mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex

Autophagy in the Pathogenesis of Disease

Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069 · see citing works

Autophagy fights disease through cellular self-digestion

Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452 · see citing works

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787 · see citing works

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S.-I., Natsume, T., Takehana, K., Yamada, N., et al. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1248 · Cited by 2,076 · see citing works

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

Jung, C. H., Jun, C. B., Ro, S.-H., Kim, Y.-M., Otto, N. M., Cao, J., Kundu, M., & Kim, D.-H. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1249 · Cited by 2,025 · see citing works

Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae

Tsukada, M., & Ohsumi, Y. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80398-e · Cited by 1,756 · see citing works

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

Ganley, I. G., Lam, D., Wang, J., Ding, X., Chen, S., & Jiang, X. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900573200 · Cited by 1,559 · see citing works

Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex

Kamada, Y., Funakoshi, T., Shintani, T., Nagano, K., Ohsumi, M., & Ohsumi, Y. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.6.1507 · Cited by 1,145 · see citing works

Autophagy mediates the mitotic senescence transition

Young, A. R. J., Narita, M., Ferreira, M., Kirschner, K., Sadaie, M., Darot, J. F. J., Tavaré, S., Arakawa, S., Shimizu, S., Watt, F. M., et al. (2009) · Genes & Development · doi:10.1101/gad.519709 · Cited by 1,078 · see citing works

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

Hara, T., Takamura, A., Kishi, C., Iemura, S.-I., Natsume, T., Guan, J., & Mizushima, N. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712064 · Cited by 971 · see citing works

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

Kundu, M., Lindsten, T., Yang, C.-Y., Wu, J., Zhao, F., Zhang, J., Selak, M. A., Ney, P. A., & Thompson, C. B. (2008) · Blood · doi:10.1182/blood-2008-02-137398 · Cited by 571 · see citing works

Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae

Matsuura, A., Tsukada, M., Wada, Y., & Ohsumi, Y. (1997) · Gene · doi:10.1016/s0378-1119(97)00084-x · Cited by 489 · see citing works

A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy

Mercer, C. A., Kaliappan, A., & Dennis, P. B. (2009) · Autophagy · doi:10.4161/auto.5.5.8249 · Cited by 444 · see citing works

Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism

Chan, E. Y. W., Longatti, A., McKnight, N. C., & Tooze, S. A. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01082-08 · Cited by 435 · see citing works

An Atg1/Atg13 Complex with Multiple Roles in TOR-mediated Autophagy Regulation

Chang, Y.-Y., & Neufeld, T. P. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1250 · Cited by 418 · see citing works

Amino acid regulation of TOR complex 1

Avruch, J., Long, X., Ortiz-Vega, S., Rapley, J., Papageorgiou, A., & Dai, N. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90645.2008 · Cited by 382 · see citing works

Atg17 Functions in Cooperation with Atg1 and Atg13 in Yeast Autophagy

Kabeya, Y., Kamada, Y., Baba, M., Takikawa, H., Sasaki, M., & Ohsumi, Y. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0669 · Cited by 345 · see citing works

Role of Unc51.1 and its binding partners in CNS axon outgrowthPreprint

Tomoda, T., Kim, J. H., Zhan, C., & Hatten, M. E. (2004) · Genes & Development · doi:10.1101/gad.1151204 · Cited by 191 · see citing works

UNC-51/ATG1 kinase regulates axonal transport by mediating motor–cargo assemblyPreprint

Toda, H., Mochizuki, H., Flores, R., Josowitz, R., Krasieva, T. B., LaMorte, V. J., Suzuki, E., Gindhart, J. G., Furukubo-Tokunaga, K., & Tomoda, T. (2008) · Genes & Development · doi:10.1101/gad.1734608 · Cited by 141 · see citing works

Evolution of Atg1 function and regulation

Chan, E. Y. W., & Tooze, S. A. (2009) · Autophagy · doi:10.4161/auto.8709 · Cited by 138 · see citing works

Identification of Mouse ULK1, a Novel Protein Kinase Structurally Related toC. elegansUNC-51

Yan, J. C., Kuroyanagi, H., Kuroiwa, A., Matsuda, Y., Tokumitsu, H., Tomoda, T., Shirasawa, T., & Muramatsu, M.-A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8546 · Cited by 126 · see citing works

A Mouse Serine/Threonine Kinase Homologous to C. elegans UNC51 Functions in Parallel Fiber Formation of Cerebellar Granule Neurons

Tomoda, T., Bhatt, R. S., Kuroyanagi, H., Shirasawa, T., & Hatten, M. E. (1999) · Neuron · doi:10.1016/s0896-6273(00)81031-4 · Cited by 125 · see citing works

Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons

Zhou, X., Babu, J. R., da Silva, S., Shu, Q., Graef, I. A., Oliver, T., Tomoda, T., Tani, T., Wooten, M. W., & Wang, F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701402104 · Cited by 122 · see citing works

The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans

Lai, T. S., & Garriga, G. (2004) · Development · doi:10.1242/dev.01457 · Cited by 62 · see citing works

Genetic interactions betweenDrosophila melanogasterAtg1 and paxillin reveal a role for paxillin in autophagosome formation

Chen, G., Lee, J. Y., Tang, H.-W., Debnath, J., Thomas, S. Μ., & Settleman, J. E. (2008) · Autophagy · doi:10.4161/auto.5141 · Cited by 60 · see citing works

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600 · see citing works

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

Inoki, K., Kim, J., & Guan, K. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134537 · Cited by 800 · see citing works

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

Egan, D. F., Chun, M. G. H., Vamos, M., Zou, H., Rong, J., Miller, C. J., Lou, H. J., Raveendra-Panickar, D., Yang, C.-C., Sheffler, D. J., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.05.031 · Cited by 715 · see citing works

mTORC1 signaling and the metabolic control of cell growth

Ben‐Sahra, I., & Manning, B. D. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.02.012 · Cited by 641 · see citing works

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., et al. (2010) · Science · doi:10.1126/science.1182228 · Cited by 570 · see citing works

Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response

Lin, Y., Jiang, M. H., Chen, W., Zhao, T., & Wei, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109249 · Cited by 505 · see citing works

AMPK in skeletal muscle function and metabolism

Kjøbsted, R., Hingst, J. R., Fentz, J., Foretz, M., Sanz, M.-N., Pehmøller, C. K., Shum, M., Marette, A., Mounier, R., Treebak, J. T., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700442r · Cited by 496 · see citing works

Obesity, inflammation, and liver cancer

Sun, B., & Karin, M. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.09.020 · Cited by 496 · see citing works

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

Rehman, S. K., Haynes, J., Collignon, E., Brown, K. R., Wang, Y., Nixon, A. M. L., Bruce, J. P., Wintersinger, J. A., Singh Mer, A., Lo, E. B. L., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.018 · Cited by 495 · see citing works

Biogenesis and Cargo Selectivity of Autophagosomes

Weidberg, H., Shvets, E., & Elazar, Z. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052709-094552 · Cited by 466 · see citing works

Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest

Ganley, I. G., Wong, P., Gammoh, N., & Jiang, X. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.024 · Cited by 382 · see citing works

A new perspective on NAFLD: Focusing on lipid droplets

Scorletti, E., & Carr, R. M. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.11.009 · Cited by 376 · see citing works

Sestrins Orchestrate Cellular Metabolism to Attenuate Aging

Lee, J. H., Budanov, A. V., & Karin, M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.018 · Cited by 339 · see citing works

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

Zhang, D., Contu, R., Latronico, M. V. G., Zhang, J. L., Rizzi, R., Catalucci, D., Miyamoto, S., Huang, K., Ceci, M., Gu, Y., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43008 · Cited by 338 · see citing works

Cellular stress response pathways and ageing: intricate molecular relationships

Kourtis, N., & Tavernarakis, N. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.162 · Cited by 304 · see citing works

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Lee, J. H., Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H.-W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.004 · Cited by 295 · see citing works

AMPK, Mitochondrial Function, and Cardiovascular Disease

Wu, S., & Zou, M.-H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144987 · Cited by 286 · see citing works

Inhibition of mTOR induces a paused pluripotent state

Bulut-Karslioglu, A., Biechele, S., Jin, H., Macrae, T. A., Hejna, M., Gertsenstein, M., Song, J. S., & Ramalho-Santos, M. (2016) · Nature · doi:10.1038/nature20578 · Cited by 283 · see citing works

Cellular and metabolic functions for autophagy in cancer cells

Kenific, C. M., & Debnath, J. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.09.001 · Cited by 261 · see citing works

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

Liu, P., Gan, W., Inuzuka, H., Lazorchak, A. S., Gao, D., Arojo, O., Liu, D., Wan, L., Zhai, B., Yu, Y., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2860 · Cited by 256 · see citing works

Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment

Abcouwer, S. F., & Gardner, T. W. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12412 · Cited by 252 · see citing works

Novel synthetic small‐molecule activators of AMPK as enhancers of autophagy and amyloid‐β peptide degradation

Vingtdeux, V., Chandakkar, P., Zhao, H., d’Abramo, C., Davies, P., & Marambaud, P. (2010) · The FASEB Journal · doi:10.1096/fj.10-167361 · Cited by 229 · see citing works

MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin

Wang, Z., Wang, N., Liu, P., Chen, Q., Situ, H., Xie, T., Zhang, J., Peng, C. Y., Lin, Y., & Chen, J. (2014) · Oncotarget · doi:10.18632/oncotarget.2192 · Cited by 225 · see citing works

AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization

Mack, H. I. D., Zheng, B., Asara, J. M., & Thomas, S. Μ. (2012) · Autophagy · doi:10.4161/auto.20586 · Cited by 221 · see citing works

Cancer Cell MetabolismPreprint

Cairns, R. A., Harris, I. S., McCracken, S. A., & Mak, T. W. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.012856 · Cited by 223 · see citing works

Differential Roles of GSK-3β During Myocardial Ischemia and Ischemia/Reperfusion

Zhai, P., Sciarretta, S., Galeotti, J., Volpe, M., & Sadoshima, J. (2011) · Circulation Research · doi:10.1161/circresaha.111.249532 · Cited by 218 · see citing works

Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy

Marinković, M., Šprung, M., Buljubašić, M., & Novak, I. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8023821 · Cited by 213 · see citing works

AMPK regulates autophagy by phosphorylating BECN1 at threonine 388

Zhang, D., Wang, W., Sun, X., Xu, D., Wang, C., Zhang, Q., Wang, H., Luo, W., Chen, Y., Chen, H., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1185576 · Cited by 211 · see citing works

mTOR-Dependent Cell Survival MechanismsPreprint

Hung, C., García-Haro, L., Sparks, C. A., & Guertin, D. A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008771 · Cited by 205 · see citing works

Tumor Suppression and Promotion by Autophagy

Ávalos, Y., Canales, J., Bravo, R., Criollo, A., Lavandero, S., & Quest, A. F. G. (2014) · BioMed Research International · doi:10.1155/2014/603980 · Cited by 197 · see citing works

Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles

Kenney, J. W., Moore, C. E., Xuemin, W., & Proud, C. G. (2014) · Advances in Biological Regulation · doi:10.1016/j.jbior.2014.04.003 · Cited by 182 · see citing works

Regulation of Autophagy by Kinases

Sridharan, S., Jain, K., & Basu, A. (2011) · Cancers · doi:10.3390/cancers3022630 · Cited by 182 · see citing works

Integration of autophagy, proteasomal degradation, unfolded protein response and apoptosis.

Benbrook, D. M., & Long, A. (2012) · PubMed · Cited by 173 · see citing works

Autophagy in colorectal cancer: An important switch from physiology to pathology

Burada, F. (2015) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v7.i11.271 · Cited by 165 · see citing works

Cell Death in the Developing Brain after Hypoxia-Ischemia

Thornton, C., Leaw, B., Mallard, C. E., Nair, S., Jinnai, M., & Hagberg, H. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00248 · Cited by 163 · see citing works

Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK

Liu, J., Chang, F., Li, F., Fu, H., Wang, J., Zhang, S., Zhao, J., & Yin, D. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.05.042 · Cited by 151 · see citing works

The variability of autophagy and cell death susceptibility

Loos, B., Engelbrecht, A., Lockshin, R. A., Klionsky, D. J., & Zakeri, Z. (2013) · Autophagy · doi:10.4161/auto.25560 · Cited by 148 · see citing works

Autophagosome formation in mammalian cells

Burman, C., & Ktistakis, N. T. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0222-z · Cited by 141 · see citing works

Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130

Joachim, J., Jefferies, H. B. J., Razi, M., Frith, D., Snijders, A. P., Chakravarty, P., Judith, D., & Tooze, S. A. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.11.018 · Cited by 141 · see citing works

Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction

Alers, S., Löffler, A. S., Paasch, F., Dieterle, A. M., Keppeler, H., Lauber, K., Campbell, D. G., Fehrenbacher, B., Schaller, M., Wesselborg, S., et al. (2011) · Autophagy · doi:10.4161/auto.7.12.18027 · Cited by 138 · see citing works

Autophagy and Cancer Metabolism

Goldsmith, J., Levine, B., & Debnath, J. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-416618-9.00002-9 · Cited by 136 · see citing works

Autophagy and Non-Alcoholic Fatty Liver Disease

Lavallard, V., & Gual, P. (2014) · BioMed Research International · doi:10.1155/2014/120179 · Cited by 133 · see citing works

Autophagy proteins in macroendocytic engulfment

Florey, O., & Overholtzer, M. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.04.005 · Cited by 132 · see citing works

In Response to Precision Medicine: Current Subcellular Targeting Strategies for Cancer Therapy

Li, Z., Zou, J., & Chen, X. S. (2022) · Advanced Materials · doi:10.1002/adma.202209529 · Cited by 132 · see citing works

Autophagy Promotes Replication of Influenza A Virus In Vitro

Wang, R., Zhu, Y., Zhao, J., Ren, C., Li, P., Chen, H., Jin, M., & Zhou, H. (2018) · Journal of Virology · doi:10.1128/jvi.01984-18 · Cited by 126 · see citing works

New insights into the function of Atg9

Webber, J. L., & Tooze, S. A. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.020 · Cited by 123 · see citing works

Connections between endoplasmic reticulum stress-associated unfolded protein response, mitochondria, and autophagy in arsenic-induced carcinogenesis

Wadgaonkar, P., & Chen, F. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.04.004 · Cited by 120 · see citing works

Rapamycin Upregulates Autophagy by Inhibiting the mTOR-ULK1 Pathway, Resulting in Reduced Podocyte Injury

Wu, L., Feng, Z., Cui, S., Hou, K., Tang, L., Zhou, J., Cai, G., Xie, Y., Hong, Q., Fu, B., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063799 · Cited by 117 · see citing works

Autophagy in Hypertensive Heart Disease

Wang, Z. V., Rothermel, B. A., & Hill, J. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r109.025023 · Cited by 116 · see citing works

DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX

Guan, J.-J., Zhang, X.-D., Sun, W., Qi, L., Wu, J.-C., & Qin, Z.-H. (2015) · Cell Death & Disease · doi:10.1038/cddis.2014.546 · Cited by 105 · see citing works

The emergence of noncoding RNAs as Heracles in autophagy

Zhang, J., Wang, P., Wan, L., Xu, S., & Pang, D. (2017) · Autophagy · doi:10.1080/15548627.2017.1312041 · Cited by 105 · see citing works

Autophagy in Cancer: Regulation by Small Molecules

Limpert, A. S., Lambert, L. J., Bakas, N. A., Bata, N., Brun, S. N., Shaw, R. J., & Cosford, N. D. P. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.10.004 · Cited by 104 · see citing works

Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity

López-Lluch, G. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.005 · Cited by 103 · see citing works

AMPK and Cancer

Wang, Z., Wang, N., Liu, P., & Xie, X. (2016) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-319-43589-3_9 · Cited by 103 · see citing works

Modulating Mitophagy in Mitochondrial Disease

Dombi, E., Mortiboys, H., & Poulton, J. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170616101741 · Cited by 99 · see citing works

Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation

Kimball, S. R., Gordon, B. S., Moyer, J. E., Dennis, M. D., & Jefferson, L. S. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.03.008 · Cited by 97 · see citing works

MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin

Huang, N., Wu, J., Qiu, W., Lyu, Q., He, J., Xie, W., Xu, N., & Zhang, Y. (2015) · Cancer Biology & Therapy · doi:10.1080/15384047.2015.1040963 · Cited by 96 · see citing works

Identification of Small Molecule Inhibitors of Phosphatidylinositol 3-Kinase and Autophagy

Farkas, T., Daugaard, M., & Jäättelä, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.269134 · Cited by 91 · see citing works

Heat shock proteins as hallmarks of cancer: insights from molecular mechanisms to therapeutic strategies

Zuo, W., Pang, Q., Zhu, X., Yang, Q., Zhao, Q., He, G., Han, B., & Huang, W. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01601-1 · Cited by 88 · see citing works

Autophagy in airway diseases: a new frontier in human asthma?

Zeki, A. A., Yeganeh, B., Kenyon, N. J., Post, M., & Ghavami, S. (2015) · Allergy · doi:10.1111/all.12761 · Cited by 87 · see citing works

Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic β-cell apoptosis

Lambelet, M., Terra, L. F., Fukaya, M., Meyerovich, K., Labriola, L., Cardozo, A. K., & Allagnat, F. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0121-5 · Cited by 85 · see citing works

Small-Molecule Activators of AMP-Activated Protein Kinase (AMPK), RSVA314 and RSVA405, Inhibit Adipogenesis

Vingtdeux, V., Chandakkar, P., Zhao, H., Davies, P., & Marambaud, P. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00163 · Cited by 81 · see citing works

Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice

Huang, M., Wang, L., Jin, D., Zhang, Z., Chen, T., Jia, C., Wang, Y., Zhen, X.-C., Huang, B., Yan, B., et al. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-203231 · Cited by 81 · see citing works

Autophagy, signaling and obesity

Lavallard, V., Meijer, A. J., Codogno, P., & Gual, P. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.003 · Cited by 81 · see citing works

Autophagy, NAFLD and NAFLD-Related HCC

Wu, W. K. K., Zhang, L., & Chan, M. T. V. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-8684-7_10 · Cited by 78 · see citing works

Drug discovery targeting the mTOR pathway

Martelli, A. M., Buontempo, F., & McCubrey, J. A. (2018) · Clinical Science · doi:10.1042/cs20171158 · Cited by 76 · see citing works

The Multifaceted Roles of Autophagy in Tumors—Implications for Breast Cancer

Debnath, J. (2011) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-011-9223-3 · Cited by 75 · see citing works

Circ_0009910 promotes imatinib resistance through ULK1-induced autophagy by sponging miR-34a-5p in chronic myeloid leukemia

Cao, H., Miao, C., Sang, L., Huang, Y., Zhang, R., Sun, L., & Jiang, Z. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117255 · Cited by 72 · see citing works

Autophagy in Stem Cell Biology: A Perspective on Stem Cell Self-Renewal and Differentiation

Chen, X., He, Y., & Lu, F. (2018) · Stem Cells International · doi:10.1155/2018/9131397 · Cited by 72 · see citing works

Sestrin2: multifaceted functions, molecular basis, and its implications in liver diseases

Lu, C., Jiang, Y., Xu, W., & Bao, X. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05669-4 · Cited by 72 · see citing works

Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer

Rodríguez-Hernández, M. A., de la Cruz‐Ojeda, P., López-Grueso, M. J., Navarro‐Villarán, E., Requejo-Aguilar, R., Castejón‐Vega, B., Negrete, M., Gallego, P., Vega-Ochoa, Á., Víctor, V. M., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101510 · Cited by 72 · see citing works

Crosstalk of Hedgehog and mTORC1 Pathways

Larsen, L. J., & Møller, L. B. (2020) · Cells · doi:10.3390/cells9102316 · Cited by 65 · see citing works

Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability

Zou, J., Yue, F., Jiang, X., Li, W., Yi, J., & Liu, L. (2013) · Biochemical Journal · doi:10.1042/bj20130306 · Cited by 64 · see citing works

Sestrins at the crossroad between stress and aging

Lee, J. H., Bodmer, R., Bier, E., & Karin, M. (2010) · Aging · doi:10.18632/aging.100157 · Cited by 64 · see citing works

Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection

Fan, X., Tian, C., Wang, H., Xu, Y., Ren, K., Zhang, B., Chen, G., Shi, Q., Meng, G., Zhang, L.-B., et al. (2015) · Scientific Reports · doi:10.1038/srep14728 · Cited by 63 · see citing works

Caveolin-1, a stress-related oncotarget, in drug resistance

Wang, Z., Wang, N., Liu, P., Peng, F., Tang, H., Chen, Q., Xu, R., Dai, Y., Lin, Y. H., Xie, X., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5789 · Cited by 62 · see citing works

Lethal weapons: DAP-kinase, autophagy and cell death: DAP-kinase regulates autophagy.

Bialik, S., & Kimchi, A. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.11.004 · Cited by 67 · see citing works

Autophagosome biogenesis machinery.

Walker, S. A., & Ktistakis, N. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.10.027 · Cited by 55 · see citing works

Advances in indole-containing alkaloids as potential anticancer agents by regulating autophagy

Luo, M.-L., Huang, W., Zhu, H.-P., Peng, C. Y., Zhao, Q., & Han, B. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112827 · Cited by 59 · see citing works

The pleiotropic roles of sphingolipid signaling in autophagy

Li, Y., Li, S., Qin, X.-J., Hou, W., Dong, H., Yao, L., & Xiong, L. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.215 · Cited by 58 · see citing works

Autophagic Cellular Responses to Physical Exercise in Skeletal Muscle

Tam, B. T., & Siu, P. M. (2014) · Sports Medicine · doi:10.1007/s40279-013-0140-z · Cited by 59 · see citing works

Sustained activation of autophagy suppresses adipocyte maturation via a lipolysis-dependent mechanism

Zhang, X., Wu, D., Wang, C., Luo, Y., Ding, X., Yang, X., Silva, F. D., Arenas, S., Weaver, J. M., Mandell, M. A., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1703355 · Cited by 58 · see citing works

Autophagy in cancers including brain tumors: role of MicroRNAs

Pourhanifeh, M. H., Mahjoubin‐Tehran, M., Karimzadeh, M. R., Mirzaei, H. R., Razavi, Z. S., Sahebkar, A., Hosseini, N., Mirzaei, H., & Hamblin, M. R. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00587-w · Cited by 59 · see citing works

The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation

Kim, J. H., Seo, D., Kim, S., Choi, D. W., Park, J. S., Ha, J., Choi, J., Lee, J.-H., Jung, S. M., Seo, K., et al. (2018) · EMBO Reports · doi:10.15252/embr.201744378 · Cited by 56 · see citing works

Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging

Kim, M., Park, H. L., Park, H., Ro, S., Nam, S., Reed, J. M., Guan, J., & Lee, J. H. (2013) · Autophagy · doi:10.4161/auto.24811 · Cited by 56 · see citing works

Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes?

López‐Lluch, G., Hernández‐Camacho, J. D., Fernández‐Ayala, D. J. M., & Navas, P. (2018) · Biogerontology · doi:10.1007/s10522-018-9768-2 · Cited by 57 · see citing works

Herbal Extracts and Natural Products in Alleviating Non-alcoholic Fatty Liver Disease via Activating Autophagy

Zhang, L. R., Yao, Z., & Ji, G. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01459 · Cited by 56 · see citing works

The Atg17-Atg31-Atg29 Complex Coordinates with Atg11 to Recruit the Vam7 SNARE and Mediate Autophagosome-Vacuole Fusion

Liu, X., Mao, K., Yu, A., Omairi‐Nasser, A., Austin, J. R., Glick, B. S., Yip, C. K., & Klionsky, D. J. (2016) · Current Biology · doi:10.1016/j.cub.2015.11.054 · Cited by 55 · see citing works

A review of the mechanism of DDIT4 serve as a mitochondrial related protein in tumor regulation

Ding, F., Gao, F., Zhang, S., Lv, X., Chen, Y., & Liu, Q. (2021) · Science Progress · doi:10.1177/0036850421997273 · Cited by 54 · see citing works

Tsc1 Regulates the Balance Between Osteoblast and Adipocyte Differentiation Through Autophagy/Notch1/β-Catenin Cascade

Choi, H. K., Yuan, H., Fang, F., Wei, X., Liu, L., Li, Q., Guan, J., & Liu, F. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3530 · Cited by 54 · see citing works

Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics

Bata, N., & Cosford, N. D. P. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.1c00130 · Cited by 55 · see citing works

Vorinostat-induced autophagy switches from a death-promoting to a cytoprotective signal to drive acquired resistance

Dupéré-Richer, D., Kinal, M., Ménasché, V., Nielsen, T. H., Rincon, S. V. D., Pettersson, F., & Miller, W. H. (2013) · Cell Death and Disease · doi:10.1038/cddis.2012.210 · Cited by 53 · see citing works

The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity

Gan, L., Seki, A., Shen, K., Iyer, H., Han, K., Hayer, A., Wollman, R., Ge, X.-C., Lin, J., Dey, G., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0321-6 · Cited by 42 · see citing works

BNIP3 is essential for mediating 6-thioguanine- and 5-fluorouracil-induced autophagy following DNA mismatch repair processing

Zeng, X., & Kinsella, T. J. (2010) · Cell Research · doi:10.1038/cr.2010.40 · Cited by 52 · see citing works

ULK1 phosphorylates Sec23A and mediates autophagy-induced inhibition of ER-to-Golgi traffic

Gan, W., Zhang, C., Siu, K. Y., Satoh, A., Tanner, J. A., & Yu, S. S. B. (2017) · BMC Cell Biology · doi:10.1186/s12860-017-0138-8 · Cited by 52 · see citing works

PI3K/AKT/mTOR pathway plays a major pathogenetic role in glycogen accumulation and tumor development in renal distal tubules of rats and men

Ribback, S., Cigliano, A., Kroeger, N., Pilo, M. G., Terracciano, L., Burchardt, M., Bannasch, P., Calvisi, D. F., & Dombrowski, F. (2015) · Oncotarget · doi:10.18632/oncotarget.3675 · Cited by 51 · see citing works

The Physiological Role of Mitophagy: New Insights into Phosphorylation Events

Hirota, Y., Kang, D., & Kanki, T. (2012) · International Journal of Cell Biology · doi:10.1155/2012/354914 · Cited by 50 · see citing works

Autophagy and LRRK2 in the Aging Brain

Albanese, F., Novello, S., & Morari, M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01352 · Cited by 51 · see citing works

“Get the Balance Right”: Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders

Castets, P., Frank, S., Sinnreich, M., & Rüegg, M. A. (2016) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-160153 · Cited by 49 · see citing works

Downregulation of MicroRNA-193b-3p Promotes Autophagy and Cell Survival by Targeting TSC1/mTOR Signaling in NSC-34 Cells

Li, C., Chen, Y., Chen, X., Wei, Q., Cao, B., & Shang, H. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00160 · Cited by 45 · see citing works

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

Jung, C. H., Jun, C. B., Ro, S.-H., Kim, Y.-M., Otto, N. M., Cao, J., Kundu, M., & Kim, D.-H. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1249 · Cited by 2,025 · see citing works

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S.-I., Natsume, T., Takehana, K., Yamada, N., et al. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1248 · Cited by 2,076 · see citing works

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

Dunlop, E. A., Hunt, D. K., Acosta-Jaquez, H. A., Fingar, D. C., & Tee, A. R. (2011) · Autophagy · doi:10.4161/auto.7.7.15491 · Cited by 219 · see citing works

The role of the Atg1/ULK1 complex in autophagy regulation

Mizushima, N. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.004 · Cited by 1,062 · see citing works

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy

Puente, C., Hendrickson, R. C., & Jiang, X. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.689646 · Cited by 223 · see citing works