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Act1, a U-box E3 Ubiquitin Ligase for IL-17 Signaling
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The adaptor protein Act1 functions as a ubiquitin ligase to mediate interleukin-17 receptor–dependent activation of nuclear factor-κB.
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“GATA4 induced the expression of TRAF3IP2, an E3 ubiquitin ligase for TRAF6 (51) (Fig. 4C)”
From The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. (2015) · cites this paper as [51]
In the citing paper
“Act1 has E3 Ubiquitin ligase activity”
From The IL-17 Family of Cytokines in Health and Disease (2019) · cites this paper as Liu et al., 2009
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Cites
SWISS-MODEL: an automated protein homology-modeling server
Schwede, T. F. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg520 · Cited by 5,592
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
Interleukin-17 Family Members and Inflammation
Kolls, J. K., & Lindén, A. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.018 · Cited by 2,371
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
Wang, C., Deng, L., Hong, M., Akkaraju, G. R., Inoue, J.-I., & Chen, Z. J. (2001) · Nature · doi:10.1038/35085597 · Cited by 2,125
Self-citationDeng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C., & Chen, Z. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00126-4 · Cited by 1,872
Self-citationThe IL-23/IL-17 axis in inflammation
Iwakura, Y. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28508 · Cited by 1,068
QMEAN: A comprehensive scoring function for model quality assessment
Benkert, P., Tosatto, S. C. E., & Schomburg, D. (2007) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.21715 · Cited by 1,030
Conti, H. R., Shen, F., Nayyar, N., Stocum, E., Sun, J. N., Lindemann, M. J., Ho, A. W., Hai, J. H., Yu, J. J., Jung, J. W., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081463 · Cited by 1,024
Essential function for the kinase TAK1 in innate and adaptive immune responses
Sato, S., Sanjo, H., Takeda, K., Ninomiya‐Tsuji, J., Yamamoto, M., Kawai, T., Matsumoto, K., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1255 · Cited by 974
Nonproteolytic Functions of Ubiquitin in Cell Signaling
Chen, Z. J., & Sun, L. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.014 · Cited by 948
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Items 101–200 of 224
Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses
Xie, Z.-H., Qu, Y., Leng, Y., Sun, W., Ma, S., Wei, J., Hu, J.-G., & Zhang, X. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s79431 · Cited by 40
Immune diseases caused by mutations in kinases and components of the ubiquitin system
Cohen, P. (2014) · Nature Immunology · doi:10.1038/ni.2892 · Cited by 40
Liu, S., Zhang, Q., Chen, C., Ge, D., Qu, Y., Chen, R., Fan, Y.-M., Li, N., Tang, W. W., Zhang, W., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7296 · Cited by 40
Li, X., Ye, C., Mulati, M., Sun, L., & Qian, F. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113992 · Cited by 36
Self-citationCruz, A., Ludovico, P., Torrado, E., Gama, J. B., Sousa, J., Gaifem, J., Appelberg, R., Rodrigues, F. J. S., Cooper, A. M., Pedrosa, J., et al. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00498 · Cited by 35
Debackere, K., Marcelis, L., Demeyer, S., Bempt, M. V., Mentens, N., Gielen, O., Jacobs, K., Broux, M., Verhoef, G. E. G., Michaux, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24037-4 · Cited by 35
Tang, X., Ghimire, S., Liu, W., Fu, X., Zhang, H., Sun, F., Zhang, N., & Si, H. (2021) · Physiologia Plantarum · doi:10.1111/ppl.13475 · Cited by 35
Cheng, P., Yu, F., Chen, S.-J., Feng, X. M., Jia, Z.-H., Hu, S., Cui, X.-L., Zhou, Y., Niu, Q., Liang, L., et al. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123674 · Cited by 36
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Ladjevac, N., Milovanović, M., Jevtović, A., Arsenijević, D., Stojanović, B., Stojanovic, M. D., Stojanović, B., Arsenijević, N., Arsenijević, A., & Milovanović, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129874 · Cited by 36
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Sun, H., Zhong, D., Wang, C., Sun, Y., Zhao, J., & Li, G. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000491810 · Cited by 32
Zepp, J. A., Wu, L., Wen, Q., Ouyang, W., Aronica, M. A., ERZURUM, S. C., & Li, X. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402647 · Cited by 33
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Marı́n, I. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-331 · Cited by 31
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Lin, W., Wang, N., Zhou, K., Su, F., Jiang, Y., Shou, J., Liu, H., Ma, C., Qian, Y., Wang, K., et al. (2018) · EMBO Reports · doi:10.15252/embr.201744951 · Cited by 30
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Wu, L., Zepp, J. A., & Li, X. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0106-3_13 · Cited by 32
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Self-citationMa, Z., Yu, Z., Hu, C., & Yi, H. (2019) · Frontiers in Immunology · doi:10.2139/ssrn.3441816 · Cited by 31
Yoshida, T., Das, N. A., Carpenter, A. J., Izadpanah, R., Kumar, S., Gautam, S., Bender, S. B., Siebenlist, U. K., & Chandrasekar, B. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109690 · Cited by 30
Lambert, S., Swindell, W. R., Tsoi, L. C., Stoll, S. W., & Elder, J. T. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.12.032 · Cited by 30
Zhu, Z., Wang, L., Hao, R., Zhao, B., Sun, L., & Ye, R. D. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600447 · Cited by 29
Pathak, J. L., Fang, Y., Chen, Y., Ye, Z., Guo, X., Yan, Y., Zha, J., Liang, D., Ke, X., Yang, L., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.628139 · Cited by 29
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Wu, L., Wang, C., Boisson, B., Misra, S., Rayman, P. A., Finke, J. H., Puel, A., Casanova, J., & Li, X. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400715 · Cited by 28
Self-citationHe, R.-R., Wu, S., Gao, R., Chen, J., Peng, Q., Hu, H., Zhu, L., Du, Y., Sun, W., Ma, X., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001223 · Cited by 27
Sønder, S. U., Paun, A., Ha, H., Johnson, P. F., & Siebenlist, U. K. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103233 · Cited by 28
Yang, Y., Tan, H.-B., Zhang, X., Zhang, Y., Lin, Q., Huang, M., Lin, Z., Mo, J.-Z., Zhang, Y., Lan, T., et al. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115165 · Cited by 26
Roussel, L., & Rousseau, S. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.11.088 · Cited by 26
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Ho, A. W., Garg, A. V., Monin, L., Simpson-Abelson, M. R., Kinner, L. B., & Gaffen, S. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070168 · Cited by 25
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“Act1 is both an adaptor for TRAFs and an E3 ubiquitin ligase necessary for NF-kB activation by IL-17 (18).”
BackgroundRyzhakov, G., Blazek, K. D., & Udalova, I. A. (2011) · Journal of Molecular Evolution · doi:10.1007/s00239-011-9450-7 · Cited by 22
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Sun, H., Zhong, D., Jin, J., Liu, Q., Wang, H., & Li, G. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.10.046 · Cited by 21
Guo, W., Xu, F., Zhuang, Z., Liu, Z., Xie, J., & Bai, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.662362 · Cited by 21
Lei, H., Li, Y., Xu, H., Wang, Z., Li, X., Liu, M., & Wu, Y. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2040-8 · Cited by 21
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Dai, X., Murakami, M., Shiraishi, K., Muto, J., Tohyama, M., Mori, H., Utsunomiya, R., & Sayama, K. (2022) · European Journal of Immunology · doi:10.1002/eji.202149706 · Cited by 20
Yang, Y., Chen, Y., Yu, L., Zhang, X., Shang, J., Fan, J., Zhang, R., Ren, J., & Duan, X. (2022) · Inflammation Research · doi:10.1007/s00011-022-01674-z · Cited by 19
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Hile, G. A., Kahlenberg, J. M., & Gudjonsson, J. E. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108405 · Cited by 18
Liu, S., Wu, F., Wu, Z., Li, Y., Zhang, S., & Yu, N. (2019) · Experimental Dermatology · doi:10.1111/exd.13871 · Cited by 16
Bulek, K., Chen, X., Parron, V. I., Sundaram, A., Herjan, T., Ouyang, S., Liu, C., Majors, A. K., Zepp, J. A., Gao, J., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801025 · Cited by 16
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Huang, S. U.-S., & O’Sullivan, K. M. (2022) · doi:10.20944/preprints202203.0021.v1 · Cited by 65
Ryzhakov, G., Blazek, K. D., Lai, C., & Udalova, I. A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200428 · Cited by 13
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Lipovsky, A. I., Slivka, P. F., Su, Z., Wang, Y., Paulsboe, S. E., Wetter, J. B., Namovic, M. T., Gauvin, D. M., Perron, D. C., Gauld, S. B., et al. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.10.029 · Cited by 11
Klyucherev, T. O., Peshkova, M., Yurkanova, M. D., Kosheleva, N. V., Svistunov, A. А., Liang, X., & Timashev, P. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125766 · Cited by 12
Chen, C., Zhang, Q., Liu, S., Lambrechts, M., Qu, Y., & You, Z. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00343 · Cited by 12
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Ma, X., Kuai, L., Song, J., Luo, Y., Ru, Y., Wang, M., Gao, C., Jiang, W., Liu, Y., Bai, Y., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116194 · Cited by 10
Giltiay, N. V., Lu, Y., Cullen, J. L., Jørgensen, T. N., Shlomchik, M. J., & Li, X. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300152 · Cited by 10
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Li, H., Hong, W., Jin, X., Li, G., Zhou, G., & Fan, L. (2019) · FEBS Letters · doi:10.1002/1873-3468.13380 · Cited by 10
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Li, X., Zhang, K., Yang, X., Cheng, Y., Huang, S., Deng, W., Hu, Y., Li, T., Duan, H., Mo, X., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01325-3 · Cited by 9
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Jiang, Y.-F., Wang, Y.-N., Xue, K., Ma, J., Xu, S., Wang, K., & Guo, P. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01371-4 · Cited by 7
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Shen, J., Fu, B., Wu, Y., Yang, Y., Lin, X., Lin, H., Liu, H., & Huang, W. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.811611 · Cited by 6
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Dong, X., Han, X., Gao, J., Li, C., Luo, Z., Zhu, Z., Su, Y., Yao, S., Zhang, F., Xu, J., et al. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118796 · Cited by 5
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Yu, N., Lambert, S., Bornstein, J. J., Nair, R. P., Enerbäck, C., & Elder, J. T. (2018) · Genes and Immunity · doi:10.1038/s41435-017-0007-7 · Cited by 5
Ren, X., Zhou, N., Li, D., Jing, Y., Wang, Y., He, G., Ma, S., Sun, Y., & Wang, Y. N. (2023) · Phytomedicine Plus · doi:10.1016/j.phyplu.2023.100505 · Cited by 5
Tian, L., Wang, Y., Shen, L., Zong, M., Fan, J., Lu, Y., Cheng, X., Du, L., Zhang, L., & Xiao, F. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04695-7 · Cited by 4
Self-citationCosta, K. A., Araujo, A. C., Fonseca, P. A. D. S., Silva, H. T., Menegatto, L. S., de Freitas, L. A., Cardoso, C. M., Filho, I. C., Otto, P. I., da Costa, R. L. D., et al. (2025) · Veterinary Parasitology · doi:10.1016/j.vetpar.2025.110498 · Cited by 7
Genetic alterations of interleukin-17 and related genes in human prostate cancer.
Lan, R., Zhang, K., Niu, T., & You, Z. (2019) · PubMed Central · Cited by 4
Lan, M., Lei, X., Yu, L., Mazur, M., Ning, J., Lee, J., Bai, L., Gu, H., Li, Q., Yang, L., et al. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.115333 · Cited by 3
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Li, Y., Vyas, S., Dráber, P., Bechara, R., & Gaffen, S. L. (2026) · Science Immunology · doi:10.1126/sciimmunol.adq6406 · Cited by 2
Pan, H., Wang, T., Che, Y., Li, X., Cui, Y., Chen, Q., Wu, Z., Yi, J., & Wang, B. (2023) · Infection and Drug Resistance · doi:10.2147/idr.s424746 · Cited by 2
Self-citationChou, S.-P., Chuang, Y., & Chen, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910691 · Cited by 2
The Ubiquitin–Proteasome System in Asthma: Mechanisms and Therapeutic Possibilities
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Verdier, J., & Ruemmele, F. M. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2013.829471 · Cited by 2
Fine-tuning immunity: ubiquitin-dependent regulation of interleukin-17A expression by Th17 cells
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Ramachandran, R., Manan, A., Kim, E., & Choi, S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148092 · Cited by 1
Zhou, X., Xie, J., Yu, S.-F., Li, S., & Chi, C. (2025) · Aquaculture · doi:10.1016/j.aquaculture.2025.743295 · Cited by 1
Interleukin-17A (IL-17A): Molecular Mechanisms and Its Roles in Immune and Neuroimmune Systems
Sanaka, S., Kubo, A., Kamiya, S., Nakamura, K., & Sasaki, T. (2026) · Receptors · doi:10.3390/receptors5020016 · Cited by 3
Vunakizumab for IL-17A–Mediated Diseases: A Review in Psoriasis and Spondyloarthritis
Yan, H., Chen, Y., Song, Y., Yan, M., & Yan, K. (2026) · Biologics · doi:10.2147/btt.s500475 · Cited by 1
IL-17 in B Cell Biology and Systemic Lupus Erythematosus
Doreau, A., Bastid, J., Bélot, A., Eliaou, J., & Bonnefoy, N. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9371-7_21 · Cited by 1
Lai, Y., & Dong, C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.10014-1 · Cited by 1
Zhang, W., Wang, L., Wang, Y., Wang, Y., & Qingrong, G. (2020) · Molecular Breeding · doi:10.1007/s11032-020-01181-1 · Cited by 1
RetractedIL-17 Receptor Family: Structure, Signal Transduction, and Function
Shen, F. (2012) · Springer eBooks · doi:10.1007/978-3-0348-0522-3_3
Structure and IL-17 Receptor Signaling
Tsang, M., & Gaffen, S. L. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9371-7_9
EXPRESSION OF TH17-LYMPHOCYTE ADAPTER – TRAF3IP2 IN THE SKIN OF PSORIASIS PATIENTS
Khairutdinov, V. R., Mikhailichenko, A. F., Piskunova, A. A., Бычкова, Н. В., Samtsov, A. V., & Имянитов, Е. Н. (2014) · Medical Immunology (Russia) · doi:10.15789/1563-0625-2011-6-597-602
THE ROLE OF TRAF6 PHOSPHORYLATION IN Src/TRAF6-MEDIATED IKK, JNK, Akt ACTIVATION AND TUMORIGENESIS
Jeong, Y. S. (2014) · Digital Commons-TMC (Texas Medical Center)
Metadata
- Authors
- Liu, C., Qian, W., Qian, Y., Giltiay, N. V., Lu, Y., Swaidani, S., Misra, S., Deng, L., Chen, Z. J., & Li, X.
- Affiliations
- Cleveland Clinic (US)
- Department of Immunology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44915, USA.
- The University of Texas Southwestern Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Liu, Caini
- Qian, Youcun
- Li, Xiaoxia
- ORCID
- Venue
- Science Signaling
- Published
- 2009-10-13
- Volume
- 2
- Issue
- 92
- Pages
- ra63-ra63
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC3182834
- OpenAlex
- W2145468317
- Cited by
- 224
- References
- 34
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 3 · 2023: 9 · 2022: 15 · 2021: 12 · 2020: 8 · 2019: 18 · 2018: 13 · 2017: 13 · 2016: 11 · 2015: 11 · 2014: 16 · 2013: 13 · 2012: 15
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL098935)
- National Institute of General Medical Sciences (R01GM080271)
- National Institute of Allergy and Infectious Diseases (R01AI065470)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- Act1, U-box E3 ubiquitin ligase, IL-17 signaling, IL-17 receptor, TRAF6, NF-κB activation, Th17 cells, ubiquitination, inflammation
- MeSH terms
- Amino Acid Sequence, Animals, Humans, Mice, Transgenic, Molecular Sequence Data, Mutation, Signal Transduction, Cytokines, Sequence Homology, Amino Acid, Interleukin-17, Ubiquitin-Protein Ligases, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins, TNF Receptor-Associated Factor 6, Adaptor Proteins, Signal Transducing, Mice
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