Cited by 183Axon Guidance and Neuronal SignalingNerve injury and regenerationNeurogenesis and neuroplasticity mechanisms

Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac

Open access
Deinhardt, Katrin, Kim, Taeho, Spellman, Daniel S., Mains, Richard E., Eipper, Betty A., Neubert, Thomas A., Chao, Moses V., Hempstead, Barbara L.·2011·Science Signaling

Abstract

Whereas NGF promotes neurite outgrowth, the precursor form proNGF triggers neurite retraction.

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Crossref · 10.1126/scisignal.2002060

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  • Pro-BDNF binding to p75NTR induces pruning of axons and dendrites.

    “Pro-BDNF binding to p75NTR has also been shown to induce pruning of axons and dendrites85,88–91 and promote long-term depression (LTD)92–94.”

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Authors
Deinhardt, K., Kim, T., Spellman, D. S., Mains, R. E., Eipper, B. A., Neubert, T. A., Chao, M. V., & Hempstead, B. L.
Affiliations
  • New York University (US)
  • Weill Cornell Medicine (US)
  • UConn Health (US)
Corresponding author
  • Kim, Taeho
  • Hempstead, Barbara L.
Venue
Science Signaling
Published
2011-12-06
Volume
4
Issue
202
Pages
ra82-ra82
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
OpenAlex
W2046114399
Cited by
183
References
42
Citations by year
2026: 6 · 2025: 10 · 2024: 7 · 2023: 28 · 2022: 13 · 2021: 9 · 2020: 15 · 2019: 16 · 2018: 7 · 2017: 11 · 2016: 14 · 2015: 11 · 2014: 20 · 2013: 7 · 2012: 9
FWCI
4.77
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • ePrints Soton (University of Southampton) (acceptedVersion)
Funders
  • National Institutes of Health (1s10rr017990-01)
  • National Institute on Drug Abuse (R01DA015464, DA-15464)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-32948, R01DK032948, R56DK032948)
  • National Institute of Neurological Disorders and Stroke (R01NS021072, R01NS064114, NS30687, NS-21072, R01NS030687, NS050276, P30NS050276, R56NS021072, NS64114)
  • National Center for Research Resources (RR017990)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-23315, P01HD023315)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
proNGF, p75 neurotrophin receptor, SorCS2, sortilin, trios, Rac, fascin, actin dynamics, neuronal morphology, hippocampal neurons, axon guidance
MeSH terms
Actins, Animals, Carrier Proteins, Cell Line, Cells, Cultured, Humans, Microfilament Proteins, Models, Neurological, Nerve Tissue Proteins, Receptors, Cell Surface, Signal Transduction, Growth Cones, Guanine Nucleotide Exchange Factors, rac GTP-Binding Proteins, Receptor, Nerve Growth Factor, Mice, Rats

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