Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex
Open accessAbstract
IL-17 is an inflammatory cytokine produced primarily by a unique lineage of CD4 T cells that plays critical roles in the pathogenesis of multiple autoimmune diseases. IL-17RA is a ubiquitously expressed receptor that is essential for IL-17 biologic activity. Despite widespread receptor expression, the activity of IL-17 is most classically defined by its ability to induce the expression of inflammatory cytokines, chemokines, and other mediators by stromal cells. The lack of IL-17 responsiveness in mouse stromal cells genetically deficient in IL-17RA is poorly complemented by human IL-17RA, suggesting the presence of an obligate ancillary component whose activity is species specific. This component is IL-17RC, a distinct member of the IL-17R family. Thus, the biologic activity of IL-17 is dependent on a complex composed of IL-17RA and IL-17RC, suggesting a new paradigm for understanding the interactions between the expanded family of IL-17 ligands and their receptors.
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IL-17A signaling is mediated through IL-17 receptor A (IL-17RA) and IL-17RC.
“IL-17A signaling is mediated through IL-17 receptor A (IL-17RA) and IL-17RC,74,75”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [75]
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- Authors
- Toy, D., Kugler, D., Wolfson, M., Bos, T. V., Gurgel, J., Derry, J., Tocker, J., & Peschon, J.
- Affiliations
- Amgen (United States) (US)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-07-01
- Volume
- 177
- Issue
- 1
- Pages
- 36-39
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2114180142
- Cited by
- 570
- References
- 30
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 14 · 2023: 20 · 2022: 31 · 2021: 26 · 2020: 21 · 2019: 29 · 2018: 19 · 2017: 29 · 2016: 27 · 2015: 41 · 2014: 25 · 2013: 27 · 2012: 32
- FWCI
- 21.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amgen
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- IL-17, IL-17RA, IL-17RC, heteromeric receptors, IL-17 signaling, CD4+ T cells, stromal cells, autoimmune disease, inflammatory cytokines
- MeSH terms
- Animals, Cell Line, Cell Line, Transformed, Fibroblasts, Humans, Ligands, Mice, Inbred C57BL, Signal Transduction, Receptors, Interleukin, Mice, Knockout, Interleukin-17, Protein Subunits, Mice, Receptors, Interleukin-17
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