Cited by 250Redox biology and oxidative stressNitric Oxide and Endothelin EffectsMitochondrial Function and Pathology

Nitric Oxide Regulates Mitochondrial Fatty Acid Metabolism Through Reversible Protein S -Nitrosylation

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Doulias, Paschalis-Thomas, Tenopoulou, Margarita, Greene, Jennifer L., Raju, Karthik, Ischiropoulos, Harry·2013·Science Signaling

Abstract

S -nitrosylation increases the catalytic efficiency of an enzyme critical to fatty acid β-oxidation.

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Registry

Crossref · 10.1126/scisignal.2003252

Cites

35 of 35 references verified0 citation errors · 0 not checkable

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  • NO from NOS-2 inhibits mitochondria.

    “potentially mediated by the well-known inhibition of mitochondria by NO from NOS-2 (BalPrice et al., 2002) (Kelly and O'Neill, 2015) (Doulias et al., 2013).”

    From TET2 Regulates the Neuroinflammatory Response in Microglia (2019) · cites this paper as Doulias et al., 2013

    The Discussion (page unavailable) reports that eNOS-derived nitric oxide activates a mitochondrial fatty-acid oxidation enzyme; it does not address whether NO from NOS-2 inhibits mitochondria. Searches for NOS-2, inducible nitric oxide synthase, and mitochondrial respiration inhibition found no passage making that claim. (LLM, conf=0.72)

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Research works printed but not linked: 1

  1. [18]Koshland DE The application and usefulness of the ratio k(cat)/K(M). Bioorg. Chem 2002 30 211 213 12406705

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Authors
Doulias, P.-T., Tenopoulou, M., Greene, J. L., Raju, K., & Ischiropoulos, H.
Affiliations
  • Children's Hospital of Philadelphia (US)
  • Children’s Hospital of Philadelphia Research Institute and Departments of Pediatrics and Pharmacology, Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Corresponding author
  • Raju, Karthik
  • Ischiropoulos, Harry
Venue
Science Signaling
Published
2013-01
Volume
6
Issue
256
Pages
rs1-rs1
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
OpenAlex
W2160610690
Cited by
250
References
35
Citations by year
2026: 6 · 2025: 18 · 2024: 17 · 2023: 16 · 2022: 15 · 2021: 21 · 2020: 23 · 2019: 16 · 2018: 17 · 2017: 16 · 2016: 20 · 2015: 24 · 2014: 20 · 2013: 20
FWCI
12.55
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (AG 13966, R01AG013966, T32AG000255)
  • National Heart, Lung, and Blood Institute (R01HL054926, HL054926)
  • National Institute of Environmental Health Sciences (ES013508, P30ES013508)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
nitric oxide, S-nitrosylation, S-nitrosocysteine, post-translational modification, mitochondrial fatty acid metabolism, fatty acid beta-oxidation, VLCAD, endothelial nitric oxide synthase, mitochondrial bioenergetics, glycolysis, gluconeogenesis, TCA cycle, oxidative phosphorylation
MeSH terms
Analysis of Variance, Animals, Cysteine, Energy Metabolism, Fatty Acids, Liver, Mitochondria, Nitric Oxide, Oxidation-Reduction, Protein Processing, Post-Translational, Mass Spectrometry, Signal Transduction, Mutagenesis, Site-Directed, DNA Primers, S-Nitrosothiols, Proteomics, Acyl-CoA Dehydrogenase, Long-Chain, Mice

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