Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac
Open accessAbstract
Whereas NGF promotes neurite outgrowth, the precursor form proNGF triggers neurite retraction.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Pro-BDNF binding to p75NTR induces pruning of axons and dendrites.
“Pro-BDNF binding to p75NTR has also been shown to induce pruning of axons and dendrites85,88–91 and promote long-term depression (LTD)92–94.”
From Neuronal plasticity and neurotrophic factors in drug responses (2017) · cites this paper as [90]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Lifeact: a versatile marker to visualize F-actin
Riedl, J., Crevenna, A. H., Kessenbrock, K., Yu, J. H., Neukirchen, D., Bista, M., Bradke, F., Jenne, D., Holak, T. A., Werb, Z., et al. (2008) · Nature Methods · doi:10.1038/nmeth.1220 · Cited by 2,189 · see citing works
Regulation of Cell Survival by Secreted Proneurotrophins
Lee, R., Kermani, P., Teng, K. K., & Hempstead, B. L. (2001) · Science · doi:10.1126/science.1065057 · Cited by 1,670 · see citing works
Self-citationFunctions of the neurotrophins during nervous system development: What the knockouts are teaching us
Snider, W. D. (1994) · Cell · doi:10.1016/0092-8674(94)90048-5 · Cited by 1,428 · see citing works
Teng, H. K., Teng, K. K., Lee, R., Wright, S., Tevar, S., Almeida, R. D., Kermani, P., Torkin, R., Chen, Z.-Y., Lee, F. S., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5123-04.2005 · Cited by 1,013 · see citing works
Self-citationSortilin is essential for proNGF-induced neuronal cell death
Nykjaer, A., Lee, R., Teng, K. K., Jansen, P., Madsen, P., Nielsen, M. S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T. E., et al. (2004) · Nature · doi:10.1038/nature02319 · Cited by 962 · see citing works
Self-citationNeurotrophins regulate dendritic growth in developing visual cortex
McAllister, A. K., Lo, D. C., & Katz, L. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90171-x · Cited by 959 · see citing works
AXON RETRACTION AND DEGENERATION IN DEVELOPMENT AND DISEASE
Luo, L., & O’Leary, D. D. M. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135632 · Cited by 844 · see citing works
Brain‐derived neurotrophic factor and the development of structural neuronal connectivity
Cohen‐Cory, S., Kidane, A. H., Shirkey, N. J., & Marshak, S. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20774 · Cited by 589 · see citing works
Neuronal Chemotaxis: Chick Dorsal-Root Axons Turn Toward High Concentrations of Nerve Growth Factor
Gundersen, R. W., & Barrett, J. N. (1979) · Science · doi:10.1126/science.493992 · Cited by 523 · see citing works
Role of fascin in filopodial protrusion
Vignjevic, D. M., Kojima, S.-I., Aratyn-Schaus, Y., Danciu, O. C., Svitkina, T., & Borisy, G. G. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200603013 · Cited by 485 · see citing works
Debant, A., Serra‐Pages, C., Seipel, K., O'Brien, S., Tang, M. H. Y., Park, S. H., & Streuli, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.11.5466 · Cited by 467 · see citing works
Shutes, A., Onesto, C., Picard, V., Leblond, B., Schweighoffer, F., & Der, C. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703571200 · Cited by 336 · see citing works
Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury
Harrington, A. W., Leiner, B., Blechschmitt, C., Arevalo, J. C., Lee, R., Mörl, K., Meyer, M., Hempstead, B. L., Yoon, S. O., & Giehl, K. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305755101 · Cited by 269 · see citing works
Self-citationMigrastatin analogues target fascin to block tumour metastasis
Chen, L., Yang, S., Jakoncic, J., Zhang, J. J., & Huang, X.-Y. (2010) · Nature · doi:10.1038/nature08978 · Cited by 268 · see citing works
Ono, S., Yamakita, Y., Yamashiro, S., Matsudaira, P. T., Gnarra, J. R., Obinata, T., & Matsumura, F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.4.2527 · Cited by 185 · see citing works
Domeniconi, M., Zampieri, N., Spencer, T., Hilaire, M., Mellado, W., Chao, M. V., & Filbin, M. T. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.029 · Cited by 180 · see citing works
Self-citationAssay of Cdc42, Rac, and Rho GTPase Activation by Affinity Methods
Planat‐Benard, V., & Bokoch, G. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)45028-8 · Cited by 173 · see citing works
Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning
Xu, N., & Henkemeyer, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2254 · Cited by 158 · see citing works
Suter, U., Heymach, J. V., & Shooter, E. M. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07778.x · Cited by 153 · see citing works
Estrach, S., Schmidt, S., Diriong, S., Penna, A., Blangy, A., Fort, P., & Debant, A. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00658-9 · Cited by 152 · see citing works
Trio Mediates Netrin-1-Induced Rac1 Activation in Axon Outgrowth and Guidance
Briançon‐Marjollet, A., Ghogha, A., Nawabi, H., Triki, I., Auziol, C., Fromont, S., Piché, C., Enslen, H., Chébli, K., Cloutier, J., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00998-07 · Cited by 150 · see citing works
Volosin, M., Trotter, C., Cragnolini, A., Kenchappa, R. S., Light, M., Hempstead, B. L., Carter, B. D., & Friedman, W. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2841-08.2008 · Cited by 149 · see citing works
Self-citationNeurotrophin receptors: Old friends with new partners
Schecterson, L. C., & Bothwell, M. A. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20767 · Cited by 132 · see citing works
Chattopadhyay, M., Mata, M. M., & Fink, D. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5530-07.2008 · Cited by 126 · see citing works
Huber, L. J., & Chao, M. V. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1019 · Cited by 117 · see citing works
Self-citationNeurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin
Shonukan, T., Bagayogo, I., McCrea, P., Chao, M. V., & Hempstead, B. L. (2003) · Oncogene · doi:10.1038/sj.onc.1206561 · Cited by 107 · see citing works
Self-citationMolecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
Feng, D., Kim, T., Özkan, E., Light, M. P., Torkin, R., Teng, K. K., Hempstead, B. L., & García, K. C. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.12.030 · Cited by 105 · see citing works
Self-citationA Cell Active Chemical GEF Inhibitor Selectively Targets the Trio/RhoG/Rac1 Signaling Pathway
Bouquier, N., Vignal, E., Charrasse, S., Weill, M., Schmidt, S., Léonetti, J., Blangy, A., & Fort, P. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.04.012 · Cited by 101 · see citing works
Kantor, D. B., & Kolodkin, A. L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00364-7 · Cited by 80 · see citing works
Analysis of G-protein-coupled receptor dimerization following chemokine signaling
Mellado, M., Martínez‐A, C., & Rodrı́guez-Frade, J. M. (2002) · Methods · doi:10.1016/s1046-2023(02)00093-2 · Cited by 67 · see citing works
Seipel, K., Medley, Q. G., Kedersha, N., Zhang, X. A., O’Brien, S. P., Serra‐Pages, C., Hemler, M. E., & Streuli, M. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.12.1825 · Cited by 67 · see citing works
Kidins220/ARMS regulates Rac1-dependent neurite outgrowth by direct interaction with the RhoGEF Trio
Neubrand, V. E., Thomas, C., Schmidt, S., Debant, A., & Schiavo, G. (2010) · Journal of Cell Science · doi:10.1242/jcs.064055 · Cited by 64 · see citing works
Multiple novel isoforms of Trio are expressed in the developing rat brain
McPherson, C. E., Eipper, B. A., & Mains, R. E. (2005) · Gene · doi:10.1016/j.gene.2004.12.028 · Cited by 62 · see citing works
Self-citationKim, T., & Hempstead, B. L. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.118 · Cited by 52 · see citing works
Self-citationFerraro, F., Ma, X., Sobota, J. A., Eipper, B. A., & Mains, R. E. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-05-0503 · Cited by 49 · see citing works
Self-citationSong, J. K., & Giniger, E. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22525 · Cited by 40 · see citing works
Naska, S., Lin, D. C. C., Miller, F. D., & Kaplan, D. R. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.05.015 · Cited by 36 · see citing works
Kichev, A., Ilieva, E. V., Piñol‐Ripoll, G., Podlesniy, P., Ferrer, I., Portero‐Otín, M., Pamplona, R., & Espinet, C. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090018 · Cited by 29 · see citing works
Axon Pruning in the Developing Vertebrate Hippocampus
Faulkner, R. L., Low, L. K., & Cheng, H.-J. (2006) · Developmental Neuroscience · doi:10.1159/000096207 · Cited by 28 · see citing works
Rossol, M., Quandt, D., & Hauschildt, S. (2001) · Cell Motility and the Cytoskeleton · doi:10.1002/1097-0169(200102)48:2 · Cited by 14 · see citing works
Becker, B. E., & Gard, D. L. (2000) · Cell Motility and the Cytoskeleton · doi:10.1002/1097-0169(200012)47:4 · Cited by 13 · see citing works
The receptor tyrosine phosphatase CRYP? affects growth cone morphology
Mueller, B. K., Ledig, M. M., & Wahl, S. (2000) · Journal of Neurobiology · doi:10.1002/1097-4695(200008)44:2 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/7260130 · Cited by 456 · see citing works
The Role of BDNF on Neural Plasticity in Depression
Yang, T., Nie, Z., Shu, H., Kuang, Y., Chen, X., Cheng, J., Yu, S., & Liu, H. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00082 · Cited by 435 · see citing works
BDNF and Hippocampal Synaptic Plasticity
Leal, G., Bramham, C. R., & Duarte, C. B. (2017) · Vitamins and Hormones · doi:10.1016/bs.vh.2016.10.004 · Cited by 425 · see citing works
Brain-derived neurotrophic factor in mood disorders and antidepressant treatments
Castrén, E., & Kojima, M. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.010 · Cited by 337 · see citing works
Yang, J., Harte‐Hargrove, L. C., Siao, C.-J., Marinic, T. E., Clarke, R., Ma, Q., Jing, D., LaFrancois, J. J., Bath, K. G., Mark, W. H., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.040 · Cited by 333 · see citing works
Self-citationSchwann cell interactions with axons and microvessels in diabetic neuropathy
Gonçalves, N. P., Vægter, C. B., Andersen, H., Østergaard, L., Calcutt, N. A., & Jensen, T. S. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.201 · Cited by 308 · see citing works
Longo, F. M., & Massa, S. M. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4024 · Cited by 294 · see citing works
Neuronal plasticity and neurotrophic factors in drug responses
Castrén, E., & Antila, H. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.61 · Cited by 284 · see citing works
Neurotrophin signalling: novel insights into mechanisms and pathophysiology
Mitre, M., Mariga, A., & Chao, M. V. (2017) · Clinical Science · doi:10.1042/cs20160044 · Cited by 263 · see citing works
Self-citationIbáñez, C. F., & Simi, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.03.007 · Cited by 238 · see citing works
Gray, J. D., Milner, T. A., & McEwen, B. S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.034 · Cited by 242 · see citing works
Pinton, S., Sampaio, T. B., Savall, A. S. P., & Gutierrez, M. Z. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.205084 · Cited by 219 · see citing works
Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction
Anastasia, A., Deinhardt, K., Chao, M. V., Will, N. E., Irmady, K., Lee, F. S., Hempstead, B. L., & Bracken, C. (2013) · Nature Communications · doi:10.1038/ncomms3490 · Cited by 215 · see citing works
Self-citationBrain-Derived Neurotrophic Factor: Three Ligands, Many Actions.
Hempstead, B. L. (2015) · Europe PMC (PubMed Central) · Cited by 203 · see citing works
Self-citationThe Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met
McGregor, C., & ENGLISH, A. W. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00522 · Cited by 176 · see citing works
Cellular and molecular mechanisms regulating neuronal growth by brain‐derived neurotrophic factor
González‐Gutiérrez, A., Moya‐Alvarado, G., González-Billault, C. E., & Bronfman, F. C. (2016) · Cytoskeleton · doi:10.1002/cm.21312 · Cited by 154 · see citing works
Houlton, J., Abumaria, N., Hinkley, S. F. R., & Clarkson, A. N. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00790 · Cited by 138 · see citing works
The Biological Functions and Signaling Mechanisms of the p75 Neurotrophin Receptor
Kraemer, B. R., Yoon, S. O., & Carter, B. D. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-45106-5_6 · Cited by 125 · see citing works
Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS
Domènech-Estévez, E., Baloui, H., Meng, X.-S., Zhang, Y., Deinhardt, K., Dupree, J. L., Einheber, S., Chrast, R., & Salzer, J. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3521-15.2016 · Cited by 111 · see citing works
Self-citationDeinhardt, K., & Chao, M. V. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.054 · Cited by 114 · see citing works
Self-citationDeciphering Proneurotrophin Actions
Hempstead, B. L. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-45106-5_2 · Cited by 106 · see citing works
Self-citationSorCS2 is required for BDNF-dependent plasticity in the hippocampus
Glerup, S., Bølcho, U., Mølgaard, S., Boggild, S., Vægter, C. B., Smith, A. H., Nieto-González, J. L., Ovesen, P. L., Pedersen, L. F., Fjorback, A. N., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.108 · Cited by 96 · see citing works
The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors
Savas, J. N., Ribeiro, L. F., Wierda, K. D. B., Wright, R., DeNardo, L. A., Rice, H. C., Chamma, I., Wang, Y., Zemla, R., Lavallée‐Adam, M., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.007 · Cited by 92 · see citing works
Glerup, S., Olsen, D., Vægter, C. B., Gustafsen, C., Sjogaard, S., Hermey, G., Kjølby, M., Mølgaard, S., Ulrichsen, M., Boggild, S., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.022 · Cited by 87 · see citing works
Dynamic Nature of the p75 Neurotrophin Receptor in Response to Injury and Disease
Meeker, R. B., & Williams, K. S. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-014-9566-9 · Cited by 93 · see citing works
Irmady, K., Jackman, K. A., Padow, V. A., Shahani, N., Martin, L. A., Cerchietti, L. C. A., Unsicker, K., Iadecola, C., & Hempstead, B. L. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1982-13.2014 · Cited by 90 · see citing works
Self-citationMizui, T., Ishikawa, Y., Kumanogoh, H., & Kojima, M. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2015.12.019 · Cited by 88 · see citing works
iPlasticity: Induced juvenile‐like plasticity in the adult brain as a mechanism of antidepressants
Umemori, J., Winkel, F., Didio, G., Llach Pou, M., & Castrén, E. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12683 · Cited by 80 · see citing works
Vps10 Family Proteins and the Retromer Complex in Aging-Related Neurodegeneration and Diabetes
Lane, R. F., George‐Hyslop, P. S., Hempstead, B. L., Small, S. A., Strittmatter, S. M., & Gandy, S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3359-12.2012 · Cited by 77 · see citing works
Self-citationSiao, C.-J., Lorentz, C. U., Kermani, P., Marinic, T. E., Carter, J., McGrath, K., Padow, V. A., Mark, W. H., Falcone, D. J., Cohen‐Gould, L., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111749 · Cited by 77 · see citing works
Self-citationAntipsychotics Activate mTORC1-Dependent Translation to Enhance Neuronal Morphological Complexity
Bowling, H. L., Zhang, G., Bhattacharya, A., Pérez-Cuesta, L. M., Deinhardt, K., Hoeffer, C. A., Neubert, T. A., Gan, W., Klann, E., & Chao, M. V. (2014) · Science Signaling · doi:10.1126/scisignal.2004331 · Cited by 64 · see citing works
Self-citationTau misfolding efficiently propagates between individual intact hippocampal neurons
Hallinan, G. I., Vargas-Caballero, M., West, J., & Deinhardt, K. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1590-19.2019 · Cited by 59 · see citing works
Self-citationGiza, J. I., Kim, J., Meyer, H. C., Anastasía, A., Dincheva, I., Zheng, C. I., Lopez, K. C., Bains, H., Yang, J., Bracken, C., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.024 · Cited by 61 · see citing works
Self-citationFast-diffusing p75 NTR monomers support apoptosis and growth cone collapse by neurotrophin ligands
Marchetti, L., Bonsignore, F., Gobbo, F., Amodeo, R., Calvello, M., Jacob, A., Signore, G., Spagnolo, C. S., Porciani, D., Mainardi, M., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902790116 · Cited by 60 · see citing works
Shanks, H. R. C., Chen, K., Reiman, E. M., Blennow, K., Cummings, J. L., Massa, S. M., Longo, F. M., Börjesson‐Hanson, A., Windisch, M., & Schmitz, T. W. (2024) · Nature Medicine · doi:10.1038/s41591-024-02977-w · Cited by 62 · see citing works
Mesentier-Louro, L. A., Rosso, P., Carito, V., Méndez‐Otero, R., Santiago, M. F., Rama, P., Lambìase, A., & Tirassa, P. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1154-1 · Cited by 56 · see citing works
Pro‐neurotrophins, sortilin, and nociception
Lewin, G. R., & Nykjær, A. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12466 · Cited by 55 · see citing works
Fascin Regulates the Migration of Subventricular Zone-Derived Neuroblasts in the Postnatal Brain
Sonego, M., Gajendra, S., Parsons, M., Ma, Y., Hobbs, C., Zentar, M. P., Williams, G. H., Machesky, L. M., Doherty, P., & Lalli, G. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0653-13.2013 · Cited by 54 · see citing works
Wang, J., Chen, Y., Zhang, C., Xiang, Z., Ding, J., & Han, X. (2019) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.03.106 · Cited by 55 · see citing works
VPS10P Domain Receptors: Sorting Out Brain Health and Disease
Malik, A. R., & Willnow, T. E. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.08.003 · Cited by 52 · see citing works
Spatiotemporal expression analysis of the growth factor receptor SorCS3
Oetjen, S., Mahlke, C., Hermans‐Borgmeyer, I., & Hermey, G. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23606 · Cited by 53 · see citing works
Delbary-Gossart, S., Lee, S., Baroni, M., Lamarche, I., Arnone, M., Canolle, B., Lin, A., Sacramento, J. A., Salegio, E. A., Castel, M., et al. (2016) · Brain · doi:10.1093/brain/aww074 · Cited by 52 · see citing works
Malik, A., Szydłowska, K., Nizińska, K., Asaro, A., van Vliet, E., Popp, O., Dittmar, G., Fritsche-Guenther, R., Kirwan, J., Nykjaer, A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.027 · Cited by 46 · see citing works
Melatonin: A Neurotrophic Factor?
Miranda-Riestra, A., Estrada‐Reyes, R., Torres-Sánchez, E. D., Carreño, S., Ortíz, G. G., & Benítez‐King, G. (2022) · Molecules · doi:10.3390/molecules27227742 · Cited by 45 · see citing works
Baho, E., Chattopadhyaya, B., Lavertu-Jolin, M., Mazziotti, R. M., Awad, P. N., Chehrazi, P., Groleau, M., Jahannault-Talignani, C., Sanon, N. T., Vaucher, E., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2881-18.2019 · Cited by 44 · see citing works
Chataigner, L. M. P., Leloup, N. O. L., & Janssen, B. J. C. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00129 · Cited by 44 · see citing works
Structural insights into SorCS2–Nerve Growth Factor complex formation
Leloup, N. O. L., Chataigner, L. M. P., & Janssen, B. J. C. (2018) · Nature Communications · doi:10.1038/s41467-018-05405-z · Cited by 44 · see citing works
Gray, J. D., Rubin, T. G., Kogan, J. F., Marrocco, J., Weidmann, J., Lindkvist, S., Lee, F. S., Schmidt, E. F., & McEwen, B. S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.219 · Cited by 38 · see citing works
Pick, J. E., Malumbres, M., & Klann, E. (2012) · Learning & Memory · doi:10.1101/lm.027383.112 · Cited by 42 · see citing works
Fascin1 in carcinomas: Its regulation and prognostic value
Ma, Y., & Machesky, L. M. (2014) · International Journal of Cancer · doi:10.1002/ijc.29260 · Cited by 41 · see citing works
Detection of p75NTR Trimers: Implications for Receptor Stoichiometry and Activation
Anastasia, A., Barker, P. A., Chao, M. V., & Hempstead, B. L. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0591-15.2015 · Cited by 41 · see citing works
Self-citationp75 NTR , but Not proNGF, Is Upregulated Following Status Epilepticus in Mice
VonDran, M. W., LaFrancois, J. J., Padow, V. A., Friedman, W., Scharfman, H. E., Milner, T. A., & Hempstead, B. L. (2014) · ASN NEURO · doi:10.1177/1759091414552185 · Cited by 41 · see citing works
Self-citationSympathetic denervation of peri-infarct myocardium requires the p75 neurotrophin receptor
Lorentz, C. U., Parrish, D. C., Alston, E. N., Pellegrino, M. J., Woodward, W. R., Hempstead, B. L., & Habecker, B. A. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.08.015 · Cited by 40 · see citing works
Self-citationKojima, M., & Mizui, T. (2017) · Vitamins and hormones · doi:10.1016/bs.vh.2016.11.006 · Cited by 40 · see citing works
The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review
Reitz, C. (2014) · Molecular Genetics and Genomics · doi:10.1007/s00438-014-0939-9 · Cited by 39 · see citing works
Szarowicz, C., Steece‐Collier, K., & Caulfield, M. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23148011 · Cited by 41 · see citing works
Neurotrophins and Their Receptors: BDNF’s Role in GABAergic Neurodevelopment and Disease
Caño, C. H.-D., Varela-Andrés, N., Cebrián-León, A., & Deogracias, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158312 · Cited by 40 · see citing works
Ma, Q., Yang, J., Li, T., Milner, T. A., & Hempstead, B. L. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.008 · Cited by 36 · see citing works
Self-citationRPM-1 regulates axon termination by affecting growth cone collapse and microtubule stability
Borgen, M. A., Wang, D., & Grill, B. J. (2017) · Development · doi:10.1242/dev.154187 · Cited by 37 · see citing works
SorCS2 is required for social memory and trafficking of the NMDA receptor
Yang, J., Ma, Q., Dincheva, I., Giza, J. I., Jing, D., Marinic, T. E., Milner, T. A., Rajadhyaksha, A. M., Lee, F. S., & Hempstead, B. L. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0650-7 · Cited by 35 · see citing works
Self-citationFinding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease
Salašová, A., Monti, G., Andersen, O. M., & Nykjær, A. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00576-2 · Cited by 35 · see citing works
Maltby, C. J., Schofield, J. P. R., Houghton, S. D., O’Kelly, I., Vargas‐Caballero, M., Deinhardt, K., & Coldwell, M. J. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa699 · Cited by 37 · see citing works
Self-citationMass Spectrometry for Proteomics-Based Investigation
Woods, A. G., Sokolowska, I., Wetie, A. G. N., Channaveerappa, D., Dupree, E. J., Jayathirtha, M., Aslebagh, R., Wormwood, K. L., & Darie, C. C. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-15950-4_1 · Cited by 34 · see citing works
The Abl pathway bifurcates to balance Enabled and Rac signaling in axon patterning in Drosophila
Kannan, R., Song, J.-K., Karpova, T., Clarke, A., Shivalkar, M., Wang, B. L., Kotlyanskaya, L., Kuzina, I., Gu, Q., & Giniger, E. (2017) · Development · doi:10.1242/dev.143776 · Cited by 35 · see citing works
Lane, R. F., Shineman, D. W., Steele, J., Lee, L. H., & Fillit, H. M. (2012) · Advances in pharmacology · doi:10.1016/b978-0-12-394816-8.00007-6 · Cited by 33 · see citing works
Kraft, R., Kahn, A., Medina‐Franco, J. L., Orlowski, M. L., Baynes, C., López-Vallejo, F., Barnard, K., Maggiora, G. M., & Restifo, L. L. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.008243 · Cited by 33 · see citing works
Inhibiting proBDNF to mature BDNF conversion leads to ASD-like phenotypes in vivo
Yang, F., You, H., Mizui, T., Ishikawa, Y., Takao, K., Miyakawa, T., Li, X., Bai, T., Xia, K., Zhang, L., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02595-5 · Cited by 34 · see citing works
DEPENDENCE OF REGENERATED SENSORY AXONS ON CONTINUOUS NEUROTROPHIN-3 DELIVERY
Hou, S., Nicholson, L., van Niekerk, E. V., Motsch, M., & Blesch, A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5041-11.2012 · Cited by 34 · see citing works
Neurotrophin-3 and neurotrophin-4: The unsung heroes that lies behind the meninges
Omar, N. A., Kumar, J., & Teoh, S. L. (2022) · Neuropeptides · doi:10.1016/j.npep.2022.102226 · Cited by 30 · see citing works
Rare variants in the neurotrophin signaling pathway implicated in schizophrenia risk
Kranz, T. M., Goetz, R. R., Walsh‐Messinger, J., Goetz, D. M., Antonius, D., Dolgalev, I., Heguy, A., Seandel, M., Malaspina, D., & Chao, M. V. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.07.002 · Cited by 30 · see citing works
Self-citationHao, M., Chen, L., He, J., Zhao, X., Xia, H., Chen, X., Yu, L., Qiu, J., Feng, S., Sang, Y., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202214869 · Cited by 29 · see citing works
Howard, L., Wyatt, S. L., Nagappan, G., & Davies, A. M. (2013) · Development · doi:10.1242/dev.085266 · Cited by 28 · see citing works
Growth factors and hormones pro‐peptides: the unexpected adventures of the BDNF prodomain
Zanin, J. P., Unsain, N., & Anastasía, A. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.13993 · Cited by 28 · see citing works
Spatiotemporal patterns of sortilin and SorCS2 localization during organ development
Boggild, S., Mølgaard, S., Glerup, S., & Nyengaard, J. R. (2016) · BMC Cell Biology · doi:10.1186/s12860-016-0085-9 · Cited by 27 · see citing works
Mass Spectrometry for Proteomics-Based Investigation
Woods, A. G., Sokolowska, I., Wetie, A. G. N., Wormwood, K. L., Aslebagh, R., Patel, S. J., & Darie, C. C. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-06068-2_1 · Cited by 24 · see citing works
Mercado, N. M., Stancati, J. A., Sortwell, C. E., Mueller, R. L., Boezwinkle, S. A., Duffy, M. F., Fischer, D. L., Sandoval, I. M., Manfredsson, F. P., Collier, T. J., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105175 · Cited by 23 · see citing works
Olsen, D., Wellner, N., Kaas, M., de Jong, I. D., Sotty, F., Didriksen, M., Glerup, S., & Nykjaer, A. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01199-9 · Cited by 16 · see citing works
Campero-Romero, A. N., Real, F. H., Santana-Martínez, R. A., Molina‐Villa, T., Aranda, C., Ríos‐Castro, E., & Tovar‐y‐Romo, L. B. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01561-4 · Cited by 23 · see citing works
Irradiation increases brain-derived neurotrophic factor precursor signaling in the mouse hippocampus
Wang, Z., Zhong, X., Xu, Y., He, J., Liu, Z. H., Nai, A., Niu, L., Luo, S. S., Yang, H., Zeng, J. Y., et al. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107186 · Cited by 21 · see citing works
The Structure of the Pro-domain of Mouse proNGF in Contact with the NGF Domain
Yan, R., Yalinca, H., Paoletti, F., Gobbo, F., Marchetti, L., Kuzmanic, A., Lamba, D., Gervasio, F. L., Konarev, P. V., Cattaneo, A., et al. (2018) · Structure · doi:10.1016/j.str.2018.09.013 · Cited by 20 · see citing works
Pathogenic tau does not drive activation of the unfolded protein response
Pitera, A. P., Asuni, A. A., O'Connor, V. M., & Deinhardt, K. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008263 · Cited by 20 · see citing works
Self-citationBaker, L. A., Momen, M. M., McNally, R. M., Berres, M. E., Binversie, E. E., Sample, S. J., & Muir, P. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.593515 · Cited by 19 · see citing works
Speidell, A. P., Asuni, G. P., Avdoshina, V., Scognamiglio, S., Forcelli, P. A., & Mocchetti, I. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00398 · Cited by 19 · see citing works
Forge, A., Taylor, R., Dawson, S. J., Lovett, M., & Jagger, D. J. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006692 · Cited by 19 · see citing works
Retrograde apoptotic signaling by the p75 neurotrophin receptor
Pathak, A., & Carter, B. D. (2017) · Neuronal Signaling · doi:10.1042/ns20160007 · Cited by 18 · see citing works
Wang, C., Fang, C., Zou, Y., Yang, J., & Sawan, M. (2023) · Journal of Neural Engineering · doi:10.1088/1741-2552/acb295 · Cited by 19 · see citing works
Fading memories in aging and neurodegeneration: Is p75 neurotrophin receptor a culprit?
Wong, L., Wang, Z., Ang, S. R. X., & Sajikumar, S. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101567 · Cited by 18 · see citing works
Interrogating Synaptic Architecture: Approaches for Labeling Organelles and Cytoskeleton Components
Reshetniak, S., & Rizzoli, S. O. (2019) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2019.00023 · Cited by 17 · see citing works
Rajan, S., Yoon, J., Wu, H., Srapyan, S., Baskar, R., Ahmed, G., Yang, T., Grintsevich, E. E., Reisler, E., & Terman, J. R. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2309955120 · Cited by 16 · see citing works
Shanks, H. R. C., Onuska, K. M., Massa, S. M., Schmitz, T. W., & Longo, F. M. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.110 · Cited by 17 · see citing works
SorCS2 binds progranulin to regulate motor neuron development
Thomasen, P. B., Salašová, A., Kjær-Sørensen, K., Woloszczuková, L., Lavický, J., Login, H., Tranberg-Jensen, J., Almeida, S. A. D. O., Beel, S., Kavková, M., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113333 · Cited by 16 · see citing works
Self-citationZhang, H., McCarroll, A., Peyton, L., de León‐Guerrero, S. D., Zhang, S., Gowda, P., Sirkin, D., ElAchwah, M., Duhe, A., Wood, W., et al. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.08.003 · Cited by 15 · see citing works
Boggild, S., Mølgaard, S., Glerup, S., & Nyengaard, J. R. (2018) · The Journal of Comparative Neurology · doi:10.1002/cne.24403 · Cited by 14 · see citing works
Brain-derived neurotrophic factor – a key player in the gastrointestinal system
Singh, A. (2023) · Gastroenterology Review · doi:10.5114/pg.2023.132957 · Cited by 15 · see citing works
Zeinieh, M. P., Salehi, A. H., Rajkumar, V. S., & Barker, P. A. (2014) · Journal of Cell Science · doi:10.1242/jcs.152173 · Cited by 14 · see citing works
Cutuli, D., & Sampedro-Piquero, P. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220624111855 · Cited by 13 · see citing works
Goncharuk, S. A., Artemieva, L. E., Nadezhdin, K. D., Arseniev, A. S., & Mineev, K. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-70721-8 · Cited by 13 · see citing works
Ramanujan, A., Li, Z., Ma, Y., Lin, Z., & Ibáñez, C. F. (2024) · EMBO Reports · doi:10.1038/s44319-024-00064-2 · Cited by 12 · see citing works
Cleavage of p75 neurotrophin receptor is linked to Alzheimer’s disease
Chao, M. V. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.214 · Cited by 12 · see citing works
Self-citationLong‐distance regressive signaling in neural development and disease
Pathak, A., Clark, S. A., Bronfman, F. C., Deppmann, C. D., & Carter, B. D. (2020) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.382 · Cited by 12 · see citing works
- Authors
- Deinhardt, K., Kim, T., Spellman, D. S., Mains, R. E., Eipper, B. A., Neubert, T. A., Chao, M. V., & Hempstead, B. L.
- Affiliations
- New York University (US)
- Weill Cornell Medicine (US)
- UConn Health (US)
- Corresponding author
- Kim, Taeho
- Hempstead, Barbara L.
- ORCID
- Venue
- Science Signaling
- Published
- 2011-12-06
- Volume
- 4
- Issue
- 202
- Pages
- ra82-ra82
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC3360552
- OpenAlex
- W2046114399
- Cited by
- 183
- References
- 42
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 7 · 2023: 28 · 2022: 13 · 2021: 9 · 2020: 15 · 2019: 16 · 2018: 7 · 2017: 11 · 2016: 14 · 2015: 11 · 2014: 20 · 2013: 7 · 2012: 9
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- Funders
- National Institutes of Health (1s10rr017990-01)
- National Institute on Drug Abuse (R01DA015464, DA-15464)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-32948, R01DK032948, R56DK032948)
- National Institute of Neurological Disorders and Stroke (R01NS021072, R01NS064114, NS30687, NS-21072, R01NS030687, NS050276, P30NS050276, R56NS021072, NS64114)
- National Center for Research Resources (RR017990)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-23315, P01HD023315)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- proNGF, p75 neurotrophin receptor, SorCS2, sortilin, trios, Rac, fascin, actin dynamics, neuronal morphology, hippocampal neurons, axon guidance
- MeSH terms
- Actins, Animals, Carrier Proteins, Cell Line, Cells, Cultured, Humans, Microfilament Proteins, Models, Neurological, Nerve Tissue Proteins, Receptors, Cell Surface, Signal Transduction, Growth Cones, Guanine Nucleotide Exchange Factors, rac GTP-Binding Proteins, Receptor, Nerve Growth Factor, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review