 2022: 31 · 2021: 26 · 2020: 21 · 2019: 29 · 2018: 19 · 2017: 29 · 2016: 27 · 2015: 41 · 2014: 25 · 2013: 27 · 2012: 32
FWCI
21.11
Type
journal article
Language
en
Open access
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Amgen
Topics
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
IL-17, IL-17RA, IL-17RC, heteromeric receptors, IL-17 signaling, CD4+ T cells, stromal cells, autoimmune disease, inflammatory cytokines
MeSH terms
Animals, Cell Line, Cell Line, Transformed, Fibroblasts, Humans, Ligands, Mice, Inbred C57BL, Signal Transduction, Receptors, Interleukin, Mice, Knockout, Interleukin-17, Protein Subunits, Mice, Receptors, Interleukin-17

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